Symptom Improvement Following Treatment with the Inhaled Dual Phosphodiesterase 3 and 4 Inhibitor Ensifentrine in Patients with Moderate to Severe COPD – A Detailed Analysis

Efficacy and safety of a first-in-class inhaled PDE3/4 inhibitor (ensifentrine) vs salbutamol in asthma

(2019) Leif Bjermer et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

The short term bronchodilator effects of the dual PDE3 and PDE4 inhibitor RPL554 in COPD

(2018) Dave Singh et al.   EUROPEAN RESPIRATORY JOURNAL

Greater dyspnea is associated with lower health-related quality of life among European patients with COPD

(2017) Jean-Bernard Gruenberger et al.   International Journal of Chronic Obstructive Pulmonary Disease

Now We Know Who You Are: A Clear Description of Mononuclear Phagocyte Subsets in the Human Lung

(2016) Dave Singh et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Effect of Roflumilast and Inhaled Corticosteroid/Long-Acting β2-Agonist on Chronic Obstructive Pulmonary Disease Exacerbations (RE2SPOND). A Randomized Clinical Trial

(2016) Fernando J. Martinez et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Effect of roflumilast on exacerbations in patients with severe chronic obstructive pulmonary disease uncontrolled by combination therapy (REACT): a multicentre randomised controlled trial

(2015) Fernando J Martinez et al.   LANCET

Resource Use and Costs up to Two Years Post Diagnosis Among Newly Diagnosed COPD Patients in the UK Primary Care Setting: A Retrospective Cohort Study

(2014) Yogesh Suresh Punekar et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

The impact of COPD on health status: findings from the BOLD study

(2013) Christer Janson et al.   EUROPEAN RESPIRATORY JOURNAL

Efficacy and safety of RPL554, a dual PDE3 and PDE4 inhibitor, in healthy volunteers and in patients with asthma or chronic obstructive pulmonary disease: findings from four clinical trials

(2013) Lui G Franciosi et al.   Lancet Respiratory Medicine

Symptom variability in patients with severe COPD: a pan-European cross-sectional study

(2010) R. Kessler et al.   EUROPEAN RESPIRATORY JOURNAL

Dual PDE3/4 inhibitors as therapeutic agents for chronic obstructive pulmonary disease

(2009) Katharine H Banner et al.   BRITISH JOURNAL OF PHARMACOLOGY