Article
Cardiac & Cardiovascular Systems
Xinying Yang, Xiaoyu Du, Ke Ma, Guoqi Li, Zhuohui Liu, Wei Rong, Huangtai Miao, Fuli Zhu, Qinghua Cui, Shaowei Wu, Yulin Li, Jie Du
Summary: This study found that circulating miR-26a-5p, miR-21-5p, and miR-191-5p levels were lower in patients who experienced major adverse cardiovascular events after acute myocardial infarction compared to those who did not. Multivariate conditional logistic regression analysis showed that these miRNAs were significantly inversely associated with incident primary composite outcomes. Combining these miRNAs with B-type natriuretic peptide improved risk scores recommended in the current guidelines.
CANADIAN JOURNAL OF CARDIOLOGY
(2021)
Review
Medicine, General & Internal
Ioan Tilea, Andreea Varga, Razvan Constantin Serban
Summary: AMI remains a leading cause of mortality worldwide, and fast and reliable diagnosis is crucial in reducing mortality. New biomarker detection methods have the potential to improve AMI diagnosis and management, overcoming current limitations.
Article
Multidisciplinary Sciences
Yasmina Chouik, Fanny Lebosse, Marie-Laure Plissonnier, Jean-Christophe Lega, Pierre Pradat, Teresa Antonini, Miroslava Subic, Kerstin Hartig-Lavie, Domitille Erard, Francois Villeret, Celine Guichon, Audrey Payance, Sylvie Radenne, Pierre-Emmanuel Rautou, Fabien Zoulim, Massimo Levrero
Summary: Bacterial infections are a common and dangerous complication in patients with acute decompensation of cirrhosis. This study investigated the potential of circulating microRNAs to diagnose bacterial infections and predict survival in these patients. The analysis found that certain miRNAs can be used as biomarkers to accurately diagnose bacterial infections, and a combination of other miRNAs can help predict survival. Circulating miRNAs show dysregulation in patients with acute decompensation of cirrhosis, suggesting their potential as diagnostic and prognostic tools.
Article
Cardiac & Cardiovascular Systems
Kai M. Eggers, Lars Lindhagen, Tomasz Lars Lindhagen Baron, David Erlinge, Marcus Hjort, Tomas Jernberg, Gyorgy Marko-Varga, Melinda Rezeli, Jonas Spaak, Bertil Lindahl
Summary: This study analyzed the prognostic value of 175 biomarkers in acute myocardial infarction patients, and found that TRAIL-R2, CA-125, FGF-23 emerged as risk predictors for all-cause mortality and heart failure hospitalizations. However, the prognostic value of biomarkers was abrogated following additional adjustment for clinical variables.
EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE
(2021)
Review
Medicine, General & Internal
Jia Wang, Liwenjing Xu, Lu Tian, Qiyu Sun
Summary: The study demonstrates the effectiveness of miR-208 as a biomarker for early diagnosis of acute myocardial infarction, with high sensitivity and specificity, being able to differentiate between AMI patients and healthy controls.
Review
Pharmacology & Pharmacy
Arun K. Sharma, Priyanka Bisht, Bishal Gupta, Sayeed Akhtar, Sirajudeen Shaik Alavudeen, Obaid Afzal, Abdulmalik S. A. Altamimi
Summary: Current research focuses on small non-coding RNA molecules (miRNAs), which have emerged as potential biomarkers with variable diagnostic values and false-positives in different conditions that limit their clinical preference. The pathology of myocardial infarction and the alterations in miRNAs for their specificity, stability, and prognostic value at the early stage of acute myocardial infarction (AMI) are thoroughly examined. The study concludes that novel biomarkers, including miRNA-1, miRNA-208a/b, and miRNA-499, could be used to predict the emergence of AMI at an early stage.
DRUG DISCOVERY TODAY
(2023)
Review
Cardiac & Cardiovascular Systems
Soudeh Ghafouri-Fard, Mahdi Gholipour, Mohammad Taheri
Summary: miRNAs play a crucial role in the pathophysiological process of CAD, with up-regulated and down-regulated miRNAs associated with the development of CAD, which can be utilized for diagnostic and prognostic evaluation of CAD.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Tuttolomondo Domenico, Antonelli Rita, Setti Giacomo, Ardissino Diego, Pertinhez Thelma, Gallo Mariana, Niccoli Giampaolo, Nicolini Francesco, Georgaki Maria, Formica Francesco, Borrello Bruno, Meleti Marco, Cassi Diana
Summary: Salivary biomarkers, such as cardiac troponin, C-reactive protein, and adiponectin, show potential for the early identification of acute myocardial infarction (AMI). However, further studies are needed to confirm their effectiveness as substitutes for serological markers.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Review
Medical Laboratory Technology
Yudong Wu, Qian Li, Renshuai Zhang, Xiaoli Dai, Wujun Chen, Dongming Xing
Summary: MicroRNAs, approximately 20-24 nucleotides in length, are considered reliable diagnostic and prognostic biomarkers for various diseases due to their reflection of disease progression and drug resistance. They play a crucial role in the diagnosis, prognosis, and treatment response prediction of diseases, potentially improving cure rates.
CLINICA CHIMICA ACTA
(2021)
Article
Hematology
Jamshid Motaei, Mohammad Amin Kerachian, Seied Asadollah Mousavi, Kamran Alimoghadam, Ardeshir Ghavamzadeh, Saba Manoochehrabadi, Mohammad Ahmadvand, Marjan Yaghmaie
Summary: This study validated the potential of circulating microRNAs as diagnostic biomarkers for aGVHD, identifying significant changes in miR-455-3p, miR-5787, and miR-548a-3p expression in aGVHD patients, with potentially high diagnostic accuracy. In silico analysis provided insights into the roles of these microRNAs in GVHD, immune regulation, and inflammatory response. This suggests miR-455-3p, miR-5787, and miR-548a-3p could serve as potential noninvasive biomarkers and therapeutic targets in aGVHD.
ANNALS OF HEMATOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Cristian Statescu, Larisa Anghel, Bogdan-Sorin Tudurachi, Andreea Leonte, Laura-Catalina Benchea, Radu-Andy Sascau
Summary: Despite lacking an ideal biomarker for risk assessment in patients with AMI, recent studies have shown promising results. Several novel biomarkers related to the pathophysiological processes in AMI patients have been identified, and their inclusion in multi-biomarker strategies may provide additional prognostic value. Additionally, the use of artificial intelligence algorithms for risk stratification and prognostic assessment has the potential to significantly improve outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Caelan Taggart, Ryan Wereski, Nicholas L. Mills, Andrew R. Chapman
Summary: The increased use of high-sensitivity cardiac troponins in clinical practice has raised awareness of non-ischaemic myocardial injury. While such injuries can be caused by various diseases, evidence suggests that patients' clinical outcomes are poor.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Alina Ioana Scarlatescu, Miruna Mihaela Micheu, Nicoleta-Monica Popa-Fotea, Maria Dorobantu
Summary: MicroRNAs have emerged as promising tools in the field of cardiovascular diseases, with potential in diagnostic, prognostic, and therapeutic applications for patients with ST elevation myocardial infarction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Marta Lozano-Prieto, David Adlam, Marcos Garcia-Guimaraes, Ancor Sanz-Garcia, Paula Vera-Tome, Fernando Rivero, Javier Cuesta, Teresa Bastante, Anna A. Baranowska-Clarke, Alicia Vara, Enrique Martin-Gayo, Miguel Vicente-Manzanares, Pilar Martin, Nilesh J. Samani, Francisco Sanchez-Madrid, Fernando Alfonso, Hortensia de la Fuente
Summary: The study found that specific miRNAs have significantly different expression in the plasma of SCAD and AT-AMI patients, and the combined expression of these four miRNAs can better distinguish between the two diseases. Functional analysis revealed an association of these miRNAs with blood vessel biology, TGF-beta pathway, and cytoskeletal traction force.
Review
Biochemistry & Molecular Biology
Attila A. Seyhan
Summary: There is an urgent need for robust and reliable biomarkers for early diagnosis, prognosis, and prediction of response to specific treatments in aggressive and deadly cancers, such as pancreatic cancer. Liquid biopsy-based miRNA profiling shows potential for fulfilling this need. MiRNAs are non-coding RNAs that regulate gene expression and have emerged as potential diagnostic, prognostic, predictive, and therapeutic biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Lei Zhang, Yuan Zhang, Fei Yu, Xin Li, Huijuan Gao, Peifeng Li
Summary: This paper systematically reviews the role of circRNAs in myocardial infarction (MI) and explores their potential in diagnosis and clinical therapies.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Hongjing Cai, Pengchao Tian, Jie Ju, Tao Wang, Xinzhe Chen, Kai Wang, Fei Wang, Xue Yu, Shaocong Wang, Yin Wang, Chan Shan, Peifeng Li
Summary: This study demonstrates that doxorubicin induces apoptosis in cardiomyocytes and identified a dysregulated long noncoding RNA (lncRNA), lnc5745, in doxorubicin-treated cardiomyocytes. Overexpression of lnc5745 alleviates cardiomyocyte apoptosis induced by doxorubicin both in vitro and in vivo, while silencing lnc5745 promotes cardiomyocyte apoptosis. Additionally, Rab2A, a direct target of lnc5745, has a protective effect in doxorubicin-induced cardiotoxicity. Mechanistically, Rab2A interacts with p53 and promotes its phosphorylation, thereby activating the apoptotic pathway.
CELL DEATH DISCOVERY
(2022)
Review
Fisheries
Zhixia Zhou, Yanxin He, Shoushi Wang, Yin Wang, Peipei Shan, Peifeng Li
Summary: Autophagy is a conserved cellular process essential for maintaining metabolism and energy balance, with implications in various physiological functions and clinical diseases. However, little is known about autophagy in teleost fish. This review provides an overview of the current knowledge of autophagy in teleosts, focusing on its physiological and pathological regulation in different processes. The potential options for targeting autophagy in teleosts for domestication, farming, or therapeutic strategies are also explored.
Review
Biotechnology & Applied Microbiology
Huijuan Gao, Xin Li, Xiatian Chen, Deng Hai, Chuang Wei, Lei Zhang, Peifeng Li
Summary: Probiotics are live microorganisms with health-promoting effects that are widely used in various fields. Lactobacillus acidophilus, an important human intestinal probiotic, has been extensively studied since its discovery in 1900, and has key roles in human health with potential applications in functional, edible probiotic preparations due to its resistance to acid and bile salts. Discussions on the research progress and future development of probiotic products are ongoing.
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Review
Physiology
Xiatian Chen, Chengzhen Shi, Yin Wang, Hua Yu, Yu Zhang, Jiaxuan Zhang, Peifeng Li, Jinning Gao
Summary: Patients with diabetes often experience severe vascular complications, which are influenced by glycolipid metabolism disorder. Hyperglycemia and hyperlipidemia trigger inflammation and oxidative stress, leading to endothelial dysfunction and vascular damage. Additionally, epigenetic modifications play a role in the pathogenesis of diabetes.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Oncology
Man Wang, Yuan Zhang, Wenguang Chang, Lei Zhang, Konstantinos N. Syrigos, Peifeng Li
Summary: Pyroptosis, a form of programmed cell death, is closely associated with cancer initiation and development. Noncoding RNAs (ncRNAs), including microRNAs (miRNAs), long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs), play essential roles in modulating pyroptosis and affecting various hallmarks of cancer. This review provides an overview of the complex roles of ncRNAs in regulating pyroptosis, with a focus on their underlying mechanisms and potential applications as biomarkers and therapeutic targets in cancer.
FRONTIERS IN ONCOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Qinrui Fu, Leilei Yu, Yin Wang, Peifeng Li, Jibin Song
Summary: Chronic diseases claim millions of lives every year, and it is important to develop advanced drugs for better treatment. Nanotheranostics, which integrate diagnosis and treatment into a single nanosystem, have shown great potential. However, their applications in nanomedicine are still in the early stages.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Medicine, Research & Experimental
Zeyu Jiang, Meihua Zhang, Peifeng Li, Yin Wang, Qinru Fu
Summary: Computed tomography (CT) is a widely used diagnostic tool in hospitals worldwide, but it faces limitations in distinguishing soft tissues from normal organs and tumors. To improve imaging sensitivity and contrast, various nanomaterial-based CT contrast agents have been developed. In this review, we discuss CT contrast agents based on gold (Au), bismuth (Bi), lanthanide (Ln), and transition metal (TM) nanomaterials, along with their applications in image-guided therapy. Additionally, we summarize the use of CT image-guided therapy for various diseases and highlight the future perspectives of CT contrast agents and their biomedical applications.
Review
Engineering, Biomedical
Congcong Li, Yin Wang, Pei-Feng Li, Qinrui Fu
Summary: Nucleic acid nanomaterials, which have good biocompatibility, biodegradability, and programmability, are often combined with inorganic nanomaterials to improve their biological stability. However, the undefined toxic side effects of composite nanocarriers hinder their in vivo application. Recently, nanostructures composed entirely of DNA oligonucleotides have been rapidly developed as a nanotool to avoid potential biotoxicity and have been applied in biomedicine. This review discusses the assembly strategies of pure nucleic acid nanomaterials based on rolling circle amplification products and their applications in biosensing, bioimaging, and biomedicine.
ACTA BIOMATERIALIA
(2023)
Article
Oncology
Linlin Guo, Chaoying Liu, Chunyan Jiang, Yanhan Dong, Lynn Htet Htet Aung, Han Ding, Yanyan Gao
Summary: Mitochondria-mediated apoptosis is the primary cause of cardiomyocyte death. MCUR1 and miR-124 play important roles in regulating cardiomyocyte apoptosis. This study shows that miR-124 can inhibit cardiomyocyte apoptosis by activating MCUR1, suggesting their potential as biomarkers for myocardial injury and infarction.
MOLECULAR MEDICINE REPORTS
(2023)
Review
Immunology
Zhixia Zhou, Cuibo Leng, Zhan Wang, Linhai Long, Yiju Lv, Ziru Gao, Yin Wang, Shoushi Wang, Peifeng Li
Summary: Research in the past two decades has confirmed that noncoding RNAs (ncRNAs), present in cells from yeast to vertebrates, are functional regulators involved in cellular and physiological processes. Dysregulation of ncRNAs is linked to imbalances in cellular homeostasis and the development of diseases. In mammals, ncRNAs like long noncoding RNAs (lncRNAs) and microRNAs (miRNAs) serve as biomarkers and intervention targets in growth, development, immunity, and disease progression. The lncRNA-miRNA-mRNA axis, in which lncRNAs act as competing endogenous RNAs (ceRNAs), is the predominant mode of lncRNA-miRNA crosstalk. However, the role and mechanism of the lncRNA-miRNA-mRNA axis in teleost species have received little attention. This review provides an overview of the physiological and pathological regulation of the teleost lncRNA-miRNA-mRNA axis in growth and development, reproduction, skeletal muscle, immunity to bacterial and viral infections, and stress-related immune responses. It also explores the potential application of the lncRNA-miRNA-mRNA axis in the aquaculture industry.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Chunyan Jiang, Xin Liu, Zhenhua Li, Lulu Zeng, Rong Wang, Han Ding, Yuepeng Jin, Lifei Zheng
Summary: A protein-based nanocomposite was designed as a stabilizer and carrier for efficient delivery of ferrous ions to hepatoma cells, triggering ferroptosis. In vivo therapeutic outcomes showed low side effects and high tumor-inhibiting ratio in a hepatocellular carcinoma model.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Integrative & Complementary Medicine
Cheng-Xi Li, Yu-Meng Wang, Wen-Jing Zhang, Shu Zhang, Jian-Ping Li, Tong Zhou, Jin-Ao Duan, Jian-Ming Guo
Summary: Inflammatory bowel disease can be alleviated by Chinese herbal medicine Abelmoschus manihot through promoting IL-10 secretion and modulating gut microbiota. This study provides evidence that the protective effects of AM on IBD are IL-10-dependent and mediated by its regulation on gut microbial dysbiosis.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Tianxiang Li, Yanyan Yang, Hongzhao Qi, Weigang Cui, Lin Zhang, Xiuxiu Fu, Xiangqin He, Meixin Liu, Pei-feng Li, Tao Yu
Summary: CRISPR/Cas9 gene-editing technology is an ideal tool for treating diseases by repairing mutations or disrupting disease-causing genes. However, effectively delivering the CRISPR system to diseased cells in vivo is currently lacking, and nonviral vectors with target recognition functions may be the focus of future research. Pathological and physiological changes resulting from disease onset can be used for targeted delivery or gene editing.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Otorhinolaryngology
Changjiang Li, Yi Fang, Min Chen, Jian Chen, Haitao Wu, Peijie He, Lei Cheng
Summary: The application of CO2 laser surgery combined with a self-made laryngeal dilator is feasible and effective for the treatment of adult glottic stenosis.
ACTA OTO-LARYNGOLOGICA
(2023)
