期刊
CURRENT OPINION IN ONCOLOGY
卷 28, 期 6, 页码 511-517出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/CCO.0000000000000331
关键词
circulating tumor cells; flow cytometry; minimal residual disease; survival
类别
资金
- Cooperative Research Thematic Network grants of the Red de Cancer (Cancer Network of Excellence) [RD12/0036/0048, RD12/0036/0058, RD12/0036/0046, RD12/0036/0069]
- Instituto de Salud Carlos III, Spain
- Instituto de Salud Carlos III/Subdireccion General de Investigacion Sanitaria [FIS: PI060339, 06/1354, 02/0905, 01/0089/01-02, PS09/01897/01370, G03/136, Sara Borrell: CD13/00340]
- Asociacion Espanola Contra el Cancer, Spain [GCB120981SAN]
- International Myeloma Foundation (IMF) Junior Grant
- Black Swan Research Initiative of the IMF
- Multiple Myeloma Research Foundation Research Fellow Award
- Qatar National Research Fund (QNRF) Award [7-916-3-237]
- AACR-Millennium Fellowship in Multiple Myeloma Research [15-40-38-PAIV]
- European Research Council (ERC) Starting Grant
Purpose of reviewAlthough the input of multiparameter flow cytometry (MFC) into the clinical management of multiple myeloma patients has faced some reluctance, continuously growing evidence supports the utility of MFC in this disease.Recent findingsMFC immunophenotyping of bone marrow and peripheral blood plasma cells affords cost-effective assessment of clonality, and provides prognostic information on the risk of progression in smoldering multiple myeloma, and the identification of active multiple myeloma patients with dismal outcome (e.g., high numbers of circulating tumor cells) or long-term survival despite suboptimal responses through the characterization of monoclonal gammopathy of undetermined significance-like phenotypes. Extensive data indicate that minimal residual disease (MRD) monitoring can be used as biomarker to evaluate treatment efficacy and act as surrogate for survival. The time has come to address within clinical trials the exact role of baseline risk factors and MRD monitoring for tailored therapy in multiple myeloma, which implies systematic usage of highly sensitive cost-effective, readily available, and standardized MRD techniques such as MFC.SummaryNext-generation MFC should be considered mandatory in the routine evaluation of multiple myeloma patients both at diagnosis and after therapy, and represents an attractive technique to integrate with high-throughput DNA and RNA-seq methods to help in understanding the mechanisms behind dissemination and chemoresistance of multiple myeloma.
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