Article
Multidisciplinary Sciences
Masashi Takeuchi, Hideaki Suzuki, Yasuharu Matsumoto, Yoku Kikuchi, Kentaro Takanami, Toshihiro Wagatsuma, Jun Sugisawa, Satoshi Tsuchiya, Kensuke Nishimiya, Kiyotaka Hao, Shigeo Godo, Tomohiko Shindo, Takashi Shiroto, Jun Takahashi, Kiichiro Kumagai, Masahiro Kohzuki, Kei Takase, Yoshikatsu Saiki, Satoshi Yasuda, Hiroaki Shimokawa
Summary: The study aimed to investigate the association between preoperative cerebral blood flow (CBF) and delirium after transcatheter aortic valve implantation (DAT), and to determine if CBF measurement is useful for predicting DAT. The results showed that preoperative CBF in the insula was associated with DAT, and could be used for prediction.
Article
Geriatrics & Gerontology
Esther M. Wesselink, Masieh Abawi, Nynke H. M. Kooistra, Teus H. Kappen, Pierfrancesco Agostoni, Marielle Emmelot-Vonk, Wietze Pasma, Wilton A. Klei, Romy C. Jaarsveld, Charlotte S. Dongen, Pieter A. F. M. Doevendans, Arjen J. C. Slooter, Pieter R. Stella
Summary: Postoperative delirium (POD) is a common complication after transcatheter aortic valve replacement (TAVR), but the study found that intraoperative hypotension (IOH) is not independently associated with POD occurrence after TAVR. Other factors besides intraoperative hypotension may explain the occurrence of delirium.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Article
Cardiac & Cardiovascular Systems
Markus Krane, Johannes Boehm, Anatol Prinzing, Johannes Ziegelmueller, Johannes Holfeld, Ruediger Lange
Summary: Aortic valve neocuspidization using autologous pericardium offers a low reoperation rate within the first 2 years, with excellent hemodynamic performance and stable parameters within the first year.
ANNALS OF THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Flavien Vincent, Julien Ternacle, Tom Denimal, Mylene Shen, Bjorn Redfors, Cedric Delhaye, Matheus Simonato, Nicolas Debry, Basile Verdier, Bahira Shahim, Thibault Pamart, Hugues Spillemaeker, Guillaume Schurtz, Francois Pontana, Vinod H. Thourani, Philippe Pibarot, Eric Van Belle
Summary: TAVR is rapidly expanding its indications, but faces technical challenges and knowledge gaps when dealing with patients with bicuspid aortic valve (BAV). Physicians need to understand the BAV anatomy and TAVR procedure planning comprehensively to guide treatment decisions.
Article
Cardiac & Cardiovascular Systems
Tania Luque, Francisco J. Noriega, Angela McInerney, Alejandro Travieso, Daniel Corrochano, Gabriela Tirado-Conte, Carlos Ferrera, Salvador Fossati, Pilar Jimenez-Quevedo, Ivan Nunez-Gil, Nieves Gonzalo, Javier Escaned, Carlos Macaya, Antonio Fernandez-Ortiz, Luis Nombela-Franco, Ana Viana-Tejedor
Summary: In patients admitted to ACCU after TAVR, delirium is a common complication which is associated with factors such as prior cognitive impairment, peripheral arterial disease, use of general anaesthesia, and prolonged mechanical ventilation. Patients with delirium have a longer hospital stay and higher mortality rates.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Keti Vitanova, Syed Zaid, Gilbert H. L. Tang, Tsuyoshi Kaneko, Vinayak N. Bapat, Thomas Modine, EXPLANT TAVR Investigators
Summary: In this study, the outcomes of AVR and root replacement after TAVR explantation were compared. The results showed no differences in short-term mortality and morbidities between the two groups, although they had different clinical characteristics.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Geriatrics & Gerontology
Marc Humbert, Christophe J. Buela, Olivier Muller, Helene Krief, Pierre Monney
Summary: This study aimed to investigate the incidence, predictors, and relationship with cognitive performance of delirium in older patients undergoing aortic valve replacement surgery. Delirium occurred in about one in five patients, mostly within the first three postoperative days, suggesting the importance of early identification and intervention strategies. Cognitive performance and STS risk scores were found to be associated with delirium incidence in older patients undergoing AVR.
Review
Geriatrics & Gerontology
Xiaoteng Ma, Huijun Chu, Kangning Han, Qiaoyu Shao, Yi Yu, Shuo Jia, Dunliang Wang, Zhijian Wang, Yujie Zhou
Summary: This study conducted an updated systematic review and meta-analysis on postoperative delirium (POD) after transcatheter aortic valve replacement (TAVR). The findings showed that POD is common after TAVR and is associated with an increased risk of mortality. Accurate identification of risk factors for POD after TAVR and implementation of preventive measures are critical to improve prognosis.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Cardiac & Cardiovascular Systems
Shinichi Fukuhara, Chan Tran N. Nguyen, Karen M. Kim, Bo Yang, Gorav Ailawadi, Himanshu J. Patel, G. Michael Deeb
Summary: Despite the rapid adoption of transcatheter aortic valve replacement (TAVR), there are limited data on aortic valve reintervention after initial TAVR. A retrospective study reviewed 1487 patients who underwent TAVR and found that 24 (1.6%) required aortic valve reintervention. Most patients were deemed unsuitable for repeat TAVR due to concurrent cardiac procedures, unfavorable anatomy, or endocarditis. Therefore, careful assessment of TAVR repeatability should be considered in the initial TAVR evaluation, especially for younger patients who may require aortic valve reintervention.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Alessandra Francica, Mikhail Dodonov, Filippo Tonelli, Gaetano Paolino, Gabriele Pesarini, Flavio Ribichini, Giuseppe Faggian, Francesco Onorati
Summary: This report describes a rare case of early postoperative fatal ViV-TAVR thrombosis despite adequate anticoagulation in addition to dual antiplatelet therapy.
ANNALS OF THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Kees van der Wulp, Marleen H. van Wely, Yvonne Schoon, Priya Vart, Marcel G. M. Olde Rikkert, Wim J. Morshuis, Niels van Royen, Michel W. A. Verkroost, Helmut R. Gehlmann, Leen A. F. M. Van Garsse, Peter C. Kievit
Summary: This study highlights impaired mobility as the best single predictor for postoperative delirium and 2-year mortality in high-risk elderly patients undergoing TAVI. Prospective multicenter studies are needed to further explore and optimize the use of predictors for delirium in TAVI care pathways.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Michel Pompeu B. O. Sa, Jef Van den Eynde, Matheus Simonato, Luiz Rafael P. Cavalcanti, Ilias P. Doulamis, Viktoria Weixler, Polydoros N. Kampaktsis, Michele Gallo, Pietro L. Laforgia, Konstantin Zhigalov, Arjang Ruhparwar, Alexander Weymann, Philippe Pibarot, Marie-Annick Clavel
Summary: Valve-in-valve transcatheter aortic valve replacement (ViV TAVR) shows lower 30-day mortality, major bleeding, and shorter hospital stay compared to redo surgical aortic valve replacement (redo SAVR), but is associated with higher rates of severe patient-prosthesis mismatch. There is a lack of comparative studies with long-term follow-up results.
JACC-CARDIOVASCULAR INTERVENTIONS
(2021)
Article
Cardiac & Cardiovascular Systems
James C. Witten, Emily Durbak, Penny L. Houghtaling, Shinya Unai, Eric E. Roselli, Faisal G. Bakaeen, Douglas R. Johnston, Lars G. Svensson, Wael Jaber, Eugene H. Blackstone, Gosta B. Pettersson
Summary: The study confirms the long-term acceptable hemodynamic performance and durability of aortic allografts, suggesting that concern about structural failure should not limit their use. Modifiable risk factors for structural failure include recipient hypertension, allograft size, and donor age.
ANNALS OF THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Alberto Alperi, Josep Rodes-Cabau, Matheus Simonato, Didier Tchetche, Gaetan Charbonnier, Henrique B. Ribeiro, Azeem Latib, Matteo Montorfano, Marco Barbanti, Sabine Bleiziffer, Bjorn Redfors, Mohamed Abdel-Wahab, Abdelhakim Allali, Giuseppe Bruschi, Massimo Napodano, Marco Agrifoglio, Anna Sonia Petronio, Cristina Giannini, Albert Chan, Ran Kornowski, Nili Schamroth Pravda, Matti Adam, Alessandro Iadanza, Stephane Noble, Andrew Chatfield, Magdalena Erlebach, Joerg Kempfert, Timm Ubben, Harindra Wijeysundera, Moritz Seiffert, Thomas Pilgrim, Won-Keun Kim, Luca Testa, David Hildick-Smith, Roberto Nerla, Claudia Fiorina, Christina Brinkmann, Lars Conzelmann, Didier Champagnac, Francesco Saia, Henrik Nissen, Hafid Amrane, Brian Whisenant, Jasmin Shamekhi, Lars Sondergaard, John G. Webb, Danny Dvir
Summary: In a large series of ViV-TAVR procedures, the incidence of periprocedural PPI was relatively low and decreased with the use of new-generation THV systems. Older age, larger THV size, and previous right bundle branch block were associated with an increased risk of PPI. Although there were no significant differences in 30-day mortality between the PPI and no-PPI groups, PPI patients exhibited a trend toward higher mortality risk at follow-up.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Valerie Pavlicek, Felix Mahfoud, Katharina Bubel, Peter Fries, Sebastian Ewen, Michael Boehm, Bruno Scheller, Christian Ukena
Summary: The aim of this study was to investigate clinical, anatomical, procedural, and electrophysiological parameters predicting intraventricular conduction disturbances (ICA) after transcatheter aortic valve replacement (TAVR). The results showed that new-onset left bundle branch block (BBB) and diabetes mellitus independently predicted high-degree atrioventricular block (HAVB) requiring permanent pacemaker (PPM) implantation, and helped identify high-risk patients.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Anesthesiology
Simon T. Dillon, Hasan H. Otu, Long H. Ngo, Tamara G. Fong, Sarinnapha M. Vasunilashorn, Zhongcong Xie, Lisa J. Kunze, Kamen V. Vlassakov, Ayesha Abdeen, Jeffrey K. Lange, Brandon E. Earp, Zara R. Cooper, Eva M. Schmitt, Steven E. Arnold, Tammy T. Hshieh, Richard N. Jones, Sharon K. Inouye, Edward R. Marcantonio, Towia A. Libermann
Summary: Using SOMAscan assay, this study identifies acute and longer-term proteome changes associated with surgery in plasma and cerebrospinal fluid (CSF) in older patients. The findings suggest potential biomarkers for neuroinflammation and provide insights into the neuroinflammatory response to surgery.
ANESTHESIA AND ANALGESIA
(2023)
Article
Geriatrics & Gerontology
Tammy T. Hshieh, Eva M. Schmitt, Tamara G. Fong, Steve Arnold, Michele Cavallari, Bradford C. Dickerson, Simon T. Dillon, Richard N. Jones, Towia A. Libermann, Edward R. Marcantonio, Alvaro Pascual-Leone, Mouhsin M. Shafi, Alexandra Touroutoglou, Thomas G. Travison, Ray Yun Gou, Douglas Tommet, Ayesha Abdeen, Brandon Earp, Lisa Kunze, Jeffrey Lange, Kamen Vlassakov, Sharon K. Inouye
Summary: The SAGES II study aims to enhance our understanding of the correlation between delirium and dementia by examining various biomarkers in older adults undergoing major surgery. The study utilizes a range of assessment methods and techniques, including cognitive testing, neuroimaging, and neurophysiology. This study provides valuable insights into the relationship between delirium and dementia.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Geriatrics & Gerontology
Jessica M. Ross, Emiliano Santarnecchi, Shu Jing Lian, Tamara G. Fong, Alexandra Touroutoglou, Michele Cavallari, Thomas G. Travison, Edward R. Marcantonio, Towia A. Libermann, Eva M. Schmitt, Sharon K. Inouye, Mouhsin M. Shafi, Alvaro Pascual-Leone
Summary: Post-surgical delirium is a serious complication that can lead to cognitive decline and loss of function. This study found that neurophysiologic measures, such as resting-state EEG and transcranial magnetic stimulation, could predict the risk of delirium in older patients undergoing surgery.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Geriatrics & Gerontology
Franchesca Arias, Fan Chen, Haley Shiff, Edward R. Marcantonio, Richard N. Jones, Eva M. Schmitt, Eran Metzger, Tamara G. Fong, Thomas G. Travison, Sharon K. Inouye
Summary: The study found that higher paternal education was associated with lower incidence and severity of postoperative delirium, while higher maternal education was related to lower delirium incidence but did not reach statistical significance. The effect of paternal education on delirium incidence was independent of other patient characteristics, suggesting that examining early-life exposures may provide unique insights into the risks and pathogenesis of delirium.
CLINICAL GERONTOLOGIST
(2023)
Article
Cardiac & Cardiovascular Systems
Fayeza Ahmad, Rosie Fountotos, Michael Goldfarb, Neetika Bharaj, Haroon Munir, John Marsala, Lawrence G. Rudski, Jonathan Afilalo
Summary: This study successfully targeted frailty in cardiovascular disease patients using a multicomponent intervention, resulting in improved physical performance and functioning during their hospital stay.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
Article
Clinical Neurology
Tammy T. Hshieh, Ray Yun Gou, Richard N. Jones, Douglas L. Leslie, Edward R. Marcantonio, Guoquan Xu, Thomas G. Travison, Tamara G. Fong, Eva M. Schmitt, Sharon K. Inouye
Summary: This study examines the healthcare costs associated with delirium in older hospitalized patients with and without Alzheimer's disease and related dementias (ADRD). The findings show that patients with ADRD are more likely to develop delirium and have higher costs associated with delirium compared to non-ADRD patients. The costs increase progressively over the course of one year for ADRD patients, while the increase is consistent across time periods for non-ADRD patients.
ALZHEIMERS & DEMENTIA
(2023)
Article
Geriatrics & Gerontology
Rosie Fountotos, Fayeza Ahmad, Neetika Bharaj, Haroon Munir, John Marsala, Lawrence G. Rudski, Michael Goldfarb, Jonathan Afilalo
Summary: This study aimed to investigate the effects of an in-hospital multicomponent intervention on patient-centered outcomes in older patients with acute cardiovascular disease and frailty. The intervention improved health-related quality of life and mood but did not significantly impact disability scores.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Letter
Geriatrics & Gerontology
Ashley Kuzmik, John Hannan, Marie Boltz, Priyanka Shrestha, Erica K. K. Husser, Donna M. M. Fick, Edward R. R. Marcantonio
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Multidisciplinary Sciences
Chen-Yang Su, Sirui Zhou, Edgar Gonzalez-Kozlova, Guillaume Butler-Laporte, Elsa Brunet-Ratnasingham, Tomoko Nakanishi, Wonseok R. Jeon, David Morrison, Laetitia Laurent, Jonathan Afilalo, Marc Afilalo, Danielle Henry, Yiheng Chen, Julia Carrasco-Zanini, Yossi Farjoun, Maik Pietzner, Nofar Kimchi, Zaman Afrasiabi, Nardin Rezk, Meriem Bouab, Louis Petitjean, Charlotte Guzman, Xiaoqing Xue, Chris Tselios, Branka Vulesevic, Olumide Adeleye, Tala Abdullah, Noor Almamlouk, Yara Moussa, Chantal DeLuca, Naomi Duggan, Erwin Schurr, Nathalie Brassard, Madeleine Durand, Diane Marie Del Valle, Ryan A. Thompson, Mario Cedillo, Eric Schadt, Kai W. Nie, Nicole Simons, Konstantinos Mouskas, Nicolas Zaki, Manishkumar Patel, Hui Xie, Jocelyn Harris, Robert Marvin, Esther Cheng, Kevin Tuballes, Kimberly Argueta, Ieisha Scott, Celia M. T. Greenwood, Clare A. Paterson, Michael Hinterberg, Claudia Langenberg, Vincenzo Forgetta, Joelle Pineau, Vincent Mooser, Thomas D. Marron, Noam Beckmann, Seunghee W. Kim-schulze, Alexander Charney, Sacha E. Gnjatic, Daniel Kaufmann, Miriam Merad, J. Brent Richards
Summary: Measuring the abundance of 4701 proteins in the blood can help predict COVID-19 severity and guide clinical treatment.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Joseph Somech, Aayushi Joshi, Rita Mancini, Jessica Chetrit, Caroline Michel, Richard Sheppard, Viviane Nguyen, Mathieu Walker, Nadia Giannetti, Abhinav Sharma, Delina Maghakian, Esther Laforest, Jonathan Afilalo
Summary: This study found that three physical frailty scales were significantly associated with death, hospitalization, and reduced health-related quality of life in ambulatory patients with heart failure. Therefore, questionnaire or performance-based physical frailty scales can be used to offer prognostic value and a therapeutic target in this vulnerable population.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Medicine, General & Internal
Timothy S. S. Anderson, Shoshana J. J. Herzig, Bocheng Jing, W. John Boscardin, Kathy Fung, Edward R. R. Marcantonio, Michael A. A. Steinman
Summary: This study found that intensive pharmacologic antihypertensive treatment was associated with a greater risk of adverse events among hospitalized older adults with elevated blood pressures. These findings do not support the treatment of elevated inpatient blood pressures without evidence of end organ damage, and highlight the need for randomized clinical trials of inpatient blood pressure treatment targets.
JAMA INTERNAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Satoshi Yoshiji, Guillaume Butler-Laporte, Tianyuan Lu, Julian Daniel Sunday Willett, Chen-Yang Su, Tomoko Nakanishi, David R. Morrison, Yiheng Chen, Kevin Liang, Michael Hultstrom, Yann Ilboudo, Zaman Afrasiabi, Shanshan Lan, Naomi Duggan, Chantal DeLuca, Mitra Vaezi, Chris Tselios, Xiaoqing Xue, Meriem Bouab, Fangyi Shi, Laetitia Laurent, Hans Markus Munter, Marc Afilalo, Jonathan Afilalo, Vincent Mooser, Nicholas J. Timpson, Hugo Zeberg, Sirui Zhou, Vincenzo Forgetta, Yossi Farjoun, J. Brent Richards
Summary: In this study, researchers found that the plasma protein nephronectin plays a partial mediating role in linking obesity to COVID-19 severity. By using Mendelian randomization and omics analyses, they identified 1,216 proteins influenced by body mass index, and found that an increase in nephronectin levels was associated with higher odds of critically ill COVID-19 cases. This study sheds light on the mechanisms underlying the relationship between obesity and COVID-19 severity.
Review
Cardiac & Cardiovascular Systems
Tadhg Prendiville, Aoife Leahy, Ahmed Gabr, Fayeza Ahmad, Jonathan Afilalo, Glen Philip Martin, Mamas Mamas, Ivan P. Casserly, Abdirahman Mohamed, Anastasia Saleh, Elaine Shanahan, Margaret O'Connor, Rose Galvin
Summary: Based on the meta-analysis of preoperative frailty assessment using the CFS, it was found that frail individuals have a higher risk of mortality within 12 months after aortic valve intervention. These data support the importance of assessing frailty in elderly patients prior to aortic valve surgery.
Meeting Abstract
Cardiac & Cardiovascular Systems
Tadhg Prendiville, Aoife Leahy, Fayeza Ahmad, Ahmed Gabr, Jonathan Afilalo, A. Mamas Mamas, Ivan P. Casserly, Margaret O'Connor, Rose Galvin
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Leslie Unger, Jonathan Afilalo, Ding Yi Zhang, Ali Shaat
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)