Review
Biochemistry & Molecular Biology
Shengfeng Wan, Shengkai Wan, Xiaojing Jiao, Huixia Cao, Yue Gu, Lei Yan, Yan Zheng, Peiyuan Niu, Fengmin Shao
Summary: This article discusses the pathogenesis and treatment advances of diabetic kidney disease, emphasizing the need for developing new therapies to effectively control DKD and reduce morbidity and mortality in humans.
Review
Neurosciences
Mahdieh Golzari-Sorkheh, Carla E. Brown, Donald F. Weaver, Mark A. Reed
Summary: Alzheimer's disease is the most common form of dementia, but there is currently no curative drug. Recent failures in drug trials have cast doubt on the amyloid hypothesis approach to AD therapeutics design, leading to exploration of new neurochemical processes as potential drug targets. Among these, neuroinflammation, particularly the NLRP3 complex, is emerging as a leading candidate for further research.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Thayane Crestani, Renato O. Crajoinas, Leonardo Jensen, Leno L. Dima, Perrine Burdeyron, Thierry Hauet, Sebastien Giraud, Clara Steichen
Summary: After a three-week diet rich in sodium oxalate, rats developed stable chronic kidney disease with reduced glomerular filtration rate, elevated blood urea levels, and proteinuria. The model also displayed classical CKD complications such as elevated blood pressure and reduced hematocrit, making it a potential tool for research into CKD mechanisms and therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Hung-Jin Huang, Yu-Hsuan Lee, Li-Chin Sung, Yi-Jie Chen, Yu-Jhe Chiu, Hui-Wen Chiu, Cai-Mei Zheng
Summary: Renal inflammation and fibrosis are correlated with kidney function deterioration and CKD. Current therapies have limited effects, so innovative approaches are needed to mitigate CKD progression.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Review
Pharmacology & Pharmacy
Jordyn M. Thomas, Brooke M. Huuskes, Christopher G. Sobey, Grant R. Drummond, Antony Vinh
Summary: Chronic kidney disease (CKD) is an inflammatory condition, and the inflammasome and pro-inflammatory cytokine IL-18 play important roles in its development. Regulating the signaling pathways of the inflammasome and IL-18 may serve as potential targets for CKD treatment.
PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Immunology
Wei Xiong, Xian-Fang Meng, Chun Zhang
Summary: Metabolic syndrome can lead to metabolic disorders and impair kidney structure and function, while persistent inflammation exacerbates renal damage. Inflammasomes are key in initiating inflammation, and understanding their role in kidney damage caused by metabolic disorders can provide new therapeutic perspectives for kidney diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Multidisciplinary Sciences
Hongliang Zhang, Jie Gao, Yujie Tang, Tengchuan Jin, Jinhui Tao
Summary: Inflammasomes play a crucial role in both the innate and adaptive immune systems, acting as a bridge between these two components to maintain a fine balance in immune responses. Understanding the function of inflammasomes in lymphocytes can provide new insights into the mechanisms and treatment of various diseases, including autoimmune diseases and tumors.
JOURNAL OF ADVANCED RESEARCH
(2023)
Review
Immunology
Shasha Chen, Zhiyong Liao, Pinglong Xu
Summary: Mitochondria play versatile roles in cellular processes and have emerged as critical components in innate immunity. This review provides a comprehensive exploration of the multifaceted mechanisms underlying the interactions between mitochondria and innate immune responses. It discusses the roles of healthy mitochondria as platforms for signalosome assembly, the release of mitochondrial components as signaling messengers, and the regulation of signaling via mitophagy. Additionally, it explores the impacts of mitochondrial proteins and metabolites on modulating innate immune responses, immune cell polarization, and their implications in infectious and inflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Food Science & Technology
Po-Yen Lee, Ching-Chih Liu, Shu-Chi Wang, Kai-Yin Chen, Tzu-Chieh Lin, Po-Len Liu, Chien-Chih Chiu, I-Chen Chen, Yu-Hung Lai, Wei-Chung Cheng, Wei-Ju Chung, Hsin-Chih Yeh, Chi-Han Huang, Chia-Cheng Su, Shu-Pin Huang, Chia-Yang Li
Summary: ZEA suppresses macrophage-mediated innate immunity activated by LPS, attenuating the production of proinflammatory mediators and cytokines, inhibiting inflammatory signaling pathways, and repressing inflammasome activation. This suggests that ZEA-contaminated food intake may decrease innate immunity and increase adverse effects during infection.
Review
Pharmacology & Pharmacy
Pieter Dujardin, Roosmarijn E. Vandenbroucke, Lien Van Hoecke
Summary: The ultimate cause of Alzheimer's disease (AD) is still unknown, but the immune system plays a key role in its pathogenesis. Immunotherapy holds promise as a novel therapy for treating AD, but further research is needed to understand the interaction between AD and the different parts of our immune system.
DRUG DISCOVERY TODAY
(2022)
Article
Transplantation
Marja Puurunen, Caroline Kurtz, Alistair Wheeler, Kyra Mulder, Kyle Wood, Anna Swenson, Gary Curhan
Summary: This study aimed to assess whether 24-hour urine oxalate excretion is associated with the risk of chronic kidney disease (CKD). The results showed that as the urine oxalate excretion increased, the risk of developing CKD also increased. Therefore, future studies should investigate whether reducing urine oxalate can decrease the risk of CKD.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Immunology
Ruifeng Wang, Jingjing Zhang, Dandan Li, Guiling Liu, Yuqin Fu, Qing Li, Lei Zhang, Long Qian, Li Hao, Yiping Wang, David C. H. Harris, Deguang Wang, Qi Cao
Summary: This study investigated the frequency of circulating ILC subsets in various chronic kidney diseases (CKD) and found an increase in these subsets correlated with certain disease features. This suggests a possible role for ILCs in CKD.
CLINICAL IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ying Chen, Xingyan Ye, Germaine Escames, Wangrui Lei, Xin Zhang, Meng Li, Tong Jing, Yu Yao, Zhenye Qiu, Zheng Wang, Dario Acuna-Castroviejo, Yang Yang
Summary: The NOD-like receptor protein 3 (NLRP3) inflammasome is crucial in regulating innate immune responses and has been implicated in various inflammation-related diseases. This review discusses the activation and regulatory mechanism of the NLRP3 inflammasome, its role in different diseases, and potential therapeutic strategies targeting this complex.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2023)
Review
Medicine, General & Internal
Philip Chiu-Tsun Tang, Alex Siu-Wing Chan, Cai-Bin Zhang, Cristina Alexandra Garcia Cordoba, Ying-Ying Zhang, Ka-Fai To, Kam-Tong Leung, Hui-Yao Lan, Patrick Ming-Kuen Tang
Summary: Chronic kidney disease (CKD) is a major global health issue with complex pathogenic mechanisms and currently lacks effective therapeutic strategies. Immune cell dysfunction leads to inflammation and fibrosis, with TGF-beta 1 playing a critical role in promoting CKD progression.
FRONTIERS IN MEDICINE
(2021)
Review
Cell Biology
Valery Shestopalov, Markus Spurlock, Oliver W. Gramlich, Markus H. Kuehn
Summary: Glaucoma is a multifactorial disease that causes progressive vision loss by affecting retinal ganglion cells. Early events in the disease include oxidative, metabolic, or mechanical stress on RGC, leading to inflammatory responses and potential loss of RGC.
Review
Urology & Nephrology
Celeste Witting, Craig B. Langman, Dean Assimos, Michelle A. Baum, Annamaria Kausz, Dawn Milliner, Greg Tasian, Elaine Worcester, Meaghan Allain, Melissa West, Felix Knauf, John C. Lieske
Summary: Enteric hyperoxaluria, a unique condition caused by gastrointestinal disorders, can lead to kidney stones and even kidney failure. Current treatments involve correcting underlying gastrointestinal issues, modifying diet, and using calcium salts to bind oxalate, but there is still a lack of clinical evidence regarding their efficacy. Further research is necessary to understand the risk factors for adverse outcomes and evaluate the long-term effectiveness of existing treatments, as well as develop new therapeutic approaches.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Editorial Material
Urology & Nephrology
Martin Reichel, Felix Knauf
KIDNEY INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
Jing Liu, Maria Clarissa Tio, Ashish Verma, Insa M. Schmidt, Titilayo O. Ilori, Felix Knauf, Finnian R. Mc Causland, Sushrut S. Waikar
Summary: This study aimed to investigate predictors of urinary calcium excretion and its association with adverse clinical outcomes in chronic kidney disease (CKD). The results showed that estimated glomerular filtration rate (eGFR) was positively correlated with 24-hour urinary calcium excretion. The determinants of urinary calcium excretion differed between sexes and levels of CKD. Lower urinary calcium excretion was associated with higher risks of adverse outcomes, but these associations were greatly attenuated or nullified after adjustment for baseline eGFR.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Tong Liu, Inci Dogan, Michael Rothe, Julius V. Kunz, Felix Knauf, Maik Gollasch, Friedrich C. Luft, Benjamin Gollasch
Summary: The differences in oxylipins between arterial and venous blood in hemodialysis patients were evaluated in this study. It was found that hemodialysis increases arteriovenous differences in certain oxylipin metabolites, possibly due to the release and accumulation of metabolites in the venous blood stream. The decreased activity of soluble epoxide hydrolase contributed to these changes.
Letter
Urology & Nephrology
Anja Pfau, Felix Knauf
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tong Liu, Inci Dogan, Michael Rothe, Julius V. Kunz, Felix Knauf, Maik Gollasch, Friedrich C. Luft, Benjamin Gollasch
Summary: This study found differences in erythrocyte epoxy fatty acid profiles in arterial and venous blood in patients with renal failure who underwent hemodialysis treatment. The LOX pathway metabolites in erythrocytes showed arteriovenous differences after dialysis, indicating potential deleterious effects on circulation.
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
(2022)
Article
Medicine, Research & Experimental
Rebecca Ingenhoff, Juliet Nandawula, Trishul Siddharthan, Isaac Ssekitoleko, Richard Munana, Benjamin E. Bodnar, Ivan Weswa, Bruce J. Kirenga, Gerald Mutungi, Markus van der Giet, Robert Kalyesubula, Felix Knauf
Summary: This study aims to evaluate the effectiveness of a community health worker (CHW)-led intervention in blood pressure control among hypertensive patients in low-income and middle-income countries (LMICs). The intervention includes monthly household visits by trained CHWs for monitoring, assessment, and counseling. The results of this study will provide important information for hypertension management in LMIC settings.
Article
Biochemistry & Molecular Biology
Tong Liu, Inci Dogan, Michael Rothe, Jana Reichardt, Felix Knauf, Maik Gollasch, Friedrich C. Luft, Benjamin Gollasch
Summary: Uremia alters LCFA metabolism and increases the risk of cardiovascular events in chronic kidney disease (CKD) patients. Hemodialysis treatment influences blood LCFA bioaccumulation and transformation. Our study reveals the effect of hemodialysis on the fatty acid content differences in mature erythrocytes. These findings have implications for understanding the relationship between nutrition and cardiovascular health in patients with kidney disease.
Review
Urology & Nephrology
Theresa Ermer, Lama Nazzal, Maria Clarissa Tio, Sushrut Waikar, Peter S. Aronson, Felix Knauf
Summary: The maintenance of oxalate homeostasis is crucial for overall health, as disruptions in this balance can lead to kidney disease and cardiovascular complications. Recent studies have highlighted the importance of metabolic pathways, the microbiome, epithelial oxalate transporters, and adequate oxalate excretion in maintaining oxalate homeostasis.
NATURE REVIEWS NEPHROLOGY
(2023)
Article
Public, Environmental & Occupational Health
Rebecca Ingenhoff, Richard Munana, Ivan Weswa, Julia Gaal, Isaac Sekitoleko, Hillary Mutabazi, Benjamin E. Bodnar, Tracy L. Rabin, Trishul Siddharthan, Robert Kalyesubula, Felix Knauf, Christine K. Nalwadda
Summary: The study aims to explore perceptions of task shifting screening and referral for hypertension and diabetes to community health workers (CHWs) in rural Uganda, as a shortage of healthcare workers and an increasing burden of non-communicable diseases (NCDs) have resulted in gaps in care delivery for NCDs in low- and middle-income countries (LMICs).
Article
Urology & Nephrology
Craig B. Langman, Dean Assimos, Melanie Blank, Juan Calle, Andreas Grauer, Annamaria Kausz, Dawn Milliner, Lama Nazzal, Kimberly Smith, Greg Tasian, Aliza Thompson, Kyle D. Wood, Elaine Worcester, Sixun Yang, Meaghan A. Malley, Felix Knauf, John C. Lieske
Summary: Enteric hyperoxaluria is a medical condition associated with increased urinary oxalate excretion, leading to kidney stone events and kidney failure. Currently, there are no approved therapies for this condition and it is unclear how to evaluate the efficacy of potential treatments. This study reviews potential clinical outcome measures and surrogate endpoints, but gaps in the data prevent definitive recommendations from being made.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Microbiology
Alex Kayongo, Theda Ulrike Patricia Bartolomaeus, Till Birkner, Lajos Marko, Ulrike Loeber, Edgar Kigozi, Carolyne Atugonza, Richard Munana, Denis Mawanda, Rogers Sekibira, Esther Uwimaana, Patricia Alupo, Robert Kalyesubula, Felix Knauf, Trishul Siddharthan, Bernard S. Bagaya, David P. Kateete, Moses L. Joloba, Nelson K. Sewankambo, Daudi Jjingo, Bruce Kirenga, William Checkley, Sofia K. Forslund
Summary: Even with ART available, HIV-infected individuals are still at high risk of noninfectious lung diseases. Recent studies suggest a link between respiratory microbiota and chronic lung inflammation. This study investigates the microbiome patterns and associations among people living with HIV (PLWH) and COPD in Sub-Saharan Africa. The results reveal significant alterations in the respiratory microbiota among PLWH, indicating the potential of using the sputum microbiome for COPD prognostic and risk stratification strategies.
MICROBIOLOGY SPECTRUM
(2023)
Article
Urology & Nephrology
Tobias Sieckmann, Gunnar Schley, Neslihan Oegel, Simon Kelterborn, Felix J. Boivin, Michael Faehling, Muhammad I. Ashraf, Martin Reichel, Emilia Vigolo, Andrea Hartner, Falk-Bach Lichtenberger, Tilman Breiderhoff, Felix Knauf, Christian Rosenberger, Felix Aigner, Kai Schmidt-Ott, Holger Scholz, Karin M. Kirschner
Summary: Experimental models have shown that impaired polyamine homeostasis contributes to various kidney pathologies, including ischemia-reperfusion, transplantation, rhabdomyolysis, cyclosporine treatment, arterial hypertension, diabetes, unilateral ureteral obstruction, high oxalate feeding, and adenine-induced injuries. These injuries lead to reduced expression of polyamine synthesis enzymes and increased expression of polyamine degrading enzymes, resulting in an imbalance of kidney polyamines.
KIDNEY INTERNATIONAL
(2023)
Article
Medicine, Research & Experimental
Anja Pfau, Karen I. Lopez-Cayuqueo, Nora Scherer, Matthias Wuttke, Annekatrin Wernstedt, Daniela Gonzalez Fassrainer, Desiree E. C. Smith, Jiddeke M. van de Kamp, Katharina Ziegeler, Kai-Uwe Eckardt, Friedrich C. Luft, Peter S. Aronson, Anna Koettgen, Thomas J. Jentsch, Felix Knauf
Summary: Sulfate is important for various physiological processes in the human body. The transporter SLC26A1 plays a crucial role in sulfate reabsorption in the kidney. Through genetic analysis and functional experiments, it is confirmed that SLC26A1 is a sulfate transporter in humans. Rare SLC26A1 variants are associated with lower plasma sulfate levels at the population level.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Gastroenterology & Hepatology
David Holthaus, Martin R. Kraft, Susanne M. Krug, Silver Wolf, Antonia Mueller, Estefania Delgado Betancourt, Madeleine Schorr, Gudrun Holland, Felix Knauf, Joerg-Dieter Schulzke, Toni Aebischer, Christian Klotz
Summary: This study used a human organoid model to recapitulate the pathogenic events leading to gastrointestinal illness caused by Giardia duodenalis, revealing a previously unknown sequence of events that resulted in intestinal barrier dysfunction.