Article
Nutrition & Dietetics
Lifang Zhang, Jessica Cao, Haiqiang Yang, Phillip Pham, Umer Khan, Breanna Brown, Yanhong Wang, Tarek Zieneldien, Chuanhai Cao
Summary: Coffee consumption, regardless of brand or type, is beneficial for stalling the progression and development of A beta-related Alzheimer's disease (AD). All coffees tested have beneficial health effects for AD through lowering A beta 1-40 and A beta 1-42 production, with Dunkin' Donuts (R) medium roast coffee demonstrating the most consistent and optimal cell survival rates and A beta concentration, while Starbucks (R) coffee exhibited the highest cell toxicity rates among the tested coffees.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Guangsu Zhu, Jianxin Zhao, Hao Zhang, Wei Chen, Gang Wang
Summary: This study found that the administration of bifidobacteria improved behavioral abnormalities and synaptic plasticity in an AD mouse model. The microbiome and metabolomic profiles of the mice indicated a correlation between specific bacterial taxa and their metabolites with AD-associated behaviors, suggesting the involvement of the gut-brain axis in the pathophysiology of AD. Overall, B. breve CCFM1025 and WX represent a novel probiotic dietary intervention for delaying the progression of AD by modulating the gut microbiome.
Article
Biochemistry & Molecular Biology
Sareer Ahmad, Myeung Hoon Jo, Muhammad Ikram, Amjad Khan, Myeong Ok Kim
Summary: The study revealed that Luteolin has protective effects against amyloid-beta-induced neuroinflammation, amyloidogenesis, and synaptic dysfunction in mice, potentially through inhibition of JNK signaling and modulation of inflammatory and cell death markers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Meiyu Wan, Shengqi Sun, Xiaoke Di, Minghui Zhao, Fengjuan Lu, Zhifei Zhang, Yang Li
Summary: The study confirms that ICA can repair neuronal damage, enhance synaptic plasticity, and ultimately improve learning and memory impairment through the regulation of the BDNF-Tr kappa B signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Clinical Neurology
Daniel L. Kober, Melissa D. Stuchell-Brereton, Colin E. Kluender, Hunter B. Dean, Michael R. Strickland, Deborah F. Steinberg, Samantha S. Nelson, Berevan Baban, David M. Holtzman, Carl Frieden, Jennifer Alexander-Brett, Erik D. Roberson, Yuhua Song, Tom J. Brett
Summary: The study using comprehensive biolayer interferometry analysis revealed that TREM2 binds apoE through a protein-mediated mechanism, with slight affinity differences among isoforms; TREM2 and sTREM2 can directly bind mAβ42 and potently inhibit Aβ42 polymerization, suggesting a potential role in preventing AD pathogenesis.
ALZHEIMERS & DEMENTIA
(2021)
Article
Immunology
Tamar Smit, Paul R. Ormel, Jacqueline A. Sluijs, Lianne A. Hulshof, Jinte Middeldorp, Lot D. de Witte, Elly M. Hol, Vanessa Donega
Summary: Dysregulation of microglial function is involved in Alzheimer's disease pathogenesis, with changes in immune and inflammatory pathways linked to genetic risk factors. Aβ oligomers may induce a protective response rather than an inflammatory profile in vitro.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Biochemistry & Molecular Biology
Patricia Lam, Chitra Vinnakota, Beatriz Calvo-Flores Guzman, Julia Newland, Katie Peppercorn, Warren P. Tate, Henry J. Waldvogel, Richard L. M. Faull, Andrea Kwakowsky
Summary: Alzheimer's disease is a neurodegenerative disorder that requires the development of disease-modifying treatments. Recent evidence suggests that the GABA neurotransmitter system undergoes remodeling in AD, disrupting the excitatory/inhibitory balance in the brain. This study explores the expression levels of KCC2 and NKCC1 in AD and finds that chronic exposure to beta-amyloid alters the balance of KCC2 and NKCC1 expression in mouse hippocampal tissue. Furthermore, the study reveals that the drug bumetanide, used for AD therapy, is highly neurotoxic.
Article
Biochemistry & Molecular Biology
Giuseppe Caruso, Cristina Benatti, Nicolo Musso, Claudia G. Fresta, Annamaria Fidilio, Giorgia Spampinato, Nicoletta Brunello, Claudio Bucolo, Filippo Drago, Susan M. Lunte, Blake R. Peterson, Fabio Tascedda, Filippo Caraci
Summary: The study showed that carnosine can protect macrophages from cell death and apoptosis induced by Aβ 1-42 oligomers, decrease oxidative stress, enhance macrophage phagocytic activity, and rescue fractalkine receptor CX3CR1. These new findings support the therapeutic potential of carnosine in the context of AD pathology, highlighting its multimodal mechanism of action.
Article
Endocrinology & Metabolism
Amir Arabi, Seyed Asaad Karimi, Iraj Salehi, Rasool Haddadi, Alireza Komaki
Summary: The study investigated the protective effect of sesamin (Ses) on beta-amyloid (A beta)-induced long-term potentiation (LTP) impairment in male rats. The results showed that Ses enhanced the EPSP slope and PS amplitude of LTP in the DG granular cells and corrected the oxidative stress caused by A beta. Therefore, Ses can prevent A beta-induced LTP impairment, possibly through its preventive effects on oxidative stress.
METABOLIC BRAIN DISEASE
(2023)
Article
Pharmacology & Pharmacy
Yuhang Gong, Yanfeng Li, Xin Liu, Ling He
Summary: By using GPR40 agonist and antagonist for external treatment in AD mice, it was found that GPR40 receptor could significantly improve cognitive deficits by up-regulating gut-brain peptides and inhibiting inflammation-related proteins, suggesting it as a potential therapeutic target for AD-related encephalopathy.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Geriatrics & Gerontology
Maxime Vande Vyver, Louise Daeninck, Gino De Smet, Najat Aourz, Surajit Sahu, Sebastiaan Engelborghs, Kris Pauwels, Dimitri De Bundel, Ilse Smolders
Summary: We investigated the impact of A beta(1-42) oligomers on seizure susceptibility in mice and found no effect after intracerebral injection. Despite confirming the presence of A beta(1-42) oligomers, it remains unclear whether our findings or previous studies best represent the role of these oligomers in seizures in AD.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Biology
Xiru Xu, Yuan Fang, Biao Zhang, Shichao Teng, Xiang Wu, Jing Zhang, Xiaoqun Gu, Meixia Ma
Summary: In this study, the specific mechanism of action of the Bushen Yizhi Formula in treating Alzheimer's disease (AD) was investigated. The results demonstrated that the formula exerted its therapeutic effects on AD by influencing endoplasmic reticulum stress (ERS) through the IRE1a signaling pathway. It was able to alleviate cell damage, decrease in cell viability, increase apoptosis, regulate the cell cycle, and improve learning and memory abilities in AD model rats.
Article
Biophysics
Parshant Kumar Sharma, Eun-Seong Kim, Sachin Mishra, Enkhzaya Ganbold, Ryun-Sang Seong, Yu Mi Kim, Geon-Ho Jahng, Hak Young Rhee, Ho-Seong Han, Do Hoon Kim, Sang Tae Kim, Nam-Young Kim
Summary: The study developed a highly sensitive and novel method to detect Aβ, a hallmark biomarker of AD, using an interdigitated capacitive biosensor. The results showed that the biosensor exhibited good specificity and sensitivity, enabling real-time detection of oAβ in the femto-molar range. Additionally, the fabricated capacitive biochip demonstrated long-term stability and suitability for point-of-care diagnostic applications.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Plant Sciences
Xiping Yang, Jingke Zhi, Haifeng Leng, Yu Chen, Haoran Gao, Jinming Ma, Jing Ji, Qinghua Hu
Summary: HJ105 shows therapeutic effects in A beta(1-42)-associated AD by decreasing apoptosis, oxidative stress, and neuroinflammation, partly through suppression of Keap1-Nrf2 complex generation.
Article
Behavioral Sciences
Camila Andre Cazarin, Ana Paula Dalmagro, Ana Elisa Goncalves, Thaise Boeing, Luisa Mota da Silva, Rogerio Correa, Luiz Carlos Klein-Junior, Bernardo Carlesso Pinto, Thais Savoldi Lorenzett, Thales Uchoa da Costa Sobrinho, Angelo de Fatima, Tiago Coelho de Assis Lage, Sergio Antonio Fernandes, Marcia Maria de Souza
Summary: This study investigated the effects of UA enantiomers on cognitive deficits and neuroinflammation in mice with AD. The results showed that UA improved learning and memory, reduced oxidative stress markers, decreased neuroinflammation, and restored cognitive deficits induced by A beta 1-42 administration in mice.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Review
Chemistry, Multidisciplinary
Huihui Zeng, Yujie Qi, Zheyu Zhang, Chuntai Liu, Weijun Peng, Yi Zhang
Summary: Alzheimer's disease is a progressive and fatal neurodegenerative condition with no current efficient therapy. Recent advancements in nanotechnology show promise in offering therapeutic options for AD treatment, particularly through nanomaterial-based drug delivery systems.
CHINESE CHEMICAL LETTERS
(2021)
Article
Integrative & Complementary Medicine
Zhe-yu Zhang, Chun-hu Zhang, Jing-jing Yang, Pan-pan Xu, Peng-ji Yi, Mu-li Hu, Wei-jun Peng
Summary: This study investigated the effects of Bushen Tiansui formula (BSTSF) on cognitive performance and transfer RNA-derived small RNAs (tsRNAs) in a rat model of Alzheimer's disease (AD). The results showed that BSTSF treatment improved learning and memory deficits in AD rats and regulated the expression of tsRNAs in the hippocampus. Additionally, bioinformatic analyses indicated that the BSTSF treatment-related tsRNAs may have therapeutic roles in AD through various signaling pathways and biological functions.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2021)
Article
Immunology
Xin Cheng, Xiaowei Wang, Kechao Nie, Lin Cheng, Zheyu Zhang, Yang Hu, Weijun Peng
Summary: TREM2 is highly expressed in most cancers and is associated with prognosis, tumor mutational burden, microsatellite instability, and DNA methylation. In 6 selected tumor types, TREM2 gene expression was negatively correlated with most immune cell infiltration levels but positively correlated with M1 and M2 macrophages infiltration levels. The correlation with TREM2 expression differed according to T cell subtype.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Wanjun Ma, Shanshan Wei, Weijun Peng, Taoli Sun, Jianhua Huang, Rong Yu, Bikui Zhang, Wenqun Li
Summary: Polygonatum sibiricum polysaccharides (PSP) attenuates D-galactose-induced heart aging by inhibiting oxidative stress, suggesting its potential as an effective Chinese herbal active constituent for anti-aging therapy.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Oncology
Lin Cheng, Tong Han, Bolin Chen, Kechao Nie, Weijun Peng
Summary: TBX5-AS1 was identified as a key eRNA in LUAD, potentially exerting its role through the PI3K/AKT pathway, Ras signaling pathway, etc., with TBX5 as its regulatory target. Experimental results indicated the association of TBX5-AS1 with patient survival in multiple tumors.
Article
Chemistry, Medicinal
Jiaqin Liu, Jian Liu, Xiaoliang Tong, Weijun Peng, Shanshan Wei, Taoli Sun, Yikun Wang, Bikui Zhang, Wenqun Li
Summary: Through network pharmacology, molecular docking, and cell experiments, this study identified the potential bioactive ingredients, candidate agents, and key targets of Huai Hua San against ulcerative colitis. The PI3K-AKT signaling pathway may play a crucial role in the therapeutic mechanism.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Correction
Biotechnology & Applied Microbiology
Wanjun Ma, Shanshan Wei, Weijun Peng, Taoli Sun, Jianhua Huang, Rong Yu, Bikui Zhang, Wenqun Li
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Immunology
Zheng Xiao, Kechao Nie, Tong Han, Lin Cheng, Zheyu Zhang, Weijun Peng, Dazun Shi
Summary: By analyzing TNF family members in colorectal cancer, a signature was generated to predict prognosis and immunotherapy response. Low-risk patients showed better overall survival, immune characteristics, and sensitivity to immunotherapy compared to high-risk patients.
JOURNAL OF IMMUNOLOGY RESEARCH
(2021)
Article
Immunology
Yaqiong Liu, Lin Cheng, Wei Huang, Xin Cheng, Weijun Peng, Dazun Shi
Summary: A novel GI-related miRNA signature (GIMiSig) was developed to stratify gastric cancer patients into distinct risk groups, with different survival outcomes and immunotherapy efficacy. The high-risk group showed decreased UBQLN4 expression, higher immune cell accumulation, lower TTN mutation frequency, worse immunotherapy efficacy, and cancer-associated pathways, while the low-risk group exhibited UBQLN4 overexpression, lower immune cell fraction, higher TTN mutation frequency, better response to immunotherapy, and GI-related pathways. The results may provide new clues for improving gastric cancer outcomes.
JOURNAL OF IMMUNOLOGY RESEARCH
(2021)
Article
Immunology
Xin Cheng, Yucheng Cao, Xiaowei Wang, Lin Cheng, Yaqiong Liu, Jun Lei, Weijun Peng, Dazun Shi
Summary: This study provides a comprehensive analysis of the role of KLRB1 gene in different types of cancer. The results show that KLRB1 is downregulated in multiple cancers while upregulated in kidney cancer. Patients with high expression of KLRB1 have better prognosis in most cancer types, and the expression of KLRB1 is associated with tumor immune signatures and chemotherapeutic drug sensitivity.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Review
Chemistry, Medicinal
Mengshi Tang, Yan Zeng, Weijun Peng, Xi Xie, Yongyu Yang, Biting Ji, Fen Li
Summary: This article reviews the effects of quercetin (QUE) on both articular and extra-articular manifestations of rheumatoid arthritis (RA), suggesting that QUE can inhibit inflammation and bone damage in the joints, as well as provide neuroprotection and cytoprotection.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Review
Geriatrics & Gerontology
Yuqing Liu, Xin Chen, Yutong Che, Hongli Li, Zheyu Zhang, Weijun Peng, Jingjing Yang
Summary: Alzheimer's disease poses a serious threat to the health and safety of the elderly population and is a major public health concern. Long non-coding RNAs (lncRNAs) have been shown to play important roles in AD pathogenesis, providing potential avenues for the discovery of novel therapeutic targets and drugs for the disease.
Article
Cell Biology
Zhengjun Lin, Ke Pang, Hongli Li, Xianghong Zhang, Jia Wan, Tao Zheng, Tang Liu, Weijun Peng
Summary: The study demonstrates that the risk signature based on irlncRNA can reliably predict prognosis, effectively predict the immune landscape of patients with STS, and is significantly associated with chemosensitivity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Plant Sciences
Zheyu Zhang, Bo Yang, Jianhua Huang, Wenqun Li, Pengji Yi, Min Yi, Weijun Peng
Summary: This study found that PSP improved cognitive function during brain ageing by modulating various RNAs involved in synaptic activity. PSP regulated nine mRNAs, three miRNAs, and two circRNAs in the competing endogenous RNA network.
PHARMACEUTICAL BIOLOGY
(2021)
Article
Medicine, General & Internal
Lin Cheng, Tong Han, Zheyu Zhang, Pengji Yi, Chunhu Zhang, Sifang Zhang, Weijun Peng
Summary: A prognostic signature of six autophagy-related lncRNAs was established for colorectal cancer (CRC) patients, showing significant clinical implications for predicting outcomes and potential guidance for tailored therapy. The qRT-PCR analysis confirmed higher expression of lncRNAs in CRC tissues compared to adjacent tissues, indicating potential prognostic value for CRC patients. Gene set enrichment analysis revealed enrichment of the lncRNAs in CRC-related signalling pathways, supporting their potential as biomarkers for prognosis prediction in CRC.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
