Article
Medicine, General & Internal
Jelena Kornej, Qiuxi Huang, Sarah R. Preis, Steven A. Lubitz, Darae Ko, Joanne M. Murabito, Emelia J. Benjamin, Ludovic Trinquart
Summary: The study found that cardiovascular mortality among atrial fibrillation (AF) cases decreased over time, regardless of age. With advancing age, history of heart failure, and history of myocardial infarction, the risk of cardiovascular death also increased.
Article
Cardiac & Cardiovascular Systems
Jianhua Wu, Ramesh Nadarajah, Yoko M. Nakao, Kazuhiro Nakao, Chris Wilkinson, J. Campbell Cowan, A. John Camm, Chris P. Gale
Summary: This study aimed to investigate the mortality and hospitalization rates following atrial fibrillation (AF) diagnosis. The study found that cardiovascular and cerebrovascular mortality rates have declined, while non-cardio/cerebrovascular mortality rates have remained stable. The overall hospitalization rates have increased, particularly for non-cardio/cerebrovascular causes.
EUROPEAN HEART JOURNAL
(2023)
Article
Multidisciplinary Sciences
Steffen Blum, Stefanie Aeschbacher, Michael Coslovsky, Pascal B. Meyre, Philipp Reddiess, Peter Ammann, Paul Erne, Giorgio Moschovitis, Marcello Di Valentino, Dipen Shah, Juerg Schlaepfer, Rahel Mueller, Juerg H. Beer, Richard Kobza, Leo H. Bonati, Elisavet Moutzouri, Nicolas Rodondi, Christine Meyer-Zuern, Michael Kuehne, Christian Sticherling, Stefan Osswald, David Conen
Summary: This study aimed to investigate the association between types of atrial fibrillation (AF) and adverse outcomes. Through the follow-up of 3843 AF patients, it was found that the type of AF was not associated with the incidence of stroke or systemic embolism.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Wei Xu, Qirui Song, Han Zhang, Juan Wang, Xinghui Shao, Shuang Wu, Jun Zhu, Jun Cai, Yanmin Yang
Summary: This study aimed to assess the effect of baseline blood pressure on all-cause mortality in patients with atrial fibrillation (AF). The results showed that a systolic blood pressure (SBP) ≤ 110 mmHg or > 160 mmHg and a diastolic blood pressure (DBP) < 70 mmHg were associated with an increased risk of all-cause mortality. Therefore, excessively low blood pressure may not be an optimal target for patients with AF.
CHINESE MEDICAL JOURNAL
(2023)
Article
Endocrinology & Metabolism
Juan Xu, Yimeng Sun, Dandan Gong, Yu Fan
Summary: This meta-analysis study found that preexisting diabetes has a significant impact on cardiovascular and all-cause mortality in patients with atrial fibrillation. Patients with diabetes have a higher risk of death.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Wei-Ru Chiou, Min- Su, Ying-Hsiang Lee, Po-Lin Lin, Cheng-Wei Liu
Summary: This retrospective study evaluated the effects of reduced-dose rivaroxaban on older patients with nonvalvular atrial fibrillation. The results showed that reduced-dose rivaroxaban was associated with lower risks of all-cause mortality and hospitalization for heart failure in this population.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Anastasios Papanastasiou, Anastasios Kartas, Athanasios Samaras, Eleni Vrana, Andreas Papazoglou, Dimitrios Moysidis, Amalia Baroutidou, Michail Botis, Evaggelos Liampas, Ioannis Vouloagkas, Evangelia Mareti, Efstratios Karagiannidis, Haralambos Karvounis, Apostolos Tzikas, George Giannakoulas
Summary: In this study, it was found that there were no significant differences in the risk of all-cause death, stroke, and major bleeding between NOAC and VKA users in elderly atrial fibrillation patients after OAC treatment.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2022)
Article
Medicine, Research & Experimental
Olurotimi O. Mesubi, Adam G. Rokita, Neha Abrol, Yuejin Wu, Biyi Chen, Qinchuan Wang, Jonathan M. Granger, Anthony Tucker-Bartley, Elizabeth D. Luczak, Kevin R. Murphy, Priya Umapathi, Partha S. Banerjee, Tatiana N. Boronina, Robert N. Cole, Lars S. Maier, Xander H. Wehrens, Joel L. Pomerantz, Long-Sheng Song, Rexford S. Ahima, Gerald W. Hart, Natasha E. Zachara, Mark E. Anderson
Summary: Diabetes mellitus (DM) and atrial fibrillation (AF) are significant public health issues, with diabetes being an independent risk factor for AF. This study found that ROS and protein O-GlcNAcylation (OGN) play a role in the development of diabetic AF, with CaMKII identified as a critical proarrhythmic signal.ROS primarily promotes AF through oxidized CaMKII, while OGN promotes AF through a CaMKII-independent mechanism.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Cell Biology
Lian He, Rong He, Jiabin Huang, Chen Zou, Yu Fan
Summary: Frailty is associated with higher risk of all-cause mortality and major bleeding in patients with atrial fibrillation. Determination of frailty status may play an important role in risk classification of AF patients.
AGEING RESEARCH REVIEWS
(2022)
Article
Cardiac & Cardiovascular Systems
Michael Nabauer, Michael Oeff, Andrea Gerth, Karl Wegscheider, Anika Buchholz, Karl Georg Haeusler, Peter Hanrath, Thomas Meinertz, Ursula Ravens, Claudia Sprenger, Ulrich Tebbe, Eik Vettorazzi, Paulus Kirchhof, Gunter Breithardt, Gerhard Steinbeck
Summary: The study found that mortality in atrial fibrillation patients primarily stems from heart failure, peripheral artery disease, chronic obstructive lung disease, chronic kidney disease, and diabetes mellitus, which should be targeted in efforts to lower mortality. Additionally, sex-specific age was identified as the strongest predictor of mortality.
Article
Medicine, General & Internal
Marco Vitolo, Marco Proietti, Jacopo F. Imberti, Niccolo Bonini, Giulio Francesco Romiti, Davide A. Mei, Vincenzo L. Malavasi, Igor Diemberger, Laurent Fauchier, Francisco Marin, Michael Nabauer, Tatjana S. Potpara, Gheorghe-Andrei Dan, Gregory Y. H. Lip, Giuseppe Boriani
Summary: This study analyzed patients with paroxysmal atrial fibrillation and found that clinical factors related to cardiac remodeling were associated with AF progression. The one-year follow-up showed that a significant number of patients developed persistent or permanent AF, and this progression was associated with an increased risk of all-cause death.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Xia Zhong, Huachen Jiao, Dongsheng Zhao, Jing Teng
Summary: This study investigates the association between serum uric acid levels and paroxysmal atrial fibrillation (AF) and reveals a significant correlation between elevated uric acid levels and paroxysmal AF in female patients in China.
SCIENTIFIC REPORTS
(2022)
Review
Cardiac & Cardiovascular Systems
Patricia Alphonse, Sohaib Virk, Jhonna Collins, Timothy Campbell, Stuart P. Thomas, Christopher Semsarian, Saurabh Kumar
Summary: Atrial fibrillation is highly prevalent in patients with hypertrophic cardiomyopathy and is associated with major adverse clinical outcomes, including thromboembolism, heart failure, sudden death, and all-cause mortality. Aggressive screening and treatment of AF may have a significant prognostic impact on outcomes in HCM.
CLINICAL RESEARCH IN CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Anastasios Kartas, Athanasios Samaras, Evangelos Akrivos, Eleni Vrana, Andreas S. Papazoglou, Dimitrios Moysidis, Anastasios Papanastasiou, Amalia Baroutidou, Michail Botis, Evangelos Liampas, Ioannis Vouloagkas, Efstratios Karagiannidis, Haralambos Karvounis, John Parissis, Apostolos Tzikas, George Giannakoulas
Summary: In patients with both heart failure and atrial fibrillation, the presence of heart failure was independently associated with a higher risk of death, with mortality risk increasing significantly as left ventricular ejection fraction decreased.
Article
Cardiac & Cardiovascular Systems
Yu-Feng Wang, Chao Jiang, Liu He, Xin Du, Cai-Hua Sang, De-Yong Long, Ri-Bo Tang, Jian-Zeng Dong, Gregory Y. H. Lip, Chang-Sheng Ma
Summary: The study analyzed data from Chinese Atrial Fibrillation registry (CAFR) and found that ABC pathway compliance was associated with lower rates of all-cause death and composite adverse outcomes in Chinese AF patients, demonstrating the benefits of integrated care for AF management.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Katherine S. Allan, Emma O'Neil, Margaret M. Currie, Steve Lin, John L. Sapp, Paul Dorian
Summary: Sudden cardiac arrest is a common event, and digital technologies such as smartphones, wearable devices, and machine learning algorithms can improve survival rates through various strategies like educating bystanders and monitoring at-risk individuals.
CANADIAN JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Husam Abdel-Qadir, Madison Gunn, Iliana C. Lega, Andrea Pang, Peter C. Austin, Sheldon M. Singh, Cynthia A. Jackevicius, Karen Tu, Paul Dorian, Douglas S. Lee, Dennis T. Ko
Summary: The longer the duration of diabetes and the higher the glycated hemoglobin level, the significantly higher the stroke rate in patients with AF and diabetes.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Letter
Radiology, Nuclear Medicine & Medical Imaging
Matteo Fronza, Paaladinesh Thavendiranathan, Gauri Rani Karur, Husam Abdel-Qadir, Jacob A. Udell, Rachel M. Wald, Kate Hanneman
Article
Cardiac & Cardiovascular Systems
Mahbod Rahimi, Paul Dorian, Sheldon Cheskes, Gerald Lebovic, Steve Lin
Summary: This study analyzed the effects of amiodarone and lidocaine on the return of spontaneous circulation (ROSC) in relation to the time of treatment for patients with out-of-hospital cardiac arrest. The probability of ROSC decreased as time to drug administration increased, and the effect of amiodarone to restore ROSC declined with longer times to drug administration.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Husam Abdel-Qadir, Leo E. Akioyamen, Jiming Fang, Andrea Pang, Andrew C. T. Ha, Cynthia A. Jackevicius, David A. Alter, Peter C. Austin, Clare L. Atzema, R. Sacha Bhatia, Gillian L. Booth, Sharon Johnston, Irfan Dhalla, Moira K. Kapral, Harlan M. Krumholz, Candace D. McNaughton, Idan Roifman, Karen Tu, Jacob A. Udell, Harindra C. Wijeysundera, Dennis T. Ko, Michael J. Schull, Douglas S. Lee
Summary: Despite universal healthcare and prescription medication coverage in Canada, residents of socioeconomically disadvantaged neighborhoods are less likely to visit cardiologists or receive treatment after atrial fibrillation diagnosis, even though they have a higher burden of cardiovascular disease and risk of adverse outcomes.
Article
Medicine, General & Internal
Kieran L. Quinn, Husam Abdel-Qadir, Kali Barrett, Emily Bartsch, Andrea Beaman, Tor Biering-Sorensen, Michael Colacci, Alex Cressman, Allan Detsky, Alexi Gosset, Mats H. Lassen, Chris Kandel, Yaariv Khaykin, Lauren Lapointe-Shaw, Erik Lovblom, Derek R. MacFadden, Bruce Perkins, Kenneth J. Rothman, Kristoffer G. Skaarup, Nathan Stall, Terence Tang, Chris Yarnell, Jonathan Zipursky, Matthew T. Warkentin, Mike Fralick
Summary: This study compared the risk of mortality for patients hospitalized with COVID-19 and found wide variation among hospitals. The majority of this variation was explained by differences in patient characteristics.
JOURNAL OF HOSPITAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Maya S. Sheth, Bing Yu, Anna Chu, Joan Porter, Derrick Y. Tam, Laura E. Ferreira-Legere, Shaun G. Goodman, Michael E. Farkouh, Dennis T. Ko, Husam Abdel-Qadir, Jacob A. Udell
Summary: The study analyzed the impact of using low-dose rivaroxaban and aspirin on patients with coronary artery disease and peripheral artery disease. The results showed that applying this treatment strategy to eligible patients can significantly reduce the risk of adverse cardiovascular events, but may also increase the risk of major bleeding. Patients with multiple risk factors may benefit more from this treatment.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Letter
Oncology
Husam Abdel-Qadir, Paaladinesh Thavendiranathan, Peter C. Austin, Douglas S. Lee, Eitan Amir, Kinwah Fung, Geoffrey M. Anderson
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
(2023)
Article
Cardiac & Cardiovascular Systems
Katherine S. Allan, Katherine L. Mason, Jodi Garner, Katie N. Dainty, Dirk Huyer, Kris Cunningham, Paul Dorian, Krystina B. Lewis
Summary: Sudden cardiac death (SCD) in younger individuals is often caused by heritable cardiac conditions, leaving families with unanswered questions about the cause of death and their own risk. This study explored the experiences of families of young SCD victims and found that their interactions with others and the timing and format of information received influenced their understanding of the cause of death, perceived risk, and decision to pursue further screening.
CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES
(2023)
Article
Cardiac & Cardiovascular Systems
Bisan Shweikialrefaee, Dennis T. Ko, Jiming Fang, Andrea Pang, Peter C. Austin, Paul Dorian, Sheldon M. Singh, Cynthia A. Jackevicius, Karen Tu, Douglas S. Lee, Husam Abdel-Qadir
Summary: This study found that statin use is associated with a lower stroke rate in patients with atrial fibrillation (AF), while higher levels of low-density lipoprotein are associated with a higher stroke rate.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Erika Nakajima, Bisan Shweikialrefaee, Peter C. Austin, Dennis T. Ko, Husam Abdel-Qadir
Summary: Using administrative data, this study found that a Type 2 diagnosis can be used to verify secondary atrial fibrillation (AF) in patients first diagnosed with AF while hospitalized for other causes, with a positive predictive value of 99.7%.
Editorial Material
Cardiac & Cardiovascular Systems
Paul Dorian, Paul Angaran
CANADIAN JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Hifza Buhari, Jiming Fang, Lu Han, Peter C. Austin, Paul Dorian, Cynthia A. Jackevicius, Amy Y. X. Yu, Moira K. Kapral, Sheldon M. Singh, Karen Tu, Dennis T. Ko, Clare L. Atzema, Emelia J. Benjamin, Douglas S. Lee, Husam Abdel-Qadir
Summary: This study aimed to examine the relationship between sex differences in age and cardiovascular care and stroke in atrial fibrillation (AF). The results showed that females had higher rates of stroke in AF even after adjusting for other factors. Older age and inequities in cardiovascular care partially explained the higher stroke rates in females with AF.
EUROPEAN HEART JOURNAL
(2023)