Article
Public, Environmental & Occupational Health
Yi-Hsuan Chen, Chi-Tai Fang, Ming-Chieh Shih, Kuan-Yin Lin, Shu-Sen Chang, Zong-Tai Wu, Yu-Yao Lee, Chang-Hsun Chen
Summary: The study found that routine HIV testing was associated with lower rates of late diagnosis, HIV-related mortality, and all-cause mortality compared to nonroutine testing based on individual risk assessment.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2022)
Review
Medicine, General & Internal
Robert Luo, Youyi Fong, Debi Boeras, Ilesh Jani, Lara Vojnov
Summary: This study aimed to compare the clinical effect of point-of-care HIV testing versus laboratory-based testing in HIV-exposed infants. The results showed that point-of-care testing significantly shortened the time to result delivery, time to antiretroviral therapy initiation, and increased the proportion of HIV-positive infants starting antiretroviral therapy within 60 days compared with standard of care.
Article
Multidisciplinary Sciences
Refeletswe Lebelonyane, Pamela Bachanas, Lisa Block, Faith Ussery, Mary Grace Alwano, Tafireyi Marukutira, Shenaaz El Halabi, Michelle Roland, William Abrams, Gene Ussery, James A. Miller, Shahin Lockman, Tendani Gaolathe, Molly Pretorius Holme, Shannon Hader, Lisa A. Mills, Kathleen Wirth, Naomi Bock, Janet Moore
Summary: Through the Botswana Combination Prevention Project, increases in knowledge of HIV-positive status and ART coverage were achieved towards the 95-95 targets. The increases in HIV testing and ART use among men and youth were essential in reaching these targets.
Review
Pharmacology & Pharmacy
Erin M. B. Scholz, Angela D. M. Kashuba
Summary: Finding a cure for HIV is still a top priority despite advances in treatment, as chronic HIV infection is linked to an increased risk of comorbidities and the importance of adhering to daily antiretroviral therapy. Viral recrudescence from cellular reservoirs in lymphoid tissues is central to the pathology of HIV, and understanding ARV concentrations and distribution in lymph nodes may explain their maintenance as HIV reservoirs and viral rebound upon treatment interruption.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Virology
Elena Bruzzesi, Arianna Gabrieli, Davide Bernasconi, Giulia Marchetti, Andrea Calcagno, Diego Ripamonti, Andrea Antinori, Nicola Squillace, Antonella Cingolani, Antonio Muscatello, Alessandra Bandera, Andrea Gori, Stefano Rusconi, Silvia Nozza, INACTION Study Grp
Summary: The introduction of antiretroviral therapy (ART) during primary HIV-1 infection (PHI) can restrict the establishment of HIV reservoirs. This study aimed to assess the effect of three different ART regimens on HIV-DNA load in individuals living with HIV (PLWH) who started ART in PHI. The results showed that regardless of the treatment regimen, the HIV-DNA load in PLWH decreased during the treatment period.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Infectious Diseases
Yuanyuan Qin, Yihong Zhou, Songtao Liu, Yanqiu Lu, Min Liu, Jing Yuan, Jingmin Nie, Jing Ouyang, Hao Wu, Yingmei Qin, Zhongsheng Jiang, Guoqiang Zhou, Qun Tian, Ke Lan, Yang Zhou, Xinping Yang, Kaiyin He, Jun Liu, Vijay Harypursat, Yaokai Chen
Summary: This study aimed to evaluate the optimal timing of antiretroviral therapy (ART) initiation for HIV-positive patients with talaromycosis. The results showed that patients who initiated ART early had lower mortality rates and lower rates of AIDS-defining events or death compared to those who deferred ART initiation.
JOURNAL OF INFECTION
(2022)
Article
Multidisciplinary Sciences
Njambi Njuguna, Nelly Mugo, Omu Anzala, Marianne Mureithi, Elizabeth Irungu, Joyce Wamicwe, Jared M. Baeten, Renee Heffron
Summary: A risk scoring tool was developed using data from KenyaEMR to identify individuals likely to have unsuppressed viral load 18 months post-ART initiation. The tool could improve efficiency in differentiated care models.
Article
Immunology
Monisha Sharma, Edinah Mudimu, Kate Simeon, Anna Bershteyn, Jienchi Dorward, Lauren R. Violette, Adam Akullian, Salim S. Abdool Karim, Connie Celum, Nigel Garrett, Paul K. Drain
Summary: Based on data from the STREAM trial in South Africa, point-of-care (POC) testing is a promising strategy to improve patient outcomes in moderately sized clinics in South Africa. Results are most sensitive to changes in the intervention impact on enrollment into community-based ART delivery.
Review
Immunology
Morris Madzime, Theresa M. Rossouw, Annette J. Theron, Ronald Anderson, Helen C. Steel
Summary: Neutrophils and platelets play important roles in HIV infection and disease, and further research is needed to understand their impact on immune response. While antiretroviral agents can correct neutropenia, questions remain about their effects on neutrophil function and platelet activation.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Laszlo Kovacs, Taylor C. Kress, Eric J. Belin de Chantemele
Summary: The introduction of combination antiretroviral therapy has increased the life expectancy of people living with HIV, but has also made them more susceptible to cardiovascular disease. Both viral infection and antiretroviral therapy contribute to endothelial dysfunction, which is a major factor in the development of atherosclerosis-related cardiovascular disease, especially in females.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2022)
Article
Microbiology
Tonatiuh Abimael Baltazar-Diaz, Fernando Amador-Lara, Jaime F. Andrade-Villanueva, Luz Alicia Gonzalez-Hernandez, Rodolfo Ismael Cabrera-Silva, Karina Sanchez-Reyes, Monserrat Alvarez-Zavala, Aldo Valenzuela-Ramirez, Susana Del Toro-Arreola, Miriam Ruth Bueno-Topete
Summary: Antiretroviral therapies are associated with weight gain and metabolic syndrome in HIV-infected patients. This study evaluated the association between gut microbiota and different treatment regimens in HIV-infected patients with metabolic syndrome. The results revealed that both INSTI-based and PI-based regimens were associated with decreased gut microbiota diversity compared to healthy controls. Additionally, the specific bacterial genera were differentially abundant in the two treatment groups with metabolic syndrome.
Article
Obstetrics & Gynecology
Nivashnee Naicker, Nonhlanhla Yende-Zuma, Ayesha B. M. Kharsany, Hlengiwe Shozi, Duduzile Nkosi, Anushka Naidoo, Nigel Garrett, Salim S. Abdool Karim
Summary: Pregnancy rates following HIV acquisition in South Africa are high, highlighting the importance of timely provision of antiretroviral therapy and contraception counseling for women recently diagnosed with HIV. The study also showed improvements in CD4 count and HIV viral load trajectories in pregnant women over time.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Multidisciplinary Sciences
Attaullah, Kamil Zeb, Ilyas Khan, Riaz M. Ahmad, Sayed Eldin
Summary: This paper investigates a mathematical model and demonstrates the dynamics of HIV/AIDS disease transmission using a continuous Galerkin-Petrov time discretization method. A comparison between different schemes is made and the impact of various nonlinear source terms is shown in an extended model. The basic reproduction number is determined, and the stability of disease-free and unique endemic equilibrium states of the HIV model is assessed using the Routh-Hurwitz criterion.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Andres Esteban-Cantos, Javier Rodriguez-Centeno, Juan C. Silla, Pilar Barruz, Fatima Sanchez-Cabo, Gabriel Saiz-Medrano, Julian Nevado, Beatriz Mena-Garay, Maria Jimenez-Gonzalez, Rosa de Miguel, Jose I. Bernardino, Roco Montejano, Julen Cadinanos, Cristina Marcelo, Lucia Gutierrez-Garcia, Patricia Martinez-Martin, Cedrick Wallet, Francois Raffi, Berta Rodes, Jose R. Arribas
Summary: This study investigates the effects of antiretroviral therapy (ART) on HIV-induced epigenetic modifications. It found that ART initiation modified DNA methylation levels at 845 CpG positions, with 49.3% of the changes being restored to the uninfected state. Untreated HIV infection was associated with DNA methylation changes in biological processes regulating the immune system and antiviral responses. Changes in DNA methylation levels after ART initiation were weakly correlated with changes in CD4+ cell counts and the CD4/CD8 ratio.
Article
Infectious Diseases
Basma Abdi, Mouna Chebbi, Marc Wirden, Elisa Teyssou, Sophie Sayon, Romain Palich, Sophie Seang, Marc-Antoine Valantin, Anne Simon, Roland Tubiana, Christine Katlama, Vincent Calvez, Anne-Genevieve Marcelin, Cathia Soulie
Summary: This study revealed similar integrase inhibitor resistance profiles in the CNS and plasma among a population of HIV-1 viraemic patients, with the majority of patients infected with non-B subtypes.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Medicine, General & Internal
Cristina Fernandez, Nick J. Beeching
Article
Infectious Diseases
I. Eckerle, V. T. Briciu, O. Ergonul, M. Lupse, A. Papa, A. Radulescu, S. Tsiodras, C. Tsitou, C. Drosten, V. R. Nussenblatt, C. B. Reusken, L. A. Sigfrid, N. J. Beeching
CLINICAL MICROBIOLOGY AND INFECTION
(2018)
Review
Infectious Diseases
E. Petersen, N. Petrosillo, M. Koopmans
CLINICAL MICROBIOLOGY AND INFECTION
(2018)
Article
Infectious Diseases
Fiona McGill, Michael J. Griffiths, Laura J. Bonnett, Anna Maria Geretti, Benedict D. Michael, Nicholas J. Beeching, David McKee, Paula Scarlett, Ian J. Hart, Kenneth J. Mutton, Agam Jung, Guleed Adan, Alison Gummery, Wan Aliaa Wan Sulaiman, Katherine Ennis, Antony P. Martin, Alan Haycox, Alastair Miller, Tom Solomon
LANCET INFECTIOUS DISEASES
(2018)
Review
Immunology
Nicholas J. Beeching, Jordi Carratala, Raymund R. Razonable, Isabel Oriol, Eduardo Garcia Vilela
Review
Immunology
Wanessa Trindade Clemente, Ligia Camera Pierrotti, Edson Abdala, Michele I. Morris, Luiz S. Azevedo, Rogelio Lopez-Velez, Manuel Cuenca-Estrella, Julian Torre-Cisneros, Eskild Petersen, Luis Fernando A. Camargo, Alissa Jade Wright, Nicholas J. Beeching, Eduardo Garcia Vilela, Guilherme Santoro-Lopes, Oscar Len, Raquel S. B. Stucchi, Oriol Manuel, Luciana Costa Faria, Hakan Leblebicioglu, Shirish Huprikar, Israel Molina, Paulo Henrique Orlandi Mourao, Camille N. Kotton, Jose Maria Aguado
Letter
Medicine, General & Internal
Cristina Fernandez, Nick Beeching
Article
Microbiology
Tom Wingfield, Robert Ball, Stephen D. Woolley, Fiona Campbell, Richard M. Heath, Nick J. Beeching, Lance Turtle
JOURNAL OF CLINICAL MICROBIOLOGY
(2018)
Article
Immunology
Matthew K. O'Shea, Thomas E. Fletcher, Julius Muller, Rachel Tanner, Magali Matsumiya, J. Wendi Bailey, Jayne Jones, Steven G. Smith, Gavin Koh, William G. Horsnell, Nicholas J. Beeching, James Dunbar, Duncan Wilson, Adam F. Cunningham, Helen McShane
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Infectious Diseases
Asuman Inan, Hakan Erdem, Nazif Elaldi, Serda Gulsun, Mustafa K. Karahocagil, Abdullah U. Pekok, Mehmet Ulug, Recep Tekin, Mile Bosilkovski, Safak Kaya, Asli Haykir-Solay, Tuna Demirdal, Selcuk Kaya, Mahmut Sunnetcioglu, Alper Sener, Selma Tosun, Emsal Aydin, Serap Ural, Tansu Yamazhan, Murat Muhcu, Ergin Ayaslioglu, Seval Bilgic-Atli, Ayse Erbay, Pinar Ergen, Ayten Kadanali, Suzan Sahin, Elif Sahin-Horasan, Ali Avci, Yakup Cag, Nicholas J. Beeching
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2019)
Article
Infectious Diseases
Seif S. Al-Abri, Roger Hewson, Hanan Al-Kindi, Idris Al-Abaidani, Amina Al-Jardani, Amal Al-Maani, Samira Almahrouqi, Barry Atkinson, Adil Al-Wahaibi, Bader Al-Rawahi, Shyam Bawikar, Nicholas J. Beeching
PLOS NEGLECTED TROPICAL DISEASES
(2019)
Article
Infectious Diseases
Tom E. Fletcher, Hakan Leblebicioglu, Ilkay Bozkurt, Mustafa Sunbul, Heval Bilek, Zahide Asik, Sener Barut, Ferdi Gunes, Umit Gemici, Roger Hewson, Duncan Wilson, Matt K. O'Shea, Tom Woolley, Brian Faragher, Kiran Parmar, David G. Lalloo, Nick J. Beeching, Beverley J. Hunt
LANCET INFECTIOUS DISEASES
(2019)
Editorial Material
Microbiology
Hugh Adler, James Cruise, Jun Yong, Amit Patel, Magda Mikhail, Michael B. J. Beadsworth, Nicholas J. Beeching
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)
Review
Infectious Diseases
Nick J. Beeching, Hilpi Rautelin, Jean-Paul Stahl, Truls M. Leegaard
Summary: The European curricula and examinations for medical specialists in Clinical Microbiology (Medical) and Infectious Diseases are well-established, providing benchmarks for national authorities to improve clinical practice, patient care, and physician mobility by harmonizing postgraduate training and assessment.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Infectious Diseases
Alejandro Arenas-Pinto, Wolfgang Stohr, Amanda Clarke, Ian Williams, Nicholas J. Beeching, Jane Minton, Vincent Lee, Nicholas Paton