Review
Cell Biology
Angelika Bielach-Bazyluk, Edyta Zbroch, Hanna Mysliwiec, Alicja Rydzewska-Rosolowska, Katarzyna Kakareko, Iwona Flisiak, Tomasz Hryszko
Summary: Skin aging is influenced by both intrinsic and extrinsic factors, with UV radiation being a major extrinsic factor. Sirtuin 1 plays a key role in regulating protein, histone, and chromatin expression, demonstrating beneficial effects on skin aging but with controversial role in carcinogenesis.
Review
Biochemistry & Molecular Biology
Georgeta Bocheva, Radomir M. Slominski, Andrzej T. Slominski
Summary: The active metabolites of vitamin D-3 and lumisterol have antiaging and photoprotective effects on the skin through immunomodulation, antioxidative responses, and DNA repair mechanisms. They interact with multiple nuclear receptors and have potential for preventing, attenuating, or treating premature skin aging. Further clinical evaluation of topically applied derivatives is needed for future trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Hyunji Lee, Yongjun Hong, Miri Kim
Summary: Skin aging is a complex process influenced by intrinsic and extrinsic factors, which affect the structure and function of the skin. Aging skin typically shows epidermal atrophy and decreased cell numbers in the dermis, affecting fibroblast function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Jingwen Ma, Yan Teng, Youming Huang, Xiaohua Tao, Yibin Fan
Summary: This article discusses the characteristics of photoaging and the protective role of autophagy in skin cells damaged by UV radiation. Autophagy is a crucial cellular process that clears or recycles damaged components in cells, playing a key role in cell survival and adaptive responses.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Charareh Pourzand, Andrea Albieri-Borges, Nico N. Raczek
Summary: Reactive oxygen species (ROS) and redox-active labile iron (LI) play significant roles in skin aging and damage. Sunlight exposure promotes oxidative damage, and the interplay between ROS and LI has important consequences for the skin.
Article
Biochemistry & Molecular Biology
Su Jin Lee, Ji Eun Kim, Yun Ju Choi, Jeong Eun Gong, So Hae Park, Bounleuane Douangdeuane, Onevilay Souliya, Ju Min Park, Hee Seob Lee, Bae-Hwan Kim, Dae Youn Hwang
Summary: The methanol extracts of Dipterocarpus tuberculatus Roxb. (MED) showed therapeutic effects against UV-induced photoaging by enhancing antioxidant activity, anti-apoptotic effects, ECM modulation, skin appearances, and anti-inflammatory response in both NHDF cells and nude mice. The identified active components in MED, along with the recovered levels of NO concentration, SOD activity, and Nrf2 expression, contributed to the observed anti-photoaging effects. Furthermore, MED treatment suppressed COX-2-induced iNOS mediated pathway, inflammatory cytokine expression, and inflammasome activation in UV-radiated NHDF cells.
Review
Medicine, Research & Experimental
Evanthia Gouveri, Nikolaos Papanas
Summary: Metformin, a drug commonly used for diabetes, has been proposed as an anti-aging factor with potential protective effects on skin aging. Experimental studies suggest that it may reduce activity of nuclear factor kappa B and inhibit the secretion of pro-inflammatory cytokines induced by UVB. However, more research is needed, especially in humans, to further investigate this potential and determine if metformin can be used to delay skin aging.
ADVANCES IN THERAPY
(2023)
Review
Dermatology
Meiling Tai, Jieli Chen, Jiawen Chen, Xiaoyan Shen, Jiahui Ni
Summary: Aging is a complex biological process and the aging level of the skin directly reflects the aging level of the body. Photoaging caused by ultraviolet radiation is an important stimulus, and while oxidative stress has been a focus of research, endoplasmic reticulum stress also plays a significant role in photoaging.
EXPERIMENTAL DERMATOLOGY
(2023)
Review
Pharmacology & Pharmacy
Anyamanee Chaiprasongsuk, Uraiwan Panich
Summary: Ethnopharmacological studies are valuable in the development of botanical products for preventing and treating various skin problems caused by UV radiation. Understanding the role of phytochemicals in skin damage and aging can help develop effective photoprotective agents. Phytochemicals can regulate cell homeostasis and improve skin integrity and function, delaying the aging process.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Veronica Cocetta, Jessica Cadau, Miriam Saponaro, Isabella Giacomini, Stefano Dall'Acqua, Stefania Sut, Daniela Catanzaro, Genny Orso, Giorgia Miolo, Luca Menilli, Andrea Pagetta, Eugenio Ragazzi, Monica Montopoli
Summary: The skin, as the essential barrier of the human body, is continuously influenced by internal and external factors, affecting its integrity and physiological functions. Maintaining the integrity of the skin barrier and slowing down the skin aging process is crucial. Salvia haenkei extract has been identified as a potential anti-senescence agent, showing positive effects on restoring skin barrier integrity.
Review
Biochemistry & Molecular Biology
Xin He, Fang Wan, Wenhui Su, Weidong Xie
Summary: With the improvement of living standards and the increase in the aging population, more and more people are interested in aging and anti-aging. Skin aging, especially among women, is an important aspect of aging. The market for anti-aging products in the cosmetics field is growing. This article reviews the recent research and development progress of skin aging and related active compounds. The results show that the popular theories on skin aging include free radicals and oxidative stress, inflammation, photoaging, and nonenzymatic glycation. There are numerous reports on active ingredients with anti-aging activities, with most compounds sourced from natural products and acting by scavenging oxygen free radicals and enhancing antioxidant defenses. This review provides important references for future research and development. However, ideal compounds or products are still lacking and further investigation is needed.
Article
Nutrition & Dietetics
Julianne Rizzo, Mildred Min, Sarah Adnan, Nasima Afzal, Jessica Maloh, Cindy Chambers, Vivien Fam, Raja Sivamani
Summary: Preliminary findings indicate that consuming soy-derived isoflavones has positive effects on the skin, such as protecting against oxidative damage, stimulating collagen production, and increasing hydration. This study investigated the effects of oral supplementation with soy protein isolate containing added isoflavones on various aspects of skin aging in postmenopausal women. The results showed that the intervention group had reduced wrinkle severity and pigmentation while experiencing improved skin hydration compared to the control group. These findings suggest that dietary soy protein supplementation with isoflavones may be beneficial for improving skin aging in postmenopausal women.
Review
Biochemistry & Molecular Biology
Georgeta Bocheva, Radomir M. Slominski, Zorica Janjetovic, Tae-Kang Kim, Markus Boehm, Kerstin Steinbrink, Russel J. Reiter, Konrad Kleszczynski, Andrzej T. Slominski
Summary: The skin, as the largest organ in the human body, is prone to aging due to both internal and external factors. Aging is characterized by clinical features and changes in cellular and extracellular components. Melatonin and its metabolites have the potential to counteract skin aging by regulating molecular mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Guanghui Sun, Yongkang Dang, Yanke Lin, Wanying Zeng, Zongjian Wu, Xingwang Zhang, Dong Dong, Baojian Wu
Summary: The study reveals that Scutellaria baicalensis Georgi (SBG) can counteract skin aging by antagonizing REV-ERB alpha and increasing BMAL1 expression. This leads to reduced skin wrinkles, increased levels of antioxidant enzymes and collagen, and improved skin structure and function.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Renan Paulo Martin, Patricia Varela, Caio Peres Gomes, Maryana Mara Marins, Rafael Filippelli-Silva, Samira Yarak, Juliana L. M. Soares, Adriana Sanudo, Jolanta Idkowiak-Baldys, Siming Chen, Cheng Hwang, Yong Zhuang, John Lyga, Joao Bosco Pesquero, Edileia Bagatin
Summary: In a study on menopausal women, differences in skin structure and gene expression between exposed and unexposed areas were observed. Photoaging in menopausal women may modulate lipid and amino acids metabolism and impact pathways related to inflammation, keratinization, metabolism, cellular homeostasis, immune response, fibrogenesis, and filament formation. These findings could lead to the development of new therapies for skin health and aging control.
MOLECULAR BIOLOGY REPORTS
(2022)
