期刊
FRONTIERS IN MICROBIOLOGY
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fmicb.2020.517461
关键词
influenza virus; post-translational modifications; replication cycle; pathogenesis; virus-host interaction; innate immune response
类别
资金
- National Key Research and Development Project of China [2016YFD0500202-1, 2016YFD0501601]
- China Postdoctoral Science Foundation [2016T90515]
- earmarked fund for China Agriculture Research System [CARS-40]
- Qing Lan Project of Higher Education Institutions of Jiangsu Province, China
- High-End Talent Support Program of Yangzhou University, China
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
Throughout various stages of its life cycle, influenza A virus relies heavily on host cellular machinery, including the post-translational modifications (PTMs) system. During infection, influenza virus interacts extensively with the cellular PTMs system to aid in its successful infection and dissemination. The complex interplay between viruses and the PTMs system induces global changes in PTMs of the host proteome as well as modifications of specific host or viral proteins. The most common PTMs include phosphorylation, ubiquitination, SUMOylation, acetylation, methylation, NEDDylation, and glycosylation. Many PTMs directly support influenza virus infection, whereas others contribute to modulating antiviral responses. In this review, we describe current knowledge regarding the role of PTMs in different stages of the influenza virus replication cycle. We also discuss the concerted role of PTMs in antagonizing host antiviral responses, with an emphasis on their impact on viral pathogenicity and host range.
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