Article
Cell Biology
Jia Shen, Siyu Zhao, Mei Peng, Yanguo Li, Lichao Zhang, Xiaoping Li, Yunyi Hu, Mingrou Wu, Suoyu Xiang, Xiaoying Wu, Jiahua Liu, Beibei Zhang, Zebin Chen, Datao Lin, Huanyao Liu, Wenyan Tang, Jun Chen, Xi Sun, Qi Liao, Geoff Hide, Zhijun Zhou, Zhao-Rong Lun, Zhongdao Wu
Summary: Schistosoma parasites exhibit host specificity in infection, and this study reveals that macrophages in Microtus fortis can attach to and kill schistosomula, providing insights into the host-parasite interactions and potential strategies for schistosomiasis control.
Article
Immunology
Bikash R. R. Giri, Shun Li, Chuantao Fang, Lin Qiu, Shi Yan, Maria Y. Y. Pakharukova, Guofeng Cheng
Summary: This study characterized the miRNA profiles of T cells in the liver and blood of S. japonicum infected mice, and found distinct miRNA landscapes between these two systems. The differential expression of miRNAs was associated with T cell immune responses. These findings contribute to a better understanding of the regulation of T cells during S. japonicum infection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Engineering, Biomedical
Hu Qian, Zhimin Ye, Lanping Pi, Jun Ao
Summary: This review summarizes the progress of antimicrobial GSNO applications, focusing on their anti-infective performance, underlying antibacterial mechanisms, and application in anti-infective biomaterials. The accurate overview of the roles and applications of GSNO in antibacterial biomaterials sheds new light on future studies.
MATERIALS TODAY BIO
(2022)
Article
Chemistry, Applied
Mark Wainwright
Summary: The global fight against SARS-CoV-2 has led to rapid advancements in science and healthcare, but prior to this, global infection control research was primarily focused on increasing rates of antimicrobial resistance. Antimicrobial dyes may be a promising avenue for infection control as they possess pan-microbial activity.
Article
Parasitology
Chen Zhou, Junhui Li, Chen Guo, Zhaoqin Zhou, Zhen Yang, Yu Zhang, Jie Jiang, Yu Cai, Jie Zhou, Yingzi Ming
Summary: The study compared the composition of gut microbiota in patients with chronic and advanced Schistosoma japonicum infection, revealing differences between the two groups. Patients with advanced infection had lower diversity and abundance of intestinal flora compared to those with chronic infection, with certain bacteria potentially serving as biomarkers for diagnosis. Analysis also showed that microbiota function shifted towards metabolism-related functions in the advanced infection group.
PARASITES & VECTORS
(2022)
Article
Multidisciplinary Sciences
Yuntian Xing, Jiakai Yao, Guoli Qu, Jianrong Dai, Bainian Feng
Summary: A series of aryl pyrrole derivatives were synthesized and tested for their molluscicidal activity on the intermediate host of Schistosoma japonicum, Oncomelania hupensis. Among these derivatives, Compound 6 (C6) exhibited the strongest molluscicidal activity against adult O. hupensis, with bromide on the pyrrole ring being essential for its activity. This study provides valuable insights into potential compound design and development for controlling S. japonicum transmission.
Article
Parasitology
Chen Zhou, Junhui Li, Chen Guo, Zhaoqin Zhou, Zhen Yang, Yu Zhang, Jie Jiang, Yu Cai, Jie Zhou, Meng Xia, Yingzi Ming
Summary: The study revealed alterations in gut microbiota and metabolites in patients with different stages of Schistosoma japonicum infection, which were correlated with disease progression. This inter-omics analysis may provide insights into the mechanisms of S. japonicum infection progression and aid in identifying new potential targets for diagnosis and prognosis, although further validation with a larger sample size and investigation into underlying mechanisms are needed.
PARASITES & VECTORS
(2023)
Article
Immunology
Youxiang Zhang, De-Hui Xiong, Yangyang Li, Guina Xu, Baoxin Zhang, Yang Liu, Shan Zhang, Qing Huang, Simin Chen, Fansheng Zeng, Jingyi Guo, Bin Li, Zhiqiang Qin, Zuping Zhang
Summary: The study showed that USP21 plays a crucial role in regulating immune interactions between Schistosoma and its host, with potential implications for treating hepatic fibrosis in patients with schistosomiasis. This was evidenced by changes in Th1 and Th17 responses amplified by Tregs and reduced levels of liver immunopathology in USP21 knockout mice.
JOURNAL OF IMMUNOLOGY RESEARCH
(2021)
Article
Microbiology
Yang Hong, Qinghong Guo, Xue Zhou, Liying Tang, Cheng Chen, Zheng Shang, Kerou Zhou, Zhizhong Zhang, Jinming Liu, Jiaojiao Lin, Bin Xu, Jun-Hu Chen, Zhiqiang Fu, Wei Hu
Summary: The prevalence and infectious intensity of schistosomiasis japonica has significantly decreased in China. However, more accurate and sensitive diagnostic methods are urgently required for the further control and elimination of the disease.
Article
Immunology
Alice H. Costain, Alexander T. Phythian-Adams, Stefano A. P. Colombo, Angela K. Marley, Christian Owusu, Peter C. Cook, Sheila L. Brown, Lauren M. Webb, Rachel J. Lundie, Hermelijn H. Smits, Matthew Berriman, Andrew S. MacDonald
Summary: Schistosomiasis is a globally significant disease, and the severity and pathology of the infection are directly related to the host's immune response. However, the current understanding of the immune trajectory of schistosomiasis during infection and across different tissue sites is not comprehensive and up-to-date. This study investigates the immune responses at different stages of the parasite lifecycle and in three affected tissue sites, and provides novel insights into the transcriptomic changes in the liver during schistosomiasis. The study also highlights the crucial role of CD11c(+) cells in coordinating and regulating Th2 inflammation during infection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Parasitology
Yixiao Tang, Yuanxi Shen, Yang Hong, Zuhang Zhang, Qi Zhai, Zhiqiang Fu, Hao Li, Ke Lu, Jiaojiao Lin
Summary: The study suggests a potential mutual regulation between miR-181a and the TLR4 signaling pathway during S. japonicum infection. miR-181a may regulate the expression of pro-inflammatory factors through the TLR4 receptor pathway and participate in the immunomodulatory effect of anti-S. japonicum infection. Differential expression of miR-181a in different hosts may affect the disease progression and parasite survival.
PARASITES & VECTORS
(2021)
Article
Public, Environmental & Occupational Health
Lijuan Zhang, Shan Lv, Chunli Cao, Jing Xu, Shizhu Li
Summary: The endemic status of schistosomiasis in China appeared to decrease continuously from 2015 to 2019. There was no significant decrease in snail habitats during this time period, with new habitats being detected or recurring in some regions. Strategies for snail control should focus on key areas, and efforts to understand the causes of newly-detected snail habitats and recurrent areas should be strengthened to prevent the spread of snails.
Article
Biochemistry & Molecular Biology
Lichao Zhang, Lifu Wang, Suoyu Xiang, Yunyi Hu, Siyu Zhao, Yao Liao, Zifeng Zhu, Xiaoying Wu
Summary: This study found that the Sj16 protein in Schistosoma japonicum plays a role in evading the host's immune attack and causing continuous infection. The application of CRISPR/Cas9 technique for gene editing in S. japonicum was also confirmed to be effective.
Article
Parasitology
Da-Bing Lu, Qiu-Fu Yu, Jie-Ying Zhang, Meng-Tao Sun, Man-Man Gu, Joanne P. Webster, You-Sheng Liang
Summary: Research shows that unpaired female and male schistosomes can survive within their definitive host for at least 1 year and produce viable eggs after subsequent pairing, posing an additional biological challenge in achieving elimination of schistosomiasis.
INTERNATIONAL JOURNAL FOR PARASITOLOGY
(2021)
Article
Parasitology
Yuntian Xing, Suyang Zhang, Guoli Qu, Jianrong Dai, Jiakai Yao, Bainian Feng
Summary: This study isolated 196 strains of actinomycetes from marshland soil samples and tested their molluscicidal activity against Oncomelania hupensis. A183 strain showed the highest molluscicidal efficiency. The extracted EWEA from actinomycetes A183 significantly reduced the activity of mitochondrial respiratory chain complex I, indicating its potential as a molluscicide against O. hupensis.
Article
Chemistry, Multidisciplinary
Zichuan Liu, Zhigang Xia, Jianyu Huang, Qi Wang, Jiaxin Liu, Zhenhua Wu, Weilin Xu, Bin Su
Summary: A self-powered electrochemical system using flexible magnetoelectric flag generators is proposed for the degradation of organic contaminations in water without the need for a power supply.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Engineering, Environmental
Congcan Shi, Xue Zhang, Azadeh Nilghaz, Zhenhua Wu, Tao Wang, Bocheng Zhu, Guiming Tang, Bin Su, Junfei Tian
Summary: Solar-driven interfacial evaporation is a promising solution for water scarcity, but faces challenges such as inefficient thermal energy utilization and difficulties in scaling up production. In this study, a low-cost and scalable photo-thermal material was developed using delignified spent coffee ground (D-SCG) functionalized with polypyrrole (PPy) nanoparticles. A 3D solar evaporator fabricated with PPy@D-SCG and polylactic acid (PLA) demonstrated higher water evaporation rate and photothermal conversion efficiency than previous natural materials-based solar evaporators, with potential applications in wastewater purification.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Electrical & Electronic
Jie Huang, Tao Song, Xu Qi, Taotao Mao, Chen Zhang, Peisheng Liang, Wei Wang, Jiao Jiao, Na Yao, Kaichun Zhang, Zhenhua Wu, Tao Zhao, Min Hu, Yanyu Wei, Yubin Gong, Diwei Liu
Summary: A frequency-tunable gyrotron with multi-band radiation has been designed, manufactured, and experimentally investigated. The frequency tuning scheme employing transverse modes switching and axial mode transition is used to achieve multiband radiation. Three modes TE02, TE43, and TE24 are excited successively with the increase of the magnetic field, and their main operating frequencies are 140, 250, and 263 GHz, respectively. Experimental results show that a certain frequency-tuning range can be obtained at each frequency band by exciting a series of high-order axial modes.
IEEE TRANSACTIONS ON ELECTRON DEVICES
(2023)
Article
Mechanics
Zhenqi Nie, Huiheng Wang, Bin Lu, Fan Zhang, Mingbo Wang, Zhenhua Wu, Xianyue Gang, Lijun Li
Summary: Currently, the leveling of aerial working platforms is conducted manually, leading to issues such as low accuracy, low efficiency, poor robustness, and poor adaptability. To address this, a battery-electric drive-electric control integrated aerial working chassis is proposed, along with an attitude and load coupling control model designed by the team. Performance tests show that the chassis and control system can rapidly and synchronously achieve the leveling and load homogenization of the chassis, indicating potential for being promoted as special vehicles with leveling requirements.
MECHANICS BASED DESIGN OF STRUCTURES AND MACHINES
(2023)
Article
Optics
Jiang-Tao Liu, Yuan Zhang, Xunming Cai, Jinbao Huang, Kun Luo, Hongxu Li, Dejian Zhang, Zhenhua Wu
Summary: Computational ghost imaging can be used to display the characteristics of digital data, especially periodicity. The use of optical imaging methods for analyzing binary data has unique advantages, particularly in anti-interference. Computational ghost imaging enables robust analysis and imaging of binarized signals, even in the presence of strong noise, random amplitude, and phase changes, making it highly valuable in fields such as big data analysis, meteorology, astronomy, economics, and more.
Article
Oncology
Ying Lin, Bo Yu, Haifeng Sun, Hongyu Zhang, Zhihuang Hu, Yao Zhang, Zhenhua Wu, Si Sun, Xinmin Zhao, Hui Yu, Xianghua Wu, Yuan Li, Jialei Wang, Huijie Wang
Summary: This research explored the efficacy of different treatments in thoracic SMARCA4-deficient undifferentiated tumor (SD-UT) and compared the differences in prognosis, clinicopathology, and genomics between SD-UT and SMARCA4-deficient non-small cell lung cancer (SD-NSCLC). The study found that immune checkpoint inhibitor (ICI) plus chemotherapy significantly improved progression-free survival in Stage IV SD-UT patients. The genetic study revealed frequent mutations of SMARCA4, TP53, and LRP1B in SD-UT.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Correction
Multidisciplinary Sciences
Robert. D. D. Bell, Ethan. A. A. Winkler, Itender Singh, Abhay. P. P. Sagare, Rashid Deane, Zhenhua Wu, David. M. M. Holtzman, Christer Betsholtz, Annika Armulik, Jan Sallstrom, Bradford. C. C. Berk, Berislav. V. V. Zlokovic
Article
Optics
Shaojie Chang, Zhenhua Wu, Diwei Liu, Renbin Zhong, Zhaoyun Duan, Yanyu Wei, Yubin Gong, Min Hu
Summary: In this study, we propose a novel approach to enhance the second harmonic of electron beams and increase the output power at higher frequencies. By using a planar grating for fundamental modulation and a transmission grating for harmonic coupling, the proposed structure achieves a high power output of the second harmonic signal. Computational investigations demonstrate that this configuration can generate a 0.202 THz signal with an output power of 4.59 W at an electron beam density of 50 A/cm2 and a voltage of 31.5 kV. The reduced current density in the G-band has significant implications for the advancement of terahertz vacuum devices.
Article
Optics
Yanli Xu, Shengyi Yang, Rong Li, Shanjin Lv, Zhenhua Wu, Jiangtao Liu
Summary: Most UV passive optics lack tunability and external modulation methods due to poor tunability of wide-bandgap semiconductor materials in UV working media. This study explores the excitation of magnetic dipole resonances in the solar-blind UV region using hafnium oxide metasurfaces and elastic dielectric polydimethylsiloxane (PDMS). The near-field interactions between the resonant dielectric elements can be modulated by mechanical strain of the PDMS substrate, enabling the flattening of resonant peak beyond the solar-blind UV wavelength range and switching on or off the optical switch in the solar-blind UV region. The device offers a simple design and can be applied in UV polarization modulation, optical communications, and spectroscopy.
Article
Psychiatry
Shengmin Zhang, Kaiyu Shi, Nan Lyu, Yunshu Zhang, Guangming Liang, Wufang Zhang, Xijin Wang, Hong Wen, Liping Wen, Hong Ma, Jijun Wang, Xin Yu, Lili Guan
Summary: DNA methylation was found to be involved in the development of neurodevelopmental disorders (NDDs) by affecting neurodevelopment and the immune system. Significant differentially methylated positions (DMPs) annotated to the CYP2E1 gene and altered methylation levels of FYN, STAT3, RAC1, and NR4A2 genes were associated with the development of schizophrenia (SZ) and intellectual disability (ID).
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2023)
Article
Chemistry, Multidisciplinary
Shixin Li, Zhenhua Wu
Summary: FinFET devices and Silicon-On-Insulator (SOI) devices are two mainstream technical routes that come after the planar MOSFET reached its scaling limit. SOI FinFET devices combine the advantages of both FinFET and SOI devices and can be further enhanced by SiGe channels. This study presents an optimization strategy for the Ge fraction in SiGe Channels of SGOI FinFET devices. Simulation results of RO circuits and SRAM cells demonstrate that adjusting the Ge fraction can enhance the performance and power efficiency of different circuits for various applications.
Proceedings Paper
Engineering, Electrical & Electronic
Na Li, Shihui Qiu, Zhenhua Wu, Hongju Mao
Summary: With the widespread use of assisted reproduction technology, there is still room for improvement in cell cryopreservation, especially for rare cells. This study introduces a cryopreservation system composed of pico-liter-volume droplets, which offers advantages such as single cell manipulation, high throughput, easy handleability, great performance, and customizability to optimize reagent formula for individual responses.
2023 IEEE 36TH INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS, MEMS
(2023)
Proceedings Paper
Engineering, Electrical & Electronic
Shihui Qiu, Na Li, Zhenhua Wu, Jianlong Zhao, Hongju Mao
Summary: This platform enables the isolation of tumor cells from WBCs and performs fluorescence in situ hybridization (FISH) in a single chip. The platform offers several advantages: (1) Precise cell isolation based on differences in cell size and protein biomarkers; (2) In situ analysis prevents contamination; (3) Single-cell level FISH analysis for CTCs is achieved; (4) Reagent and time savings; (5) Low costs and automation prospects. Hence, the platform holds potential for single-cell level FISH assays.
2023 IEEE 36TH INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS, MEMS
(2023)
Article
Acoustics
Deshi Meng, Lijun Li, Zhenhua Wu
Summary: This study presents the design and experimental validation of acoustic metamaterials with ventilation and broadband asymmetric absorption. An asymmetric absorbing cell (AAC) consisting of detuned Helmholtz resonators connected by sound channels achieves near-perfect sound absorption from the left port, while maintaining a ventilation ratio of 40%. Parallel three-cell asymmetric absorber (PTAA) formed by paralleling three AACs exhibits broadband asymmetric absorption. Additionally, a multi-asymmetric absorber (MAA) with a frequency range of 1000 Hz to 1750 Hz and air circulation capability is designed and fabricated using 3D printing technology.
JOURNAL OF LOW FREQUENCY NOISE VIBRATION AND ACTIVE CONTROL
(2023)
Article
Medicine, Research & Experimental
Zan-Xiong Chen, Hong-Qian Liu, Zhen-Hua Wu, Jun-Lian He, Hao-Jie Zhong
Summary: This study found that the frequency of circulating ILC3s was elevated and positively correlated with levels of serum uric acid and serum creatinine in patients with HUA. Although there was no significant difference in the plasma concentration of IL-17A between patients with HUA and healthy controls, positive correlations between plasma IL-17A and the concentration of serum uric acid and frequency of circulating ILC3s were observed in the patients with HUA.
ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
