Review
Biochemistry & Molecular Biology
Anna Kawalec, Katarzyna Kilis-Pstrusinska
Summary: This article summarizes the current evidence on the impact of microbiota alterations on immune-mediated primary glomerulonephritis in children. It focuses on the link between dysbiosis and the onset or recurrence of idiopathic nephrotic syndrome, immunoglobulin A nephropathy, and membranous nephropathy. The aim is to describe possible pathomechanisms, differences in gut microbiota composition between pediatric patients and healthy controls, and the potential usage of microbiota manipulations in supportive therapy. It also highlights the need for further research in this field.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Youssef Bouferraa, Andrea Chedid, Ghid Amhaz, Ahmed El Lakkiss, Deborah Mukherji, Sally Temraz, Ali Shamseddine
Summary: The gut microbiota plays a significant role in modulating tumor treatment, particularly in response to and resistance of immune checkpoint inhibitors. Modulating the microbial environment may offer a potential pathway to overcoming treatment resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Mario Caldarelli, Laura Franza, Pierluigi Rio, Antonio Gasbarrini, Giovanni Gambassi, Rossella Cianci
Summary: The microbiota has a significant impact on health and disease, including inflammation and immune disorders, as well as complex conditions such as neurological, psychiatric, gastrointestinal, and cardiovascular diseases. The gut microbiota may serve as an intermediary in the close interaction between the kidneys and the cardiovascular system, known as the gut-kidney-heart axis.
Review
Immunology
Kaijin Yao, Yina Xie, Jiali Wang, Yongda Lin, Xiutian Chen, Tianbiao Zhou
Summary: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that primarily affects women of childbearing age and causes damage to multiple organs. The pathogenesis of SLE involves genetic and environmental factors, and there is currently no effective cure for SLE. Recent evidence suggests that gut microbiota, as an environmental factor, can trigger autoimmunity and contribute to the development of SLE. Modulating gut microbiota through dietary intervention, drug therapy, probiotics, and fecal microbiome transplantation may be a potential treatment for SLE. This review summarizes the dysbiosis of gut microbiota in SLE, potential mechanisms linking gut microbiota and SLE, and immune dysregulation associated with gut microbiota in SLE.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Medicine, Research & Experimental
Min'an Zhao, Jiayi Chu, Shiyao Feng, Chuanhao Guo, Baigong Xue, Kan He, Lisha Li
Summary: The gut microbiota plays a crucial role in maintaining host health by enhancing digestion, protecting the intestinal barrier, and interacting with the immune system. Dysbiosis of the gut microbiota, caused by various factors, is a major contributor to inflammatory diseases. The mechanisms underlying these diseases resulting from gut microbiota dysbiosis are not well categorized.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Ludovico Abenavoli, Giuseppe Guido Maria Scarlata, Maria Rosaria Paravati, Luigi Boccuto, Francesco Luzza, Emidio Scarpellini
Summary: Liver transplantation is the preferred treatment for patients with certain liver conditions, but rejection after transplantation is a significant issue. The gut microbiota is involved in the gut-liver axis and can affect the immune response, potentially leading to graft rejection. Evaluating changes in the gut microbiota composition is essential for monitoring the success of liver transplantation and implementing appropriate preventive measures.
Review
Biochemistry & Molecular Biology
Javier Calleja-Conde, Victor Echeverry-Alzate, Kora-Mareen Buhler, Pedro Duran-Gonzalez, Jose Angel Morales-Garcia, Lucia Segovia-Rodriguez, Fernando Rodriguez de Fonseca, Elena Gine, Jose Antonio Lopez-Moreno
Summary: The human gut houses a diverse population of microorganisms called microbiota which play a key role in maintaining immune and metabolic homeostasis. Factors like diet and alcohol can influence the composition of gut bacteria, with alcohol consumption disrupting the intestinal barrier integrity and leading to a compromised mucosal immunity. This disruption allows bacteria to enter the blood tissue and affect organs like the liver and brain, contributing to the link between alcohol consumption, gut microbiota, and the immune system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Sonali Dagar, Jagdeep Singh, Aastha Saini, Yashwant Kumar, Seema Chhabra, Ranjana Walker Minz, Lekha Rani
Summary: Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes joint damage and various symptoms. The imbalance between different immune cells and changes in gut microbiota may contribute to the development of RA. Further research on gut bacteria, fungi, and viruses could provide new insights into the etiology and potential therapeutic targets for RA.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Changlu Qi, Yiting Cai, Kai Qian, Xuefeng Li, Jialiang Ren, Ping Wang, Tongze Fu, Tianyi Zhao, Liang Cheng, Lei Shi, Xue Zhang
Summary: The gut microbiota plays a crucial role in maintaining health, and disruptions can lead to disorders. The gutMDisorder database provides a valuable resource for studying dysbiosis, and the latest version offers expanded data and improved features.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Immunology
Jipeng Yan, Jin Zhao, Xiaoxuan Ning, Yunlong Qin, Yan Xing, Yuwei Wang, Qing Jia, Boyong Huang, Rui Ma, Changhui Lei, Meilan Zhou, Zixian Yu, Yumeng Zhang, Wei-Feng Guo, Shiren Sun
Summary: This study demonstrates for the first time the alterations of gut microbiota in patients with AL amyloidosis and successfully establishes and validates a microbial-based diagnostic model. This provides a foundation for future research on microbe-based strategies for diagnosis and treatment in patients with AL amyloidosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Saravana Babu Chidambaram, Musthafa Mohamed Essa, A. G. Rathipriya, Muhammed Bishir, Bipul Ray, Arehally M. Mahalakshmi, A. H. Tousif, Meena K. Sakharkar, Rajpal Singh Kashyap, Robert P. Friedland, Tanya M. Monaghan
Summary: The human microbiota plays a crucial role in regulating various physiological processes and is involved in bidirectional communication with the brain through the Gut-Brain Axis (GBA). Disruptions in the gut microbiota, known as gut dysbiosis, contribute to the pathogenesis of neurodegenerative diseases by triggering chronic neuroinflammation, impaired autophagy, and accumulation of misfolded proteins. Modulating the gut microbiota through interventions such as prebiotics, probiotics, dietary changes, and fecal microbial transplantation (FMT) shows promise as a therapeutic strategy for neurodegenerative diseases.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Cell Biology
Hilal Bashir, Sanpreet Singh, Raghwendra Pratap Singh, Javed N. Agrewala, Rashmi Kumar
Summary: Age-related loss of immune tolerance leads to autoimmune and inflammatory diseases. Aging and gut dysbiosis disrupt the tolerance of dendritic cells, which are responsible for maintaining immune tolerance. Our study reveals that gut dysbiosis in both aged and young mice leads to the loss of dendritic cell tolerance, highlighting the importance of gut microbiota in immune responses.
Article
Urology & Nephrology
Mengfei Li, Lixue Wei, Jing Sun, Qianshen Zhu, He Yang, Yu Zhang, Chao Zhang, Lin Xi, Rong Zhao, Xuanyi Du
Summary: This study analyzed the composition of the gut microbiota in patients with idiopathic membranous nephropathy (IMN) compared to healthy controls. The results showed significant differences in alpha- and beta-diversity between the two groups. IMN patients had increased abundance of Proteobacteria and decreased abundance of Bacteroidota compared to healthy controls. The study also found a negative correlation between Actinobacteriota abundance and estimated glomerular filtration rate. These findings suggest that IMN patients have an altered gut microbiome that may be related to kidney function.
Review
Physiology
Yumeng Zhang, Jin Zhao, Yunlong Qin, Yuwei Wang, Zixian Yu, Xiaoxuan Ning, Shiren Sun
Summary: Analysis of gut microbiota in patients with IMN revealed that the expansion of Proteobacteria and depletion of Lachnospira may be critical features of IMN. This finding provides important clues for the pathogenesis, diagnosis, and treatment of IMN.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Jin Shang, Yiding Zhang, Ruixue Guo, Wenli Liu, Jun Zhang, Ge Yan, Feng Wu, Wen Cui, Peipei Wang, Xuejun Zheng, Ting Wang, Yijun Dong, Jing Zhao, Li Wang, Jing Xiao, Hong Shang, Zhanzheng Zhao
Summary: This study aims to establish a non-invasive diagnostic model for membranous nephropathy (MN) using gut microbiome analysis and explore the relationship between gut microbiome and MN pathogenesis. The results show that the diversity and richness of gut microbiome are significantly lower in MN patients compared to healthy individuals. The diagnostic model based on seven key operational taxonomic units (OTUs) achieves excellent efficiency and also performs well in different regions. In a rat model, elimination of gut microbiome prevents MN model establishment, while fecal microbiome transplantation restores the phenotype of protein urine. Gut microbiome analysis may serve as a non-invasive tool for MN diagnosis, and early intervention in gut microbiome could potentially reduce urinary protein level in MN.
