Review
Neurosciences
Cedric Bressan, Armen Saghatelyan
Summary: Neuronal migration is a crucial process in brain development, involving complex interactions between external micro-environmental cues and intrinsic mechanisms. In the adult brain, neuroblasts not only migrate to the olfactory bulb but may also deviate to areas of injury.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Cell Biology
Cedric Bressan, Armen Saghatelyan
Summary: Cell migration is regulated by autophagy, with energy levels affecting autophagy regulation through AMPK activation. The dynamic balance between autophagy and energy levels is crucial for maintaining neuronal migration and coping with diverse micro-environmental factors.
Article
Cell Biology
Yue Hong, Hui Xia, Xiao Li, Ruyi Fan, Qing Li, Zhewen Ouyang, Shan Tang, Liang Guo
Summary: This study investigates the important functions of two conserved genes, BnaC06.NTT1b and BnaA07.NTT1a, in Brassica napus. These genes play a vital role in regulating ATP/ADP homeostasis in plastids and have significant effects on glycolysis and membrane lipid composition.
Article
Biochemistry & Molecular Biology
Wenyong Ding, Minghua Qi, Li Ma, Xuefei Xu, Yingfei Chen, Wenli Zhang
Summary: The study revealed that ANT1 is potentially involved in the pathogenesis of Parkinson's disease (PD) by promoting the formation of protein aggregates with alpha-synuclein, leading to neurodegenerative injury. Additionally, ANT1 supplementation in neuronal cells showed protective roles against MPP+-induced cytotoxicity. This investigation advances the understanding of ANT1 in PD etiology and provides valuable insights for potential drug targets and biomarkers in PD management.
CELL AND BIOSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Robert J. Lake, Rabeya Bilkis, Hua-Ying Fan
Summary: The study reveals a dynamic interplay between CSB and PARP1 in oxidative stress relief, with CSB facilitating PARP1's chromatin association and sustaining the DNA damage signal initiated by PARP1.
Article
Biochemistry & Molecular Biology
Max-Hinderk Schuler, Alyssa M. English, Tianyao Xiao, Thane J. Campbell, Janet M. Shaw, Adam L. Hughes
Summary: Amino acids are crucial for cellular function, but elevated levels can lead to cellular toxicity. The mitochondrial-derived compartment (MDC) has been identified as a protective mechanism against amino acid stress, promoting amino acid catabolism and maintaining homeostasis through nutrient transporter remodeling.
Review
Cell Biology
Guilherme Ventura, Jakub Sedzinski
Summary: During embryogenesis, cell migration is a common active mechanism for tissue development. Our understanding of cell migration has been mainly based on in vitro studies, focusing on cells' ability to navigate and respond to the mechanical properties of the extracellular matrix. However, the complexity of the tissue environments in vivo has limited our knowledge of cell migration in vivo.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Food Science & Technology
Valentina Cecarini, Massimiliano Cuccioloni, Yadong Zheng, Laura Bonfili, Chunmei Gong, Mauro Angeletti, Pedro Mena, Daniele Del Rio, Anna Maria Eleuteri
Summary: The study investigates how phenyl-gamma-valerolactone metabolites modulate cellular proteolysis by inhibiting proteasomes, upregulating autophagy, and inhibiting cathepsin B activity, resulting in reduced amyloid-beta (1-42) peptides. The findings suggest that these metabolites have neuroprotective effects by regulating intracellular proteolysis and could be potential targets for AD preventive and therapeutic strategies.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Neurosciences
Tanadet Pipatpolkai, Samuel G. Usher, Natascia Vedovato, Frances M. Ashcroft, Phillip J. Stansfeld
Summary: This study investigates the regulation of K-ATP channel activity by ATP and PIP2. The results show that ATP and PIP2 occupy different binding pockets but share a single amino acid residue, K39. Simulations suggest that K39 has a greater preference for coordinating with PIP2 than with ATP. The study suggests that PIP2 and ATP interact allosterically to regulate K-ATP channel activity.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Neurosciences
Yangmin Zheng, Yue Hu, Ziping Han, Feng Yan, Sijia Zhang, Zhenhong Yang, Fangfang Zhao, Lingzhi Li, Junfen Fan, Rongliang Wang, Yumin Luo
Summary: The study found that lomitapide has a neuroprotective effect after stroke, increasing survival rate, reducing neuronal damage, improving neurological function, inhibiting apoptosis and inflammation, promoting autophagy, and inhibiting pro-inflammatory microglia migration. This suggests that lomitapide may be a potential therapeutic drug for the treatment of stroke.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Review
Cell Biology
Yahao Gao, Changshui Wang, Di Jiang, Gang An, Feng Jin, Junchen Zhang, Guangkui Han, Changmeng Cui, Pei Jiang
Summary: Autophagy is a dynamic process that maintains cell homeostasis by digesting proteins and organelles. Its effect on neural tissue is debated, with some suggesting a protective role and others suggesting it can induce cell death. Oxidative stress, autophagy, and endoplasmic reticulum stress (ERS) are important defense mechanisms in cells under stress. They are integrated and amplified in pathophysiological conditions to promote disease progression. The interactions between oxidative stress, autophagy and ERS in neuronal cell death and survival are reviewed.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Ioana Genescu, Mar Anibal-Martinez, Vladimir Kouskoff, Nicolas Chenouard, Caroline Mailhes-Hamon, Hugues Cartonnet, Ludmilla Lokmane, Filippo M. Rijli, Guillermina Lopez-Bendito, Frederic Gambino, Sonia Garel
Summary: This study reveals the interaction between thalamic activity and Cajal-Retzius cells (CRc) in the construction of the cortical layer 1 (L1). Thalamic activity and NMDA receptors regulate the early density of CRc, which in turn affects the distribution of upper layer interneurons and excitatory synapses, resulting in a significant impact on the activity of output pyramidal neuron dendrites.
Article
Biology
Katrin Moller, Max Brambach, Ambra Villani, Elisa Gallo, Darren Gilmour, Francesca Peri
Summary: The migration of the centrosome in microglia is a crucial step in the engulfment of apoptotic cells. Additionally, microglia demonstrate plasticity in their phagocytic ability, as they can switch between different modes of engulfment under certain conditions.
Article
Developmental Biology
Qiushi Wang, Ruijun He, Lianwan Chen, Qi Zhang, Jin Shan, Peng Wang, Xia Wang, Yanmei Zhao
Summary: In nematodes, MIG-23 regulates sperm migration by modulating extracellular ATP levels, which is essential for major sperm protein dynamics and sperm motility.
Article
Biochemistry & Molecular Biology
Sabyasachi Dash, Chandravanu Dash, Jui Pandhare
Summary: Cocaine induces persistent cellular changes in brain reward regions by altering neuronal gene expression via chromatin remodeling. The energy-dependent PARP-1 catalyzed PARylation of p53 by cocaine results in nuclear accumulation of p53 and induction of proline oxidase, a gene involved in cellular metabolism. These findings demonstrate a novel metabolic pathway in response to cocaine treatment.
Article
Biochemistry & Molecular Biology
Matthias Gralle, Simon Labrecque, Charleen Salesse, Paul De Koninck
Summary: Insulin signaling through the insulin receptor in the brain is proposed to be important for memory, with specific distribution on dendritic shafts and spines. The dynamics of the insulin receptor are not affected by excitatory synapses, but are immobilized by inhibitory synapse components. Additionally, insulin receptor mobility is reduced by factors such as tumor necrosis factor alpha and cholesterol depletion, suggesting association with sphingolipid-rich membrane domains.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Cell Biology
Danielle Jeong, Daniela Lozano Casasbuenas, Archana Gengatharan, Kyshona Edwards, Armen Saghatelyan, David R. Kaplan, Freda D. Miller, Scott A. Yuzwa
Article
Cell Biology
Cedric Bressan, Armen Saghatelyan
Summary: Cell migration is regulated by autophagy, with energy levels affecting autophagy regulation through AMPK activation. The dynamic balance between autophagy and energy levels is crucial for maintaining neuronal migration and coping with diverse micro-environmental factors.
Article
Biochemistry & Molecular Biology
Archana Gengatharan, Sarah Malvaut, Alina Marymonchyk, Majid Ghareghani, Marina Snapyan, Judith Fischer-Sternjak, Jovica Ninkovic, Magdalena Gotz, Armen Saghatelyan
Summary: The study found that melatonin signaling affects neural stem cell activation, while multiple microenvironmental signals converge on intracellular Ca2+ pathways to regulate the quiescence and activation of neural stem cells.
Review
Neurosciences
Cedric Bressan, Armen Saghatelyan
Summary: Neuronal migration is a crucial process in brain development, involving complex interactions between external micro-environmental cues and intrinsic mechanisms. In the adult brain, neuroblasts not only migrate to the olfactory bulb but may also deviate to areas of injury.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Developmental Biology
Alina Marymonchyk, Sarah Malvaut, Armen Saghatelyan
Summary: This review discusses the use of in vivo imaging methods to study NSC dynamics and recent live-imaging results related to specific intracellular pathways that enable NSCs to integrate and decode different micro-environmental signals. Future directions for research that may provide answers to unresolved questions regarding NSC physiology are also discussed.
Article
Multidisciplinary Sciences
Clara A. Amegandjin, Mayukh Choudhury, Vidya Jadhav, Josianne Nunes Carrico, Ariane Quintal, Martin Berryer, Marina Snapyan, Bidisha Chattopadhyaya, Armen Saghatelyan, Graziella Di Cristo
Summary: Regulators of mTORC1, such as Tsc1, play a significant role in neurodevelopmental disorders associated with autism, intellectual disabilities, and epilepsy. The mTORC1 signaling pathway is essential for regulating and maintaining cortical parvalbumin cell connectivity and social behavior.
NATURE COMMUNICATIONS
(2021)
Review
Biochemical Research Methods
Jeffrey K. Cornuault, Gabriel Byatt, Marie-Eve Paquet, Paul De Koninck, Sylvain Moineau
Summary: The zebrafish model is gaining attention for investigating microbiota-host interactions due to its low cost, ability to assess large cohorts, and availability of optical methodologies. Recent findings have revealed the modulation of zebrafish gut microbiota by exogenous microbes, nutrition, and environmental factors. This model also shows potential for assessing the impact of gut microbiota on brain development.
CURRENT OPINION IN BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Armen Saghatelyan
Summary: Somatic stem cells use Ca2+ signaling to dynamically adjust their quiescence and activation states, and different Ca2+ signatures and extracellular cues impact the responses of stem cells to niche signals.
Article
Multidisciplinary Sciences
Valerie Van Steenbergen, Flavie Lavoie-Cardinal, Youcef Kazwiny, Marianna Decet, Tobie Martens, Patrik Verstreken, Werend Boesmans, Paul De Koninck, Pieter Vanden Berghe
Summary: The correct distribution of organelles and vesicles in cells is crucial for cell functioning. In polarized cells such as neurons, the transport of mitochondria, which play a key role in producing energy and buffering calcium, is especially important. This study found that the molecular conformation of tubulin affects mitochondrial transport in neurons. The position of a mitochondrion within or at the rim of a microtubule bundle determines the impact of tubulin conformation on mitochondrial transport.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Medicine, Research & Experimental
Cedric Bressan, Marta Snapyan, Marina Snapyan, Johannes Klaus, Francesco di Matteo, Stephen P. Robertson, Barbara Treutlein, Martin Parent, Silvia Cappello, Armen Saghatelyan
Summary: This study found that neuronal progenitor cells derived from PH patients with specific mutations displayed altered migratory dynamics when transplanted in mouse brains. The affected migration was linked to impaired autophagy, resulting in the accumulation of paxillin. Enhancement of autophagy through metformin treatment promoted migration of PH patients-derived cells.
EMBO MOLECULAR MEDICINE
(2023)
Article
Computer Science, Artificial Intelligence
Anthony Bilodeau, Constantin V. L. Delmas, Martin Parent, Paul De Koninck, Audrey Durand, Flavie Lavoie-Cardinal
Summary: This study proposes a weakly supervised MICRoscopy Analysis neural network (MICRA-Net) that can be trained on a simple main classification task using image-level annotations to solve more complex tasks such as semantic segmentation. MICRA-Net relies on extracted latent information from a trained model to achieve similar performances as established architectures, reducing the annotation burden in microscopy datasets.
NATURE MACHINE INTELLIGENCE
(2022)
