Article
Neurosciences
Antonin Blot, Morgane M. Roth, Ioana Gasler, Mitra Javadzadeh, Fabia Imhof, Sonja B. Hofer
Summary: Research shows that responses of mouse LP neurons mainly derive from feedforward inputs from V1, combined with information from multiple brain regions. Signals from LP projections to different higher visual areas are tuned to specific features of visual stimuli and their locomotor context.
Article
Multidisciplinary Sciences
Shan Shen, Xiaolong Jiang, Federico Scala, Jiakun Fu, Paul Fahey, Dmitry Kobak, Zhenghuan Tan, Na Zhou, Jacob Reimer, Fabian Sinz, Andreas S. Tolias
Summary: Cortical activity is regulated by a complex network of feedforward and feedback connectivity. The feedback circuit between lateromedial area and V1 activates somatostatin-expressing interneurons, while the feedback circuit between vibrissal M1 and vibrissal S1 targets vasoactive intestinal peptide-expressing interneurons. The different feedback circuits implement different dynamic non-linear operations.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Xuanjing Wu, Gideon A. Sarpong, Jingyun Zhang, Izumi Sugihara
Summary: A comprehensive study on neuronal tracing from various locations of the pontine nuclei in mice revealed different patterns of cortical projection to the cerebellum. The pontine subareas relay the corticopontine projection to specific lobules of the cerebellum, contributing to its functional organization.
Article
Cell Biology
Allison N. Gerber, Kaveh Abdi, Nevil J. Singh
Summary: The research identifies a mechanism involving the cytokine IL-12 that can control the spread of pathogens throughout the body, although it does not affect parasite burden at the infection site. The findings suggest that early secretion of IL-12p40 monomers by sentinel cells may prepare distal host tissues for potential pathogen arrival.
Article
Neurosciences
Simon Musall, Xiaonan R. R. Sun, Hemanth Mohan, Xu An, Steven Gluf, Shu-Jing Li, Rhonda Drewes, Emma Cravo, Irene Lenzi, Chaoqun Yin, Bjoern M. Kampa, Anne K. K. Churchland
Summary: Distinct cortical pyramidal neuron types have unique contributions to behavioral decisions. The interactions among diverse cortical and subcortical areas are important for successful decision outcomes. Investigating the cell types that comprise cortical circuits and their dynamics is crucial for understanding complex behavior.
NATURE NEUROSCIENCE
(2023)
Article
Neurosciences
Divya P. Narayanan, Hiroaki Tsukano, Amber M. Kline, Koun Onodera, Hiroyuki K. Kato
Summary: Understanding computational principles in hierarchically organized sensory systems requires functional parcellation of brain structures and their precise targeting for manipulations. This study evaluated the accuracy of area delineation in brain atlases by mapping functionally-identified auditory cortices onto bregma-based stereotaxic coordinates. The results showed that functional mapping in individual animals is essential for dissecting cortical area-specific roles with high precision.
Article
Biology
Sagar Raturi, Asha Nair, Keiko Shinoda, Himansha Singh, Boyan Bai, Satoshi Murakami, Hideaki Fujitani, Hendrik W. van Veen
Summary: Researchers describe functional ion pathways within the MATE transporter NorM from Vibrio cholerae (NorM-VC). By creating chimeric proteins and mutants of NorM-VC and NorM-PS, they dissect the localization of ion-coupling events and roles of conserved catalytic carboxylates in H+ binding and Na+ coordination, with findings useful to the field of transporters and drug resistance pumps.
COMMUNICATIONS BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Zheng Gan, Vijayan Gangadharan, Sheng Liu, Christoph Koerber, Linette Liqi Tan, Han Li, Manfred Josef Oswald, Juhyun Kang, Jesus Martin-Cortecero, Deepitha Maennich, Alexander Groh, Thomas Kuner, Sebastian Wieland, Rohini Kuner
Summary: The primary motor cortex (M1) regulates the sensory and aversive-emotional components of neuropathic pain through distinct pathways, offering potential for pain relief.
Article
Anatomy & Morphology
Matthew Adusei, J. Michael Hasse, Farran Briggs
Summary: Direct feedback connections from mid-level extrastriate visual cortex to the LGN were observed, supporting complementary reciprocal circuits at multiple processing stages. These connections could provide a substrate for residual vision following V1 damage, different from V1.
BRAIN STRUCTURE & FUNCTION
(2021)
Article
Chemistry, Multidisciplinary
Xiaoyan Sun, Jiangbing Xiang, Runkai Chen, Zhijun Geng, Lintao Wang, Yiqiong Liu, Shuaifei Ji, Huating Chen, Yan Li, Cuiping Zhang, Peng Liu, Tao Yue, Lei Dong, Xiaobing Fu
Summary: The research introduces a practical strategy for engineering functional human sweat glands via cell reprogramming and organoid technology. The successful regeneration of functional sweat glands in vitro and in vivo highlights the translational potential for personalized sweat gland regeneration in patients with extensive skin defects.
Article
Multidisciplinary Sciences
Jermyn Z. See, Natsumi Y. Homma, Craig A. Atencio, Vikaas S. Sohal, Christoph E. Schreiner
Summary: Coordinated neuronal ensembles in the auditory cortex can capture specific and unspecific stimulus processing information, while individual neurons can represent both aspects through membership in multiple ensembles. This demonstrates the ability of single neuron spike trains to convey multiple aspects contributing to cortical processing.
SCIENTIFIC REPORTS
(2021)
Article
Ecology
Guangru Wang, Fen Yu, Hongyan Wu, Shuzhen Hu, Shujin Wu, Nancai Pei, Jianmin Shi, Hans Lambers
Summary: The functional differences between culm roots and rhizome roots in running bamboos are explored. Culm roots primarily provide anchorage, resource acquisition, and nutrient storage, while rhizome roots mainly play a role in resource acquisition. These functional differences explain the dominant performance of running bamboos in limestone hills.
FUNCTIONAL ECOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jennifer Y. Li, Charles A. Hass, Ian Matthews, Amy C. Kristl, Lindsey L. Glickfeld
Summary: The study found significant differences in neuronal interconnections, intrinsic properties, and interneuron densities in different higher order visual cortical areas, especially between medial and lateral areas. These differences suggest that cortical areas have distinct profiles for excitability and integration of V1 inputs, enabling specialized filtering of incoming information.
Article
Cell Biology
Hyungju Jeon, Hoji Lee, Dae-Hyuk Kwon, Jiwon Kim, Keiko Tanaka-Yamamoto, Jang Soo Yook, Linqing Feng, Hye Ran Park, Yong Hoon Lim, Zang-Hee Cho, Sun Ha Paek, Jinhyun Kim
Summary: Researchers used neuroanatomical techniques to construct a comprehensive connectivity map of the subthalamic nucleus (STN) in mice, identifying three types of pathways. The study also confirmed the existence of these pathways in the human STN using MRI tractography. Additionally, the researchers identified two functional types of glutamatergic STN neurons and studied their synaptic connectivity in the indirect and hyperdirect pathways.
Article
Multidisciplinary Sciences
Qi Wang, Jia-Jie Zhu, Lizhao Wang, Yan-Peng Kan, Yan-Mei Liu, Yan-Jiao Wu, Xue Gu, Xin Yi, Ze-Jie Lin, Qin Wang, Jian-Fei Lu, Qin Jiang, Ying Li, Ming-Gang Liu, Nan-Jie Xu, Michael X. Zhu, Lu-Yang Wang, Siyu Zhang, Wei-Guang Li, Tian-Le Xu
Summary: The study found two distinct projection neuron subpopulations within the insular cortex responsible for encoding fear and extinction memories. Reciprocal inhibition between these subpopulations controls the emergence of fear or extinction memory.
NATURE COMMUNICATIONS
(2022)
Article
Biology
Janelle M. P. Paken, Scott C. Lowe, Evelyn Dylda, Sander W. Keemink, Stephen P. Currie, Christopher A. Coutts, Nathalie L. Rochefort
Article
Immunology
Elaine O'Loughlin, Janelle M. P. Pakan, Deniz Yilmazer-Hanke, Kieran W. McDermott
JOURNAL OF NEUROINFLAMMATION
(2017)
Correction
Neurosciences
Clare Howarth, Brad A. Sutherland, Hyun B. Choi, Chris Martin, Barbara Lykke Lind, Lila Khennouf, Jeffrey M. LeDue, Janelle M. P. Pakan, Rebecca W. Y. Ko, Graham Ellis-Davies, Martin Lauritzen, Nicola R. Sibson, Alastair M. Buchan, Brian A. MacVicar
JOURNAL OF NEUROSCIENCE
(2017)
Article
Neurosciences
Clare Howarth, Brad Sutherland, Hyun B. Choi, Chris Martin, Barbara Lykke Lind, Lila Khennouf, Jeffrey M. LeDue, Janelle M. P. Pakan, Rebecca W. Y. Ko, Graham Ellis-Davies, Martin Lauritzen, Nicola R. Sibson, Alastair M. Buchan, Brian A. MacVicar
JOURNAL OF NEUROSCIENCE
(2017)
Article
Neurosciences
Janelle M. P. Pakan, Valerio Francioni, Nathalie L. Rochefort
CURRENT OPINION IN NEUROBIOLOGY
(2018)
Article
Neurosciences
Rebecca M. Long, Janelle M. P. Pakan, David J. Graham, Peter L. Hurd, Cristian Gutierrez-Ibanez, Douglas R. Wylie
JOURNAL OF NEUROPHYSIOLOGY
(2018)
Article
Neurosciences
Lynette Lim, Janelle M. P. Pakan, Martijn M. Selten, Andre Marques-Smith, Alfredo Llorca, Sung Eun Bae, Nathalie L. Rochefort, Oscar Marin
NATURE NEUROSCIENCE
(2018)
Article
Multidisciplinary Sciences
Sander W. Keemink, Scott C. Lowe, Janelle M. P. Pakan, Evelyn Dylda, Mark C. W. van Rossum, Nathalie L. Rochefort
SCIENTIFIC REPORTS
(2018)
Article
Cell Biology
Janelle M. P. Pakan, Stephen P. Currie, Lukas Fischer, Nathalie L. Rochefort
Article
Optics
Sergey Turtaev, Ivo T. Leite, Tristan Altwegg-Boussac, Janelle M. P. Pakan, Nathalie L. Rochefort, Tomas Cizmar
LIGHT-SCIENCE & APPLICATIONS
(2018)
Article
Cell Biology
Julia U. Henschke, Alan T. Price, Janelle M. P. Pakan
Summary: The study found that in mice, the primary auditory region (A1) shows more suppression of neuronal activity during locomotion, while the dorsal auditory cortex (AuD) shows more enhanced responses. Additionally, AuD is more highly connected to the motor cortex, and different subpopulations of neurons in AuD respond differently to locomotion.
Article
Multidisciplinary Sciences
Weilun Sun, Ilseob Choi, Stoyan Stoyanov, Oleg Senkov, Evgeni Ponimaskin, York Winter, Janelle M. P. Pakan, Alexander Dityatev
Summary: The study demonstrates that neurons in the retrosplenial cortex are capable of encoding multiple task-related dimensions across learning, particularly showing enhanced performance in tasks requiring cognitive flexibility. Chemogenetic inactivation of the RSC disrupts behavioral context discrimination during learning phases, but does not affect recall of previously formed associations, suggesting a crucial role for the RSC in context-value updating.
NATURE COMMUNICATIONS
(2021)
Article
Biology
Jiechang Tang, Rou Xue, Yan Wang, Min Li, Hongbo Jia, Janelle M. P. Pakan, Longhui Li, Xiaowei Chen, Xingyi Li
Summary: In this study, a robust and accessible method for chronically recording CF calcium signals in freely behaving mice was established, which may extend the toolbox for studying cerebellar function and related disorders.
Meeting Abstract
Endocrinology & Metabolism
C. Howarth, B. A. Sutherland, H. B. Choi, C. Martin, B. L. Lind, L. Khennouf, J. M. P. Pakan, G. C. R. Ellis-Davies, M. J. Lauritzen, N. R. Sibson, A. M. Buchan, B. A. MacVicar
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2016)