Article
Immunology
Chengcheng Peng, Duo Zhang, Chenghui Li, Yiquan Li, He Zhang, Nan Li, Pengpeng Xiao
Summary: This study gathered Rhinolophus sinicus samples and used metavirome techniques to obtain enriched viral sequences of the Rhinolophus sinicus-specific virome. Chikungunya virus (CHIKV) and Japanese encephalitis virus (JEV) present in Rhinolophus sinicus were validated through PCR. Notably, it was the first time JEV was isolated from Rhinolophus sinicus. The newly isolated JEV sequence showed increased infectivity during passaging in Vero cells.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Duo Zhang, Min Zheng, Ying Zhang, Guanrong Feng, Chengcheng Peng, Chenghui Li, Yiquan Li, He Zhang, Nan Li, Pengpeng Xiao
Summary: Metavirome sequencing and PCR analysis of pangolin samples from Guangxi Province, China revealed the presence of various viral sequences, including Japanese encephalitis virus, Getah virus, and chikungunya virus. Additionally, sudden and recurrent viruses were observed, prompting future dissemination tests.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Virology
Yuan Fang, Emad I. M. Khater, Jing-Bo Xue, Enas H. S. Ghallab, Yuan-Yuan Li, Tian-Ge Jiang, Shi-Zhu Li
Summary: This systematic review examines the prevalence of mosquito-borne viruses (MBVs) in Egypt. The study finds that dengue virus (DENV) and West Nile virus (WNV) have shown an increase in seropositivity rates, and spillover events have been recorded. The surveillance system for MBVs in Egypt has deficiencies and calls for the establishment of an early warning system and a joint system for medical care and public health.
Review
Virology
Oselyne T. W. Ong, Eloise B. Skinner, Brian J. Johnson, Julie M. Old
Summary: Australia is home to several endemic mosquito-borne viruses that affect non-human vertebrates. The unique island biogeography of Australia and endemic vertebrate species make it highly susceptible to foreign mosquito species establishing and mosquito-borne viruses becoming endemic.
Review
Entomology
Zhao-Yang Wang, Kai-Xiao Nie, Ji-Chen Niu, Gong Cheng
Summary: Mosquito-borne viruses (MBVs) pose a significant threat to global public health, including dengue virus, Zika virus, Japanese encephalitis virus, West Nile virus, and chikungunya virus. Mosquito saliva contains proteins that not only facilitate blood feeding but also play important roles in regulating local and systemic infection, as well as modulating the host immune responses. This review discusses the physiological functions of mosquito salivary proteins (MSPs), their impact on MBV transmission, and the current progress and challenges in developing MSP-based MBV transmission blocking vaccines.
Article
Biochemical Research Methods
Fahmida Nasrin, Indra Memdi Khoris, Ankan Dutta Chowdhury, Sjakurrizal El Muttaqein, Enoch Y. Park
Summary: To prevent viral diseases, the development of a disposable, rapid, and convenient biosensor with high sensitivity and reliability is highly desired. In this study, a practical impedimetric biosensor has been created on a disposable electrode for the detection of two mosquito-borne viruses. The biosensor fabrication involves the formation of a conductive film, physical binding of gold nanoparticles-polyaniline, and biofunctionalization. The disposable electrode has been designed to detect Chikungunya virus and Zika virus separately with a wide linear range and low detection limits.
BIOTECHNOLOGY JOURNAL
(2023)
Review
Medicine, General & Internal
Lukas Wilkman, Clas Ahlm, Magnus Evander, Olivia Wesula Lwande
Summary: Five endemic mosquito-borne viruses in Fennoscandia have significant impact on human health, but their incidence remains unknown due to underdiagnosing and lack of surveillance. The complex transmission and lack of clear case definition criteria make prevention and diagnosis of Fennoscandian moboviruses challenging, leading to potential misdiagnosis. Some infections have long-term effects such as malaise, rash, and joint pain. Research on mobovirus diseases is mainly focused on a few pathogens, neglecting many others. This review aims to summarize current medically relevant knowledge of moboviruses in Fennoscandia while highlighting unknown and overlooked aspects.
FRONTIERS IN MEDICINE
(2023)
Article
Microbiology
Fengjuan Tian, Jimin He, Shanlin Shang, Zhongyan Chen, Yumei Tang, Man Lu, Changzhi Huang, Xiaofang Guo, Yigang Tong
Summary: Mosquitoes play a significant role in spreading complex pathogens, particularly through their feeding habits on mammalian blood. Surveillance of mosquito-borne viruses is crucial in preventing and controlling arboviral diseases. This study focused on the neighborhoods along the Sino-Vietnam border in Yunnan Province, China, and identified various mosquito species and mosquito-borne viruses, including some previously unreported viruses in China. These findings emphasize the importance of viral surveillance and prevention measures in border areas to prevent future outbreaks.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Takayuki Amemiya, Katsuhisa Horimoto, Kazuhiko Fukui
Summary: The study focused on applying computational drug repositioning to five mosquito-borne viral infections, identifying 77 drug candidates and 146 proteins for these diseases. Signature molecules and pathways for each virus infection were determined based on omics analyses, and drugs were classified according to the degree of target proteins in the protein-protein interaction network.
SCIENTIFIC REPORTS
(2021)
Article
Public, Environmental & Occupational Health
John F. Anderson, Durland Fish, Philip M. Armstrong, Michael J. Misencik, Angela Bransfield, Francis J. Ferrandino, Theodore G. Andreadis, Mark D. Stenglein, Marylee L. Kapuscinski
Summary: Mosquitoes were collected and tested for viruses in the Florida Everglades and Collier County for 12 months. A total of 31 mosquito species and 7 viruses were identified. The study indicates that as human communities expand into the Everglades, there is an increased risk of exposure to arboviruses.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2022)
Article
Chemistry, Analytical
Fahmida Nasrin, Kenta Tsuruga, Doddy Irawan Setyo Utomo, Ankan Dutta Chowdhury, Enoch Y. Park
Summary: The treatment for mosquito-borne viral diseases such as dengue virus (DENV), Zika virus (ZIKV), and chikungunya virus (CHIKV) has become challenging due to delayed diagnosis processes. A common platform that can detect these viruses with high sensitivity and selectivity is in high demand. Through the use of an electrochemical impedimetric method and a common matrix of gold-polyaniline and sulfur, nitrogen-doped graphene quantum dot nanocomposites, successful detection of four serotypes of DENV and ZIKV, and CHIKV has been achieved with a low LOD of femtogram mL(-1).
Article
Virology
Jingjing Jiang, Stephanie J. Ramos, Preeti Bangalore, Dustin Elwood, Kathleen A. Cashman, Sagar B. Kudchodkar, Katherine Schultheis, Holly Pugh, Jewell Walters, Jared Tur, Jian Yan, Ami Patel, Kar Muthumani, Connie S. Schmaljohn, David B. Weiner, Laurent M. Humeau, Kate E. Broderick
Summary: The emergence of concurrent infectious diseases poses a complex burden on global public health systems. DNA vaccines have shown promise as a versatile platform for rapidly deployable, safe vaccines against multiple viruses. Proof-of-concept studies in animals demonstrate robust cellular and humoral immune responses to multivalent DNA vaccines, suggesting their potential in developing vaccines for emerging infectious diseases.
Article
Parasitology
Mohamed F. F. Sallam, Shelley Whitehead, Narayani Barve, Amely Bauer, Robert Guralnick, Julie Allen, Yasmin Tavares, Seth Gibson, Kenneth J. J. Linthicum, Bryan V. V. Giordano, Lindsay P. P. Campbell
Summary: Mosquito vectors of EEEV and WNV in the USA vary in their composition and abundance, which affects pathogen transmission risk and vector control management. This study used CRF to examine spatial co-occurrence patterns between mosquito vectors and found that landscape and climate variables did not substantially improve the prediction of vector species abundance. The majority of vector species were positively dependent on other mosquito species, indicating that they may be habitat generalists.
PARASITES & VECTORS
(2023)
Article
Infectious Diseases
Laura Koenenkamp, Ute Ziegler, Torsten Naucke, Martin H. Groschup, Imke Steffen
Summary: Flavivirus diagnostics are complicated by cross-reactivity of antibodies between different species, especially in regions with multiple endemic viruses. This study developed a luciferase immunoprecipitation system to compare antibody responses against TBEV and WNV in dogs. The NS1 protein was found to be a suitable antigen for distinguishing between the two viruses, with sensitivity and specificity similar to virus neutralization tests.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Public, Environmental & Occupational Health
Alan P. Dupuis, Melissa A. Prusinski, Alexis Russell, Collin O'Connor, Joseph G. Maffei, JoAnne Oliver, John J. Howard, James A. Sherwood, Keith Tober, Ilia Rochlin, Moses Cucura, Bryon Backenson, Laura D. Kramer
Summary: Serum samples from white-tailed deer harvested in New York State from 2007 to 2015 were tested for antibodies against nine mosquito-borne viruses. The majority of the deer were seropositive against at least one virus, with adults showing a significantly higher positivity rate than fawns. Different regions showed varying rates of exposure to different viruses, with the results highlighting the value of white-tailed deer as an indicator of arbovirus distribution and recent transmission.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Biology
Morgan P. Kain, Eloise B. Skinner, Andrew F. van den Hurk, Hamish McCallum, Erin A. Mordecai
Summary: The study introduces a nested approach to quantify the importance of hosts and vectors by integrating their physiological competence with ecological traits. Results indicate that interactions between hosts and vectors play a significant role in the transmission of Ross River virus, highlighting the importance of physiological competence in vectors.
Review
Biology
Lisa Couper, Johannah E. Farner, Jamie M. Caldwell, Marissa L. Childs, Mallory J. Harris, Devin G. Kirk, Nicole Nova, Marta Shocket, Eloise B. Skinner, Lawrence H. Uricchio, Moises Exposito-Alonso, Erin A. Mordecai
Summary: The study focuses on the importance of adaptive evolution for species persistence under climate change, particularly in short-lived ectotherms like mosquitoes. Despite knowledge gaps, common methods such as common garden and selection experiments can be used to fill these data gaps and improve our understanding of mosquito climate adaptation.
Article
Agricultural Economics & Policy
Nicole Nova, Tejas S. Athni, Marissa L. Childs, Lisa Mandle, Erin A. Mordecai
Summary: Global change plays a significant role in driving the emergence of infectious diseases, and interdisciplinary collaboration is needed to find more effective and sustainable interventions for disease prevention.
ANNUAL REVIEW OF RESOURCE ECONOMICS
(2022)
Article
Ecology
Devin Kirk, Mary O'Connor, Erin A. Mordecai
Summary: This study investigated the temperature dependence of parasitism in individual hosts and at the population level. The findings indicate a strong positive correlation between individual- and population-level parasitism, although some environmentally transmitted systems showed thermal optima differences between individual and population levels. Simple models were also used to simulate different transmission modes and yielded similar results. The study suggests that information on the temperature dependence at either the individual or population level can be useful for predicting temperature dependence at the other level, especially in vector-borne parasite systems. However, environmentally transmitted parasitism may operate differently and require further trait-based studies.
JOURNAL OF ANIMAL ECOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Krish Seetah, Hannah Moots, David Pickel, Marit Van Cant, Alessandra Cianciosi, Erin Mordecai, Mark Cullen, Yvonne Maldonado
Summary: COVID-19 has had a significant impact on global public health and economy. Non-pharmaceutical interventions are crucial as pharmaceutical interventions take time. Anthropological and historical perspectives provide insights for future non-pharmaceutical interventions. Inadequate quarantine and containment infrastructure hinder effective pandemic response. Longitudinal assessment of past interventions and addressing historical legacies are essential for implementing effective quarantine policies and infrastructure. Social equity and compassion are emphasized in containment measures.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Parasitology
Lisa Couper, Erin A. Mordecai
Summary: The study identified three previously unrecognized vectors of dog heartworm transmission in California and the climate and land cover variables associated with the presence of each species. The results provide important guidance for surveillance and control efforts targeting these vector species.
PARASITES & VECTORS
(2022)
Article
Infectious Diseases
Morgan P. Kain, Eloise B. Skinner, Tejas S. Athni, Ana L. Ramirez, Erin A. Mordecai, Andrew F. van den Hurk
Summary: Understanding the ecology of mosquito-borne arboviruses and the role of different mosquito species in virus transmission is crucial for disease control. This study examined data from Australian mosquito species and viruses of public health concern to further validate and quantify traditional vector-virus groupings. The findings reinforce existing groupings but also highlight significant variations within them.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Parasitology
Karen M. M. Holcomb, Sarabeth Mathis, J. Erin Staples, Marc Fischer, Christopher M. M. Barker, Charles B. B. Beard, Randall J. J. Nett, Alexander C. C. Keyel, Matteo Marcantonio, Marissa L. L. Childs, Morgan E. E. Gorris, Ilia Rochlin, Marco Hamins-Puertolas, Evan L. L. Ray, Johnny A. A. Uelmen, Nicholas DeFelice, Andrew S. S. Freedman, Brandon D. D. Hollingsworth, Praachi Das, Dave Osthus, John M. M. Humphreys, Nicole Nova, Erin A. A. Mordecai, Lee W. W. Cohnstaedt, Devin Kirk, Laura D. D. Kramer, Mallory J. J. Harris, Morgan P. P. Kain, Emily M. X. Reed, Michael A. A. Johansson
Summary: This study evaluated the prediction of West Nile virus neuroinvasive disease (WNND) using forecasts submitted to the 2020 WNV Forecasting Challenge. The results showed that simple models based on historical WNND cases performed better than more complex models and had better calibration of uncertainty. Forecast skill improved throughout the 2020 season and certain data and characteristics were found to be associated with forecast skill variation.
PARASITES & VECTORS
(2023)
Article
Infectious Diseases
Gowri Vadmal, Caroline Glidden, Barbara Han, Bruno Carvalho, Adrian Castellanos, Erin Mordecai
Summary: This study created a database of sandfly traits and used predictive models to determine important factors in parasite transmission for American Cutaneous Leishmaniasis (ACL). The study found that transmission occurs at the interface between domestic habitats and well-preserved forests. The authors also generated predictions of potential vectors, including Psychodopygus amazonensis and Nyssomia antunesi, which can contribute to a better understanding of the transmission system and risks.
PLOS NEGLECTED TROPICAL DISEASES
(2023)
Article
Green & Sustainable Science & Technology
Eloise B. Skinner, Caroline K. Glidden, Andrew J. MacDonald, Erin A. Mordecai
Summary: Using human footprint index and machine learning, this study demonstrates the relationship between human pressure and the occurrence of diverse vector-borne diseases. The findings highlight the importance of predicting the impact of human-environment interactions on pathogen transmission to mitigate disease risks.
NATURE SUSTAINABILITY
(2023)
Review
Infectious Diseases
Ah-Young Lim, Yalda Jafari, Jamie M. Caldwell, Hannah E. Clapham, Katy A. M. Gaythorpe, Laith Hussain-Alkhateeb, Michael A. Johansson, Moritz U. G. Kraemer, Richard J. Maude, Clare P. McCormack, Jane P. Messina, Erin A. Mordecai, Ingrid B. Rabe, Robert C. Reiner Jr, Sadie J. Ryan, Henrik Salje, Jan C. Semenza, Diana P. Rojas, Oliver J. Brady
Summary: Aedes-borne diseases pose a global threat, and geostatistical models are used to create predictive risk maps. However, different diseases require different data and approaches.
BMC INFECTIOUS DISEASES
(2023)
Article
Anthropology
Mallory. J. J. Harris, Kimberly. J. J. Cardenas, Erin. A. A. Mordecai
Summary: During infectious disease outbreaks, the behavior based on perceived risk can change epidemic dynamics and produce large later waves, depending on group division. This study developed a compartmental model to investigate the impacts of awareness separation and mixing separation on disease transmission and awareness-based protective behavior in a population split into two groups. The simulations showed that groups that are more separated in awareness have smaller differences in mortality, and fatigue can drive additional infection waves. Counterintuitively, more protective vaccine or immunity may indirectly lead to more infections by reducing perceived risk of infection.
EVOLUTIONARY HUMAN SCIENCES
(2023)
Article
Ecology
Sherine Ismail, Johannah Farner, Lisa Couper, Erin Mordecai, Kelsey Lyberger
Summary: Parasites have important roles in regulating aquatic ecosystems, but the effects of climate warming on their ecology and disease transmission are not well understood. This study investigates the impact of temperature on host-parasite interactions and disease transmission using mosquitoes and parasites as a model system. The findings show that temperature affects parasite growth and infection rates, with peak performance temperatures varying among parasite populations. These results emphasize the need to consider both host and parasite thermal responses, as well as intraspecific variation, when predicting the impacts of climate change on disease in aquatic ecosystems.
Article
Environmental Sciences
Susanne H. Sokolow, Nicole Nova, Isabel J. Jones, Chelsea L. Wood, Kevin D. Lafferty, Andres Garchitorena, Skylar R. Hopkins, Andrea J. Lund, Andrew J. MacDonald, Christopher LeBoa, Alison J. Peel, Erin A. Mordecai, Meghan E. Howard, Julia C. Buck, David Lopez-Carr, Michele Barry, Matthew H. Bonds, Giulio A. De Leo
Summary: Environmentally mediated infectious diseases pose a significant global health problem, particularly in tropical and impoverished countries. The burden of these diseases is closely linked to rural poverty, political stability, and wealth. Innovative social and ecological interventions are needed to address this issue and achieve global health and sustainability goals.
LANCET PLANETARY HEALTH
(2022)
Review
Respiratory System
Kevin R. Cromar, Susan C. Anenberg, John R. Balmes, Allen A. Fawcett, Marya Ghazipura, Julia M. Gohlke, Masahiro Hashizume, Peter Howard, Eric Lavigne, Karen Levy, Jaime Madrigano, Jeremy A. Martinich, Erin A. Mordecai, Mary B. Rice, Shubhayu Saha, Noah C. Scovronick, Fatih Sekercioglu, Erik R. Svendsen, Benjamin F. Zaitchik, Gary Ewart
Summary: This study conducted a systematic review and meta-analysis to estimate the health impacts of increased temperatures on mortality risk in different global regions. The results showed that increased average annual temperatures were associated with a net increase in mortality risk ranging from 0.1% to 1.1% per 1 degrees C. The expert panel made recommendations for improving the estimation of health impacts in economic-climate models.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
