期刊
TOXINS
卷 12, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/toxins12100643
关键词
T-2 toxin; adsorbents; rats; antidote
资金
- University of Hradec Kralove (Faculty of Science), Czech Republic [VT2019-2021]
- National Natural Science Foundation of China [31972741]
- Medical Faculty of the Military Medical Academy, the University of Defence in Belgrade, Republic of Serbia [MFVMA/04/20-22]
In this paper, the potential antidote efficacy of commercially available formulations of various feed additives such as Minazel-Plus, Mycosorb, and Mycofix was considered by recording their incidence on general health, body weight, and food and water intake, as well as through histopathology and semiquantitative analysis of gastric alterations in Wistar rats treated with the T-2 toxin in a single-dose regimen of 1.67 mg/kg p.o. (1 LD50) for 4 weeks. As an organic adsorbent, Mycosorb successfully antagonized acute lethal incidence of the T-2 toxin (protective index (PI) = 2.25; p < 0.05 vs. T-2 toxin), and had adverse effects on body weight gain as well as food and water intake during the research (p < 0.001). However, the protective efficacy of the other two food additives was significantly lower (p < 0.05). Treatment with Mycosorb significantly reduced the severity of gastric damage, which was not the case when the other two adsorbents were used. Our results suggest that Mycosorb is a much better adsorbent for preventing the adverse impact of the T-2 toxin as well as its toxic metabolites compared with Minazel-plus or Mycofix-plus, and it almost completely suppresses its acute toxic effects and cytotoxic potential on the gastric epithelial, glandular, and vascular endothelial cells.
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