Article
Geriatrics & Gerontology
Lisa Martin, Maurizio Muscaritoli, Isabelle Bourdel-Marchasson, Catherine Kubrak, Barry Laird, Bruno Gagnon, Martin Chasen, Ioannis Gioulbasanis, Ola Wallengren, Anne C. Voss, Francois Goldwasser, R. Thomas Jagoe, Chris Deans, Federico Bozzetti, Florian Strasser, Lene Thoresen, Sean Kazemi, Vickie Baracos, Pierre Senesse
Summary: The research aggregated data from Canadian and European studies to evaluate the associations of reduced food intake and CRP with cancer-associated weight loss and overall survival. The study identified important factors such as reduced food intake and CRP levels that were associated with cancer-associated cachexia. These findings may help improve the diagnosis and classification of cancer-related wasting.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Cardiac & Cardiovascular Systems
Amanda R. Vest, Joronia Chery, Laura Telfer, Matthew Lawrence, Michael S. Kiernan, Gregory Couper, Edward Saltzman, Didjana Celkupa, Masashi Kawaborie, William W. Wong, Alex Coston
Summary: There were significant gains in skeletal muscle mass among LVAD recipients with advanced systolic heart failure during the first 6 months of LVAD support.
CIRCULATION-HEART FAILURE
(2022)
Article
Nutrition & Dietetics
Alessio Molfino, Sara Emerenziani, Giuseppe Tonini, Daniele Santini, Antonietta Gigante, Michele Pier Luca Guarino, Chiara Nuglio, Giovanni Imbimbo, Annalisa La Cesa, Michele Cicala, Maurizio Muscaritoli
Summary: This study evaluated the prevalence of anorexia, hypophagia, and cachexia in patients with gastrointestinal or lung cancer at time of diagnosis. The results showed that 68% of patients had cachexia, 57% had anorexia, and 48% had hypophagia. These conditions had negative impacts on patients' nutritional intake, indicating a need for early multimodal strategies to improve food intake.
FRONTIERS IN NUTRITION
(2023)
Article
Nutrition & Dietetics
Miho Yamamoto, Masafumi Nozoe, Rio Masuya, Yosuke Yoshida, Hiroki Kubo, Shinichi Shimada, Koji Shomoto
Summary: This study found that the cachexia criteria were independently associated with acute weight loss in patients with a stroke.
Review
Biochemistry & Molecular Biology
Britt van de Haterd, Kenneth Verboven, Frank Vandenabeele, Anouk Agten
Summary: Up to 60% of colorectal cancer patients develop cachexia, which is associated with adverse events during therapy. The main manifestation is skeletal muscle mass loss due to imbalance in protein synthesis and degradation. Systemic inflammation, oxidative stress, and proteolytic systems result in mitochondrial dysfunction, leading to imbalanced skeletal muscle metabolism. The role of mitochondria in the development of cancer cachexia remains unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Geriatrics & Gerontology
Preeti Lakshman Kumar, Ava C. Wilson, Alison Rocco, Michael H. Cho, Emily Wan, Brian D. Hobbs, George R. Washko, Victor E. Ortega, Stephanie A. Christenson, Xingnan Li, J. Michael Wells, Surya P. Bhatt, Dawn L. DeMeo, Sharon M. Lutz, Harry Rossiter, Richard Casaburi, Stephen Rennard, David A. Lomas, Wassim W. Labaki, Ruth Tal-Singer, Russel P. Bowler, Craig P. Hersh, Hemant K. Tiwari, Mark Dransfield, Anna Thalacker-Mercer, Deborah A. Meyers, Edwin K. Silverman, Merry-Lynn N. Mcdonald
Summary: The EFNA2 and BAIAP2 genes were found to be significantly associated with weight loss in COPD patients, potentially influencing skeletal muscle regeneration and tissue remodeling through network analysis.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Medicine, General & Internal
Naomi Nakayama, Kentaro Nakayama, Tomoka Ishibashi, Satoru Katayama, Satoru Kyo
Summary: This study aimed to clarify the impact of muscle loss during cytoreductive surgery and chemotherapy on prognosis in patients with ovarian cancer. The results showed that muscle loss, but not fat loss, was associated with worse disease-free survival and overall survival in ovarian cancer.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Food Science & Technology
Deena B. Snoke, Yuko Nishikawa, Rachel M. Cole, Ai Ni, Austin Angelotti, Yael Vodovotz, Martha A. Belury
Summary: The study suggests that dietary supplementation of naringenin can improve insulin sensitivity, reduce inflammation, slow down body weight loss, and delay tumor growth in cancer cachexia. However, it also accelerates anorexia and weight loss in the experimental mice.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Oncology
Byung Min Lee, Yeona Cho, Jun Won Kim, Sung Gwe Ahn, Jee Hung Kim, Hei Cheul Jeung, Joon Jeong, Ik Jae Lee
Summary: This study investigated the association between skeletal muscle loss and response to neoadjuvant chemotherapy in breast cancer patients. The results showed that skeletal muscle loss and cancer stage were significantly associated with poor response to neoadjuvant chemotherapy in locally advanced breast cancer patients. Accurately measuring muscle loss and delaying its progression through interventions may improve the response to neoadjuvant chemotherapy and overall clinical outcomes.
Review
Biochemistry & Molecular Biology
Iain Phillips, Mark Stares, Lindsay Allan, Judith Sayers, Richard Skipworth, Barry Laird
Summary: Lung cancer is the most common malignancy worldwide and the leading cause of cancer death. However, many patients with advanced lung cancer are too unwell for treatment, leading to poor outcomes. Cancer cachexia, which is common in patients with Non-Small Cell Lung Cancer, is one of the reasons patients are not fit for treatment. There is emerging data suggesting that multi-modal intervention may have a role in treating cachexia.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2022)
Article
Geriatrics & Gerontology
Hui-Jie Zhang, Ben-Hui Wang, Xiang Wang, Chun-Ping Huang, Si-Man Xu, Jia-Li Wang, Tian-E Huang, Wan-Li Xiao, Xiao-Li Tian, Xin-Qiang Lan, Qi-Quan Wang, Yang Xiang
Summary: The study showed that Handelin can protect against muscle atrophy in mice, promote muscle growth, and improve motor function, possibly by maintaining the balance of protein synthesis and degradation and inhibiting inflammation.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Multidisciplinary Sciences
Juquan Song, Imran H. Chowdhury, Subhadip Choudhuri, Amina E. I. Ayadi, Lizette E. Rios, Steven E. Wolf, Joseph C. Wenke, Nisha J. Garg
Summary: Burn injury leads to muscle wasting, and this study found that high mobility group box 1 (HMGB1) plays an important role in the hyper-inflammatory response and subsequent muscle impairment after burn. Neutralizing HMGB1 with antibodies reduced burn wound size and preserved muscle weight, while also decreasing cell death and autophagy markers. Furthermore, the antibodies inhibited inflammatory activation of bone marrow and T cells, and reduced inflammatory infiltrate in muscle tissues. Neutralization of HMGB1-dependent proteolytic and inflammatory responses may have beneficial effects in preventing muscle loss after severe burn injury.
SCIENTIFIC REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Wenlan Li, Kristy Swiderski, Kate T. Murphy, Gordon S. Lynch
Summary: Cancer cachexia is a progressive muscle wasting and weakness experienced by cancer patients, which can compromise treatment response and reduce quality of life. It has no effective treatment currently, but plant-derived antioxidants, especially polyphenols, show potential in attenuating cancer-related muscle loss.
Article
Oncology
Lisa Patzelt, Daniela Junker, Jan Syvaeri, Egon Burian, Mingming Wu, Olga Prokopchuk, Ulrich Nitsche, Marcus R. Makowski, Rickmer F. Braren, Stephan Herzig, Mauricio Berriel Diaz, Dimitrios C. Karampinos
Summary: This study evaluated the suitability of psoas and erector spinae muscle proton density fat fraction (PDFF) and fat volume as biomarkers for monitoring cachexia severity in an oncological cohort, and assessed regional variances in muscle parameters over time. Results showed regional variation of fat distribution in erector spinae muscles and significant changes in muscle parameters, indicating the potential of psoas muscle PDFF and fat volume as MRI-determined biomarkers for early risk stratification and disease monitoring in cancer cachexia.
Review
Biochemistry & Molecular Biology
Miriam Ferrer, Tracy G. Anthony, Janelle S. Ayres, Giulia Biffi, Justin C. Brown, Bette J. Caan, Elizabeth M. Cespedes Feliciano, Anthony P. Coll, Richard F. Dunne, Marcus D. Goncalves, Jonas Grethlein, Steven B. Heymsfield, Sheng Hui, Mariam Jamal-Hanjani, Jie Min Lam, David Y. Lewis, David McCandlish, Karen M. Mustian, Stephen O'Rahilly, Norbert Perrimon, Eileen P. White, Tobias Janowitz
Summary: Cachexia, a wasting condition, is a late consequence of diseases and causes significant harm to the body. The process and progression of cachexia are not fully understood. Shifting focus to the etiology of cachexia may lead to new therapeutic approaches.