Article
Polymer Science
Bingqing Zheng, Genqi Liu, Lingli Zhao, Gang Wang, Yue Wang
Summary: We have developed a novel molecularly imprinted two-dimensional photonic crystal hydrogels (LVFXMIPCH) sensor for the visual monitoring of levofloxacin (LVFX). By measuring the diameter of the Debye diffraction ring, the response performance of the sensor was explored. The LVFX-MIPCH sensor showed high sensitivity (as low as 10^(-12) M), excellent specific recognition, and stable reusability.
Article
Polymer Science
Xingbin Ma, Shuyu Li, Jiajie Qiu, Zijie Liu, Siyu Liu, Zhifeng Huang, Yanhong Yong, Youquan Li, Zhichao Yu, Xiaoxi Liu, Hongling Lin, Xianghong Ju, A. M. Abd El-Aty
Summary: The choice of carrier material is crucial for studying natural drug release preparations and glycosylated magnetic molecularly imprinted materials. The combination of paramagnetic Fe3O4 and carboxymethyl chitosan (CC) was used to enhance the imprinting effect and improve drug delivery in this study. The SMCMIP composite exhibited sustained release properties and showed no harmful effects on cell growth, making it a potential tool for improved therapeutic outcomes and reduced side effects.
Article
Biochemistry & Molecular Biology
Maria Stachowiak, Michal Ceglowski, Joanna Kurczewska
Summary: In this study, composite chitosan beads with incorporated molecularly imprinted polymers and iron(III) hydroxide were developed for the removal of ibuprofen from water. The adsorption properties were investigated under different conditions, and the highest adsorption capacity was achieved with the beads containing ibuprofen-imprinted monoliths. The adsorption followed the Freundlich isotherm and pseudo-second-order kinetic models, and the process was found to be endothermic and thermodynamically spontaneous. The adsorbent retained its selectivity and remained effective in real water samples for multiple desorption-adsorption cycles.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Chemistry, Multidisciplinary
Maylis Garnier, Michele Sabbah, Christine Menager, Nebewia Griffete
Summary: Hybrid molecularly imprinted polymers have the potential to enhance imaging, treatments, or a combination of both in nanomedicine, offering new interesting properties suitable for patient care.
Review
Biochemistry & Molecular Biology
Rui Liu, Alessandro Poma
Summary: Despite significant efforts in the past decades, challenges such as severe side effects and poor bioavailability continue to hinder the clinical translation of drug molecules. As a result, researchers are turning their attention to drug delivery vehicles, with molecularly imprinted polymers (MIPs) showing promise due to their selective recognition, enhanced drug loading, sustained release, and robustness in harsh conditions. This review highlights the design and development of strategies for MIPs used as drug delivery vehicles, focusing on different drug delivery mechanisms, such as rate-programmed, stimuli-responsive, and active targeting, published over the past five years.
Review
Chemistry, Multidisciplinary
Shuxin Xu, Lisheng Wang, Zhen Liu
Summary: Molecularly imprinted polymers (MIPs) are tailor-made affinity materials with unique binding cavities, which have been engineered for cancer therapy. Using nanoMIPs as alternatives to current nanomaterials offers potential solutions to existing challenges in biological ligand-based nanomedicines.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Mohammad Hassan Loghmani, Abdollah Fallah Shojaie, Seyyedeh Azadeh Hosseini
Summary: In this study, Glutathione-responsive hydrogel and molecularly imprinted polymers were synthesized by precipitation polymerization method, with an investigation into the effects of different functional monomers and crosslinking agents on particle size, drug loading, and release. Results showed that MIPs had higher binding capacity for cisplatin compared to NIPs, with EGDMA-synthesized polymers showing higher adsorption rates. Increasing levels of glutathione led to increased release of the drug from the hydrogel.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Ilker S. Bayer
Summary: Polymer nanofibers have high surface area for efficient transport, while hydrogels combine flexibility and customizable transport properties. Combining nanofibers with hydrogels advances biomedical applications, especially in sustained drug delivery. Nanofiber hydrogels can maintain drug release rates for days to months and are crucial for 3D or 4D printable systems.
Article
Pharmacology & Pharmacy
Juliana C. Quarterman, Sean M. Geary, Aliasger K. Salem
Summary: This article provides an overview of the history, types, and potential biomedical applications of implantable drug delivery systems (IDDSs). While there are still obstacles to overcome, emerging new technologies are driving the continuous development and improvement of IDDSs.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2021)
Article
Polymer Science
Min Gi Cho, Seonghoon Hyeong, Kyung Kgi Park, Sung Hyo Chough
Summary: Hydrogel type molecularly imprinted polymer for creatinine was prepared using precipitation polymerization method, showing excellent adsorption properties and selectivity, which could be applied in the separation and detection of creatinine.
Review
Chemistry, Analytical
Guiyuan Zhang, Muhammad Mujahid Ali, Xin Feng, Juntao Zhou, Lianghai Hu
Summary: Mesoporous materials have high specific surface area and pore structure, allowing them to adsorb and separate macromolecules; molecularly imprinted mesoporous materials have specific recognition capability, widely used in sample preparation and chemical/biosensing fields.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2021)
Article
Engineering, Biomedical
Giorgia Giovannini, Paolo Cinelli, Luciano F. Boesel, Rene M. Rossi
Summary: This study presents a cost-effective fluorescent-based imprinted hydrogel for rapid detection of glucose in wound exudate, overcoming the limitations of traditional detection methods and demonstrating good selectivity and sensitivity.
MATERIALS TODAY BIO
(2022)
Review
Biochemistry & Molecular Biology
Alexandra-Iulia Baraian, Bogdan-Cezar Iacob, Andreea Elena Bodoki, Ede Bodoki
Summary: Molecularly imprinted polymers (MIPs) have shown promise as drug delivery systems (DDS) due to their sustained and controlled drug release capabilities. They offer advantages such as smaller drug doses and targeted delivery, resulting in fewer side effects and higher drug concentrations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Qian Chen, Yanan Li, Shuai Zhou, Dali Chen, Muye Zhou, Qinying Chen, Yuren Lu, Naicong Cai, Can Liu, Yumeng Guo, Zijie Qiu, Xiaoyan Hou, Jiasheng Tu, Weiyang Shen, Chunmeng Sun
Summary: This study developed an in-situ gel implantation combining chemotherapy and anti-CD47 antibodies, which can effectively treat tumors, inhibit tumor recurrence and metastasis. The release kinetics ensure drugs are released in a sequential manner, killing tumor cells first and restoring immune function afterwards.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Engineering, Biomedical
Benjamin Laccetti, Julia Kornfield
Summary: Research on the barrier characteristics of the cornea by investigating the impact of micro-particles reveals that corneal tissue is effective at resisting penetration of high velocity microparticles, with penetration being less influenced by size and density. The cornea demonstrates comparable resistance to penetration as seen in previous research on skin tissue, despite its higher water content. Experimentation also shows the potential for ballistic delivery of therapeutic compounds to the corneal epithelium using low density polymer particles.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2021)
Article
Pharmacology & Pharmacy
Maria Serramito, Ana F. Pereira-da-Mota, Carlos Carpena-Torres, Fernando Huete-Toral, Carmen Alvarez-Lorenzo, Gonzalo Carracedo
Summary: The study aimed to synthesize melatonin-eluting contact lenses and evaluate the ocular kinetics of the released melatonin and its effect on tear volume and intraocular pressure.
Review
Chemistry, Multidisciplinary
Catia Domingues, Ana Santos, Carmen Alvarez-Lorenzo, Angel Concheiro, Ivana Jarak, Francisco Veiga, Isabel Barbosa, Marilia Dourado, Ana Figueiras
Summary: Worldwide development and application of nanotechnology have led to significant scientific advancements. It is important to balance the high expectations and concerns associated with this field. Nanomedicine, a specific arm of nanotechnology, focuses on the diagnosis, treatment, and monitoring of various diseases. However, the concept of nanotoxicology has also emerged as a crucial aspect of nanomedicine. More research is needed to identify potential adverse effects and ensure the safety of nanomedicines.
Article
Materials Science, Biomaterials
Alfonso Bayon-Fernandez, Alejandro Mendez-Ardoy, Carmen Alvarez-Lorenzo, Juan R. Granja, Javier Montenegro
Summary: This article introduces the design principles of a new family of self-assembling cyclic octapeptides that can be used as scaffolds for the development of self-healing hydrogels. By inserting different aromatic aldehyde pendants to modulate the hydrophobic/hydrophilic balance and fine-tune the properties of the resulting gel, self-healable hydrogels with viscoelastic properties can be formed.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Instruments & Instrumentation
Ana F. F. Pereira-da-Mota, Maria Vivero-Lopez, Piyush Garg, Chau-Minh Phan, Angel Concheiro, Lyndon Jones, Carmen Alvarez-Lorenzo
Summary: This study aimed to evaluate the release profiles of two drug-loaded contact lenses (CLs) in a 3D in vitro eye blink model and compare them with in vivo profiles. The results showed that the release of both drugs was more sustained and lower in the 3D eye model compared to in vitro release in vials. The findings suggest that the current 3D printed eye blink model could be a useful tool to measure the release of ophthalmic drugs from medicated CLs, but further optimization is needed.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Carmen Alvarez-Lorenzo, Maria Vivero-Lopez, Angel Concheiro
Summary: This study demonstrates the spontaneous formation of anisotropic gold nanoparticles (AuNPs) inside preformed contact lenses (CLs) without the need for additional reductant agents. The formation of AuNPs was achieved through a precise tuning of the monomeric composition, saline concentration, and the use of steam heat sterilization. The potential applications of incorporating AuNPs in CLs in the ocular field for prophylaxis, therapy, and diagnosis are highlighted. The developed CLs also exhibit photoresponsiveness and efficient filtering of highly penetrant light.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Carmela Tommasino, Giulia Auriemma, Carla Sardo, Carmen Alvarez-Lorenzo, Emilia Garofalo, Silvana Morello, Giovanni Falcone, Rita P. Aquino
Summary: In this study, a PCL/INU-PLA hybrid biomaterial was prepared, which showed improved surface properties, swelling ability, and in vitro biodegradation rate compared to PCL alone. The 3D printed scaffolds exhibited dimensional and structural parameters close to the digital model and showed favorable results in biocompatibility and osteogenic activity tests.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Polymer Science
Kathleen Abigail Montoya-Villegas, Mirian Angelene Gonzalez-Ayon, Carmen Alvarez-Lorenzo, Angel Licea-Claverie, Emilio Bucio, Alejandro Ramirez-Jimenez
Summary: Thermo-responsive, hydrophilic, hemo- and biocompatible poly(DEGMA-co-OEGMA) was grafted onto silicone rubber using the gamma-radiation pre-irradiation method. The size of the grafted chains was controlled using a RAFT agent. The grafted materials showed enhanced hydrophilicity and excellent hemo- and cytocompatibility, indicating potential applications in the biomedical field.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Axel Kattar, Ana Quelle-Regaldie, Laura Sanchez, Angel Concheiro, Carmen Alvarez-Lorenzo
Summary: The aim of this study was to develop cationic niosomes for the ocular delivery of epalrestat, a drug used in the treatment of diabetic eye damage. The niosomes were characterized and found to have a size of 80 nm, a charge ranging from -23 to +40 mV, and a spherical shape. The encapsulation efficiency of the niosomes was 99.76% and they showed a sustained release of the drug over 20 days. The niosomes were non-irritating, non-toxic, and showed higher permeation in the sclera compared to the unencapsulated drug.
Review
Engineering, Biomedical
Mariana Zarur, Alejandro Seijo-Rabina, Alvaro Goyanes, Angel Concheiro, Carmen Alvarez-Lorenzo
Summary: This review focuses on the recent advances in pH-responsive polymer-based scaffolds that have been demonstrated in vivo to be suitable for wound and bone healing. pH plays a critical role in the tissue regeneration process, and small changes can significantly impact the healing process. Various strategies, including changes in ionization of natural polymers, ionizable monomers and clays, reversible cross-linkers, coatings, and production of CO2 gas, have been tested to prepare pH-responsive scaffolds. These techniques have shown promise in achieving biocompatible and environment-friendly scaffolds that can be translated to clinical applications.
ACTA BIOMATERIALIA
(2023)
Review
Biochemistry & Molecular Biology
Federica Ragucci, Francesca Sireci, Francesco Cavallieri, Jessica Rossi, Giuseppe Biagini, Giovanni Tosi, Chiara Lucchi, Rodolfo Molina-Pena, Natalia Helen Ferreira, Mariana Zarur, Alba Ferreiros, William Bourgeois, Francois Berger, Miguel Abal, Audrey Rousseau, Frank Boury, Carmen Alvarez-Lorenzo, Emmanuel Garcion, Anna Pisanello, Giacomo Pavesi, Corrado Iaccarino, Luca Ghirotto, Maria Chiara Bassi, Franco Valzania
Summary: Nanotechnology shows promise in cancer treatment, particularly in the field of neuro-oncology. It is important to explore clinicians' intentions and perspectives on using this new technology in clinical practice.
Article
Engineering, Biomedical
Carmen Alvarez-Lorenzo, Mariana Zarur, Alejandro Seijo-Rabina, Barbara Blanco-Fernandez, Isabel Rodriguez-Moldes, Angel Concheiro
Summary: The imbalance between life expectancy and quality of life is increasing due to the raising prevalence of chronic diseases. Scaffolds that can mimic natural physical stimuli and deliver dynamic physical stimuli, such as electrical signals, have shown potential for more efficient tissue regeneration.
MATERIALS TODAY BIO
(2023)
Review
Chemistry, Multidisciplinary
Paola Carou-Senra, Lucia Rodriguez-Pombo, Atheer Awad, Abdul W. Basit, Carmen Alvarez-Lorenzo, Alvaro Goyanes
Summary: Inkjet printing (IJP) enables precise material deposition for personalized medicine and drug delivery. This review explores the formulation and components of pharma-inks, various substrate materials, and potential improvements through hardware, software, and artificial intelligence integration. Further exploration and optimization are needed to fully harness the healthcare capabilities of IJP.
ADVANCED MATERIALS
(2023)
