High-resolution analysis of Merkel Cell Polyomavirus in Merkel Cell Carcinoma reveals distinct integration patterns and suggests NHEJ and MMBIR as underlying mechanisms
出版年份 2020 全文链接
标题
High-resolution analysis of Merkel Cell Polyomavirus in Merkel Cell Carcinoma reveals distinct integration patterns and suggests NHEJ and MMBIR as underlying mechanisms
作者
关键词
Human genomics, Viral genomics, Viral genome, DNA replication, Viral replication, Genome sequencing, Cancer genomics, Sequence alignment
出版物
PLoS Pathogens
Volume 16, Issue 8, Pages e1008562
出版商
Public Library of Science (PLoS)
发表日期
2020-08-25
DOI
10.1371/journal.ppat.1008562
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Clinical and molecular characterization of virus-positive and virus-negative Merkel cell carcinoma
- (2020) Gabriel J. Starrett et al. Genome Medicine
- Detection and Characterization of Circulating Tumor Cells in Patients with Merkel Cell Carcinoma
- (2019) Sabine Riethdorf et al. CLINICAL CHEMISTRY
- Exploring the landscape of focal amplifications in cancer using AmpliconArchitect
- (2019) Viraj Deshpande et al. Nature Communications
- Characterization of six Merkel cell polyomavirus‐positive Merkel cell carcinoma cell lines: integration pattern suggest that Large T antigen truncating events occur before or during integration
- (2019) David Schrama et al. INTERNATIONAL JOURNAL OF CANCER
- Conversion of Sox2-dependent Merkel cell carcinoma to a differentiated neuron-like phenotype by T antigen inhibition
- (2019) Alexis Harold et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A comparative epigenome analysis of gammaherpesviruses suggests cis-acting sequence features as critical mediators of rapid polycomb recruitment
- (2019) Thomas Günther et al. PLoS Pathogens
- Minimap2: pairwise alignment for nucleotide sequences
- (2018) Heng Li BIOINFORMATICS
- Understanding the HPV integration and its progression to cervical cancer
- (2018) Mariel Araceli Oyervides-Muñoz et al. INFECTION GENETICS AND EVOLUTION
- Repair of DNA double-strand breaks by mammalian alternative end-joining pathways
- (2018) Annahita Sallmyr et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Microhomology-mediated end joining: Good, bad and ugly
- (2018) Ja-Hwan Seol et al. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
- Are there multiple cells of origin of Merkel cell carcinoma?
- (2018) J. C. Sunshine et al. ONCOGENE
- HPV integration hijacks and multimerizes a cellular enhancer to generate a viral-cellular super-enhancer that drives high viral oncogene expression
- (2018) Alix Warburton et al. PLoS Genetics
- Spontaneous lung metastasis formation of human Merkel cell carcinoma cell lines transplanted into scid mice
- (2017) Jill Knips et al. INTERNATIONAL JOURNAL OF CANCER
- Merkel cell polyomavirus and Merkel cell carcinoma
- (2017) James A. DeCaprio PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
- Merkel Cell Polyomavirus Exhibits Dominant Control of the Tumor Genome and Transcriptome in Virus-Associated Merkel Cell Carcinoma
- (2017) Gabriel J. Starrett et al. mBio
- The role of integration in oncogenic progression of HPV-associated cancers
- (2017) Alison A. McBride et al. PLoS Pathogens
- Molecular Profiling of Multiple Primary Merkel Cell Carcinoma to Distinguish Genetically Distinct Tumors From Clonally Related Metastases
- (2017) Kelly L. Harms et al. JAMA Dermatology
- Merkel cell carcinoma
- (2017) Jürgen C. Becker et al. Nature Reviews Disease Primers
- Identifying the Target Cells and Mechanisms of Merkel Cell Polyomavirus Infection
- (2016) Wei Liu et al. Cell Host & Microbe
- Genomic characterization of viral integration sites in HPV-related cancers
- (2016) Clara Bodelon et al. INTERNATIONAL JOURNAL OF CANCER
- Next generation sequencing of Cytokeratin 20-negative Merkel cell carcinoma reveals ultraviolet-signature mutations and recurrent TP53 and RB1 inactivation
- (2016) Paul W Harms et al. MODERN PATHOLOGY
- An interactive environment for agile analysis and visualization of ChIP-sequencing data
- (2016) Mads Lerdrup et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- deepTools2: a next generation web server for deep-sequencing data analysis
- (2016) Fidel Ramírez et al. NUCLEIC ACIDS RESEARCH
- An interactive environment for agile analysis and visualization of ChIP-sequencing data
- (2016) Mads Lerdrup et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Diagnosis and treatment of Merkel Cell Carcinoma. European consensus-based interdisciplinary guideline
- (2015) Celeste Lebbe et al. EUROPEAN JOURNAL OF CANCER
- Merkel cell carcinoma: Do you know your guidelines?
- (2015) Brett A. Miles et al. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
- Merkel Cell Polyomavirus Small T Antigen Is Oncogenic in Transgenic Mice
- (2015) Monique E. Verhaegen et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism
- (2015) Zheng Hu et al. NATURE GENETICS
- Mutational landscape of MCPyV-positive and MCPyV-negative Merkel cell carcinomas with implications for immunotherapy
- (2015) Gerald Goh et al. Oncotarget
- Merkel cell polyomavirus, a highly prevalent virus with tumorigenic potential
- (2015) Adam Grundhoff et al. Current Opinion in Virology
- Large T and small T antigens of Merkel cell polyomavirus
- (2015) Justin A Wendzicki et al. Current Opinion in Virology
- A Comprehensive Analysis of Replicating Merkel Cell Polyomavirus Genomes Delineates the Viral Transcription Program and Suggests a Role for mcv-miR-M1 in Episomal Persistence
- (2015) Juliane Marie Theiss et al. PLoS Pathogens
- Transcriptionally Active Regions Are the Preferred Targets for Chromosomal HPV Integration in Cervical Carcinogenesis
- (2015) Irene Kraus Christiansen et al. PLoS One
- H3K4me3 Breadth Is Linked to Cell Identity and Transcriptional Consistency
- (2014) Bérénice A. Benayoun et al. CELL
- Merkel Cell Carcinoma Dependence on Bcl-2 Family Members for Survival
- (2014) Monique E. Verhaegen et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Host DNA Damage Response Factors Localize to Merkel Cell Polyomavirus DNA Replication Sites To Support Efficient Viral DNA Replication
- (2014) S. H. Tsang et al. JOURNAL OF VIROLOGY
- Viral Carcinogenesis: Factors Inducing DNA Damage and Virus Integration
- (2014) Yan Chen et al. Cancers
- featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
- (2013) Y. Liao et al. BIOINFORMATICS
- Break-induced replication: functions and molecular mechanism
- (2013) Anna Malkova et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability
- (2013) K. Akagi et al. GENOME RESEARCH
- Mechanisms of p53 Restriction in Merkel Cell Carcinoma Cells Are Independent of the Merkel Cell Polyoma Virus T Antigens
- (2013) Roland Houben et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Merkel Cell Polyomavirus Large T Antigen Disrupts Host Genomic Integrity and Inhibits Cellular Proliferation
- (2013) J. Li et al. JOURNAL OF VIROLOGY
- Merkel Cell Polyomavirus Large T Antigen Has Growth-Promoting and Inhibitory Activities
- (2013) J. Cheng et al. JOURNAL OF VIROLOGY
- High-Affinity Rb Binding, p53 Inhibition, Subcellular Localization, and Transformation by Wild-Type or Tumor-Derived Shortened Merkel Cell Polyomavirus Large T Antigens
- (2013) S. Borchert et al. JOURNAL OF VIROLOGY
- Migrating bubble during break-induced replication drives conservative DNA synthesis
- (2013) Natalie Saini et al. NATURE
- Break-induced replication occurs by conservative DNA synthesis
- (2013) R. A. Donnianni et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- ATM and ATR Activities Maintain Replication Fork Integrity during SV40 Chromatin Replication
- (2013) Gregory A. Sowd et al. PLoS Pathogens
- Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration
- (2012) H. Thorvaldsdottir et al. BRIEFINGS IN BIOINFORMATICS
- Genome mapping on nanochannel arrays for structural variation analysis and sequence assembly
- (2012) Ernest T Lam et al. NATURE BIOTECHNOLOGY
- Fast gapped-read alignment with Bowtie 2
- (2012) Ben Langmead et al. NATURE METHODS
- Genetic variability and integration of Merkel cell polyomavirus in Merkel cell carcinoma
- (2012) C. Martel-Jantin et al. VIROLOGY
- Merkel Cell Carcinoma: A Virus-Induced Human Cancer
- (2011) Yuan Chang et al. Annual Review of Pathology-Mechanisms of Disease
- Control-FREEC: a tool for assessing copy number and allelic content using next-generation sequencing data
- (2011) Valentina Boeva et al. BIOINFORMATICS
- Human Merkel cell polyomavirus small T antigen is an oncoprotein targeting the 4E-BP1 translation regulator
- (2011) Masahiro Shuda et al. JOURNAL OF CLINICAL INVESTIGATION
- Hybrid Capture and Next-Generation Sequencing Identify Viral Integration Sites from Formalin-Fixed, Paraffin-Embedded Tissue
- (2011) Eric J. Duncavage et al. JOURNAL OF MOLECULAR DIAGNOSTICS
- Merkel Cell Polyomavirus and Two Previously Unknown Polyomaviruses Are Chronically Shed from Human Skin
- (2010) Rachel M. Schowalter et al. Cell Host & Microbe
- Rolling circle replication of human papillomavirus type 16 DNA in epithelial cell extracts
- (2010) Rika Kusumoto-Matsuo et al. GENES TO CELLS
- Merkel Cell Polyomavirus-Infected Merkel Cell Carcinoma Cells Require Expression of Viral T Antigens
- (2010) R. Houben et al. JOURNAL OF VIROLOGY
- Distinct Merkel Cell Polyomavirus Molecular Features in Tumour and Non Tumour Specimens from Patients with Merkel Cell Carcinoma
- (2010) Hélène C. Laude et al. PLoS Pathogens
- The Sequence Alignment/Map format and SAMtools
- (2009) H. Li et al. BIOINFORMATICS
- Circos: An information aesthetic for comparative genomics
- (2009) M. Krzywinski et al. GENOME RESEARCH
- Human Merkel cell polyomavirus infection I. MCV T antigen expression in Merkel cell carcinoma, lymphoid tissues and lymphoid tumors
- (2009) Masahiro Shuda et al. INTERNATIONAL JOURNAL OF CANCER
- Comparable expression and phosphorylation of the retinoblastoma protein in Merkel cell polyoma virus positive and negative Merkel cell carcinoma
- (2009) Roland Houben et al. INTERNATIONAL JOURNAL OF CANCER
- Merkel cell carcinoma of the skin: pathological and molecular evidence for a causative role of MCV in oncogenesis
- (2009) Xavier Sastre-Garau et al. JOURNAL OF PATHOLOGY
- A Microhomology-Mediated Break-Induced Replication Model for the Origin of Human Copy Number Variation
- (2009) P. J. Hastings et al. PLoS Genetics
- T antigen mutations are a human tumor-specific signature for Merkel cell polyomavirus
- (2008) M. Shuda et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Clonal Integration of a Polyomavirus in Human Merkel Cell Carcinoma
- (2008) H. Feng et al. SCIENCE
- Model-based Analysis of ChIP-Seq (MACS)
- (2008) Yong Zhang et al. GENOME BIOLOGY
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started