A greedy classifier optimization strategy to assess ion channel blocking activity and pro-arrhythmia in hiPSC-cardiomyocytes
出版年份 2020 全文链接
标题
A greedy classifier optimization strategy to assess ion channel blocking activity and pro-arrhythmia in hiPSC-cardiomyocytes
作者
关键词
Calcium channels, Potassium channels, Sodium channels, Calcium signaling, Chlorpromazine, Medical risk factors, Cardiomyocytes, Ion channels
出版物
PLoS Computational Biology
Volume 16, Issue 9, Pages e1008203
出版商
Public Library of Science (PLoS)
发表日期
2020-09-26
DOI
10.1371/journal.pcbi.1008203
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Cardiotoxicity screening of illicit drugs and new psychoactive substances (NPS) in human iPSC-derived cardiomyocytes using microelectrode array (MEA) recordings
- (2019) Anne Zwartsen et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Interpretation of field potentials measured on a multi electrode array in pharmacological toxicity screening on primary and human pluripotent stem cell-derived cardiomyocytes
- (2018) L.G.J. Tertoolen et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Proarrhythmia risk prediction using human induced pluripotent stem cell-derived cardiomyocytes
- (2018) Daiju Yamazaki et al. JOURNAL OF PHARMACOLOGICAL SCIENCES
- Safety pharmacology methods and regulatory considerations evolve together
- (2018) Michael K. Pugsley et al. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
- Automatic Optimization of an in Silico Model of Human iPSC Derived Cardiomyocytes Recapitulating Calcium Handling Abnormalities
- (2018) Michelangelo Paci et al. Frontiers in Physiology
- Composite Biomarkers Derived from Micro-Electrode Array Measurements and Computer Simulations Improve the Classification of Drug-Induced Channel Block
- (2018) Eliott Tixier et al. Frontiers in Physiology
- International Multisite Study of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Drug Proarrhythmic Potential Assessment
- (2018) Ksenia Blinova et al. Cell Reports
- Representation of Multiple Cellular Phenotypes Within Tissue-Level Simulations of Cardiac Electrophysiology
- (2018) Louise A. Bowler et al. BULLETIN OF MATHEMATICAL BIOLOGY
- CSAHi study-2: Validation of multi-electrode array systems (MEA60/2100) for prediction of drug-induced proarrhythmia using human iPS cell-derived cardiomyocytes: Assessment of reference compounds and comparison with non-clinical studies and clinical information
- (2017) Yumiko Nozaki et al. REGULATORY TOXICOLOGY AND PHARMACOLOGY
- A new paradigm for drug-induced torsadogenic risk assessment using human iPS cell-derived cardiomyocytes
- (2017) Hiroyuki Ando et al. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
- Uncertainty Quantification Reveals the Importance of Data Variability and Experimental Design Considerations for in Silico Proarrhythmia Risk Assessment
- (2017) Kelly C. Chang et al. Frontiers in Physiology
- Optimization of an In silico Cardiac Cell Model for Proarrhythmia Risk Assessment
- (2017) Sara Dutta et al. Frontiers in Physiology
- Human In Silico Drug Trials Demonstrate Higher Accuracy than Animal Models in Predicting Clinical Pro-Arrhythmic Cardiotoxicity
- (2017) Elisa Passini et al. Frontiers in Physiology
- Improved Prediction of Drug-Induced Torsades de Pointes Through Simulations of Dynamics and Machine Learning Algorithms
- (2016) M Cummins Lancaster et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- An evaluation of 30 clinical drugs against the comprehensive in vitro proarrhythmia assay (CiPA) proposed ion channel panel
- (2016) William J. Crumb et al. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
- The Comprehensive in Vitro Proarrhythmia Assay (CiPA) initiative — Update on progress
- (2016) Thomas Colatsky et al. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
- Role of Sarcoplasmic Reticulum Calcium in Development of Secondary Calcium Rise and Early Afterdepolarizations in Long QT Syndrome Rabbit Model
- (2015) Po-Cheng Chang et al. PLoS One
- Assessment of Testing Methods for Drug-Induced Repolarization Delay and Arrhythmias in an iPS Cell–Derived Cardiomyocyte Sheet: Multi-site Validation Study
- (2014) Yuji Nakamura et al. JOURNAL OF PHARMACOLOGICAL SCIENCES
- Modeling type 3 long QT syndrome with cardiomyocytes derived from patient-specific induced pluripotent stem cells
- (2013) Dongrui Ma et al. INTERNATIONAL JOURNAL OF CARDIOLOGY
- A SURFACE-BASED ELECTROPHYSIOLOGY MODEL RELYING ON ASYMPTOTIC ANALYSIS AND MOTIVATED BY CARDIAC ATRIA MODELING
- (2013) DOMINIQUE CHAPELLE et al. MATHEMATICAL MODELS & METHODS IN APPLIED SCIENCES
- MICE Models: Superior to the HERG Model in Predicting Torsade de Pointes
- (2013) James Kramer et al. Scientific Reports
- Computational assessment of drug-induced effects on the electrocardiogram: from ion channel to body surface potentials
- (2012) Nejib Zemzemi et al. BRITISH JOURNAL OF PHARMACOLOGY
- Simulation of multiple ion channel block provides improved early prediction of compounds’ clinical torsadogenic risk
- (2011) Gary R. Mirams et al. CARDIOVASCULAR RESEARCH
- Simulation of the Undiseased Human Cardiac Ventricular Action Potential: Model Formulation and Experimental Validation
- (2011) Thomas O'Hara et al. PLoS Computational Biology
- Support vector machine-based arrhythmia classification using reduced features of heart rate variability signal
- (2008) Babak Mohammadzadeh Asl et al. ARTIFICIAL INTELLIGENCE IN MEDICINE
- The hERG potassium channel and hERG screening for drug-induced torsades de pointes
- (2008) Jules C. Hancox et al. PHARMACOLOGY & THERAPEUTICS
- Blockade of HERG human K+ channels and IKr of guinea-pig cardiomyocytes by the antipsychotic drug clozapine
- (2006) So-Young Lee et al. BRITISH JOURNAL OF PHARMACOLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started