Article
Environmental Sciences
Jin Huang, Jun Zhu, Siguang Liu, Yuanrong Luo, Renxin Zhao, Feng Guo, Bing Li
Summary: This study analyzed the ARG profiles and microbial community compositions in sediments from Jiulong River Estuary and Min River Estuary in China, finding that salinity was an important factor for bacterial community but not for ARG profiles, which showed a stochastic distribution in estuarine sediments.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Geochemistry & Geophysics
Stephen Pansino, Adel Emadzadeh, Benoit Taisne
Summary: This article presents analog experiments and a numerical model on dike propagation. The experimental results show that the growth rates are similar until buoyancy becomes significant and, afterward, vertical growth dominates. The numerical model is tested on observed dikes, and the results reproduce the final dimensions.
JOURNAL OF GEOPHYSICAL RESEARCH-SOLID EARTH
(2022)
Article
Microbiology
Kaitlyn E. Kortright, Simon Doss-Gollin, Benjamin K. Chan, Paul E. Turner
Summary: This study found that selection for Escherichia coli to resist phage T6, phage U115, or albicidin often results in cross-resistance evolution, but these mutants did not exhibit measurable growth deficiencies. This suggests that when considering new antibacterial therapies, thorough investigation into the evolutionary consequences of the treatment should be conducted to avoid potential evolved trade-ups.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Engineering, Environmental
Cong Zhang, Xin Zhao, Can Wang, Israel Hakizimana, John C. Crittenden, Azhar Ali Laghari
Summary: This study investigates the effects of ARB disinfection on the risk of HGT, with an electrochemical flow-through reactor (EFTR) being used to inactivate E. coli and remove ARGs. Results show that EFTR effectively reduces ARGs concentration and decreases HGT frequency, making it a promising technology for preventing the spread of antibiotic resistance.
Article
Biochemistry & Molecular Biology
Rafael Amieva, Teresa Gil-Gil, Jose Luis Martinez, Manuel Alcalde-Rico
Summary: Multidrug efflux pumps are crucial for antibiotic resistance in bacteria, but they also modulate other aspects of bacterial physiology, such as quorum sensing and iron homeostasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Green & Sustainable Science & Technology
Zhizuan Zhou, Xiaodong Zhou, Xiaoyu Ju, Maoyu Li, Bei Cao, Lizhong Yang
Summary: This study investigates the horizontal and vertical thermal runaway propagation characteristics of lithium-iron-phosphate battery modules with different connections. It is found that during vertical propagation, almost simultaneous thermal runaway and high-temperature combustion occur in the upper batteries, posing significant thermal hazards. The upper batteries experience severer thermal runaway compared to the lower batteries, with much higher maximum temperature and heat release. The results provide valuable information for thermal runaway propagation between battery modules and contribute to the safety application of energy storage systems.
Article
Biology
Syeda Javariya Khalid, Quratul Ain, Sher Jamal Khan, Amna Jalil, Muhammad Faisal Siddiqui, Tahir Ahmad, Malik Badshah, Fazal Adnan
Summary: Finding novel biological strategies to mitigate bacterial biofilms is crucial for combating bacterial infections as biofilm-forming bacteria are highly resistant to antibiotics. This study investigated the potential of quorum quenching (QQ) enzymes, which interfere with the quorum sensing (QS) mechanism, to mitigate biofilms. Bacterial strains with QQ activity were identified and tested against multidrug-resistant Pseudomonas aeruginosa. The results showed that certain QQ strains were able to reduce biofilm formation by up to 60%. The presence of AHL-degrading enzymes was confirmed, providing insights into the mechanism of biofilm mitigation.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Environmental Sciences
Linqiong Wang, Yi Li, Zhe Zhao, Mengjie Zhu, Tong Hu
Summary: This study investigated the occurrence and abundance of antibiotics and antibiotic resistance genes (ARGs) in tidal flats of Jiangsu, China. The results showed that aquaculture contributes to ARG profiles in tidal flats and the ARG community is determined by deterministic processes. These findings have important implications for controlling environmental antibiotic resistance.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Nanoscience & Nanotechnology
Shang-Lin Yeh, Naveen Narasimhalu, Landon G. vom Steeg, Joy Muthami, Sean LeConey, Zeming He, Mica Pitcher, Harrison Cassady, Valerie J. Morley, Sung Hyun Cho, Carol Bator, Roya Koshani, Robert J. Woods, Michael Hickner, Andrew F. Read, Amir Sheikhi
Summary: Daptomycin is a cyclic anionic lipopeptide antibiotic used to treat multidrug-resistant Gram-positive bacterial infections. This study reveals the interactions between cholestyramine and Daptomycin, as well as the mechanisms of antibiotic removal from the gastrointestinal tract. The findings suggest the potential of optimizing cholestyramine adjuvant therapy and designing novel biomaterials to prevent antibiotic resistance in off-target populations.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Microbiology
Jeronimo Rodriguez-Beltran, Javier DelaFuente, Ricardo Leon-Sampedro, R. Craig MacLean, Alvaro San Millan
Summary: Plasmids play a vital role in bacterial ecology and evolution by mobilizing accessory genes through horizontal gene transfer. Recent studies show that plasmids, kept at multiple copies per cell, create islands of polyploidy in bacterial genomes, leading to evolution governed by different rules than those affecting chromosomal genes. Plasmids may accelerate bacterial evolution by promoting the evolution of plasmid-encoded genes and enhancing the adaptation of their host chromosomes.
NATURE REVIEWS MICROBIOLOGY
(2021)
Review
Environmental Sciences
Sonam Tripathi, Diane Purchase, Muthusamy Govarthanan, Ram Chandra, Sangeeta Yadav
Summary: Quorum sensing is a bacterial system that allows cells to communicate with each other, and it is linked to cell density in the microbiome. Understanding the role of quorum sensing and developing novel approaches to control it is essential in preventing microbial pathogenesis. This review provides the latest knowledge on the relationship between quorum sensing and pathogenicity and explores the potential of quorum quenching as a control mechanism.
ENVIRONMENTAL MONITORING AND ASSESSMENT
(2023)
Article
Engineering, Aerospace
V. K. Ilyin, O. Orlov, Yu A. Morozova, M. A. Skedina, S. K. Vladimirov, E. Plotnikov, A. A. Artamonov
Summary: This study presents a phenomenological model for the horizontal spread of bacterial drug resistance genes in spacecraft crews, based on experiments involving identifying microbial communities in the nasopharynx and determining gene transfer frequencies in space flight conditions. The model predicts a multiple decrease in antibiotic resistance in space conditions, while R-plasmids are expected to show increased resistance.
Article
Physics, Fluids & Plasmas
Bin-Qian Zhou, Yi-Fan Zhou, Charles Omotomide Apata, Long Jiang, Qi-Ming Pei
Summary: Cells can sense and process various signals, with noise being inevitable in the cell signaling system. Bidirectional phenotype switching in bacterial communities can generate interconversion noise and additional intrinsic noise, impacting signal amplification. The indirect impact of bidirectional phenotype switching, through transmitted noise, plays a significant role in chronic infections caused by persistent cells.
Review
Plant Sciences
Batool Khataybeh, Ziad Jaradat, Qutaiba Ababneh
Summary: This review summarizes the research on the antibacterial effects of honey, including its properties and constituents. The antibacterial activities of honey are mainly attributed to hydrogen peroxide, methylglyoxal, bee defensin-1, and phenolic compounds. In addition, certain beneficial lactic acid bacteria can survive and grow in honey, making it a potential delivery system for these agents.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Yongcheng Chen, Yifan Gao, Yue Huang, Qiao Jin, Jian Ji
Summary: This research focuses on the development of pH-sensitive curcumin-loaded nanoparticles for inhibiting quorum sensing (QS) and enhancing antibiotic therapy. The nanoparticles show enhanced biofilm penetration and increased bactericidal performance against antibiotics. Additionally, they can selectively accumulate in bacteria-infected tissues through active targeting. This research offers a promising approach to enhance the therapeutic effects of quorum sensing inhibitors and improve antibiotic treatment for biofilm-associated bacterial infections.
Article
Multidisciplinary Sciences
Baihui Liang, Baogang Quan, Junjie Li, Chantal Loton, Marie-Florence Bredeche, Ariel B. Lindner, Luping Xu
SCIENTIFIC REPORTS
(2020)
Article
Multidisciplinary Sciences
Edwin H. Wintermute, Matthieu Cisel, Ariel B. Lindner
Summary: The study analyzed student achievement on MOOC platforms through network analysis, finding that course interactions can have positive or negative effects on success. By using reliability theory to model certificate completion rates, it was discovered that user engagement is correlated with certificate rates.
Article
Virology
Ali Bektas, Michael F. Covington, Guy Aidelberg, Anibal Arce, Tamara Matute, Isaac Nunez, Julia Walsh, David Boutboul, Constance Delaugerre, Ariel B. Lindner, Fernan Federici, Anitha D. Jayaprakash
Summary: The COVID-19 pandemic has highlighted the challenges in large-scale testing, leading to the development of a DIY workflow for rapid and accurate detection of viral RNA with high sensitivity and specificity. This method improves efficiency and accuracy of testing through various techniques, allowing for quick testing at home or in healthcare settings.
Editorial Material
Biochemistry & Molecular Biology
Bastian Greshake Tzovaras, Michael Rera, Edwin H. Wintermute, Katharina Kloppenborg, Juliette Ferry-Danini, Guy Aidelberg, Rachel Aronoff, Ariel Lindner, Dusan Misevic
Summary: The purpose of biomedicine is to serve society, and reforms are needed to better integrate citizens within the research community, reimagining it as more participatory, inclusive, and responsive to societal needs.
Article
Multidisciplinary Sciences
Alexander Anders, Remy Colin, Alvaro Banderas, Victor Sourjik
Summary: Studying yeast, it was found that different mating types exhibited asymmetrical responses in pheromone secretion, leading to enhanced mating efficiency and potential selective advantage.
Article
Health Care Sciences & Services
Arno Klein, Jon Clucas, Anirudh Krishnakumar, Satrajit S. Ghosh, Wilhelm Van Auken, Benjamin Thonet, Ihor Sabram, Nino Acuna, Anisha Keshavan, Henry Rossiter, Yao Xiao, Sergey Semenuta, Alessandra Badioli, Kseniia Konishcheva, Sanu Ann Abraham, Lindsay M. Alexander, Kathleen R. Merikangas, Joel Swendsen, Ariel B. Lindner, Michael P. Milham
Summary: This study aims to improve the accessibility of mental health assessment and interventions through the MindLogger platform, addressing existing economic, geographic, and cultural barriers while advancing scientific research with various measures and tasks.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Editorial Material
Biochemistry & Molecular Biology
Tatiana Dimitriu, Dusan Misevic, Ariel B. Lindner, Francois Taddei, Sam P. Brown
Article
Biochemical Research Methods
Antoine L. Decrulle, Antoine Frenoy, Thomas A. Meiller-Legrand, Aude Bernheim, Chantal Lotton, Arnaud Gutierrez, Ariel B. Lindner
Summary: Gene overlaps can increase the stability of costly genes by purging loss-of-function mutations, converting potential mutants into evolutionary dead-ends to reduce the evolutionary potential of the system, and thus enhancing its stability over time.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Nadine Bongaerts, Zainab Edoo, Ayan A. Abukar, Xiaohu Song, Sebastian Sosa-Carrillo, Sarah Haggenmueller, Juline Savigny, Sophie Gontier, Ariel B. Lindner, Edwin H. Wintermute
Summary: This study develops engineered E. coli as a synthetic biology tool for expressing and screening metabolic targets from Mycobacterium tuberculosis.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Lionel Chiron, Matthias Le Bec, Celine Cordier, Sylvain Pouzet, Dimitrije Milunov, Alvaro Banderas, Jean-Marc Di Meglio, Benoit Sorre, Pascal Hersen
Summary: This paper introduces a method for advanced automated timelapse experiments using CyberSco.Py software. The software allows real-time image analysis and automatic adjustment of imaging acquisition parameters and device status based on the analysis. The authors demonstrate the significance of this method in cell biology through experiments related to yeast fermentation.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Haotian Guo, Joseph C. Ryan, Xiaohu Song, Adeline Mallet, Mengmeng Zhang, Victor Pabst, Antoine L. Decrulle, Paulina Ejsmont, Edwin H. Wintermute, Ariel B. Lindner
Summary: Researchers have created synthetic membraneless organelles called TEARS in Escherichia coli, which provide spatial regulation and isolation for biochemical reactions, simplifying the design-build-test cycle of bioengineering.
Meeting Abstract
Psychology, Developmental
Bennett L. Leventhal, Kseniia Konishcheva, Elie Rotenberg, Anirudh Krishnakumar, Naima Page, Laure Gares, Laetitia Almaraz, Bruno Falissard, Arno Klein, Ariel B. Lindner
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2022)
Article
Biotechnology & Applied Microbiology
Sylvain Pouzet, Jessica Cruz-Ramon, Matthias Le Bec, Celine Cordier, Alvaro Banderas, Simon Barral, Sara Castano-Cerezo, Thomas Lautier, Gilles Truan, Pascal Hersen
Summary: This study utilizes optogenetics to control beta-carotene production in Saccharomyces cerevisiae and investigates its performance across different culture scales. By building four lab-scale illumination devices with specific characteristics and conditions, the researchers evaluate optogenetic activation and beta-carotene production, optimize them independently, and combine them to create a light-inducible beta-carotene producer strain. The study highlights the importance of optimizing both components of the system independently and provides insights into the interplay and potential conflicts between optogenetic control and metabolic pathway efficiency.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Yifan Yang, Omer Karin, Avi Mayo, Xiaohu Song, Peipei Chen, Ana L. Santos, Ariel B. Lindner, Uri Alon
Summary: Genetically identical cells in the same stressful condition die at different times. The origin of this stochasticity is unclear; it may arise from different initial conditions that affect the time of demise, or from a stochastic damage accumulation mechanism that erases the initial conditions and instead amplifies noise to generate different lifespans. To understand why genetically identical cells die at different times, the authors measured damage dynamics in individual cells. They report lifespan variation comes not from initial conditions but from stochastic accumulation of damage that saturates repair systems.
NATURE COMMUNICATIONS
(2023)