Review
Cell Biology
Jing Qu, Yue Cheng, Wenchao Wu, Lixing Yuan, Xiaojing Liu
Summary: The glycocalyx plays a crucial role in inflammation and the development of vascular diseases, with endothelial dysfunction potentially leading to tissue swelling, chronic inflammation, and thrombosis. Eliminating endothelial inflammation may be a key target for treating vascular diseases. Research indicates that by disrupting the cycle of endothelial dysfunction and inflammation, the glycocalyx can help alleviate the progression of inflammation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yumin Qiu, Shiyue Xu, Xi Chen, Xing Wu, Zhe Zhou, Jianning Zhang, Qiang Tu, Bing Dong, Zhefu Liu, Jiang He, Xiaoyu Zhang, Shuangshuang Liu, Chen Su, Hui Huang, Wenhao Xia, Jun Tao
Summary: This study revealed that hypertensive patients have lower levels of NAD(+) which is associated with vascular dysfunction. Boosting NAD(+) levels through nicotinamide mononucleotide (NMN) supplementation can reduce blood pressure and improve vascular dysfunction in hypertensive patients and mice. The activation of CD38 in endothelial cells leads to NAD(+) depletion, resulting in elevated blood pressure and vascular damage.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Review
Medicine, Research & Experimental
Wan-Zhou Wu, Yong-Ping Bai
Summary: Endothelial metabolism is an important target for regulating vascular function and treating diseases. Glucose serves as the primary energy source for endothelial metabolism, supporting ATP production and cell survival. While previous studies have mainly focused on endothelial glucose metabolism, the role of glucose transporters, the gatekeepers of glucose utilization, has been overlooked. This review summarizes glucose transporter research in the vasculature, specifically focusing on GLUT1 and GLUT3 as critical transporters responsible for endothelial glucose uptake, and discusses potential directions for future research.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Yanru Duan, Shihan Zhang, Yuanyuan Xing, Ye Wu, Wen Zhao, Pinxue Xie, Huina Zhang, Xinxiao Gao, Yanwen Qin, Yajing Wang, Xinliang Ma, Yunhui Du, Huirong Liu
Summary: This study revealed that adiponectin inhibits diabetic endothelial inflammatory response by activating the Wnt/beta-catenin signaling pathway and promoting the expression of CD44 through APPL1. These findings provide a new avenue for the inhibition of diabetic endothelial inflammation.
Article
Nutrition & Dietetics
Tays Amanda Felisberto Goncalves, Viviane Silva Lima, Arthur Jose Pontes Oliveira de Almeida, Alinne Villar de Arruda, Ana Caroline Meneses Ferreira Veras, Thais Trajano Lima, Evyllen Myllena Cardoso Soares, Adhonias Correia dos Santos, Maria Eduarda Costa de Vasconcelos, Mathania Silva de Almeida Feitosa, Robson Cavalcante Veras, Isac Almeida de Medeiros
Summary: This study demonstrated the regulatory effects of carvacrol on endothelial repair in spontaneously hypertensive rats. Results showed that carvacrol promoted the migration and proliferation of endothelial progenitor cells, increased eNOS expression and activity, reduced reactive oxygen species production and cellular senescence, and improved vascular function.
Article
Biology
Yiting Zhang, Jianping Hu, Xiaoying Qu, Ke Hu
Summary: The circular RNA circRSU1 is upregulated in diabetic retinopathy patients and its interaction with miR-345-3p leads to increased TAZ levels, which contribute to the development of vascular dysfunction. Diabetic retinopathy is a major cause of visual impairment and blindness in adults with diabetes mellitus. Although circRNAs have been implicated in vascular progression, the exact role of circRNAs in diabetes-induced vascular complications remains largely unknown. The authors found that circRSU1 was significantly upregulated in diabetic retinopathy patients. Further experiments showed that knockdown of circRSU1 alleviated diabetes-induced retinal vascular dysfunction, including decreased levels of vascular endothelial growth factor, reduced inflammatory responses, and diminished oxidative stress. The study also revealed that circRSU1 interacts with miR-345-3p to upregulate TAZ expression, and downregulation of TAZ reversed the vascular dysfunction caused by increased circRSU1 expression under high glucose conditions. In conclusion, the overexpression of circRSU1 promotes vascular dysfunction through its interaction with miR-345-3p to increase TAZ levels in diabetic conditions. The findings suggest that circRSU1 may serve as a potential therapeutic target for treating vascular dysfunction in diabetes mellitus.
COMMUNICATIONS BIOLOGY
(2023)
Article
Medicine, Research & Experimental
Laura Brabenec, Katharina E. M. Hellenthal, Melanie Mueller, Sebastian Kintrup, Finnja Zurek-Leffers, Marina Kardell, Mandy Otto, Nana-Maria Wagner
Summary: Procalcitonin contributes to endothelial dysfunction by antagonizing CGRP signaling in obesity, and targeting hyperprocalcitonemia may be a means to preserve endothelial function and reduce comorbidity burden in obese subjects.
Review
Cell Biology
Shuo Feng, Jia Wei Chen, Xin Yi Shu, Muladili Aihemaiti, Jin Wei Quan, Lin Lu, Rui Yan Zhang, Chen Die Yang, Xiao Qun Wang
Summary: Hemodynamic shear stress (SS) regulates vascular homeostasis and injury through the release of endothelial microparticles (EMP), affecting physiological function of endothelial cells, inflammatory response, vascular permeability, and the coagulation system.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Food Science & Technology
Joseph Festa, Aamir Hussain, Zakia Al-Hareth, Harprit Singh, Mariasole Da Boit
Summary: Anthocyanins, a type of flavonoid polyphenols, have been studied for their potential in improving cardiovascular health and preventing endothelial dysfunction. However, their poor bioavailability raises questions about the role of their metabolites in the observed biological activity. Recent studies have used different models and concentrations to better understand the mechanisms of action of these compounds. The review highlights the need for further research on improving the bioavailability of the metabolites and exploring the effects of metabolites in mixtures.
Review
Immunology
Abbey Lightfoot, Helen M. McGettrick, Asif J. Iqbal
Summary: Leukocyte recruitment to the injury site is crucial for regulating inflammatory responses, and research on the immunoregulatory roles of galectin family members suggests that they could be a promising target for therapeutic intervention in inflammatory diseases. This review focuses on summarizing the current understanding of galectins in leukocyte trafficking during inflammation and the clinical approaches being developed to target these interactions for treating inflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Qian Li, Xiangying Ouyang, Jiang Lin
Summary: Periodontitis, an oral inflammatory disease, is associated with dysregulation of host immunoinflammatory response. It is harmful to both oral health and the onset and progress of various vascular diseases. This review aims to focus on the implications of periodontitis in vascular endothelial dysfunction.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Typhaine Anquetil, Romain Solinhac, Aude Jaffre, Gaetan Chicanne, Julien Viaud, Jean Darcourt, Cyrille Orset, Eva Geuss, Christoph Kleinschnitz, Bart Vanhaesebroeck, Denis Vivien, Karim Hnia, Vincent Larrue, Bernard Payrastre, Marie-Pierre Gratacap
Summary: Protecting endothelial cells is critical in preventing the impact of vascular leakage and edema on pathological conditions. PI3KC2 beta could be a potential new therapeutic target for treating aggravating lesions following ischemic stroke.
Article
Biochemistry & Molecular Biology
Anh-Nhung Le, Seong-Soon Park, Minh-Xuan Le, Unn Hwa Lee, Byung Kyun Ko, Hye Ryeong Lim, Ri Yu, Seong Hee Choi, Byung Ju Lee, Soo-Youn Ham, Chang Man Ha, Jeong Woo Park
Summary: Deficiency of DRG2 induces senescence and dysfunction of endothelial cells, leading to impaired angiogenesis and reduced blood flow. DRG2 deficiency upregulates arginase 2 and reactive oxygen species generation in endothelial cells. These findings highlight the significant role of DRG2 in endothelial cell senescence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Lin Li, Haining Wang, Jing Zhang, Xiao Chen, Zhongwang Zhang, Qiang Li
Summary: EPC-EVs transfer miR-199a-3p to inhibit SP1 in endothelial cells, suppressing ferroptosis and delaying the occurrence of AS.
CELL DEATH DISCOVERY
(2021)
Review
Oncology
Antonio Filippini, Luca Tamagnone, Alessio D'Alessio
Summary: Recent findings suggest that targeting endothelial cell metabolism may be an alternative strategy for antiangiogenic therapy and a novel approach for treating cardiovascular diseases. Understanding how endothelial cells adapt their metabolic status in response to changes in the tissue microenvironment could help develop innovative treatments to counteract abnormal blood vessel growth.
Letter
Hematology
Bingwen Eugene Fan, Christine Cheung
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2022)
Article
Biology
Kan Xing Wu, Natalie Jia Ying Yeo, Chun Yi Ng, Florence Wen Jing Chioh, Qiao Fan, Xianfeng Tian, Binxia Yang, Gunaseelan Narayanan, Hui Min Tay, Han Wei Hou, N. Ray Dunn, Xinyi Su, Chui Ming Gemmy Cheung, Christine Cheung
Summary: Research on PCV patients discovered that blood endothelial cells react differently under different flow speeds, and that inhibiting elevated hyaluronidase-1 in PCV patients can improve cell mechanosensitivity and repair barrier permeability.
Article
Hematology
Bingwen Eugene Fan, Shiun Woei Wong, Christina Lai Lin Sum, Gek Hsiang Lim, Bernard PuiLam Leung, Chuen Wen Tan, Kollengode Ramanathan, Rinkoo Dalan, Christine Cheung, Xin Rong Lim, Mucheli Shravan Sadasiv, David Chien Lye, Barnaby Edward Young, Eng Soo Yap, Yew Woon Chia
Summary: Sustained hypercoagulability and endotheliopathy persist in convalescent COVID-19 patients for several months after recovery. Hemostatic, endothelial, and inflammatory abnormalities are still detectable in these patients compared to their pre-recovery state. This finding is important for long-term anticoagulation therapy and follow-up of recovered patients.
AMERICAN JOURNAL OF HEMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chun-Yi Ng, Khang Leng Lee, Mark Dhinesh Muthiah, Kan Xing Wu, Florence Wen Jing Chioh, Konstanze Tan, Gwyneth Shook Ting Soon, Asim Shabbir, Wai Mun Loo, Zun Siong Low, Qingfeng Chen, Nguan Soon Tan, Huck Hui Ng, Yock Young Dan, Christine Cheung
Summary: The top cause of mortality in patients with nonalcoholic fatty liver disease (NAFLD) is cardiovascular complications. The study reveals that blood outgrowth endothelial cells (BOECs) from NAFLD subjects exhibit global transcriptional upregulation of chemokines and human leukocyte antigens. T cell intensification is observed in NAFLD patients. CXCL12-neutralizing antibody treatment helps to moderate the enhanced chemotactic effect of NAFLD BOECs in recruiting CD8(+) T lymphocytes.
Article
Geriatrics & Gerontology
Angela S. Koh, Anthony Siau, Fei Gao, Florence W. J. Chioh, Shuang Leng, Xiaodan Zhao, Liang Zhong, Ru San Tan, Poh Ling Koh, Jean-Paul Kovalik, Wee Shiong Lim, Gina S. Lee, Woon-Puay Koh, Christine Cheung
Summary: Advanced cardiac magnetic resonance imaging revealed that circulating biomarkers including galectin, MMP-9, and sUPAR were associated with left atrial dysfunction in older adults, possibly indicating fibrotic mechanisms and immune activation in left atrial aging.
Article
Biochemistry & Molecular Biology
Lay Teng Ang, Alana T. Nguyen, Kevin J. Liu, Angela Chen, Xiaochen Xiong, Matthew Curtis, Renata M. Martin, Brian C. Raftry, Chun Yi Ng, Uwe Vogel, Angelika Lander, Benjamin J. Lesch, Jonas L. Fowler, Alyssa R. Holman, Timothy Chai, Siva Vijayakumar, Fabian P. Suchy, Toshinobu Nishimura, Joydeep Bhadury, Matthew H. Porteus, Hiromitsu Nakauchi, Christine Cheung, Steven C. George, Kristy Red-Horse, Joseph B. Prescott, Kyle M. Loh
Summary: This study successfully generated >90% pure human artery or vein endothelial cells from pluripotent stem cells within 3-4 days and used them to investigate the infection and effects of Nipah and Hendra viruses on arteries. They found that these viruses preferentially infected arteries, which expressed higher levels of the viral-entry receptor. Virally infected artery cells quickly fused into syncytia containing multiple nuclei, but rapidly died. However, these viruses largely evaded innate immune detection and minimally elicited interferon signaling during artery infection.
Article
Cardiac & Cardiovascular Systems
Kai Yi Tay, Kan Xing Wu, Florence Wen Jing Chioh, Matias Ilmari Autio, Nicole Min Qian Pek, Balakrishnan Chakrapani Narmada, Sock-Hwee Tan, Adrian Fatt-Hoe Low, Michelle Mulan Lian, Elaine Guo Yan Chew, Hwee Hui Lau, Shih Ling Kao, Adrian Kee Keong Teo, Jia Nee Foo, Roger Sik Yin Foo, Chew Kiat Heng, Mark Yan Yee Chan, Christine Cheung
Summary: The study highlights the importance of the 6p24.1 locus in endothelial cell function and abnormal vascular physiology, revealing a previously unknown interaction between 6p24.1 and 10q11.21 in the development of CAD. This sheds light on a new area in understanding the mechanisms of CAD progression.
Correction
Biochemistry & Molecular Biology
Chun-Yi Ng, Khang Leng Lee, Mark Dhinesh Muthiah, Kan Xing Wu, Florence Wen Jing Chioh, Konstanze Tan, Gwyneth Shook Ting Soon, Asim Shabbir, Wai Mun Loo, Zun Siong Low, Qingfeng Chen, Walter Wahli, Nguan Soon Tan, Huck Hui Ng, Yock Young Dan, Christine Cheung
Article
Biochemistry & Molecular Biology
Natalie Jia Ying Yeo, Vanessa Wazny, Nhi Le Uyen Nguyen, Chun-Yi Ng, Kan Xing Wu, Qiao Fan, Chui Ming Gemmy Cheung, Christine Cheung
Summary: Age-related macular degeneration is a common cause of visual impairment in older populations worldwide. Wet AMD, the most common subtype, is characterized by pathological angiogenesis and is typically treated with anti-vascular endothelial growth factor therapy. However, long-term prevention of visual decline is still a challenge. Researchers have identified potential VEGF-independent pathways involved in wet AMD pathogenesis, including extracellular matrix remodeling, interleukin signaling, and amino acid metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Kan Xing Wu, Thinesshwary Yogarajah, Marcus Wing Choy Loe, Parveen Kaur, Regina Ching Hua Lee, Chee Keng Mok, Yi Hao Wong, Patchara Phuektes, Li Sze Yeo, Vincent T. K. Chow, Yong Wah Tan, Justin Jang Hann Chu
Summary: The study found that peruvoside plays an important role in limiting the formation of viral factories by regulating multiple cellular signaling pathways to promote GBF1 phosphorylation, thereby reducing the formation of viral factories. In a mouse model treated with peruvoside, the viral count was significantly reduced without any apparent cytotoxicity. These findings are of great significance for studying the mechanism of broad-spectrum antiviral drugs and provide a path for the use of peruvoside as a host-directed antiviral drug.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Engineering, Biomedical
Yufeng Shou, Ling Liu, Qimin Liu, Zhicheng Le, Khang Leng Lee, Hua Li, Xianlei Li, Dion Zhanyun Koh, Yuwen Wang, Tong Ming Liu, Zheng Yang, Chwee Teck Lim, Christine Cheung, Andy Tay
Summary: Bone marrow-derived mesenchymal stem cells (MSCs) are widely studied due to their regenerative potential and immunomodulatory properties. In this work, a 3D dynamic hydrogel using magneto-stimulation is introduced for direct manufacturing of MSCs. The technology enhances MSC spreading, proliferation, and biofunctions, and can integrate MSC manufacturing to final clinical use, offering a paradigm shift in MSC therapy.
BIOACTIVE MATERIALS
(2023)