Article
Engineering, Biomedical
Zhanrong Jia, Xuanhan Lv, Yue Hou, Kefeng Wang, Fuzeng Ren, Dingguo Xu, Qun Wang, Kelong Fan, Chaoming Xie, Xiong Lu
Summary: This study presents a mussel-inspired nanozyme-catalyzed adhesive hydrogel with multiple functions, including adhesiveness, antibacterial activity, and implantable bioelectrode capabilities. It shows great potential for various applications in the medical field.
BIOACTIVE MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Yuchan Huang, Tang Zhu, Zijuan Zhu, Huixin Yuan, Liru Tan, Pingping Yao, Yongna Qiao, Caizhen Zhu, Jian Xu
Summary: Researchers have developed a multifunctional hydrogel with self-adhesive, highly stretchable, and conductive properties by introducing polydopamine and carbon fiber into polyacrylamide hydrogel. This hydrogel can be directly adhered to the skin as a strain sensor to monitor human body motion.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Xiaohui Zhang, Jingjing Wei, Shengchang Lu, He Xiao, Qingxian Miao, Min Zhang, Kai Liu, Lihui Chen, Liulian Huang, Hui Wu
Summary: In this study, a multifunctional hydrogel with adhesive, self-healing, antibacterial, and conductive properties was prepared using dopamine methacrylate (DMA), methacrylatoethyl trimethyl ammonium chloride (DMC), and acrylic acid (AA). The hydrogel exhibited strong adhesion to various materials, good antibacterial properties, and excellent self-healing ability. This hydrogel has potential applications in electronic skin and wearable devices.
ACS APPLIED POLYMER MATERIALS
(2021)
Article
Chemistry, Physical
Xiaoyong Zhang, Jingsi Chen, Jinmei He, Yongping Bai, Hongbo Zeng
Summary: This study successfully developed mussel-inspired L-DMA-PCL hydrogels as potential wearable strain sensors, with good adhesive properties, adjustable mechanical performance, and high strain sensitivity.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Review
Chemistry, Physical
Qin Yu, Zirong Zheng, Xinhao Dong, Rui Cao, Shuheng Zhang, Xiaolin Wu, Xinya Zhang
Summary: This review discusses the use of multifunctional hydrogels to improve the performance of wearable sensors, including mechanical strength, adhesion, electrical conductivity, and antibacterial properties. Strategies for achieving durable hydrogels were examined, involving double network structures, nanocomposites, supramolecular block polymers, among others.
Article
Chemistry, Physical
Yaru Yu, Xiaowen Zhao, Lin Ye
Summary: A PVA-COOH/polydopamine (PDA) hydrogel with high adhesive strength and stretchability was developed, showing promising potential in wearable strain sensors. The hydrogel exhibited a dense network formed by dual covalent/hydrogen bonding, and could adhere to both hydrophilic and hydrophobic surfaces with high adhesion strength. Additionally, the hydrogel demonstrated conductivity with high strain sensitivity, allowing for monitoring large-scale and subtle limb motions.
APPLIED SURFACE SCIENCE
(2021)
Article
Nanoscience & Nanotechnology
Shengkai Sun, Meng Xu, Yuewu Zhao, Tingting Cheng, Ying Xiang, Xiaoxuan Liu, Jine Wang, Renjun Pei
Summary: The integration of nucleobase into conductive hydrogels enhances adhesiveness and conductivity, while reducing particle aggregation. The similar modulus of the hydrogel to brain tissue reduces inflammatory reactions caused by foreign body implantation. This method shows promise in improving biocompatibility, conductivity, and reducing inflammatory responses.
ACS APPLIED NANO MATERIALS
(2023)
Article
Polymer Science
Sumin Kim, Heewon Choi, Donghee Son, Mikyung Shin
Summary: An intrinsically conductive and tissue-adhesive granular hydrogel was fabricated using an electrohydrodynamic spraying method. This hydrogel can be applied in soft and flexible electronics to connect humans and machines.
Article
Polymer Science
Kai-Yi Chang, Ying-Nien Chou, Wei-Yu Chen, Chuh-Yean Chen, Hong-Ru Lin
Summary: This study develops a multi-functional hydrogel with a dual injection system based on the adhesive and self-healing properties of the byssus excretion found in mussels. The hydrogel has high strength, temperature sensitivity, good adhesion, self-healing properties, and antibacterial resistance. It can be used for deep wound treatment and improvement of traditional wound dressings.
Article
Materials Science, Multidisciplinary
Dan My Nguyen, Yuhang Wu, Abigail Nolin, Chun-Yuan Lo, Tianzheng Guo, Charles Dhong, David C. Martin, Laure Kayser
Summary: Electronically conductive hydrogels, with mechanical properties similar to biological tissues, are gaining popularity in bioelectronic interfaces. The integration of conducting polymers or nanoparticles into hydrogels is necessary to achieve conductivity, but it often affects the mechanical properties or leads to heterogeneous distribution. This study reports a two-step method for imparting conductivity to hydrogels without compromising their mechanical properties, resulting in homogeneous conductive hydrogels with good conductivity and similar elastic modulus to the original hydrogel.
ADVANCED ENGINEERING MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Or Berger, Claudia Battistella, Yusu Chen, Julia Oktawiec, Zofia E. Siwicka, Danielle Tullman-Ercek, Muzhou Wang, Nathan C. Gianneschi
Summary: This paper describes a synthetic polymer proteomimetic that mimics the structure and function of mussel adhesive protein. The proteomimetic exhibits improved adhesion properties compared to the natural protein and can be used as a surface adhesive for immobilizing live cells.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Biochemistry & Molecular Biology
Ying Chen, Xiaokun Fan, Jiawei Lu, Xin Liu, Jin Chen, Yi Chen
Summary: This study presents the preparation of multifunctional chitosan/polydopamine/polyacrylamide hydrogels with superior tissue adhesion, self-healing, and antibacterial properties. The hydrogels show great potential in accelerating skin tissue regeneration and promoting wound healing.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Engineering, Environmental
Shiyu Zong, Hui Lv, Chuanjie Liu, Liwei Zhu, Jiufang Duan, Jianxin Jiang
Summary: Highly ionic conductive hydrogels with adhesiveness, flexibility, waterretention and anti-freezing properties are fabricated by combining tannic acid coated cellulose nanofibers (TA@CNF), metal ion Cu2+, glycerol and polyacrylamide (PAM) chains. The hydrogels exhibit excellent electrical conductivity, mechanical properties and adhesion, making them suitable for skin sensors and biomedical monitoring.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Fuyu Song, Jiahui Zhang, Jie Lu, Yi Cheng, Yehan Tao, Changyou Shao, Haisong Wang
Summary: A multi-functional physical hydrogel adhesive with durable and repeatable adhesiveness, self-healing capability, antibacterial properties, and biocompatibility has been successfully manufactured in this study, offering a promising prospect for applications in tissue adhesion and wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Multidisciplinary
Chenlong Wang, Xiaohan Gao, Feng Zhang, Wanting Hu, Zhuxian Gao, Yuqi Zhang, Mingyu Ding, Qionglin Liang
Summary: A mussel inspired hydrogel has been developed to achieve both strong adhesion and easy detachment. The hydrogel can adhere to various material surfaces and tissues and can be easily peeled off by shear force. This work has important implications in electronic engineering and tissue repair.
Article
Chemistry, Physical
Jiao Xu, Zhenbao Luo, Sudong Wu, Yulei Li, Yun Yang, Shiyuan Lai, Fuzeng Ren, Jianjun Lin, Dengji Guo, Xujin Wang
Summary: Nanocrystalline diamond films were fabricated with a dual nanostructure by adjusting the CH4 content in the precursor gas, showing consistent lubricant properties and wear rates regardless of grain size variations. The films exhibited lower and more stable friction coefficients after irradiation due to reduced surface roughness and formation of tribofilms with a graphite-like structure. The excellent maintenance of lubrication properties post-heavy-ion irradiation suggests potential for development as anti-irradiation films in nuclear environments.
APPLIED SURFACE SCIENCE
(2022)
Article
Engineering, Biomedical
Huan He, Ziying Fei, Tailin Guo, Yue Hou, Da Li, Kefeng Wang, Fuzeng Ren, Kelong Fan, Daijun Zhou, Chaoming Xie, Chao Wang, Xiong Lu
Summary: This study developed a bioadhesive injectable hydrogel for localized immune modulation and catalytic immunotherapy in cancer treatment. The hydrogel containing a nanozyme and immune adjuvant effectively targeted the tumor microenvironment while limiting systemic exposure and enhancing therapeutic efficacy.
Article
Chemistry, Multidisciplinary
Yue Hou, Yazhen Li, Yingqi Li, Da Li, Tailin Guo, Xu Deng, Hongping Zhang, Chaoming Xie, Xiong Lu
Summary: Researchers developed a wet adhesive hydrogel by screening a series of hydrophobic alkyl monomers and adhesive catechol derivatives. The optimized hydrogel showed excellent efficacy in hemostasis and wound healing, and demonstrated immunomodulation ability through transcriptomic analysis. Additionally, conductive nanocomponents were incorporated into the hydrogel to produce a wearable device for continuous monitoring of human electrocardiogram (ECG) during swimming and in situ epicardial ECG on a living and beating heart.
Review
Chemistry, Multidisciplinary
Chaoming Xie, Yazhen Li, Xiaochuan Guo, Yonghui Ding, Xiong Lu, Shuquan Rao
Summary: The immune system plays a crucial role in protecting the body from pathogens and tumor cells while promoting tissue repair and anti-tumor activity. Systemic administration of immune agents often leads to non-specific immune activity and autoimmune complications. To address this issue, local immunomodulation using adhesive hydrogels, specifically mussel-inspired adhesive hydrogels, has been developed. These hydrogels provide targeted and controlled release of immune agents, with regulatory effects on local immune cells, maximizing therapeutic outcomes and minimizing impact on overall immune balance. This review covers the current knowledge on immune response in tissue repair and tumor therapy, the design strategies of adhesive hydrogels, and the molecular structure and immunomodulatory mechanisms of mussel-inspired adhesive hydrogels.
MATERIALS CHEMISTRY FRONTIERS
(2023)
Article
Nanoscience & Nanotechnology
Qiwen Tang, Qi Ke, Qi Chen, Xinyi Zhang, Jianyu Su, Chengyun Ning, Liming Fang
Summary: A self-powered and intrinsic bactericidal patch based on a triboelectric nanogenerator (TENG) is proposed in this study. The patch is composed of electrospun polymer tribo-layers and a chemical vapor-deposited polypyrrole electrode, which provides excellent flexibility, breathability, and wettability. The patch kills over 96% of bacteria through electrical stimulation and promotes the healing of infected diabetic rat skin wounds within 2 weeks.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Correction
Chemistry, Multidisciplinary
Yue Hou, Yazhen Li, Yingqi Li, Da Li, Tailin Guo, Xu Deng, Hongping Zhang, Chaoming Xie, Xiong Lu
Article
Chemistry, Multidisciplinary
Junchang Guo, Liansong Ye, Yuan Gao, Shuangyang Li, Lifan Zhang, Wei Liu, Tingfa Peng, Yi Mou, Chuncheng Wu, Chaoming Xie, Bing Hu, Xu Deng
Summary: In this study, a hybrid dry powder (HDP) strategy is proposed for rapid sealing of wet tissues during gastric endoscopic submucosal dissection (ESD). The HDPs form a hydrogel layer over the target tissue by absorbing water and forming electrostatic interactions, achieving strong adhesion through hydrogen bonding. The HDP-assembled hydrogel demonstrates fast adhesion to wet tissues, low swelling rate, and resistance to acidic degradation.
Article
Multidisciplinary Sciences
Huan He, Qiaozhen Qin, Fang Xu, Yitong Chen, Shuquan Rao, Chao Wang, Xiaoxia Jiang, Xiong Lu, Chaoming Xie
Summary: Developing oral nanomedicines that suppress intestinal inflammation while modulating gut microbiota and brain interactions is essential for effectively treating inflammatory bowel disease.
Article
Nanoscience & Nanotechnology
Chaoming Xie, Jiaqing Luo, Yongjie Luo, Jie Zhou, Xiaochuan Guo, Xiong Lu
Summary: This study reports a mussel-inspired approach to design a near-infrared light-responsive antibacterial hydrogel wound dressing. The hydrogel dressing possesses on-demand antibacterial and excellent wound repair properties, as well as conductivity and cell affinity. In vitro and in vivo studies demonstrated its strong tissue repair activity under near-infrared light irradiation.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Lei Yin, Qiwen Tang, Qi Ke, Xinyi Zhang, Jianyu Su, Hua Zhong, Liming Fang
Summary: In this study, an antibacterial and proangiogenic dressing is developed by encapsulating DMOG in ZIF-8 and electrospinning it with Gel-PCL. The dressing sequentially releases bactericidal zinc ions and angiogenic DMOG molecules, eliminating bacterial infection and promoting wound healing.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Jinglei Gong, Chengxinyue Ye, Jinhui Ran, Xin Xiong, Xinyi Fang, Xueman Zhou, Yating Yi, Xiong Lu, Jun Wang, Chaoming Xie, Jin Liu
Summary: The study describes a silk fibroin/gelatin patch incorporating polydopamine-mediated ultralong silk microfibers and metformin-loaded zeolitic imidazolate framework, which promotes periodontal soft and hard tissue regeneration by regulating the immunomodulatory microenvironment. The patch has reactive oxygen species-scavenging ability and anti-inflammatory activity, reducing the inflammatory response and improving periodontal ligament reconstruction. The sustained release of metformin and zinc ions from the patch confers anti-aging and immunomodulatory abilities, promoting bone regeneration.
Review
Biochemistry & Molecular Biology
Chaoming Xie, Jie Xu, Xinyi Wang, Shengxi Jiang, Yujia Zheng, Zexin Liu, Zhuo Jia, Zhanrong Jia, Xiong Lu
Summary: Smart hydrogels have the potential to accurately sense and respond to tissue microenvironment changes, making them a valuable tool for improving precision in age-related disease treatment. Accurately replicating the characteristics of natural tissues at the molecular level is crucial in the design of smart hydrogels. These hydrogels can sense various physiological and external factors and adjust their response accordingly, promoting tissue repair.
MACROMOLECULAR BIOSCIENCE
(2023)
Review
Materials Science, Multidisciplinary
Fujie Xiao, Liwei Yan, Yonghui Ding, Xiong Lu, Chaoming Xie
Summary: Osteoarthritis is a common chronic joint disease that significantly affects quality of life. Oral and intra-articular administration are the main clinical treatments, but their effectiveness is limited. Mussel-inspired materials have emerged as promising candidates for the treatment of osteoarthritis due to their enhanced drug availability and multiple pathways for alleviating the disease.
MATERIALS RESEARCH EXPRESS
(2023)
Article
Chemistry, Multidisciplinary
Donglin Gan, Ziqiang Huang, Xiao Wang, Dejia Xu, Shuquan Rao, Kefeng Wang, Fuzeng Ren, Lili Jiang, Chaoming Xie, Xiong Lu
Summary: This study proposes a mussel-inspired method for preparing a specific core-shell redox-active system, consisting of a polydopamine (PDA) modified zeolitic imidazolate framework 71 (ZIF-71) core, and a poly 3,4-ethylenedioxythiopene (PEDOT) shell. The core-shell PEDOT@PZIF-71 system provides the hydrogel with stretchability and adhesiveness, and can be applied as a functional electrode for bioelectronics and supercapacitors.
MATERIALS HORIZONS
(2023)
Article
Chemistry, Multidisciplinary
Fanxi Sun, Ang Gao, Xiaoyu Xiong, Yongli Duan, Dacheng Dai, Yifei Zhu, Chaoming Xie, Qiang Wei, Longquan Chen, Bo He, Hui Zhao, Yonghao Zheng, Xu Deng, Chen Wei, Dongsheng Wang
Summary: In this study, grayscale information encryption was achieved by controlling the kinetics of photoisomerization of donor-acceptor Stenhouse adducts on a paper surface, based on the photochromism of ester-containing molecules.
CHEMICAL COMMUNICATIONS
(2023)