Review
Pharmacology & Pharmacy
Manuel Horue, Jhonatan Miguel Silva, Ignacio Rivero Berti, Larissa Reis Brandao, Hernane da Silva Barud, Guillermo R. R. Castro
Summary: Bacterial cellulose (BC), produced by microorganisms, can be modified to produce different cellulosic formats. BC has advantages for biomedical applications such as easy moldability, high biocompatibility, and tailoring ability. Its hydroxyl residues and nanoporous morphology make it ideal for wound healing. This article discusses the characteristics of different BC structures, recent advances in BC composites, and the development of antimicrobial BC and drug delivery systems.
Article
Biochemistry & Molecular Biology
Farzana Nazir, Iffat Ashraf, Mudassir Iqbal, Tahir Ahmad, Sadia Anjum
Summary: Hydrogels were prepared by mixing protein and carbohydrate-based biopolymers to enhance mechanical properties and promote efficient cell adhesion and proliferation for wound healing applications. The use of GelMA embedded amine MCC derivatives hydrogels showed accelerated wound healing potential based on in vitro and in vivo studies.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Elmira Mohamed, Yi Wang, Philip J. Crispin, Ailene Fitzgerald, Jane E. Dahlstrom, Suzanne Fowler, David R. Nisbet, Takuya Tsuzuki, Lucy A. Coupland
Summary: Optimization of the morphological properties of nonoxidized cellulose nanofibers (CNFs) enhances hemostasis. CNFs as hemostatic materials demonstrate excellent hemostatic properties in in vitro and in vivo experiments, while also being biocompatible and biodegradable. Therefore, CNFs hold significant potential for use in surgical and first-aid environments.
MACROMOLECULAR BIOSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Vandiara Martins Moreira, Joandra Maisa da Silva Leite, Kaline de Araujo Medeiros, Karoll Moangella Andrade de Assis, Joyce Cordeiro Borges, Lucas Matheus Barreto Santana, Livia Maria Coelho de Carvalho Moreira, Larissa Pereira Alves, Tharcia Kiara Beserra de Oliveira, Joao Walter de Souza da Silveira, Dayanne Tomaz Casimiro da Silva, Bolivar Ponciano Goulart de Lima Damasceno
Summary: The study developed chitosan films associated with pentoxifylline for healing wounds. The films were prepared at two concentrations and evaluated for their structural characteristics, release properties, and wound healing effects in mice. Higher concentration of pentoxifylline in the films showed faster wound reduction, indicating the effectiveness of the combination of chitosan and pentoxifylline in promoting wound healing.
Article
Nanoscience & Nanotechnology
Fazli Wahid, Xiang-Jun Zhao, Xue-Qing Zhao, Xiao-Fang Ma, Na Xue, Xiao-Zhi Liu, Feng-Ping Wang, Shi-Ru Jia, Cheng Zhong
Summary: The study showed that BC membranes functionalized with epsilon-polylysine (epsilon-PL) and mussel-inspired polydopamine (PDA) exhibited strong antibacterial properties, potential for promoting infected wound healing, and enhanced thickness and smoothness of newborn skin.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Dermatology
Wei He, Jian Wu, Jin Xu, Dina A. Mosselhy, Yudong Zheng, Siming Yang
Summary: Bacterial cellulose (BC) is a natural polymer with good biological activity and unique physical, chemical, and biological properties, suitable for wound dressings. Different methods have been adopted to modify BC for optimizing its biocompatibility and antimicrobial activity, promoting wound healing. BC-based dressings have been applied in various types of wounds with remarkable therapeutic effects.
ADVANCES IN WOUND CARE
(2021)
Article
Chemistry, Applied
Si-Qian Chen, Qiudong Liao, Oliver W. Meldrum, Lei Guo, Kai Wang, Shuyan Zhang, Yujia Liu, Xu Chen, Jie Zhu, Lin Li
Summary: This study presents a novel in situ biopreparation method to produce BC-based hybrid hydrogels containing dextran (BC-D) and xyloglucan-dextran (BC-XG-D) with unique mechanical and rheological properties. The BC-XG-D hybrid hydrogels showed a reduced Young's modulus and a higher maximum tensile strain compared to native BC, and displayed less plastic but more viscous behavior under large shear strain deformation. The wound healing animal model experiments demonstrated that the BC-XG-D hybrid hydrogels promoted wound healing process and skin maturation.
CARBOHYDRATE POLYMERS
(2023)
Article
Chemistry, Inorganic & Nuclear
Tharwat Shaheen, Mamdouh S. El-Gamal, Said E. Desouky, Saad El Din Hassan, Ahmed M. Alemam
Summary: A new facile method for producing antimicrobial wound healing dressings was achieved by using freshly fabricated bacterial cellulose (BNC) decorated with in situ formed silver nanoparticles (AgNPs). The hybrid BNC/AgNPs showed strong antibacterial activity against various pathogens and demonstrated potential in promoting wound healing and protecting cells from oxidative stress.
JOURNAL OF CLUSTER SCIENCE
(2022)
Article
Immunology
Sumanta Ghosh, Sumedh Vaidya, Namdev More, Ravichandiran Velyutham, Govinda Kapusetti
Summary: With the emergence of functional biomaterials based on piezoelectric properties, wound healing has made progress by actively utilizing mechanical forces. In this study, a zinc oxide-incorporated cellulose acetate nanofibrous mat was fabricated and characterized using various assays. The results demonstrated the tunable piezoelectric coefficient of the nanofibrous mat and its potential for enhanced cell adhesion, proliferation, and migration, indicating accelerated wound healing.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ayesha Khalid, Ahmed Madni, Bareera Raza, Mazhar ul Islam, Amjad Hassan, Fiaz Ahmad, Hussain Ali, Taous Khan, Fazli Wahid
Summary: The study developed a potential composite film for diabetic wound healing by reinforcing the bacterial cellulose (BC) matrix with multiwalled carbon nanotubes (MWCNT). The composite film exhibited excellent antibacterial activity and accelerated the healing process of diabetic wounds.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Applied
Jiafu Shen, Ruixue Chang, Limin Chang, Yong Wang, Kuilin Deng, Dong Wang, Jianglei Qin
Summary: This study designed a biodegradable hydrogel with luminescent property, which shows great potential in drug loading and delivery, wound dressing, and tissue engineering. The hydrogel exhibits excellent biocompatibility and hemostatic activity, and it can reduce acute drug toxicity and accelerate wound repairing efficacy.
CARBOHYDRATE POLYMERS
(2022)
Article
Medicine, Research & Experimental
Ao Shi, Jialun Li, Xinyuan Qiu, Michael Sabbah, Soulmaz Boroumand, Tony Chieh-Ting Huang, Chunfeng Zhao, Andre Terzic, Atta Behfar, Steven L. Moran
Summary: This study developed a clinical-grade platelet exosome product (PEP) combined with injectable surgical fibrin sealant (TISSEEL) to promote chronic wound healing and skin regeneration. The PEP showed promising results in stimulating cellular activities and enhancing wound healing capacity.
Article
Chemistry, Multidisciplinary
Seulgi Kim, Jina Ko, Jae Hyuk Choi, Jeong Yi Kang, Chanoong Lim, Mikyung Shin, Dong Woog Lee, Jin Woong Kim
Summary: A new skin tissue adhesive system has been developed using antigen-antibody interaction, which effectively adheres to the skin surface and promotes wound healing. This system could pave the way for developing a new type of tissue adhesive for skin tissue regeneration.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Review
Polymer Science
Atiqah Salleh, Mh Busra Fauzi
Summary: The application of nanotechnologies, specifically Quantum dots (QDs), in wound healing has shown effectiveness in promoting wound healing process by their antibacterial and angiogenesis properties. Further research on QDs at the molecular level is recommended to understand cellular interactions and pathways for improved wound healing outcomes.
Article
Biochemistry & Molecular Biology
Balaji Ayyanar Chinnappan, Marimuthu Krishnaswamy, Trishna Bal, Aditya Dev Rajora
Summary: Tridax Procumbens Extracts (TPE) blended with Carboxymethylcellulose (CMC) were used to develop a film with antibacterial activity and cell proliferation capability. The film also showed effective wound healing properties in an in-vivo study using adult mice.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Physical
Izzat Zulkiflee, Ibrahim N. N. Amirrah, Nur Izzah Md Fadilah, M. F. Mohd Razip Wee, Salma Mohamad Yusop, Manira Maarof, Mh Busra Fauzi
Summary: Untreated skin wounds can delay healing and potentially lead to death from severe infection. Improper healing in these wounds often causes prolonged and excessive skin contraction, which can result in disfigurement and loss of tissue function. This study developed a bilayer biomatrix consisting of a gelatin/polyvinyl alcohol film and a collagen sponge fortified with elastin, which showed promising physicochemical and mechanical properties. The biomatrix could potentially be used as an alternative treatment for diabetic skin wound management.
Article
Food Science & Technology
Rusydatul Nabila Mahmad Rusli, Ruth Naomi, Muhammad Dain Yazid, Hashim Embong, Kokilavani Perumal, Fezah Othman, Azmiza Syawani Jasni, Siti Hadizah Jumidil, Santhra Segaran Balan, Azrina Zainal Abidin, Khairul Kamilah Abdul Kadir, Hasnah Bahari, Zainul Amiruddin Zakaria
Summary: The purpose of this study was to incorporate Bouea macrophylla extract into yoghurt and assess its toxicological effects. The results showed that Bouea macrophylla yoghurt had no negative effects on the growth and health of rodents.
Article
Nutrition & Dietetics
Ruth Naomi, Soo Huat Teoh, Rusydatul Nabila Mahmad Rusli, Hashim Embong, Hasnah Bahari, Jaya Kumar
Summary: This study aimed to investigate the impact of E. tapos in yogurt on the cognitive function of maternally obese rats under a high-fat diet. The results showed that the 50 and 500 mg/kg E. tapos supplemented groups had similar metabolic profile and memory index compared to the control group. Therefore, the conclusion of this study is that the newly formulated E. tapos in yogurt can act as an anti-obesity agent, alleviate anxiety, and enhance hippocampal-dependent memory.
Article
Nutrition & Dietetics
Ruth Naomi, Rusydatul Nabila Mahmad Rusli, Teoh Soo Huat, Hashim Embong, Hasnah Bahari, Mohd Amir Kamaruzzaman
Summary: Maternal obesity can lead to cognitive deficits and high anxiety levels in offspring, but early intervention during gestation can reduce intergenerational inheritance of obesity and have positive effects on the body composition, cognitive function, and anxiety levels of the offspring. Recent research suggests that consuming Elateriospermum tapos (E. tapos) seed extract can regulate body weight and improve stress hormones in obese dams, while probiotics can enhance a child's memory by crossing the placenta. Therefore, probiotics are speculated to be the best medium to incorporate plant extract (E. tapos extract) and assess its effects on the child's cognition.
Article
Polymer Science
Nur Izzah Md Fadilah, Nazeha Ahmat, Looi Qi Hao, Manira Maarof, Nor Fadilah Rajab, Ruszymah Binti Hj Idrus, Mh Busra Fauzi
Summary: This study aimed to validate the biological safety of ovine tendon collagen type-I (OTC-I) under ISO and GLP settings. OTC-I was successfully extracted using acetic acid, and tests showed no adverse effects or abnormalities. Therefore, OTC-I is a potential medical device candidate for wound care management.
Review
Polymer Science
Nur Amalia Ra'oh, Rohaina Che Man, Mh Busra Fauzi, Norzana Abd Ghafar, Muhamad Ramdzan Buyong, Ng Min Hwei, Wan Haslina Wan Abdul Halim
Summary: In recent decades, researchers have made numerous modifications and advancements in designing the ideal corneal biomatrix for corneal epithelial cell (CECs) or limbal epithelial stem cell (LESC) carriers. However, the optimal strategies for corneal biomatrix design and its effects on cultured CECs or LESCs have yet to be discovered. This review summarizes recent optimization strategies for developing an ideal collagen biomatrix and its interactions with CECs and LESCs.
Review
Chemistry, Multidisciplinary
Fairuz Izan Muhammad Firdaus, Ab. Karim Nashihah, Mh. Busra Mohd Fauzi, Maarof Manira, Saim Aminuddin, Yogeswaran Lokanathan
Summary: In recent years, exploring respiratory therapy guided by cell-secreted substances in vitro has become popular. This review evaluated the efficacy of using conditioned medium (CM) collected in an in vitro respiratory epithelial model. The results showed that differentiated cells from respiratory and non-respiratory systems, such as mesenchymal stem cells (MSC), could improve proliferation, migration, attachment, and protect the respiratory epithelium against cytotoxicity. CM might be a potential regenerative therapy in respiratory illnesses, but further research is needed to justify its use in clinical practice.
APPLIED SCIENCES-BASEL
(2023)
Review
Pharmacology & Pharmacy
Rabiatul Adawiyah Razali, Ubashini Vijakumaran, Mh Busra Fauzi, Yogeswaran Lokanathan
Summary: This article systematically reviewed the available evidence to assess the efficacy of functional biomaterials after endoscopic sinus surgery (ESS). The analysis showed that chitosan, gelatin, hyaluronic acid, and starch-derived materials exhibit better endoscopic scores and significant potential for use in nasal packing.
Review
Biochemistry & Molecular Biology
Nur Izzah Md Fadilah, Shou Jin Phang, Nurkhuzaiah Kamaruzaman, Atiqah Salleh, Mazlan Zawani, Arka Sanyal, Manira Maarof, Mh Busra Fauzi
Summary: Natural antioxidant-incorporated biomaterials have shown promise in promoting skin wound healing and tissue regeneration. However, the low bioavailability of these biomaterials limits their therapeutic activity at the injury site. This review summarizes recent literature on the role of antioxidant-incorporated biomaterials and their mechanisms in promoting wound healing, supported by in vitro, in vivo, and clinical studies.
Article
Food Science & Technology
Ruth Naomi, Rusydatul Nabila Mahmad Rusli, Soo Huat Teoh, Hasnah Bahari, Zainul Amiruddin Zakaria
Summary: Pre-pregnancy weight gain can lead to dysregulation in offspring's metabolic profile, resulting in cognitive decline and anxiety. However, early use of Elateriospermum tapos (E. tapos) yoghurt during gestation can improve metabolic health. This study found that supplementation with E. tapos yoghurt can reduce diabetes markers, lower cholesterol and triglyceride levels, and increase antioxidant status in female offspring.
Review
Chemistry, Medicinal
Loai A. Elfawy, Chiew Yong Ng, Ibrahim N. Amirrah, Zawani Mazlan, Adzim Poh Yuen Wen, Nur Izzah Md Fadilah, Manira Maarof, Yogeswaran Lokanathan, Mh Busra Fauzi
Summary: Burns are a global public health issue that affects many people worldwide. Traditional burn wound treatment methods using synthetic materials may have negative environmental impacts and may not be biocompatible with the human body. Tissue engineering offers a promising alternative, with sustainable biomaterials such as collagen, cellulose, and chitosan showing potential in promoting wound healing and reducing infection risk. This review focuses on the use of multifunctional green biomaterials that can revolutionize burn treatment by promoting faster and more efficient healing while minimizing scarring and tissue damage.
Review
Biochemistry & Molecular Biology
Ruth Naomi, Soo Huat Teoh, Shariff Halim, Hashim Embong, Zubaidah Hasain, Hasnah Bahari, Jaya Kumar
Summary: Obesity is a global burden due to its complications, and current approaches involve drugs and surgeries with side effects. Natural antioxidants, like flavonoids, offer a promising alternative with minimal side effects. This review explores the potential role of flavonoids in managing obesity, concluding that they provide novel therapeutic strategies by reducing adipose tissue mass, free radicals, and inflammation, and enhancing antioxidant defenses.
Article
Food Science & Technology
Ruth Naomi, Soo Huat Teoh, Hashim Embong, Santhra Segaran Balan, Fezah Othman, Kamalludin Mamat-Hamidi, Hasnah Bahari, Muhammad Dain Yazid
Summary: This study explores the pharmacological effects of bioactive compounds in E. tapos yogurt against maternal obesity using network pharmacology. The findings reveal that these compounds have favorable affinity with obesity-related genes and are involved in biological processes such as protein phosphorylation, inflammation, lipid metabolism, atherosclerosis, and signaling pathways.
Meeting Abstract
Pharmacology & Pharmacy
Ruth Naomi, Rusydatul Nabila Mahmad Rusli, Muhammad Dain Yazid, Hasnah Bahari
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Ruth Naomi, Muhammad Dain Yazid, Hashim Embong, Hasnah Bahari
JOURNAL OF NEUROCHEMISTRY
(2023)
