Review
Medicine, Research & Experimental
Florica Sandru, Mara Carsote, Razvan Cosmin Petca, Ancuta Augustina Gheorghisan-Galateanu, Aida Petca, Ana Valea, Mihai Cristian Dumitrascu
Summary: This article discusses the thyroid abnormalities caused by the COVID-19 pandemic, including disturbances in central thyroid stimulating hormone due to virus-related hypophysitis, atypical subacute thyroiditis related to virus spread or excessive cytokine production, and non-thyroid illness syndrome associated with severe illness. It emphasizes the importance of routine thyroid assays in severe COVID-19 cases and the need to monitor thyroid function post-recovery to detect potential hypothyroidism. Unanswered questions remain regarding the prognostic value of interleukin-6 in infected patients and the necessity of thyroid hormone replacement in cases of hypophysitis-related central hypothyroidism.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Review
Endocrinology & Metabolism
Elahe Meftah, Rahem Rahmati, Fatemeh Zari Meidani, Sanaz Khodadadi, Kosar Chitzan-Zadeh, Fatemeh Esfahanian, Shiva Afshar
Summary: This study systematically reviewed the literature on subacute thyroiditis (SAT) secondary to COVID-19. A total of 43 articles with 100 patients were included. The symptoms and treatment of SAT secondary to COVID-19 appear to be similar to conventional cases, but the lack of sufficient studies has limited the quality of the data available.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Dorota Dworakowska, Simon Morley, Nicola Mulholland, Ashley B. Grossman
Summary: The literature on COVID-19-related thyroid complications has grown in the past year, with a focus on the possible correlation between COVID-19 and subacute thyroiditis. While most severe COVID-19 cases show signs of the sick euthyroid syndrome, clinicians should be aware of the potential for subacute thyroiditis in the early weeks and months following even mild COVID-19 infections.
CLINICAL ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Pierpaolo Trimboli, Carlo Cappelli, Laura Croce, Lorenzo Scappaticcio, Luca Chiovato, Mario Rotondi
Summary: The size and quality of published data regarding SAT in COVID-19 patients are limited, with only a few case reports and case series available. The clinical presentation of SAT in COVID-19 patients seems to be similar to what is generally expected.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Yingjie Zhang, Yu Wang, Miao Liu, Lingge Wei, Jianmin Huang, Ziqian Dong, Meichao Guan, Weijie Wu, Jianqing Gao, Xiaojie Huang, Xin Guo, Peng Xie
Summary: This study aimed to explore the value of the FT4/TSH ratio in the etiological diagnosis of newly diagnosed patients with thyrotoxicosis. The study found that the FT4/TSH ratio can be used as a new reference index for the differential diagnosis of thyrotoxicosis.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Dorina Ylli, Leonard Wartofsky, Kenneth D. Burman
Summary: Amiodarone, a class III antiarrhythmic drug with a high iodine content, can lead to thyroid dysfunction such as hypothyroidism or thyrotoxicosis. The drug affects thyroid function by releasing excess iodine or through direct cytotoxicity on thyroid cells, necessitating personalized management strategies.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Saeed Sohrabpour, Farrokh Heidari, Ebrahim Karimi, Reza Ansari, Ardavan Tajdini, Firouzeh Heidari
Summary: This study reported 6 cases of SAT following COVID-19 infection, showing typical features of SAT in clinical manifestations and laboratory evaluations. All patients had negative COVID-19 PCR test results but positive serological tests for COVID-19.
EUROPEAN THYROID JOURNAL
(2021)
Article
Endocrinology & Metabolism
Rebecca McCowan, Edith Wild, Angela K. Lucas-Herald, Jane McNeilly, Avril Mason, Sze Choong Wong, S. Faisal Ahmed, M. Guftar Shaikh
Summary: Further research is needed to examine the relationship between COVID-19 and thyroid function in children and young people. Although the overall rates of presentation with thyroid dysfunction have not changed, there has been an increase in presentations with transient thyroid dysfunction that do not require ongoing treatment.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Primary Health Care
Clarissa de Souza, Patricia C. C. Motta, Albanett B. Nestor, Renee Coifman, Marcelo M. P. Demarzo
Summary: This case report describes a rare case of subacute thyroiditis (SAT) secondary to mild COVID-19, concomitant with a thyroid nodule diagnosed as an inflammatory pseudo nodule that completely resolved over time. Primary health care professionals should be aware of this condition and provide adequate follow-up for these patients.
Article
Biotechnology & Applied Microbiology
Mehmet Sozen, Omercan Topaloglu, Berrin Cetinarslan, Alev Selek, Zeynep Canturk, Emre Gezer, Damla Koksalan, Taner Bayraktaroglu
Summary: COVID-19 mRNA vaccine (Pfizer/BioNTech (R)) may lead to subacute thyroiditis, characterized by typical clinical symptoms such as fever and neck pain. The condition typically responds well to non-steroidal anti-inflammatory therapy. Clinicians should be aware of the risk of developing subacute thyroiditis after vaccination.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Article
Endocrinology & Metabolism
Hayri Bostan, Muhammed Erkam Sencar, Murat Calapkulu, Serdar Kayihan, Sema Hepsen, Aykut Cimsir, Umran Gul, Ilknur Ozturk Unsal, Ozgur Ozcelik, Muhammed Kizilgul, Bekir Ucan, Erman Cakal
Summary: This study investigated the impact of the COVID-19 pandemic on the incidence and characteristics of subacute thyroiditis (SAT). The study found that there was a change in the seasonal variation of SAT and an increase in the number of male patients during the pandemic, but there was no change in the incidence and clinical course of SAT.
Article
Endocrinology & Metabolism
Zhiyong Wu, Yu Zhu, Min Zhang, Chen Wang, Lingli Zhou, Wei Liu, Wenjia Yang, Meng Li, Simin Zhang, Qian Ren, Xueyao Han, Linong Ji
Summary: This study found that TRAb and FT3/TSH ratio are important indicators for distinguishing GD from AIT, with high sensitivity and specificity. The FT3/TSH ratio combined with TRAb can be a new diagnostic index for thyrotoxicosis.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
A. Jafarzadeh, M. Nemati, S. Jafarzadeh, P. Nozari, S. M. J. Mortazavi
Summary: COVID-19 vaccines, particularly mRNA-based vaccines, have been associated with rare complications like thyroid disorders. Among the reported cases, the most common thyroid abnormality following vaccination was subacute thyroiditis (SAT), followed by Graves' disease (GD). Fortunately, most cases had a favorable outcome following therapy.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2022)
Article
Endocrinology & Metabolism
Adnan Batman, Dilek Yazici, Oguz Dikbas, Kemal Agbaht, Emre Sedar Saygili, Ibrahim Demirci, Nurbanu Bursa, Gorkem Ayas, Cuneyd Anil, Mustafa Cesur, Fatma Nur Korkmaz, Adile Begum Bahcecioglu, Demet Corapcioglu, Murat Faik Erdogan, Hayri Bostan, Murat Calapkulu, Sema Hepsen, Bekir Ucan, Erman Cakal, Bagdaguel Yuksel Guler, Cem Haymana, Suleyman Hilmi Ipekci, Selami Aydin, Havva Sezer, Secil Ozisik, Oguzhan Deyneli, Faruk Alagol, Refik Tanakol, Mustafa Eroglu, Ummu Mutlu, Huelya Hacisahinogullari, Ayse Kubat Uzum, Canan Demir, Gonul Koc, Sevde Nur Firat, Tulay Omma, Nurcan Ince, Sefika Burcak Polat, Oya Topaloglu, Cevdet Aydin, Bekir cakir, Cigdem Tura Bahadir, Mehmet Guven, Mehmet Sozen, Alev Selek, Zeynep Canturk, Berrin cetinarslan, Mustafa Aydemir, Isilay Taskaldiran, Yusuf Bozkus, Ozlem Turhan Iyidir, Filiz Eksi Haydardedeoglu, Seda Erem Basmaz, Mehmet cagri Unal, Tevfik Demir, Ayten Oguz, Ozlem Celik, Merve Yilmaz, Aykut Cimsir, Serdar Kayihan, Ziynet Alphan Uc, Sakin Tekin, Omercan Topaloglu, Basak Ozgen Saydam, Yasemin Aydogan Unsal, Ozge Ozer, Goknur Yorulmaz, Kader Ugur, Sezin Dogan Cakir, Mehmet Asik, Mustafa Unubol, Selin Genc, Burak Andac, Mine Okur, Ozlem Dogan, Ersen Karakilic, Gokcen Unal Kocabas, Cem Onur Kirac, Guven Baris Cansu, Meliha Melin Uygur, Zafer Pekkolay, Sadettin Ozturk, Askin Gungunes, Eren Gurkan, Lezzan Keskin, Kenan caglayan, Yasemin Emur Guenay, Eren Imre, Selcuk Yusuf Sener, Ahmet Toygar Kalkan, Deniz Engin Gok, Mustafa Sahin
Summary: This study compared subacute thyroiditis (SAT) related to different causes and identified predictors of SAT recurrence and incident hypothyroidism. The findings showed no differences in laboratory and imaging findings between COVID-19-related SAT, SARS-CoV-2 vaccine-related SAT, and control SAT groups. SAT etiology was not an independent predictor of recurrence or hypothyroidism. Younger age and steroid therapy requirement were significant predictors of SAT recurrence, while C-reactive protein measured during SAT onset, female sex, absence of antithyroid peroxidase (TPO) positivity, and absence of steroid therapy were significant predictors of early hypothyroidism. Steroid therapy independently predicted incident hypothyroidism, which may sometimes be transient, and was associated with a lower risk of established hypothyroidism.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Sueleyman Nahit Sendur, Seda Hanife Oguz, Ugur Unluturk
Summary: This review summarizes the thyroid disorders associated with COVID-19 vaccination, including subacute thyroiditis, silent thyroiditis, Graves' disease, and Graves' orbitopathy. It outlines the clinical characteristics of each disease and discusses possible pathophysiological mechanisms. The article also highlights areas lacking evidence and proposes a research agenda.
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Environmental Sciences
Fulvio Adorni, Nithiya Jesuthasan, Elena Perdixi, Aleksandra Sojic, Andrea Giacomelli, Marianna Noale, Caterina Trevisan, Michela Franchini, Stefania Pieroni, Liliana Cori, Claudio Maria Mastroianni, Fabrizio Bianchi, Raffaele Antonelli-Incalzi, Stefania Maggi, Massimo Galli, Federica Prinelli
Summary: This study describes an internet-based survey conducted in Italy during the first and second wave of the pandemic, revealing a significant number of undiagnosed individuals who may have contributed to the spread of the virus in the community.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Immunology
Andrea Giacomelli, Massimo Galli, Stefania Maggi, Marianna Noale, Caterina Trevisan, Gabriele Pagani, Raffaele Antonelli-Incalzi, Sabrina Molinaro, Luca Bastiani, Liliana Cori, Fabrizio Bianchi, Nithiya Jesuthasan, Federica Prinelli, Fulvio Adorni
Summary: This study assessed influenza vaccine uptake during the 2020/2021 flu season and compared it with the previous season. The results showed that educational level and socio-economic deprivation were associated with flu vaccine uptake. These findings highlight the importance of considering social determinants when planning influenza vaccination campaigns.
Article
Environmental Sciences
Elisa Bustaffa, Olivia Curzio, Gabriele Donzelli, Francesca Gorini, Nunzia Linzalone, Marco Redini, Fabrizio Bianchi, Fabrizio Minichilli
Summary: A retrospective residential cohort study in Pisa investigated the relationship between vehicular traffic noise pollution and cardiovascular disease. The study found that noise exposure was associated with increased mortality and hospitalization rates for cardiovascular diseases, particularly among women. The authors recommend implementing noise prevention measures and monitoring the risk profile of the Pisa population.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Fabrizio Minichilli, Francesca Gorini, Giovanni De Filippis, Elisa Bustaffa, Anna Maria Raho, Anna Melcarne, Fabrizio Quarta, Giuseppe Maggiore, Adele Idolo, Francesca Serio, Tiziana Grassi, Francesco Bagordo, Idelberto Francesco Castorini, Giovanni Imbriani, Fabrizio Bianchi, Prisco Piscitelli
Summary: A higher incidence of lung cancer among men in the province of Lecce, southern Italy, compared to regional and national data was reported. In a specific area within the province, the incidence and mortality of lung cancer were even higher. A case-control study called PROTOS was conducted to examine potential risk factors for lung cancer in the province. The study found that excessive alcohol use in women, family cancer history, pack/year of cigarette smoking, higher industrial exposure in the cluster area, and pesticide use in agriculture without personal protective equipment all increased the risk of lung cancer. The higher incidence of adenocarcinoma in both sexes suggests that factors other than smoking, such as environmental, occupational, and lifestyle factors, may contribute to the increased risk of cancer and should be further investigated.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Silvia Baldacci, Michele Santoro, Anna Pierini, Lorena Mezzasalma, Francesca Gorini, Alessio Coi
Summary: This retrospective cohort study aimed to analyze the healthcare burden of patients with rare diseases (RDs) using a multi-database approach. The study found a decrease in the hospitalization rate over the years and observed variations in the average length of stay. Patients with RDs related to metabolism and the genitourinary system had the highest hospitalization rates, while those with rare immune system disorders and diseases of the skin and subcutaneous tissue had the longest average length of stay.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Biochemistry & Molecular Biology
Francesca Gorini, Cristina Vassalle
Summary: Type 2 diabetes is a major global public-health concern, affecting over 400 million people worldwide. Selenium has recently been identified as a determinant of T2D pathogenesis and progression, playing a crucial role in antioxidant response, thyroid hormone regulation, and glucose metabolism.
Article
Environmental Sciences
Elisa Bustaffa, Olivia Curzio, Fabrizio Bianchi, Fabrizio Minichilli, Daniela Nuvolone, Davide Petri, Giorgia Stoppa, Fabio Voller, Liliana Cori
Summary: This study investigates risk perception of geothermal plants in the Amiata area of Italy, finding that risk perception is associated with gender, age, education level, and surrounding odors.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Biochemistry & Molecular Biology
Melania Gaggini, Francesca Gorini, Cristina Vassalle
Summary: Lipids play a crucial role in the development of atherosclerosis, and the traditional lipid profile is an established tool for assessing cardiovascular risk. However, non-traditional lipids have emerged as potential predictors of cardiometabolic risk, as they provide a more comprehensive understanding of lipid/lipoprotein interactions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Beatrice Dal Pino, Francesca Gorini, Melania Gaggini, Patrizia Landi, Alessandro Pingitore, Cristina Vassalle
Summary: This study evaluated the relationship between Lp(a) and cardiovascular disease in different genders and cardiometabolic risk factors, especially in terms of prognosis. It found that elevated levels of Lp(a) were associated with worse prognosis in females with type 2 diabetes, but not in other high-risk cardiovascular states.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Melania Gaggini, Fabrizio Minichilli, Francesca Gorini, Serena Del Turco, Patrizia Landi, Alessandro Pingitore, Cristina Vassalle
Summary: This study aimed to evaluate the predictive value of neutrophil-to-lymphocyte ratio (NLR) and fibrosis-4 index (FIB-4) on coronary artery disease (CAD) mortality. The study found that elevated NLR and FIB-4 were associated with increased mortality in CAD patients. Categorization of CAD patients based on FIB-4/NLR could provide valuable information for risk stratification and reduction of residual risk.
Review
Biochemistry & Molecular Biology
Giulia Della Nera, Laura Sabatino, Melania Gaggini, Francesca Gorini, Cristina Vassalle
Summary: In addition to its role in calcium homeostasis, vitamin D has a significant impact on the cardiovascular system. Low vitamin D levels are associated with increased cardiovascular risk, morbidity, and mortality. The antioxidative and anti-inflammatory properties of vitamin D contribute to these effects. However, the optimal vitamin D status for cardiovascular health remains controversial, and this review will discuss confounding factors and the debate on the minimum blood 25(OH)D level required for optimal cardiovascular health.
Review
Biochemistry & Molecular Biology
Francesca Gorini, Alessandro Tonacci
Summary: This review summarizes the impact of gut microbiota and dietary nutrients on thyroid cancer development and the role of tumor microbiota in its etiology and prognosis. It also discusses the potential use of antioxidant nutrients as a novel strategy and the development of attractive high-nutrient foods using new technologies.
Article
Pediatrics
Joanne Given, Joan K. Morris, Ester Garne, Elisa Ballardini, Laia Barrachina-Bonet, Clara Cavero-Carbonell, Mika Gissler, Francesca Gorini, Anna Heino, Sue Jordan, Amanda J. Neville, Anna Pierini, Ieuan Scanlon, Joachim Tan, Stine K. Urhoj, Maria Loane
Summary: This study aimed to evaluate the prescription rates of insulin/insulin analogues in children aged 0-9 years with and without major congenital anomalies. The results showed that children with chromosomal anomalies had an increased risk of developing diabetes requiring insulin therapy, while children with non-chromosomal anomalies had a similar risk to the reference group. Female children had a reduced risk, and preterm births without congenital anomalies were more likely to be prescribed insulin/insulin analogues.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
