Review
Pediatrics
Gennaro D'Amato, Maria D'Amato
Summary: Respiratory allergy is closely related to air pollution and climate change. Climate change leads to an increase in trigger factors such as pollens and moulds in the atmosphere, causing rhinitis and asthma in sensitized patients. Pollen allergy is often used to study the relationship between air pollution and allergic respiratory diseases. Recent studies have shown that environmental pollution and climate change have significant negative impacts on human health, particularly on the respiratory system.
CURRENT OPINION IN PEDIATRICS
(2023)
Review
Environmental Sciences
Gennaro D'Amato, Isabella Annesi-Maesano, Benedetta Biagioni, Andrea Lancia, Lorenzo Cecchi, Maria Concetta D'Ovidio, Maria D'Amato
Summary: In recent years, the impacts of climate change on the environment have become increasingly evident. Changes in climate influence extreme weather events and alter precipitation and wind patterns. Climate change can negatively affect respiratory health, leading to the emergence of asthma and allergic respiratory illnesses. Pollen, a major component of atmospheric bioaerosols, can induce allergic symptoms. Climate change affects the timing, duration, and severity of the pollen season, leading to increased pollen allergies. Higher levels of carbon dioxide can enhance photosynthesis and increase pollen production. Pollen grains can also interact with air pollutants and be affected by extreme events, exacerbating respiratory diseases such as allergic rhinitis and asthma. Climate change may also facilitate the spread of pandemics like COVID-19.
Article
Microbiology
Celine Pattaroni, Matthew Macowan, Roxanne Chatzis, Carmel Daunt, Adnan Custovic, Michael D. Shields, Ultan F. Power, Jonathan Grigg, Graham Roberts, Peter Ghazal, Jurgen Schwarze, Mindy Gore, Steve Turner, Andrew Bush, Sejal Saglani, Clare M. Lloyd, Benjamin J. Marsland
Summary: This study reveals the relationship between early post-natal microbial and immunological features in the upper airways of newborns. The results show that the oropharynx and nasal cavity are distinct ecological niches for different microbial species, and breastfeeding can influence the microbial composition and expression of immunological features. These findings are important for understanding the development trajectories of respiratory health.
Article
Environmental Sciences
Erika Garcia, Jill Johnston, Rob McConnell, Lawrence Palinkas, Sandrah P. Eckel
Summary: This study evaluated the benefits of using low-emission vehicles (ZEVs) on respiratory health and air quality in California, and found a slower adoption rate of ZEVs in areas with lower educational attainment. The results showed that the adoption of ZEVs was associated with improvements in air quality and a decrease in asthma-related emergency department visits, but the adoption gap among low-income populations threatens the equitable distribution of these benefits.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Immunology
Vanitha Sampath, Juan Aguilera, Mary Prunicki, Kari C. Nadeau
Summary: Climate change is the main driver of various extreme weather events, which have direct and indirect impacts on human health, especially in terms of allergic diseases and asthma. This review examines the immune mechanisms behind the health risks associated with climate change events and explores the molecular and cellular processes involved in mediating these effects.
SEMINARS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Kira M. Hughes, Dwan Price, Angel A. J. Torriero, Matthew R. E. Symonds, Cenk Suphioglu
Summary: The relationship between fungal spores and asthma is not fully explored. Certain fungal spores have been found to exacerbate respiratory symptoms, with indoor and outdoor spores exhibiting different characteristics and impacts. Improvements in airborne allergen monitoring and sampling methods are needed to fill knowledge gaps, provide real-time data, and prevent asthma exacerbations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Yuo-Hsien Shiau, Su-Fen Yang, Rishan Adha, Syamsiyatul Muzayyanah, Giia-Sheun Peng
Summary: This study examines the relationship between household energy efficiency, ambient air pollution, climate change, and mortality risk from chronic respiratory diseases. The findings indicate that enhancing household energy efficiency decreases the mortality rate associated with chronic respiratory diseases. The study collected observational data in six major cities in Taiwan from 2008 to 2020.
Review
Environmental Sciences
Huan Minh Tran, Feng-Jen Tsai, Yueh-Lun Lee, Jer-Hwa Chang, Li-Te Chang, Ta-Yuan Chang, Kian Fan Chung, Han-Pin Kuo, Kang-Yun Lee, Kai-Jen Chuang, Hsiao-Chi Chuang
Summary: Climate change and air pollution have significant impacts on respiratory diseases, posing global health challenges. Climate change is predicted to increase extreme weather events, exacerbating air pollution levels and respiratory diseases. Economic growth and population expansion globally will lead to rising air pollution levels, resulting in a greater burden of respiratory diseases, particularly among vulnerable populations like children, older adults, and those with pre-existing respiratory disorders.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Allergy
Benedetta Biagioni, Lorenzo Cecchi, Gennaro D'Amato, Isabella Annesi-Maesano
Summary: Climate change has significant impacts on allergic respiratory diseases, particularly in childhood. This review discusses the direct and indirect factors of climate change that influence childhood asthma, including temperature and weather changes, air pollution, allergens, biocontaminants, biodiversity loss, and migration. It emphasizes the urgent need for adaptation and mitigation strategies to prevent further respiratory diseases and protect human health, especially in younger and future generations.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2023)
Review
Respiratory System
Firdian Makrufardi, Amja Manullang, Desy Rusmawatiningtyas, Kian Fan Chung, Sheng-Chieh Lin, Hsiao-Chi Chuang
Summary: Climate change poses a significant threat to asthma patients, increasing the risk of asthma morbidity and mortality, especially in children and females. Extreme weather events, including thunderstorms, are associated with a higher risk of asthma-related outcomes. Addressing climate change is crucial for asthma control.
EUROPEAN RESPIRATORY REVIEW
(2023)
Article
Ecology
Michiel Stas, Raf Aerts, Marijke Hendrickx, Nicolas Dendoncker, Sebastien Dujardin, Catherine Linard, Tim S. Nawrot, An Van Nieuwenhuyse, Jean-Marie Aerts, Jos Van Orshoven, Ben Somers
Summary: The study found negative associations between residential garden cover within 1 km distance and perceived stress, as well as between forest cover within 1 km distance and distress. However, higher densities of allergenic trees in forests within 2 km distance were associated with higher levels of stress and distress.
LANDSCAPE AND URBAN PLANNING
(2021)
Article
Medicine, General & Internal
Marcel Mazur, Maria Czarnobilska, Wojciech Dyga, Ewa Czarnobilska
Summary: The prevalence of asthma and allergies among children and adolescents has been increasing in the past few decades. A study analyzing data from 2014 to 2018 found that over 40% of respondents reported allergic symptoms, with nearly 50% of them not diagnosed or treated. However, there has been a reduction in the frequency of asthma and allergic rhinitis cases, indicating a positive effect on preventive measures taken in Krakow since 2010.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Pediatrics
Marilyn Urrutia-Pereira, Guillermo Guidos-Fogelbach, Dirceu Sole
Summary: This article analyzes the impacts of climate change on the development of immature respiratory and immune systems in children. The study finds that environmental issues caused by climate change, such as air pollution, climate disasters, and water resource problems, have negative effects on children's health, especially those with underdeveloped respiratory and immune systems.
JORNAL DE PEDIATRIA
(2022)
Article
Immunology
Lucia Cremades-Jimeno, Maria Angeles de Pedro, Maria Lopez-Ramos, Joaquin Sastre, Pablo Minguez, Ignacio Mahillo Fernandez, Selene Baos, Blanca Cardaba
Summary: This study prioritized biomarkers based on their functionality associated with each respiratory disease and specific molecular motifs, improving the definition and usefulness of new molecular biomarkers. The research analyzed biomarker candidates for asthma and allergies to establish comprehensive disease models, emphasizing the importance of specificity and mechanistic implications for personalized diagnostics.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Environmental Sciences
Matteo Renzi, Matteo Scortichini, Francesco Forastiere, Francesca de Donato, Paola Michelozzi, Marina Davoli, Claudio Gariazzo, Giovanni Viegi, Massimo Stafoggia, Carla Ancona, Simone Bucci, Michela Bonafede, Alessandro Marinaccio, Stefania Argentini, Roberto Sozzi, Sergio Bonomo, Salvatore Fasola, Stefania La Grutta, Achille Cernigliaro, Salvatore Scondotto, Sandra Baldacci, Sara Maio, Gaetano Licitra, Antonino Moro, Paola Angelini, Laura Bonvicini, Serena Broccoli, Marta Ottone, Paolo Giorgi Rossi, Annamaria Colacci, Federica Parmagnani, Andrea Ranzi, Claudia Galassi, Enrica Migliore, Lucia Bisceglia, Antonio Chieti, Giuseppe Brusasca, Giuseppe Calori, Sandro Finardi, Alessandro Nanni, Nicola Pepe, Paola Radice, Camillo Silibello, Gianni Tinarelli, Francesco Uboldi, Giuseppe Carlino
Summary: This study examined the short-term effects of PM10 and PM2.5 on respiratory admissions in Italy from 2006 to 2015. The results showed that exposure to these pollutants had harmful effects on the respiratory system, particularly in elderly patients and less urbanized areas.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Pharmacology & Pharmacy
Alessandro Vatrella, Angelantonio Maglio, Corrado Pelaia, Girolamo Pelaia, Carolina Vitale
EXPERT OPINION ON PHARMACOTHERAPY
(2020)
Review
Allergy
Gennaro D'Amato, Herberto Jose Chong-Neto, Olga Patricia Monge Ortega, Carolina Vitale, Ignacio Ansotegui, Nelson Rosario, Tari Haathela, Carmen Galan, Ruby Pawankar, Margarita Murrieta, Lorenzo Cecchi, Christian Bergmann, Erminia Ridolo, German Ramon, Sandra Gonzalez Diaz, Maria D'Amato, Isabella Annesi-Maesano
Article
Pharmacology & Pharmacy
Valentina Giudice, Pasquale Pagliano, Alessandro Vatrella, Alfonso Masullo, Sergio Poto, Benedetto Maria Polverino, Renato Gammaldi, Angelantonio Maglio, Carmine Sellitto, Carolina Vitale, Bianca Serio, Bianca Cuffa, Anna Borrelli, Carmine Vecchione, Amelia Filippelli, Carmine Selleri
FRONTIERS IN PHARMACOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Pasquale Ambrosino, Antonio Molino, Ilenia Calcaterra, Roberto Formisano, Silvia Stufano, Giorgio Alfredo Spedicato, Andrea Motta, Antimo Papa, Matteo Nicola Dario Di Minno, Mauro Maniscalco
Summary: This study found that endothelial function improved in convalescent COVID-19 patients after pulmonary rehabilitation, with a direct correlation between pulmonary function and endothelial health. Endothelial function testing may be useful for follow-up care in these patients.
Review
Medicine, General & Internal
Valeria Visco, Carolina Vitale, Antonella Rispoli, Carmine Izzo, Nicola Virtuoso, Germano Junior Ferruzzi, Mario Santopietro, Americo Melfi, Maria Rosaria Rusciano, Angelantonio Maglio, Paola Di Pietro, Albino Carrizzo, Gennaro Galasso, Alessandro Vatrella, Carmine Vecchione, Michele Ciccarelli
Summary: While the acute effects of SARS-CoV-2 infection have been well-documented, this review highlights the need for a better understanding of the long-term effects. The review focuses on the potential involvement of the lungs, heart, and brain in post-viral syndromes and suggests strategies for managing post-COVID-19 symptoms. These symptoms include respiratory issues, cardiovascular events, neurological manifestations, and mental health issues.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Chiara Colarusso, Angelantonio Maglio, Michela Terlizzi, Carolina Vitale, Antonio Molino, Aldo Pinto, Alessandro Vatrella, Rosalinda Sorrentino
Summary: This study identified higher levels of CRP, C5b-9, and LDH in post-COVID-19 patients, which could predict the risk of pulmonary fibrosis. Moreover, increased levels of IL-1 alpha and TGF-beta, along with decreased levels of IFN-beta, were associated with an increased risk of lung fibrosis in these patients.
Article
Biochemistry & Molecular Biology
Angelantonio Maglio, Carolina Vitale, Simona Pellegrino, Cecilia Calabrese, Maria D'Amato, Antonio Molino, Corrado Pelaia, Massimo Triggiani, Girolamo Pelaia, Cristiana Stellato, Alessandro Vatrella
Summary: The study found that mepolizumab significantly improves lung function in patients with severe eosinophilic asthma, particularly in enhancing small airway function, which is correlated with clinical benefits. Patients with high baseline peripheral blood eosinophil count and use of oral corticosteroids showed more significant improvements in small airway function after treatment.
Article
Chemistry, Analytical
Michele Ciccarelli, Fabrizio Merciai, Albino Carrizzo, Eduardo Sommella, Paola Di Pietro, Vicky Caponigro, Emanuela Salviati, Simona Musella, Veronica di Sarno, Mariarosaria Rusciano, Anna Laura Toni, Paola Iesu, Carmine Izzo, Gabriella Schettino, Valeria Conti, Eleonora Venturini, Carolina Vitale, Giuliana Scarpati, Domenico Bonadies, Antonella Rispoli, Benedetto Polverino, Sergio Poto, Pasquale Pagliano, Ornella Piazza, Danilo Licastro, Carmine Vecchione, Pietro Campiglia
Summary: This study utilized untargeted lipidomics to identify specific lipid profiles that can predict the severity and outcome of COVID-19 patients. These lipid profiles can be used for monitoring and targeted approaches during hospital admission.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Immunology
Chiara Colarusso, Michela Terlizzi, Angelantonio Maglio, Antonio Molino, Claudio Candia, Carolina Vitale, Philip M. Hansbro, Alessandro Vatrella, Aldo Pinto, Rosalinda Sorrentino
Summary: This study revealed that activation of the Absent in melanoma-2 (AIM2) inflammasome in COVID-19 long-haulers with lung fibrosis is associated with the release of IL-1 alpha, IFN-alpha, and TGF-beta. The release of IFN-alpha is caspase-1- and caspase-4-dependent, while the release of IL-1 alpha and TGF-beta is inflammasome independent. Higher expression of AIM2 in circulating CD14+ cells in PBMCs is correlated with lung fibrosis in COVID-19 patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Alessandro Vatrella, Angelantonio Maglio, Corrado Pelaia, Luigi Ciampo, Giulia Pelaia, Carolina Vitale
Summary: This review focuses on severe asthma, its different subtypes, the role of eosinophilic inflammation, and the development of targeted anti-eosinophil therapies. It discusses the unique biology of eosinophils and their involvement in asthma, as well as current and prospective therapeutic strategies.
Article
Biochemistry & Molecular Biology
Angelantonio Maglio, Carolina Vitale, Corrado Pelaia, Maria D'Amato, Luigi Ciampo, Eliana Sferra, Antonio Molino, Giulia Pelaia, Alessandro Vatrella
Summary: In this observational multicenter retrospective study, the effectiveness of mepolizumab and benralizumab in severe asthmatics treated for 12 months in a real-life setting was evaluated. The study found that 30.12% of patients on mepolizumab and 40% of patients on benralizumab achieved disease remission after 12 months. These results confirm the efficacy of anti-IL-5 biologic drugs in the treatment of severe eosinophilic asthma in a real-life setting.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Carolina Vitale, Angelantonio Maglio, Corrado Pelaia, Maria D'Amato, Luigi Ciampo, Giulia Pelaia, Antonio Molino, Alessandro Vatrella
Summary: Patients with severe OCS-dependent asthma, who are a subgroup of asthma patients with severe disease, have a high risk of complications related to chronic OCS use. The introduction of benralizumab has provided a valid alternative to OCS and has shown effectiveness in reducing exacerbations, OCS intake, and improving symptom control and lung function. Data on long-term efficacy, however, is still limited and further research is needed.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Pasquale Ambrosino, Salvatore Fuschillo, Mariasofia Accardo, Marco Mosella, Antonio Molino, Giorgio Alfredo Spedicato, Andrea Motta, Mauro Maniscalco
Summary: This study assessed the short-term variability of FeNO in clinically stable COPD patients. The results showed individual variability of FeNO, apparently unrelated to eosinophil counts but influenced by body weight. Further research is needed to determine whether FeNO can be effectively used for personalized pharmacological and rehabilitation strategies in COPD patients.
JOURNAL OF PERSONALIZED MEDICINE
(2022)