Review
Pharmacology & Pharmacy
Miaomiao Wu, Xueming Niu, Run Zhang, Zhi Ping Xu
Summary: The development of two-dimensional nanomaterials for cancer therapy has gained increasing attention due to their unique properties. This review summarizes recent progresses in developing 2D nanomaterials for cancer diagnosis and therapy based on tumor microenvironment modulation, aiming to deepen the understanding of interactions between nanomaterials and tumor microenvironment and develop reliable nanomedicines.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Review
Oncology
Yoshifumi Itoh
Summary: The progression of cancer relies on the interplay between cancer cells and the surrounding microenvironment, with proteolytic modification of the microenvironment and signaling molecules playing a crucial role.
FRONTIERS IN ONCOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Song Yang, Gaohua Han, Quan Chen, Lei Yu, Peng Wang, Qi Zhang, Jiang Dong, Wei Zhang, Junxing Huang
Summary: The study designed PEG-functionalized nanoparticles to increase radiosensitivity and found that AuPt NPs exhibit enzyme-like activity by promoting the decomposition of H2O2 in the tumor microenvironment. The results demonstrate that this approach can enhance the efficacy of radiotherapy.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Oncology
Steve Robatel, Mirjam Schenk
Summary: This review article provides an overview of the key clinical developments, limitations, and future perspectives in the treatment of pancreatic cancer. It summarizes the available treatments for pancreatic cancer patients according to tumor stage and discusses the most relevant clinical trials over the past two decades. It also focuses on the tumor microenvironment and potential targets for therapy resistance and tumor progression. The article outlines promising treatment strategies and potential combinations for further research.
Article
Medicine, Research & Experimental
Eva C. Thuenemann, Duc H. T. Le, George P. Lomonossoff, Nicole F. Steinmetz
Summary: The study investigated the use of virus-like particles as a gene delivery vehicle to transport the HSV1-TK enzyme for prodrug conversion therapy. Results showed that VLPs efficiently killed human glioblastoma cells, offering a promising new modality for cancer treatment.
MOLECULAR PHARMACEUTICS
(2021)
Article
Chemistry, Analytical
Juan Qiao, Qian Ma, Xiangfei Li, Li Qi
Summary: In this work, a protocol for self-assembling redox-responsive polymer nanoreactors was presented, overcoming the limitations of chemical oxidation and low biocompatibility. These nanoreactors showed highly selective responses to mild redox triggers and could be reduced by enzymes. The results demonstrated significantly enhanced enzymolysis efficiency and reaction rates, as well as successful detection of cell adhesion.
ANALYTICAL CHEMISTRY
(2022)
Review
Immunology
Filipa D. dos Reis, Carmen Jeronimo, Margareta P. Correia
Summary: Immunoepigenetics is a rapidly growing field that focuses on the role of epigenetic mechanisms in regulating tumor immune cell recognition and anti-tumor responses. There is increasing evidence of a connection between epigenetic regulation and prostate cancer (PCa) development and progression. The role of epigenetic-related mechanisms in regulating NK cell recognition and functions in PCa is still largely unknown. However, studies have shown that modulation of epigenetic mechanisms can enhance NK cell-mediated immune responses, which may lead to the development of novel epigenetic-based therapeutic options for PCa management.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemical Research Methods
Dustin P. Patterson, Christy Hjorth, Andrea Hernandez Irias, Nathasha Hewagama, Jessica Bird
Summary: Encapsulation of enzymes inside protein cage structures is a promising approach for the development of catalytic materials. This study focuses on the in vivo encapsulation of enzymes within the bacteriophage P22 derived virus-like particles (VLPs) and shows that some enzymes require a delay in encapsulation to ensure full activity. Sequential expression strategy leads to altered enzymatic activities compared to simultaneous coexpression strategy. These findings provide important insights for researchers investigating enzyme encapsulation and offer a potential solution for obtaining active enzymes.
ACS SYNTHETIC BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Yu Zhang, Yifeng Yang, Jinsheng Shi, Lili Wang
Summary: A new hybrid nanozyme was studied, which can improve the H2O2 concentration and acidity in the tumor microenvironment through magnetic targeting and photothermal effect, thus realizing multiple therapeutic modes for tumor therapy.
Article
Biochemical Research Methods
Dustin P. Patterson, Christy Hjorth, Andrea Hernandez Irias, Nathasha Hewagama, Jessica Bird
Summary: Encapsulation of enzymes inside protein cage structures, particularly virus-like particles, has the potential to develop new catalytic materials with enhanced properties. In this study, the in vivo encapsulation of enzymes inside bacteriophage P22 derived VLPs was examined, and it was found that some enzymes require a delay in encapsulation for proper folding and maturation. Sequential expression strategy resulted in altered enzymatic activities compared to simultaneous coexpression strategy. These findings provide important considerations and potential solutions for researchers investigating enzyme encapsulation inside confined reaction environments via in vivo routes.
ACS SYNTHETIC BIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Huajia Zhang, A. McGarry Houghton
Summary: Immune checkpoint inhibitor therapy activates tumor-killing T-cells by releasing the brake of anti-tumor immunity, but a majority of patients are refractory to the therapy. Recent studies suggest that high neutrophil content is associated with poor response rates, indicating that neutrophil antagonism may improve the efficacy of immune checkpoint inhibitor therapy.
PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Chemistry, Multidisciplinary
Xianlong Zhang, Guoliang Li, Guang Chen, Di Wu, Yongning Wu, Tony D. James
Summary: Multiple enzyme-driven biological catalytic cascades occur in living organisms, and efforts have been devoted to developing novel cascade catalytic systems mimicking these biological cascades. Nanozymes, as enzyme mimics, have significantly advanced the development of biomimetic cascade nanoreactors, leading to advancements in biosensing and biomedical applications. Progress in understanding and utilizing nanozyme-engineered biomimetic cascade catalytic nanoreactors for biosensing and biomedical applications is comprehensively covered in this article.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Liyi Fu, Xianwu Hua, Xingya Jiang, Jinjun Shi
Summary: The study presents a multistage nanoparticle strategy for systemic and cytosolic protein delivery to tumor cells by encapsulating TG-modified saporin into pH-responsive polymeric NPs for effective cancer treatment. The method showed potent inhibition of lung cancer cell growth both in vitro and in vivo, indicating its potential for clinical applications in protein therapy for cancer treatment.
Review
Health Care Sciences & Services
Alexandru Isaic, Alexandru Catalin Motofelea, Dan Costachescu, Gheorghe Nicusor Pop, Bogdan Totolici, Dorel Popovici, Razvan Gheorghe Diaconescu
Summary: This research compares the effectiveness of surgical resection, endoscopic resection, transanal resection, and radiotherapy in the treatment of rectal cancer. Surgical treatment, particularly total mesorectal excision (TME), consistently showed efficacy in achieving complete tumor resection and improving long-term survival. Endoscopic treatment and transanal resection techniques were promising for early-stage tumors but had higher rates of local recurrence. Radiotherapy, especially in combination with chemotherapy, played a crucial role in locally advanced cases, improving local control and reducing recurrence risk.
Article
Chemistry, Multidisciplinary
Fan Wu, Changgao Huang, Baohong Sun, Zhihui Zhu, Wenquan Cheng, Yanjun Chen, Chenhao Liao, Ruping Xu, Mihai'ernisaguli Maimaititu'ersun, Ninglin Zhou, Feng Han, Zheng Cai, Huijun Jiang
Summary: This study develops a versatile nano-reactor for nanocatalytic therapy. The reactor can trigger a series of catalytic reactions in the tumor micro-environment, generating hydroxyl radicals to kill cancer cells and consuming glucose and glutathione of tumor cells. Additionally, the reactor has excellent photothermal properties to enhance the catalytic reaction efficiency. Experimental results demonstrate the desirable tumor suppression effect of this nano-reactor-based therapy.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2022)
Article
Engineering, Biomedical
Zhijuan Yang, Yujie Zhu, Ziliang Dong, Yu Hao, Chunjie Wang, Quguang Li, Yumin Wu, Liangzhu Feng, Zhuang Liu
Summary: This study developed bioluminescent bacteria as an internal light source to enhance photodynamic therapy (PDT). The bioluminescence-triggered PDT showed significant advantages over conventional PDT and could also induce potent antitumor immunity. This research provides a general and highly effective therapeutic approach for diverse cancers with varying light-absorbing capacities and tumor sizes.
Article
Engineering, Biomedical
Zhijuan Yang, Danlei Tao, Wenzhao Zhong, Zhuang Liu, Liangzhu Feng, Meiwan Chen
Summary: This study presents a multifunctional nano-sonosensitizer PFCE@THPPpf-COPs, capable of alleviating tumor hypoxia and immunosuppression, and synergistically suppressing tumor growth by priming host's antitumor immunity, particularly in combination with anti-CD47 immunotherapy.
Article
Chemistry, Multidisciplinary
Longlong Tian, Ming Shao, Yimou Gong, Yu Chao, Ting Wei, Kai Yang, Qian Chen, Zhuang Liu
Summary: Monitoring dynamic changes in tumor immune markers is essential for predicting therapeutic responses to immunotherapy and traditional therapies like chemotherapy and radiotherapy. A lipid-aptamer conjugate designed in this study maintained strong binding affinity to programmed cell death-ligand 1 (PDL1) while achieving prolonged blood circulation post-injection. Additionally, the radionuclide-labeled conjugate exhibited increased tumor-homing ability for visualizing PDL1 expression changes after treatment.
SCIENCE CHINA-CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Fei Gong, Jiachen Xu, Bo Liu, Nailin Yang, Liang Cheng, Peng Huang, Chunjie Wang, Qian Chen, Caifang Ni, Zhuang Liu
Summary: In this study, CaH2 nanoparticles were prepared through liquid-phase exfoliation and used as an antitumor therapeutic agent. When injected into the tumor, the nano-CaH2 reacts with water to produce hydrogen gas, calcium ions, and hydroxyl ions, which enable hydrogen therapy, tumor calcification, and neutralization of the acidic tumor microenvironment. The results showed that the injectable nano-CaH2 dispersion significantly inhibited tumor growth and activated the immune system to promote immune cell infiltration into the tumor, resulting in robust immune responses to inhibit distant tumors. Furthermore, nano-CaH2 dispersed in lipiodol showed improved therapeutic outcomes in interventional transarterial embolization therapy compared to lipiodol alone in a liver cancer model.
Review
Pharmacology & Pharmacy
Zhouqi Meng, Yaojia Zhang, Xuanfang Zhou, Jiansong Ji, Zhuang Liu
Summary: This review article explores the recent research progress of cell-derived biomimetic nanovaccines for cancer immunotherapy, and discusses the perspectives and challenges associated with the future clinical translation of these emerging vaccine platforms.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Engineering, Biomedical
Fengyun Shen, Danlei Tao, Rui Peng, Yao He, Zhuang Liu, Jiansong Ji, Liangzhu Feng
Summary: Researchers have synthesized a covalent organic polymer with good physiological stability and sonosensitization efficacy through esterification of a water insoluble sonosensitizer with a oxaliplatin prodrug and PEG. This polymer can induce effective immunogenic cancer cell death under ultrasound exposure and also be used for real-time tracking of dyes and radioisotopes in disease tissues, enhancing the treatment outcome of SDT.
Article
Engineering, Biomedical
Minjiang Chen, Gaofeng Shu, Xiuling Lv, Xiaoling Xu, Chenying Lu, Enqi Qiao, Shiji Fang, Lin Shen, Nannan Zhang, Jun Wang, Chunmiao Chen, Jingjing Song, Zhuang Liu, Yongzhong Du, Jiansong Ji
Summary: A PT/DOX-MS microsphere was developed in this study, which showed superior efficacy in treating HCC by co-delivering doxorubicin and PT-2385. The microsphere exhibited multiple mechanisms to inhibit tumor growth, including blocking tumor cell cycle, promoting cell apoptosis, and inhibiting tumor angiogenesis.
Article
Engineering, Environmental
Yan Liu, Xinxing Ma, Yujie Zhu, Xiang Lv, Peipei Wang, Liangzhu Feng
Summary: This study developed a pH-responsive nanomedicine that inhibits EGFR and normalizes tumor vasculature, improving tumor oxygenation and reducing tumor growth. It demonstrated the therapeutic efficacy of combined chemotherapy and photodynamic therapy in TNBC models, offering a potential treatment advantage for TNBC patients.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Materials Science, Multidisciplinary
Yu Hao, Lei Zhang, Ziliang Dong, Chunjie Wang, Yu Chao, Dongxu Zhao, Yujie Zhu, Zhijuan Yang, Nailin Yang, Yikai Han, Liangzhu Feng, Zhuang Liu
Summary: This article proposes an alternative locoregional treatment strategy using percutaneously implanted catalytic couple fueled by orally administrated ethanol to effectively ablate tumors. It is shown that this strategy has a great inhibitory effect on liver and breast tumors in mice and rats, comparable to the traditional percutaneous ethanol injection therapy.
Article
Chemistry, Multidisciplinary
Ziliang Dong, Chunjie Wang, Yimou Gong, Yunyun Zhang, Qin Fan, Yu Hao, Quguang Li, Yumin Wu, Xiaoyan Zhong, Kai Yang, Liangzhu Feng, Zhuang Liu
Summary: This study presents the preparation of a multifunctional fluorinated calcium carbonate nanoregulator that can reverse tumor immunosuppression and potentiate radiotherapy by chemically modulating tumor hypoxic and acidic microenvironments.
Article
Engineering, Environmental
Xiaoyuan Yang, Nailin Yang, Lei Zhang, Dongxu Zhao, Huali Lei, Shuning Cheng, Jun Ge, Xiaoming Ma, Caifang Ni, Zhuang Liu, Liang Cheng
Summary: In this study, Mg@DOX microrods were prepared for combined magnetic hyperthermia therapy and chemotherapy under an alternating magnetic field. The microrods exhibited good thermal stability, excellent magnetothermal conversion efficiency, and penetration depth. They also facilitated the release of doxorubicin, resulting in significant cell-killing ability. In vivo experiments showed excellent combined therapeutic effects and biocompatibility of the microrods.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Li Song, Yu Hao, Chunjie Wang, Yikai Han, Yujie Zhu, Liangzhu Feng, Liyan Miao, Zhuang Liu
Summary: A liposomal nanomedicine that modulates the tumor microenvironment has been developed to enhance cancer immunotherapy. By encapsulating metformin and an oxaliplatin prodrug in liposomes, this nanomedicine reduces tumor hypoxia and induces immunogenic cell death, effectively suppressing tumor growth and reversing immunosuppression.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Multidisciplinary
Yuqi Yang, Jun Ge, Guangqiang Li, Huali Lei, Linfu Chen, Yuehan Gong, Xiaoyan Zhong, Li Wang, Yizhi Dai, Wei Tang, Jun Zou, Yuan Cheng, Zhuang Liu, Liang Cheng
Summary: In this study, a cascade bioreactor was utilized to enhance sonodynamic therapy (SDT) through sequential gas therapy (GT). The results showed that this approach not only induced satisfactory immunogenic cell death (ICD) and maturation of dendric cells (DCs), but also inhibited tumor growth when combined with anti-programmed cell death-1 (αPD-L1) immune checkpoint inhibitor, demonstrating its promising therapeutic performance on cancer.
Article
Chemistry, Multidisciplinary
Rui Shi, Ziliang Dong, Chongqing Ma, Renfei Wu, Rui Lv, Sidi Liu, Yijin Ren, Zhuang Liu, Henny C. van der Mei, Henk J. Busscher, Jian Liu
Summary: PEGylation of MNPs is crucial for enhancing their uptake in E. coli, leading to high-yield magnetic harvesting of OMVs. The magnetically harvested OMVs can be targeted to specific delivery sites in the body, showing potential for drug delivery applications.
