Review
Environmental Sciences
Marija Petrovic, Zeljka Fiket
Summary: Coal combustion is a major source of global electricity, but it also generates a significant amount of coal ash residues. This article reviews the environmental damage caused by coal ash and discusses three commonly used risk assessment methodologies: leaching assessment, groundwater assessment, and toxicity testing. It also emphasizes the need for sustainable and selective methods for recovery of critical elements from coal ash.
Article
Engineering, Environmental
Paola Romero-Crespo, Samantha Jimenez-Oyola, Bryan Salgado-Almeida, Johanna Zambrano-Anchundia, Cindy Goyburo-Chavez, Ana Gonzalez-Valoys, Pablo Higueras
Summary: This study aimed to investigate the pollution level of trace elements in farmland soil and crops collected in one of Ecuador's most important gold mining areas. The results showed that the concentration of certain elements in the soil exceeded the quality guidelines for agricultural soils, while the concentration in crops exceeded the maximum permissible levels set by FAO. The health risk assessment revealed that inhabitants of the study area are exposed to developing carcinogenic and non-carcinogenic effects due to long-term consumption of food with high trace elements.
ENVIRONMENTAL GEOCHEMISTRY AND HEALTH
(2023)
Review
Environmental Sciences
Fataneh Hashempour-baltork, Behrooz Jannat, Behrouz Tajdar-oranj, Majid Aminzare, Hamed Sahebi, Adel Mirza Alizadeh, Hedayat Hosseini
Summary: Risk assessment of heavy metals is critical in controlling and preventing risks of foodborne diseases. Fish can be used as bioindicators for exposure to potential toxic elements (PTEs), which can represent potential risks for humans. The study collected data on PTEs in fish from different fishery regions in Iran and used Monte Carlo simulation to assess health risks. The results showed that mercury intake from fish in all regions exceeded safe levels for children, and consumers of fish from the southern sea were at risk of mercury adverse health effects. The study also highlighted the high carcinogenic risk of cadmium in fish from all regions. Overall, the consumption of fish in Iran may pose health complexities for consumers, especially infants and pregnant women.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Ravindra Singh Thakur, Aditya Kumar, Onila Lugun, Nasreen Ghazi Ansari, Satgur Prasad, Triparna Das, Neha Gupta, Devendra Kumar Patel
Summary: In recent years, there has been increasing attention on the deposition of toxicants from road traffic and its impact on food items. This study focused on heavy metal pollution in street vended noodles and its association with different environmental sources. The results showed that several heavy metals exceeded the allowable limits for food products. Street vended noodles sold on high traffic density streets had higher levels of heavy metal contamination due to atmospheric deposition. Health risk assessment indicated an elevated non-carcinogenic hazard to consumers of such street vended food.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Salwinder Singh Dhaliwal, Raj Setia, Vinod Kumar, Tapan Ghosh, Sagar Taneja, Randhir Singh, Junaid Ansari, Surinder S. Kukal, Brijendra Pateriya
Summary: The study identified severe heavy metal contamination in Buddha Nullah drain, with concentrations exceeding permissible limits in water, soil and plants, particularly for cadmium and lead. The contamination poses health risks, emphasizing the need for control measures to improve water quality.
ENVIRONMENTAL EARTH SCIENCES
(2021)
Article
Environmental Sciences
Saeed Negahban, Marzieh Mokarram, Hamid Reza Pourghasemi, Huichun Zhang
Summary: The study reveals that the concentrations of cadmium and lead in the soils of Neyriz, Iran exceed global standard thresholds by 10-40 times, while copper and zinc levels are below the thresholds, indicating contamination from geological formations and Ophiolitic rock masses in the area. Natrual factors such as geological formations can contribute to soil and plant pollution, in addition to pollution caused by human activities.
ENVIRONMENTAL RESEARCH
(2021)
Article
Environmental Sciences
M. U. Khan, N. Rai
Summary: This study presents new data on the distribution and health risks of arsenic and other heavy metals in groundwater in Haridwar, India. The dominant contaminant in the groundwater was found to be iron, followed by manganese, arsenic, copper, nickel, lead, chromium, and cadmium. The study also identified the likely mechanism of arsenic release and assessed the level of heavy metal pollution and associated health risks. The results show that the heavy metal pollution level was moderate to low, but there were significant non-carcinogenic and carcinogenic health risks associated with arsenic and heavy metal contamination.
ENVIRONMENTAL EARTH SCIENCES
(2022)
Article
Environmental Sciences
Fatemeh Sanaei, Mohammad Mehdi Amin, Zhaleh Pourjam Alavijeh, Rana Azaripour Esfahani, Maryam Sadeghi, Niayesh Shabankare Bandarrig, Ali Fatehizadeh, Ensiyeh Taheri, Mashallah Rezakazemi
Summary: This study aimed to assess the content of heavy metals in consumed food crops and their potential health risks, revealing that local populations are facing potential health risks primarily related to arsenic, manganese, and molybdenum, with children being more vulnerable. The sensitivity analysis pointed to ingestion rate as the most influential factor contributing to the total risk, highlighting the need for strategies to reduce heavy metal exposure in food consumption.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Green & Sustainable Science & Technology
Kang Yan, Haizhen Wang, Zheng Lan, Jiahang Zhou, HuiZhen Fu, Laosheng Wu, Jianming Xu
Summary: Contaminated sites, especially in China, have become a significant focus of research on heavy metal pollution assessment and remediation methods. China and the USA are leading countries in related research, with a particular emphasis on mining areas and industrial zones. Cd and Pb are the most studied heavy metals, with more severe pollution observed in southeast China than in the northwest.
JOURNAL OF CLEANER PRODUCTION
(2022)
Review
Environmental Sciences
Yinghuan Qin, Yuqiang Tao
Summary: The study analyzed heavy metals and metalloids in water, sediments, and fish from 87 lakes in China, finding that some lakes are polluted by cadmium and arsenic, with sediments in many lakes contaminated by cadmium, mercury, and arsenic. Additionally, some lake fish exceeded the food limits for cadmium, lead, arsenic, and chromium, showing variations in pollution levels across different media within lakes.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Multidisciplinary Sciences
P. O. Ogungbile, A. O. Ajibare, P. O. Ayeku, J. O. Akinola
Summary: This study investigated the concentration of nine heavy metals in Oreochromis niloticus and Ipomoea aquatica in Agodi reservoir, Nigeria. The results showed that the metals accumulated more in O. niloticus than in I. aquatica. Most of the examined metals exceeded the safety limit, and O. niloticus had lower tolerance for heavy metals. Additionally, metal concentration and ecological risk quotient were higher in the wet season for O. niloticus.
SCIENTIFIC REPORTS
(2022)
Article
Environmental Sciences
Reymar R. Diwa, Marlon Elvira, Custer C. Deocaris, Mayuko Fukuyama, Lawrence P. Belo
Summary: Laguna de Bay in the Philippines, the third largest lake in Southeast Asia, is a significant source of freshwater fish. However, unregulated discharge of industrial, domestic, and agricultural wastewaters has led to heavy metal contamination in the lake, which affects the toxicity of the popular Asiatic clam. The study found that the western part of the lake had higher concentrations of certain heavy metals in the sediment compared to the eastern part, and there were correlations between the sediment and the Asiatic clam.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Agronomy
Fu Chen, Jing Ma, Muhammad Arslan Ashraf, Asma Zafar, Zafar Iqbal Khan, Kafeel Ahmad, Mona S. Alwahibi, Mohamed S. Elshikh
Summary: Concerns over water contamination have led to a comprehensive review of the hazards posed by waterborne contaminants. This study found that the use of wastewater for irrigation affects the zinc content in wheat grains, but using wastewater in a specific proportion does not have harmful effects. Further research is recommended to explore physiological and molecular aspects.
AGRICULTURAL WATER MANAGEMENT
(2022)
Article
Environmental Sciences
O. Findik, S. Aras
Summary: Damsa reservoir is a significant water source for irrigation and recreation in Cappadocia region. Indices were used to assess heavy metal pollution in the reservoir, and the main sources of pollution were identified as natural/geogenic processes and anthropogenic inputs (agricultural activities).
INTERNATIONAL JOURNAL OF ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2023)
Article
Environmental Sciences
Yang Pan, Haidi Wu, Tianyang Zhao, Liwei Yang, Lanbo Wei, Yinghua He, Haitao Su, Yunjian Zhang, Xianshu Cui, Lijun Song, Yanjun Ma, Changsheng Li, Liting Zhou, Lin Ye
Summary: This study determined the levels of 12 heavy metal(loid)s in atmospheric PM2.5 in two cities in Jilin Province, China. Arsenic and chromium were identified as the major carcinogens present, posing a high carcinogenic risk to children. The study suggests the need for stringent control measures for heavy metal(loid)s to reduce health risks.
Article
Biochemistry & Molecular Biology
Bader Saud Alotaibi, Jatin Joshi, Mohammad Raghibul Hasan, Mohd Shahnawaz Khan, Salem Hussain Alharethi, Taj Mohammad, Fahad A. Alhumaydhi, Abdelbaset Mohamed Elasbali, Md Imtaiyaz Hassan
Summary: In this study, potential inhibitors of ROCK1 were identified through structure-based virtual screening of natural compounds. Isoononin and Candidissiol showed appreciable binding affinity and selectivity towards ROCK1, and molecular dynamics simulations confirmed their stability.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Computer Science, Information Systems
Mohamed Hassaoui, Mohamed Hanini, Said El Kafhali
Summary: The use of C2 servers in cyberattacks has increased significantly, with attackers using DGA technique to hide their servers. Existing techniques for binary classification of domain names have issues with real-time detection and sensitivity to data. This paper proposes the DTFS-DGA model, which combines neural networks and traditional machine learning models to detect DGA in real-time without relying on reverse engineering and being insensitive to data size.
JOURNAL OF COMPUTER SECURITY
(2023)
Article
Biochemistry & Molecular Biology
Lamya H. Al-Wahaibi, Md Tabish Rehman, Muneera S. M. Al-Saleem, Omer A. Basudan, Ali A. El-Gamal, Mohamed S. A. Abdelkader, Mohamed F. AlAjmi, Wael M. Abdel-Mageed
Summary: The study reveals that certain abyssomicins have strong binding and inhibitory abilities against key proteins of the novel coronavirus, and they possess stable drug-like properties. These abyssomicins are considered potential candidates for further in vitro and in vivo evaluation.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Environmental Sciences
Nojood Altwaijry, Mohd Shahnawaz Khan, Gouse M. Shaik, Mohammad Tarique, Mehjbeen Javed
Summary: In this study, various parameters of oxidative stress, immune response, and abnormalities in the erythrocyte nucleus of Labeo rohita inhabiting the polluted Kshipra River, India, were measured. The heavy metal concentrations in the river water were in the order of Ni > Fe > Cd > Cr > Mn > Zn > Cu. The fish showed increased levels of antioxidant enzymes in gills, liver, and gut compared to the reference fish, but decreased levels of GST and GSH. Heavy metals also caused immunosuppression and histopathological changes in the fish. These findings highlight the potential impact of heavy metal-induced stress on fish inhabiting polluted river water and the importance of pollution control.
ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
(2023)
Meeting Abstract
Immunology
Brianna Wachter, Kalpana Manthiram, Qin Xu, Lihong Shi, Pamela Schwartzberg, Peter Burbelo, Muhammad Tauseef Rehman, Robin Dewar, Luigi Notarangelo, Ottavia Delmonte
CLINICAL IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Nojood Altwaijry, Ghaliah S. Almutairi, Mohd Shahnawaz Khan, Gouse M. Shaik, Majed S. Alokail
Summary: Amyloid fibrils accumulation can cause lethal conditions, but the use of Chlorothiazide (CTZ) can prevent or treat this disease. In this study, the effects of CTZ on hen egg white lysozyme (HEWL) aggregation were examined using various methods. The results showed that CTZ can reduce the formation of amyloid fibrils and prevent aggregation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Mohd Shahnawaz Khan, Nojood Altwaijry, Moneera Saud Al-Bagmi, Nouf Omar Alafaleq, Majed S. Alokail, Moyad Shahwan, Anas Shamsi
Summary: Proto-oncogene tyrosine-protein kinase ROS (ROS1) is a member of a receptor family that affects epithelial cell differentiation and is highly expressed in various tumors. This study identified two potential inhibitors of ROS1 through virtual screening of phytochemicals. The findings highlight the role of ROS1 in multiple physiological processes and suggest the potential use of phytochemicals for therapeutic development targeting ROS1-associated non-small cell lung cancer.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Bhanu Sharma, Md. Tabish Rehman, Mohamed F. AlAjmi, Moayad Shahwan, Tahir Hussain, Varun Jaiswal, Mohd Azhar Khan
Summary: The renin-angiotensin system (RAS) is crucial for regulating arterial pressure and fluid balance, and the angiotensin type 2 receptor (AT2R) plays a protective role in pathophysiological conditions. This study investigated the impact of single nucleotide polymorphisms (SNPs) on AT2R and its interactions with agonist and antagonist molecules. Computational analysis and molecular dynamics simulations revealed that certain mutations affect the protein conformation and ligand binding. These findings have implications for the development of better medications and future in vitro and in vivo studies.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Ajamaluddin Malik, Javed Masood Khan, Abdullah S. S. Alhomida, Mohammad Shamsul Ola, Majed S. S. Alokail, Mohd Shahnawaz Khan, Amal M. M. Alenad, Nojood Altwaijry, Nouf Omar Alafaleq, Hamza Odeibat
Summary: Several proteins and peptides have the ability to form amyloid fibrils, which can lead to a variety of diseases. The process by which these proteins transition from a folded and soluble state to an amyloid fibril is not well understood.
JOURNAL OF MOLECULAR RECOGNITION
(2023)
Article
Biochemistry & Molecular Biology
Mohd Shahnawaz Khan, Nojood Altwaijry, Nasimudeen R. Jabir, Abdulaziz Mohammed Alamri, Mohammad Tarique, Azhar U. Khan
Summary: Ovarian cancer treatment is highly challenging due to the lack of clinical symptoms and sensitivity biomarkers leading to late-stage diagnosis. This study evaluated the anticancer potential of biogenic zinc oxide nanoparticles (ZnO NPs) synthesized using pumpkin seed extracts.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Satyamvada Maurya, Amita Jain, Md Tabish Rehman, Ali Hakamy, Farkad Bantun, Mohamed F. AlAjmi, Vineeta Singh, Aafreen Zehra, Feroz Khan, Shafiul Haque, Bhartendu Nath Mishra
Summary: This study aimed to identify potential new drug targets/candidates for multi-drug-resistant Mycobacterium tuberculosis (Mtb) through computational techniques. The protein structure of ribonuclease VapC2 of Mtb H37Rv was analyzed, and docking studies were performed with 22 anti-TB drugs. Rifampicin showed the best binding energy and was selected as the parent molecule for designing derivatives. One of the derivatives, RIF-155841, showed activity in inhibiting VapC2. Molecular dynamics simulations confirmed the stability of the VapC2-RIF155841 complex, and a chemical synthesis scheme was designed for future validation.
Article
Biochemistry & Molecular Biology
Omar Noman, Fahd A. Nasr, Mohammad Z. Ahmed, Md Tabish Rehman, Wajhul Qamar, Ali S. Alqahtani, Sebastian Guenther
Summary: The aim of this study was to evaluate the anticancer efficacy of chlorojanerin against different cancer cells. The effects of chlorojanerin on cell cytotoxicity, cell cycle arrest, and cell apoptosis were investigated using various assays. RT-PCR was used to analyze the expression levels of apoptosis-related genes. Docking simulations were employed to study the binding preferences of chlorojanerin with Bcl-2. The results showed that chlorojanerin inhibited cell proliferation dose-dependently and had a promising effect against A549 lung cancer cells. The inhibition of cell growth was associated with G2/M phase cell cycle arrest and apoptosis induction. We also found that chlorojanerin altered the expression of genes involved in apoptosis initiation and could fit into the active site of Bcl-2 according to docking simulations. These findings suggest that chlorojanerin has potential as a therapeutic agent in lung cancer treatment.
Article
Pharmacology & Pharmacy
Mohammad Rashid Khan, Sheikh Fayaz Ahmad, Ahmed Nadeem, Faisal Imam, Naif O. Al-Harbi, Mohd Shahnawaz Khan, Meshal Alsahli, Khaled Alhosaini
Summary: This study explored the therapeutic outcome of Cathepsin B inhibitor (CA-074) against retinopathy and optic neuritis caused by experimental autoimmune encephalomyelitis (EAE). The findings showed that CA-074 could ameliorate optic neuritis and retinopathy by reducing inflammation, as well as reducing demyelination and axonal injuries in EAE mice.
SAUDI PHARMACEUTICAL JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Safikur Rahman, Sana Iram, Md Tabish Rehman, Afzal Hussain, Arif Tasleem Jan, Jihoe Kim
Summary: This study investigates the interaction between the sodium channel blocker amiloride and human serum albumin. The results show that amiloride specifically binds to a specific site on HSA and the complex is stabilized by van der Waals hydrogen-bonding and hydrophobic interactions. FRET analysis demonstrates that the distance between amiloride and Trp214 is crucial for efficient quenching. UV-Vis spectroscopy and circular dichroism indicate minor structural changes in HSA after binding. Molecular dynamics simulations provide further evidence of stable HSA-AML complex formation.
Article
Biochemistry & Molecular Biology
Deema Hussein, Mohamad Saka, Saleh Baeesa, Mohammed Bangash, Fahad Alghamdi, Torki Al Zughaibi, Mohamed F. Alajmi, Shafiul Haque, Md Tabish Rehman
Summary: In this study, new drug candidates that may function as KIF2C enzyme inhibitors were discovered. Through virtual screening and molecular docking experiments, the best compounds that bind with KIF2C protein were identified and further analyzed for stability and energy contribution. These findings indicate the potential of these compounds to inhibit the biological function of KIF2C and call for further research.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
