Increasing thermal stability and improving biodistribution of VEGFR2-binding affibody molecules by a combination of in silico and directed evolution approaches

Principles of Protein Stability and Their Application in Computational Design

(2018) Adi Goldenzweig et al.   Annual Review of Biochemistry

Radionuclide imaging of VEGFR2 in glioma vasculature using biparatopic affibody conjugate: proof-of-principle in a murine model

(2018) Bogdan Mitran et al.   Theranostics

Influence of Molecular Design on the Targeting Properties of ABD-Fused Mono- and Bi-Valent Anti-HER3 Affibody Therapeutic Constructs

(2018) Mohamed Altai et al.   Cells

Affibody Molecules in Biotechnological and Medical Applications

(2017) Stefan Ståhl et al.   TRENDS IN BIOTECHNOLOGY

Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability

(2016) Adi Goldenzweig et al.   MOLECULAR CELL

Novel affinity binders for neutralization of vascular endothelial growth factor (VEGF) signaling

(2015) Filippa Fleetwood et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Simultaneous targeting of two ligand-binding sites on VEGFR2 using biparatopic Affibody molecules results in dramatically improved affinity

(2014) Filippa Fleetwood et al.   Scientific Reports

Site-Specific Radiometal Labeling and Improved Biodistribution Using ABY-027, A Novel HER2-Targeting Affibody Molecule-Albumin-Binding Domain Fusion Protein

(2013) A. Orlova et al.   JOURNAL OF NUCLEAR MEDICINE

Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trial

(2013) Charles S Fuchs et al.   LANCET

Inhibiting HER3-Mediated Tumor Cell Growth with Affibody Molecules Engineered to Low Picomolar Affinity by Position-Directed Error-Prone PCR-Like Diversification

(2013) Magdalena Malm et al.   PLoS One

Binding and neutralization of vascular endothelial growth factor (VEGF) and related ligands by VEGF Trap, ranibizumab and bevacizumab

(2012) Nicholas Papadopoulos et al.   ANGIOGENESIS

A preclinical and clinical review of aflibercept for the management of cancer

(2012) Andrew Gaya et al.   CANCER TREATMENT REVIEWS

Liver uptake of radiolabeled targeting proteins and peptides: considerations for targeting peptide conjugate design

(2012) Seyed Jalal Hosseinimehr et al.   DRUG DISCOVERY TODAY

Engineering hepatocyte growth factor fragments with high stability and activity as Met receptor agonists and antagonists

(2011) Douglas S. Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HEHEHE-Tagged Affibody Molecule May Be Purified by IMAC, Is Conveniently Labeled with [99mTc(CO)3]+, and Shows Improved Biodistribution with Reduced Hepatic Radioactivity Accumulation

(2010) Vladimir Tolmachev et al.   BIOCONJUGATE CHEMISTRY

Affibody molecules: Engineered proteins for therapeutic, diagnostic and biotechnological applications

(2010) J. Löfblom et al.   FEBS LETTERS