Could Vitamins Help in the Fight Against COVID-19?

Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China

(2020) Zunyou Wu et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Pulmonary pathology of early phase 2019 novel coronavirus (COVID-19) pneumonia in two patients with lung cancer

(2020) Sufang Tian et al.   Journal of Thoracic Oncology

Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding

(2020) Roujian Lu et al.   LANCET

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

(2020) Daniel Wrapp et al.   SCIENCE

The Emerging Role of Vitamin C as a Treatment for Sepsis

(2020) Markos G. Kashiouris et al.   Nutrients

Vitamin C: an essential “stress hormone” during sepsis

(2020) Paul E. Marik   Journal of Thoracic Disease

Pathological findings of COVID-19 associated with acute respiratory distress syndrome

(2020) Zhe Xu et al.   Lancet Respiratory Medicine

Comparative genetic analysis of the novel coronavirus (2019-nCoV/SARS-CoV-2) receptor ACE2 in different populations

(2020) Yanan Cao et al.   Cell Discovery

Letter: Covid-19, and vitamin D

(2020) Alba Panarese et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Editorial: low population mortality from COVID-19 in countries south of latitude 35 degrees North supports vitamin D as a factor determining severity

(2020) Jonathan M. Rhodes et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

COVID-19 and vitamin D—Is there a link and an opportunity for intervention?

(2020) Hrvoje Jakovac   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Hispidin and Lepidine E: two Natural Compounds and Folic acid as Potential Inhibitors of 2019-novel coronavirus Main Protease (2019-nCoVMpro), molecular docking and SAR study

(2020) Talia Serseg et al.   Current Computer-Aided Drug Design

Sex-Specific SARS-CoV-2 Mortality: Among Hormone-Modulated ACE2 Expression, Risk of Venous Thromboembolism and Hypovitaminosis D

(2020) Sandro La Vignera et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

SARS-CoV-2: virus dynamics and host response

(2020) Yu Chen et al.   LANCET INFECTIOUS DISEASES

Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors

(2020) Zhenming Jin et al.   NATURE

Optimal Nutritional Status for a Well-Functioning Immune System Is an Important Factor to Protect against Viral Infections

(2020) Philip C. Calder et al.   Nutrients

A Novel Combination of Vitamin C, Curcumin and Glycyrrhizic Acid Potentially Regulates Immune and Inflammatory Response Associated with Coronavirus Infections: A Perspective from System Biology Analysis

(2020) Liang Chen et al.   Nutrients

Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths

(2020) William B. Grant et al.   Nutrients

Virtual screening and repurposing of FDA approved drugs against COVID-19 main protease

(2020) Mahmoud Kandeel et al.   LIFE SCIENCES

Early nutritional supplementation in non-critically ill patients hospitalized for the 2019 novel coronavirus disease (COVID-19): Rationale and feasibility of a shared pragmatic protocol

(2020) Riccardo Caccialanza et al.   NUTRITION

Recent Aspects on the Pathogenesis Mechanism, Animal Models and Novel Therapeutic Interventions for Middle East Respiratory Syndrome Coronavirus Infections

(2019) Sinosh Skariyachan et al.   Frontiers in Microbiology

Vitamin C Can Shorten the Length of Stay in the ICU: A Meta-Analysis

(2019) Harri Hemilä et al.   Nutrients

The Protection Potential of Antioxidant Vitamins Against Acute Respiratory Distress Syndrome: a Rat Trial

(2019) Nazli Erol et al.   INFLAMMATION

The Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) Protocol: a prospective, multi-center, double-blind, adaptive sample size, randomized, placebo-controlled, clinical trial

(2019) David N. Hager et al.   Trials

Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure

(2019) Alpha A. Fowler et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Effect of high doses of vitamin D supplementation on dengue virus replication, Toll-like receptor expression, and cytokine profiles on dendritic cells

(2019) Jahnnyer Martínez-Moreno et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

CITRIS-ALI: How statistics were used to obfuscate the true findings

(2019) Paul E. Marik et al.   Anaesthesia Critical Care & Pain Medicine

Vitamin D in Asthma

(2018) Paul E. Pfeffer et al.   CHEST

Self-Care for Common Colds: The Pivotal Role of Vitamin D, Vitamin C, Zinc, and Echinacea in Three Main Immune Interactive Clusters (Physical Barriers, Innate and Adaptive Immunity) Involved during an Episode of Common Colds—Practical Advice on Dosages and on the Time to Take These Nutrients/Botanicals in order to Prevent or Treat Common Colds

(2018) Mariangela Rondanelli et al.   Evidence-based Complementary and Alternative Medicine

Combined vitamin C, hydrocortisone, and thiamine therapy for patients with severe pneumonia who were admitted to the intensive care unit: Propensity score-based analysis of a before-after cohort study

(2018) Won-Young Kim et al.   JOURNAL OF CRITICAL CARE

Vitamin D deficiency and the pathogenesis of Crohn’s disease

(2018) John H. White   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Regulatory T Cells and Acute Lung Injury: Cytokines, Uncontrolled Inflammation, and Therapeutic Implications

(2018) Shihui Lin et al.   Frontiers in Immunology

Patterns of Death in Patients with Sepsis and the Use of Hydrocortisone, Ascorbic Acid, and Thiamine to Prevent these Deaths

(2018) Paul E. Marik   Surgical Infections

Why are RNA virus mutation rates so damn high?

(2018) Siobain Duffy   PLOS BIOLOGY

Role of Vitamin A in the Immune System

(2018) Zhiyi Huang et al.   Journal of Clinical Medicine

Vitamin D for the treatment of multiple sclerosis: a meta-analysis

(2018) Laurie McLaughlin et al.   JOURNAL OF NEUROLOGY

Vitamin A to prevent bronchopulmonary dysplasia in extremely low birth weight infants: a systematic review and meta-analysis

(2018) Shunsuke Araki et al.   PLoS One

The Role of Vitamin E in Immunity

(2018) Ga Lee et al.   Nutrients

Is Vitamin A an Antioxidant or a Pro-oxidant?

(2017) Duy Quang Dao et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Vitamin D alleviates lipopolysaccharide-induced acute lung injury via regulation of the renin-angiotensin system

(2017) Jun Xu et al.   Molecular Medicine Reports

Acute Respiratory Distress Syndrome

(2017) B. Taylor Thompson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interventions to prevent respiratory diseases - Nutrition and the developing world

(2017) Tasneem Karim et al.   Paediatric Respiratory Reviews

Vitamin C and Infections

(2017) Harri Hemilä   Nutrients

Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data

(2017) Adrian R Martineau et al.   BMJ-British Medical Journal

Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data

(2017) Adrian R Martineau et al.   BMJ-British Medical Journal

Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock

(2016) Michael W. Donnino et al.   CRITICAL CARE MEDICINE

Vitamin A Supplementation for the Prevention of Bronchopulmonary Dysplasia in Preterm Infants: An Update

(2016) Emily Schwartz et al.   NUTRITION IN CLINICAL PRACTICE

Vitamin C: the known and the unknown and Goldilocks

(2016) SJ Padayatty et al.   ORAL DISEASES

Vitamin E therapy beyond cancer: Tocopherol versus tocotrienol

(2016) Hong Yong Peh et al.   PHARMACOLOGY & THERAPEUTICS

Pulmonary Angiotensin-Converting Enzyme 2 (ACE2) and Inflammatory Lung Disease

(2016) Hongpeng Jia   SHOCK

Inactivation of Middle East respiratory syndrome coronavirus (MERS-CoV) in plasma products using a riboflavin-based and ultraviolet light-based photochemical treatment

(2016) Shawn D. Keil et al.   TRANSFUSION

Do not forget to give thiamine to your septic shock patient!

(2016) Jihad Mallat et al.   Journal of Thoracic Disease

Retinoids and Retinal Diseases

(2016) Philip D. Kiser et al.   Annual Review of Vision Science

Seeing through the dark: New insights into the immune regulatory functions of vitamin A

(2015) Chrysothemis C. Brown et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

S67 Vitamin D deficiency drives pulmonary inflammation in a human model of the acute respiratory distress syndrome induced by inhaled lipopolysaccharide in healthy volunteers

(2015) M Fitzgerald et al.   THORAX

Vitamin D deficiency contributes directly to the acute respiratory distress syndrome (ARDS)

(2015) R. C. A. Dancer et al.   THORAX

Enteral Immunomodulatory Diet (Omega-3 Fatty Acid, γ-Linolenic Acid and Antioxidant Supplementation) for Acute Lung Injury and Acute Respiratory Distress Syndrome: An Updated Systematic Review and Meta-Analysis

(2015) Congcong Li et al.   Nutrients

Vitamin D and 1,25(OH)2D Regulation of T cells

(2015) Margherita Cantorna et al.   Nutrients

Vitamin A supplements, routine immunization, and the subsequent risk of Plasmodium infection among children under 5 years in sub-Saharan Africa

(2015) Maria-Graciela Hollm-Delgado et al.   eLife

Dietary glutamine prevents the loss of intestinal barrier function and attenuates the increase in core body temperature induced by acute heat exposure

(2014) Anne D. N. Soares et al.   BRITISH JOURNAL OF NUTRITION

Vitamin D Metabolism, Mechanism of Action, and Clinical Applications

(2014) Daniel D. Bikle   CHEMISTRY & BIOLOGY

Impact of folate therapy on combined immunodeficiency secondary to hereditary folate malabsorption

(2014) Kenji Kishimoto et al.   CLINICAL IMMUNOLOGY

From SARS to MERS: crystallographic studies on coronaviral proteases enable antiviral drug design

(2014) Rolf Hilgenfeld   FEBS Journal

Niacin attenuates the production of pro-inflammatory cytokines in LPS-induced mouse alveolar macrophages by HCA2 dependent mechanisms

(2014) Ershun Zhou et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Respiratory Epithelial Cells Convert Inactive Vitamin D to Its Active Form: Potential Effects on Host Defense

(2014) S. Hansdottir et al.   JOURNAL OF IMMUNOLOGY

Vitamin C Mitigates Oxidative Stress and Tumor Necrosis Factor-Alpha in Severe Community-Acquired Pneumonia and LPS-Induced Macrophages

(2014) Yuanyuan Chen et al.   MEDIATORS OF INFLAMMATION

Potential Role of Carotenoids as Antioxidants in Human Health and Disease

(2014) Joanna Fiedor et al.   Nutrients

Vitamin D deficiency and risk of acute lung injury in severe sepsis and severe trauma: a case-control study

(2014) Nicolas Barnett et al.   Annals of Intensive Care

Age-Associated Changes in Immune Function: Impact of Vitamin E Intervention and the Underlying Mechanisms

(2014) Dayong Wu et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

Association between prehospital vitamin D status and hospital-acquired bloodstream infections

(2013) Sadeq A Quraishi et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Effects of dietary vitamin A content on antibody responses of feedlot calves inoculated intramuscularly with an inactivated bovine coronavirus vaccine

(2013) Junbae Jee et al.   AMERICAN JOURNAL OF VETERINARY RESEARCH

Association of Low Serum 25-Hydroxyvitamin D Levels and Sepsis in the Critically Ill

(2013) Takuhiro Moromizato et al.   CRITICAL CARE MEDICINE

Vitamin A Metabolism, Action, and Role in Skeletal Homeostasis

(2013) H. Herschel Conaway et al.   ENDOCRINE REVIEWS

Vitamin C: A Novel Regulator of Neutrophil Extracellular Trap Formation

(2013) Bassem Mohammed et al.   Nutrients

Mechanisms of attenuation of abdominal sepsis induced acute lung injury by ascorbic acid

(2012) Bernard J. Fisher et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Autophagy induction by vitamin D inhibits bothMycobacterium tuberculosisand human immunodeficiency virus type 1

(2012) Grant R. Campbell et al.   Autophagy

Association of low serum 25-hydroxyvitamin D levels and acute kidney injury in the critically ill*

(2012) Andrea B. Braun et al.   CRITICAL CARE MEDICINE

Vitamin B12supplementation improves rates of sustained viral response in patients chronically infected with hepatitis C virus

(2012) Alba Rocco et al.   GUT

The inflammatory response in sepsis

(2012) Markus Bosmann et al.   TRENDS IN IMMUNOLOGY

Retina, Retinol, Retinal and the Natural History of Vitamin A as a Light Sensor

(2012) Ming Zhong et al.   Nutrients

Vitamin A: biomarkers of nutrition for development

(2011) Sherry A Tanumihardjo   AMERICAN JOURNAL OF CLINICAL NUTRITION

The effect of vitamin D on bone and osteoporosis

(2011) Paul Lips et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Association of low serum 25-hydroxyvitamin D levels and mortality in the critically ill*

(2011) Andrea Braun et al.   CRITICAL CARE MEDICINE

Low serum 25-hydroxyvitamin D at critical care initiation is associated with increased mortality*

(2011) Andrea B. Braun et al.   CRITICAL CARE MEDICINE

Thiamine supplementation in the critically ill

(2011) William Manzanares et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Enteral Omega-3 Fatty Acid, γ-Linolenic Acid, and Antioxidant Supplementation in Acute Lung Injury

(2011) Todd W. Rice   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Vitamin D and the anti-viral state

(2011) Jeremy A. Beard et al.   JOURNAL OF CLINICAL VIROLOGY

Unknown

(2011) Jochen Grommes et al.   MOLECULAR MEDICINE

Vitamin D Deficiency in Critically Ill Patients

(2011)   NEW ENGLAND JOURNAL OF MEDICINE

Immunohistochemical expression of proinflammatory cytokines IL-1β, IL-6, TNF-α and involvement of COX-2, quantitatively confirmed by Western blot analysis, in Wernicke's encephalopathy

(2011) Margherita Neri et al.   PATHOLOGY RESEARCH AND PRACTICE

Fat-soluble vitamins and atopic disease: what is the evidence?

(2011) Augusto A. Litonjua   PROCEEDINGS OF THE NUTRITION SOCIETY

Bioconversion of dietary provitamin A carotenoids to vitamin A in humans

(2010) Guangwen Tang   AMERICAN JOURNAL OF CLINICAL NUTRITION

Hepatic stellate cell (vitamin A-storing cell) and its relative – past, present and future

(2010) Haruki Senoo et al.   CELL BIOLOGY INTERNATIONAL

A review of the critical role of vitamin D in the functioning of the immune system and the clinical implications of vitamin D deficiency

(2010) Gerry K. Schwalfenberg   MOLECULAR NUTRITION & FOOD RESEARCH

Immunonutrition and critical illness: An update

(2010) Barry A. Mizock   NUTRITION

The effect of vitamin A supplementation and diphtheria–tetanus–pertussis vaccination on parasitaemia in an experimental murine malaria model

(2010) Mathias Jul Jørgensen et al.   SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES

Retinoids inhibit measles virus through a type I IFN-dependent bystander effect

(2009) Claire Trottier et al.   FASEB JOURNAL

1,25-Dihydroxyvitamin D3 and IL-2 Combine to Inhibit T Cell Production of Inflammatory Cytokines and Promote Development of Regulatory T Cells Expressing CTLA-4 and FoxP3

(2009) L. E. Jeffery et al.   JOURNAL OF IMMUNOLOGY

Vitamin D-Directed Rheostatic Regulation of Monocyte Antibacterial Responses

(2009) J. S. Adams et al.   JOURNAL OF IMMUNOLOGY

Hyperhomocysteinaemia and poor vitamin B status in chronic obstructive pulmonary disease

(2009) F.L. Fimognari et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

The discovery of angiotensin-converting enzyme 2 and its role in acute lung injury in mice

(2008) Yumiko Imai et al.   EXPERIMENTAL PHYSIOLOGY

Vitamin E ingestion improves several immune functions in elderly men and women

(2008) Monica De la Fuente et al.   FREE RADICAL RESEARCH

Vitamin B12 status and rate of brain volume loss in community-dwelling elderly

(2008) A. Vogiatzoglou et al.   NEUROLOGY

Update: Effects of Antioxidant and Non-Antioxidant Vitamin Supplementation on Immune Function

(2008) Aimee L. Webb et al.   NUTRITION REVIEWS