Review
Clinical Neurology
Troels S. Jensen, Pall Karlsson, Sandra S. Gylfadottir, Signe T. Andersen, David L. Bennett, Hatice Tankisi, Nanna B. Finnerup, Astrid J. Terkelsen, Karolina Khan, Andreas C. Themistocleous, Alexander G. Kristensen, Mustapha Itani, Soren H. Sindrup, Henning Andersen, Morten Charles, Eva L. Feldman, Brian C. Callaghan
Summary: Peripheral neuropathy is a common complication of diabetes, with the most common type being distal symmetric polyneuropathy. Diagnosis of diabetic neuropathy remains challenging due to lack of a single established diagnostic standard, leading to a reliance on a hierarchical system combining symptoms, signs, and confirmatory tests for research purposes. Treatments for diabetic neuropathy focus on glycemic control and symptomatic management, with a need for large randomized clinical trials to identify the most effective interventions for improved patient outcomes.
Article
Biochemistry & Molecular Biology
Rowida Almomani, Maurice Sopacua, Margherita Marchi, Milena Sleczkowska, Patrick Lindsey, Bianca T. A. de Greef, Janneke G. J. Hoeijmakers, Erika Salvi, Ingemar S. J. Merkies, Maryam A. Ferdousi, Rayaz Malik, Dan Ziegler, Kasper W. J. Derks, Gidon Boenhof, Filippo Martinelli-Boneschi, Daniele Cazzato, Raffaella Lombardi, Sulayman G. Dib-Hajj, Stephen Waxman, Hubert J. M. M. Smeets, Monique G. Gerrits, Catharina Faber, Giuseppe Lauria
Summary: Rare SCG genetic variants may contribute to the development of painful neuropathy. Genetic profiling and SCG variant identification can provide better understanding of the genetic variability in patients with painful and painless neuropathy, leading to improved risk stratification and personalized pain treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Ilya V. Dmitriev, Anastasia S. Severina, Nikita S. Zhuravel, Madina I. Yevloyeva, Rustam K. Salimkhanov, Svetlana P. Shchelykalina, Evgeniy A. Bezunov, Minara S. Shamkhalova, Julia F. Semenova, Vadim V. Klimontov, Marina V. Shestakova
Summary: Simultaneous pancreas-kidney transplantation (SPKT) can improve long-term patient survival and restore endogenous insulin secretion in recipients with type 1 diabetes (T1D). This study evaluated CGM-derived TIR and GV in patients with T1D and functioning pancreatic grafts after SPKT.
Article
Endocrinology & Metabolism
David Rodbard
Summary: The study found that continuous glucose monitoring (CGM) metrics, such as interstitial fluid Mean Glucose level, proportion of time above range (%TAR), and proportion of time in range (%TIR), correlated with glycated haemoglobin (HbA1c) and can be used to evaluate therapeutic efficacy. Mean Glucose showed the highest correlation with %TAR but weaker correlations with %TIR or HbA1c. These metrics can be combined with indicators of hypoglycaemia and/or glycaemic variability to provide a more comprehensive assessment of glycaemic control.
DIABETES OBESITY & METABOLISM
(2023)
Article
Neurosciences
Vikram Thakur, Mayra A. Gonzalez, Maria Parada, Robert D. Martinez, Munmun Chattopadhyay
Summary: Diabetic painful neuropathy is a severe complication of diabetes, and alterations in neuroinflammatory mediators play a crucial role in its development. This study suggests that using the HDAC inhibitor FK228 can suppress NETosis and improve diabetic nerve degeneration in DPN patients.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Endocrinology & Metabolism
Uazman Alam, Ioannis N. Petropoulos, Georgios Ponirakis, Maryam Ferdousi, Omar Asghar, Maria Jeziorska, Andrew Marshall, Andrew J. M. Boulton, Nathan Efron, Rayaz A. Malik
Summary: The study suggests that vitamin D deficiency and insufficiency are associated with painful diabetic neuropathy, with more severe symptoms in patients with painful neuropathy compared to painless neuropathy. The serum 25(OH)D levels were significantly lower in patients with painful neuropathy compared to those with painless neuropathy and healthy controls.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2021)
Article
Endocrinology & Metabolism
Xueyao Yin, WeiFen Zhu, Chao Liu, Huilan Yao, Jiaxing You, Yixin Chen, Xiaofang Ying, Lin Li
Summary: This study found that perioperative time in range (TIR) and time below range (TBR) of blood glucose levels were significantly associated with the risk of major amputation in patients with diabetic foot osteomyelitis.
THERAPEUTIC ADVANCES IN ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Endocrinology & Metabolism
Jiemin Pan, Xinfeng Yan, Fengwen Li, Yinan Zhang, Lan Jiang, Congrong Wang
Summary: The study found that glucose variability (SDgluc) is an independent contributor to subclinical diabetic polyneuropathy, in addition to conventional risk factors such as diabetes duration and HbA1c.
JOURNAL OF DIABETES INVESTIGATION
(2022)
Review
Medicine, Research & Experimental
Phiwayinkosi V. Dludla, Bongani B. Nkambule, Ilenia Cirilli, Fabio Marcheggiani, Sihle E. Mabhida, Khanyisani Ziqubu, Yonela Ntamo, Babalwa Jack, Tawanda M. Nyambuya, Sidney Hanser, Sithandiwe E. Mazibuko-Mbeje
Summary: Diabetic neuropathy is a serious condition that can lead to various complications and severely impact a patient's quality of life. The use of topical capsaicin cream has shown promising results in reducing pain symptoms and improving walking, working, and sleeping in patients with painful diabetic neuropathy.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Milena Sleczkowska, Rowida Almomani, Margherita Marchi, Bianca T. A. de Greef, Maurice Sopacua, Janneke G. J. Hoeijmakers, Patrick Lindsey, Erika Salvi, Gidon J. Boenhof, Dan Ziegler, Rayaz A. Malik, Stephen G. Waxman, Giuseppe Lauria, Catharina G. Faber, Hubert J. M. Smeets, Monique M. Gerrits
Summary: Neuropathic pain is common in diabetic peripheral neuropathy (DN), and it may be caused by pathogenic ion channel gene variants. Variants in ion channel genes were found in DN patients with and without pain, suggesting their role in pain generation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Tomoya Mita, Naoto Katakami, Yosuke Okada, Hidenori Yoshii, Takeshi Osonoi, Keiko Nishida, Toshihiko Shiraiwa, Akira Kurozumi, Naohiro Taya, Satomi Wakasugi, Fumiya Sato, Ryota Ishii, Masahiko Gosho, Iichiro Shimomura, Hirotaka Watada
Summary: This study found a significant association between CGM-derived indices, such as time in range (TIR) and coefficient of variation (CV), and changes in the tissue characteristics of the carotid artery wall, providing further evidence for the association between glucose variability and atherosclerosis progression.
Article
Endocrinology & Metabolism
Joost van der Linden, John B. Welsh, Irl B. Hirsch, Satish K. Garg
Summary: This study analyzed data from 65,067 U.S. users of the G6 rtCGM System and found improvements in time-in-range (TIR) during the COVID-19 pandemic. TIR improvements varied across different regions, and were associated with COVID-19 mortality and household income.
DIABETES TECHNOLOGY & THERAPEUTICS
(2021)
Review
Endocrinology & Metabolism
Evanthia Gouveri, Nikolaos Papanas
Summary: This narrative review presents data on the role of continuous glucose monitoring (CGM) in the management of peripheral diabetic neuropathy (DPN) among individuals with type 1 and type 2 diabetes mellitus. While CGM systems are valuable tools for improving glycaemic control and reducing glycaemic variability (GV), studies on the causal relationship between CGM-derived data and the development of DPN are limited, and it is yet to be determined whether CGM measures can serve as new therapeutic targets for DPN management.
Article
Endocrinology & Metabolism
Takeru Sakai, Kazuki Aoyama, Koji Inazumi, Rieko Kikuchi, Yuki Sato, Ai Tada, Takumi Hirata, Jiro Morimoto
Summary: The study found a significant correlation between TIR, TAR and GA, with multiple regression analysis showing a significant relationship between TIR, TAR, BMI and GA. These findings support the utility of TIR as a marker of glycemic control and suggest a relation between GA and blood glucose fluctuation.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2021)
Correction
Multidisciplinary Sciences
Divija Deshpande, Nitin Agarwal, Thomas Fleming, Claire Gaveriaux-Ruff, Christoph S. N. Klose, Anke Tappe-Theodor, Rohini Kuner, Peter Nawroth
Summary: A correction to the paper has been published.
NATURE COMMUNICATIONS
(2021)
Article
Endocrinology & Metabolism
Junpeng Yang, Dongni Zhao, Yi Chen, Yuehua Ma, Xiaoyang Shi, Xiaobing Wang, Yinghua Lv, Huijuan Yuan
Summary: This study found that serum CTRP9 levels in patients with type 2 diabetes mellitus were associated with the prevalence and severity of cardiac autonomic neuropathy (CAN), serving as a reliable biomarker for exploring CAN in these patients.
JOURNAL OF DIABETES INVESTIGATION
(2021)