Article
Oncology
Qi Lu, Li Wang, Yabiao Gao, Ping Zhu, Luying Li, Xue Wang, Youping Jin, Xiuling Zhi, Jerry Yu, Xin Li, Xingjun Qin, Ping Zhou
Summary: The study revealed that lncRNA APOC1P1-3 promotes breast cancer metastasis by regulating apoptosis and anoikis resistance-related protein expression. It acts as a sponge to block the inhibition of Bcl-2 by specifically binding to miRNA-188-3p.
CANCER CELL INTERNATIONAL
(2021)
Article
Biochemical Research Methods
Lei Tian, Shu-Lin Wang
Summary: The study developed a new method (MSDNMDL) that combines miRNA-disease-lncRNA and miRNA-target networks to explore miRNA sponge networks of breast cancer more effectively.
CURRENT BIOINFORMATICS
(2021)
Article
Multidisciplinary Sciences
Dulari K. Jayarathna, Miguel E. Renteria, Jyotsna Batra, Neha S. Gandhi
Summary: This study identified stage-specific competing endogenous RNAs (ceRNAs) in breast cancer using cancer genome atlas data and investigated their molecular functions and prognostic ability. Five genes and one long non-coding RNA were found to be unique to the stage IV ceRNA network, and these genes have been described in previous breast cancer studies. Survival analysis identified prognostic microRNAs in stages I, II, and III. These findings reveal a set of unique ceRNAs in metastatic breast cancer, and further experimental work is needed to evaluate their role in metastasis. Identifying stage-specific ceRNAs will also contribute to the understanding of personalized therapeutics in breast cancer.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Shuangyan Lin, Mingyuan Zhao, Yanbo Lv, Genxiang Mao, Shiping Ding, Fang Peng
Summary: The study found that high expression of CENPU in breast cancer is associated with poor prognosis, potentially involving cell cycle progression through the PLK1 signaling pathway. Additionally, CENPU expression is significantly correlated with clinicopathological characteristics of breast cancer.
Article
Biochemistry & Molecular Biology
Maria Radanova, Mariya Levkova, Galya Mihaylova, Rostislav Manev, Margarita Maneva, Rossen Hadgiev, Nikolay Conev, Ivan Donev
Summary: There is a growing interest in studying single nucleotide polymorphisms (SNPs) in microRNA (miRNA) genes, as they may be associated with susceptibility, prognosis, and treatment response in colorectal cancer (CRC). These miRNA-SNPs could serve as non-invasive biomarkers for early detection of CRC. However, contradictory findings have been reported when different research groups investigated the same SNP in a gene for a specific miRNA, highlighting the need for more case-control studies involving participants from different ethnic backgrounds. According to our review, three miRNA-SNPs - miR-146a rs2910164, miR-27a rs895819, and miR-608 rs4919510 - appear to be promising prognostic, diagnostic, and predictive biomarkers for CRC.
Article
Cell Biology
Mohammad Taheri, Arash Safarzadeh, Bashdar Mahmud Hussen, Soudeh Ghafouri-Fard, Aria Baniahmad
Summary: The construction of ceRNA network in prostate cancer and the identification of its importance in predicting patient survival were investigated in this study. The analysis of microarray data led to the identification of differentially expressed mRNAs, lncRNAs, and miRNAs. A ceRNA network consisting of miRNAs, lncRNAs, and mRNAs was constructed, and 10 hub genes were identified. The expression levels of these hub genes showed high diagnostic value. Overall, this study introduces novel diagnostic biomarkers for prostate cancer.
Review
Cell Biology
Hui Kong, Ming-Li Sun, Xin-An Zhang, Xue-Qiang Wang
Summary: By investigating the roles and interactions of miRNA, lncRNA, and circRNA in osteoarthritis, their significance in the prevention, diagnosis, and treatment of OA can be identified as potential future therapeutic targets.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Medicine, Research & Experimental
Kai Su, Nannan Wang, Qianqian Shao, Hao Liu, Bao Zhao, Shiyin Ma
Summary: Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) play crucial roles in regulating gene expression and influencing cancer development. The regulatory network between them affects cell growth and development, disruption of which can lead to various diseases, especially cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Oncology
Yogita Chhichholiya, Harsh Vikram Singh, Sandeep Singh, Anjana Munshi
Summary: MicroRNAs (miRNAs) can negatively regulate gene expression by binding to specific mRNAs, which can lead to mRNA degradation or translational repression. Abnormal expression of various miRNAs has been linked to human cancer, including breast cancer (BC), where oncogenic or tumor-suppressor miRNAs regulate important pathways involved in BC development. Genetic variations in miRNA-encoding genes and their target genes contribute to dysregulated gene expression and the progression of BC. Therapeutic approaches for BC include chemotherapy, radiation therapy, surgery, hormone therapy, and targeted biological therapy. This review examines the genetic variations in tumor-suppressor miRNA-encoding genes and their target genes in relation to BC development and prognosis, as well as discusses potential therapeutic interventions targeting these variants for improved disease outcomes.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Article
Oncology
Jiawen Zhao, Lei Zhang, Yingzhu Zhao, Nan Wu, Xi Zhang, Rong Guo, Huimeng Li, Chunxiang Li, Kai Zheng, Dequan Liu, Shicong Tang
Summary: This study investigated the role of lncRNA HOTAIR in breast cancer cells and its molecular mechanism. The results showed that high expression of HOTAIR was associated with cell proliferation, invasion, and migration in breast cancer, and HOTAIR regulated the expression of miR-1 and GOLPH3 genes.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Article
Food Science & Technology
Pan Chao, Feng Yongheng, Zhou Jin, Zhu Yu, Yang Shiyong, Yang Kunxing, Ma Yong
Summary: This study revealed that in gastric cancer development, HOTAIR expression increases while miRNA-206 expression decreases. Knockdown of HOTAIR suppresses cell viability, increases apoptosis, inhibits invasion and migration by regulating miRNA-206, and suppresses CCND1 and CCND2 expression. HOTAIR targeting miRNA-206 and miRNA-206 targeting CCND1 and CCND2 play crucial roles in the antitumor effects in gastric cancer.
FOOD SCIENCE & NUTRITION
(2021)
Article
Cell Biology
Jingxing Liu, Shuyuan Xiao, Jing Chen
Summary: This study investigated the association between inflammation and breast cancer, and established an inflammation-related ceRNA network. It identified lncRNA LRRC75A-AS1 as a potential key player in modulating inflammation response during the initiation and progression of breast cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Medical Laboratory Technology
Meilan Zhang, Xue Bai, Xuemei Zeng, Jiangrong Liu, Feng Liu, Zhiwei Zhang
Summary: Breast cancer has the highest incidence rate among women and the circRNA-miRNA-mRNA axis plays a crucial role in its progression, serving as a potential marker for early diagnosis and treatment.
CLINICA CHIMICA ACTA
(2021)
Review
Pathology
Esmat Abdi, Saeid Latifi-Navid, Hamid Latifi-Navid
Summary: Breast cancer is the most prevalent cancer in females worldwide, with a complex interaction of variables like lifestyle, climate, genetics, and reproductive factors. Long non-coding RNAs (lncRNAs) play important roles in breast cancer development, with their polymorphisms predictive of cancer incidence and useful for early detection and customized therapy. Further large-scale trials and functional assessments are needed to validate the results and shed light on the etiology of breast cancer.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Genetics & Heredity
Zhiwen Wang, Xi Zhu, Hongyun Zhai, Yanghai Wang, Gangyue Hao
Summary: The study identified and established an mRNA-SNP-miRNA interaction network in prostate cancer, suggesting that hsa-miR-21, hsa-miR-30b, and ITGB8 may serve as new biomarkers. A nomogram model containing four variables was constructed for predicting the risk of prostate cancer.
FRONTIERS IN GENETICS
(2022)
Correction
Multidisciplinary Sciences
Shahrzad Aghaei, Behnaz Saffar, Kamran Ghaedi, Mohsen Mobini Dehkordi
JOURNAL OF ADVANCED RESEARCH
(2022)
Article
Oncology
Reza Hashemi, Maryam Peymani, Kamran Ghaedi, Hana Saffar
Summary: This study identified specific pathways in different stages of colorectal cancer (CRC) and evaluated their importance in terms of survival, drug resistance, and sensitivity. The results suggest that these pathways and top rank genes are associated with cancer progression, drug resistance, poor survival, and metastasis in CRC. Therefore, identifying and targeting these pathways at each stage could be crucial in inhibiting CRC progression.
Article
Biochemistry & Molecular Biology
Mehdi Roshanian Bakhsh, Maryam Peymani, Leila Rouhi, Kamran Ghaedi
Summary: This study aimed to introduce a new conventional chemotherapy drug based on the transcriptome of TNBC patients. Through analyzing gene expression differences in the presence of different drugs, Rapamycin was identified as a suitable drug for TNBC treatment. Rapamycin significantly affected the viability and apoptosis rate of TNBC cells.
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
(2022)
Article
Medicine, Research & Experimental
Fatemeh Kazeminasab, Maryam Baharlooie, Kamran Ghaedi
Summary: This study aimed to identify ncRNAs involved in the etiology of MAFLD as potential therapeutic targets. The results identified 127 ncRNAs associated with MAFLD, of which 25 had been previously validated for regulating PPARs. The findings suggest that these ncRNAs could aid in guiding preclinical and clinical studies to explore the therapeutic potential by targeting PPARs in MAFLD.
Article
Biotechnology & Applied Microbiology
Maryam Baharlooie, Maryam Peymani, Mohammad Hossein Nasr-Esfahani, Kamran Ghaedi
Summary: Understanding the mechanisms of cardiac progenitor formation is crucial for obtaining a sufficient population of cardiac-committed progenitor cells. This study reveals the essential role of ROS in cardiac cell differentiation, and the preventive effect of antioxidants on proper cardiac differentiation.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Oncology
Manizheh Sajadi, Mohammad Fazilti, Habibollah Nazem, Mohammad Mahdevar, Kamran Ghaedi
Summary: This study analyzed the abnormal expression of transcription factors in colorectal cancer (CRC) and their impact on patient prognosis and related pathways. The findings showed that certain transcription factors were associated with poor prognosis, while others were associated with good prognosis. A predictive model based on the expression of these transcription factors accurately predicted patient survival rates. Additionally, co-expression network analysis revealed the involvement of these transcription factors in metastatic pathways and apoptotic pathways.
CANCER CELL INTERNATIONAL
(2022)
Article
Pathology
Faramarz Vejdandoust, Rahmaneh Moosavi, Nasrin Fattahi Dolatabadi, Atefeh Zamani, Hossein Tabatabaeian
Summary: Incomplete knowledge of the molecular basis of colorectal cancer has led to its high mortality rate. By analyzing TCGA data and using qPCR, this study identified two down-regulated long noncoding RNAs (lncRNAs), MIMT1 and LINC01550, in colorectal cancer. The results suggest that MIMT1 and LINC01550 may play important roles as tumor suppressor genes and in regulating the cancer signaling pathway(s).
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
(2023)
Review
Cell Biology
Jia Jia Chan, Hossein Tabatabaeian, Yvonne Tay
Summary: The majority of human mRNAs generate alternative 3' UTRs through various processes, including RNA editing, m6A methylation, and alternative polyadenylation (APA), with 3' UTR splicing as an emerging mechanism. Regulation of these processes at the genome and transcriptome levels contribute to 3' UTR heterogeneity. Genomic variants in 3' UTR regions and aberrant 3' UTR processing are associated with cancer and their deregulation may contribute to cancer pathogenesis. In-depth characterization of these events will enhance our understanding of their significance and aid in therapeutic development.
TRENDS IN CELL BIOLOGY
(2023)
Correction
Oncology
Manizheh Sajadi, Mohammad Fazilati, Habibollah Nazem, Mohammad Mahdevar, Kamran Ghaedi
CANCER CELL INTERNATIONAL
(2023)
Review
Biochemistry & Molecular Biology
Hamed Bashiri, Hossein Tabatabaeian
Summary: Multiple myeloma, the second most prevalent hematologic malignancy, has seen increased survival rates due to novel drugs and combination therapies. However, drug resistance remains a significant issue, with autophagic activity playing a critical role. High mobility group box protein 1 (HMGB1)-dependent autophagy and proteasome suppression-induced autophagy have been found to contribute to drug resistance in multiple myeloma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Leila Asad Samani, Kamran Ghaedi, Ahmad Majd, Maryam Peymani, Masoud Etemadifar
Summary: This study aimed to assess the overlap of PD patients' transcriptomes in the substantia nigra (SN) with peripheral blood mononuclear cells (PBMCs) to discover potential biomarkers for diagnosis. Through the analysis of gene expression differences and validation using RT-qPCR, HSPA1A/B, DGKH, and NOTCH2 were identified as potential biomarkers for PD diagnosis.
NEUROLOGICAL SCIENCES
(2023)
Article
Pathology
Niloufar Salimian, Maryam Peymani, Kamran Ghaedi, Sepideh Mirzaei, Mehrdad Hashemi
Summary: Recent findings have indicated an increased expression of LINC01929 in various cancer types, accompanied by a higher mortality rate. The gene co-expression network revealed a strong association between LINC01929 and metastatic genes such as COL5A1. RT-qPCR confirmed the elevated expression of LINC01929 in colorectal, gastric, and breast cancer tissues. LINC01929 could serve as a potential candidate for diagnosis and therapy as an oncogene and regulator of metastatic pathways.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Biochemistry & Molecular Biology
Khatere Mokhtari, Maryam Peymani, Mohsen Rashidi, Kiavash Hushmandi, Kamran Ghaedi, Afshin Taheriazam, Mehrdad Hashemi
Summary: Methodological innovations over the last four decades have revolutionized transcriptome profiling, with RNA sequencing (RNA-seq) now enabling the sequencing and quantification of transcriptional outputs of individual cells or thousands of samples. This technology allows for a better understanding of the molecular mechanisms underlying cellular behaviors, particularly in the context of cancer, providing opportunities for unraveling tumor complexity and identifying novel biomarkers and treatment options. The transcriptome of colon cancer has been extensively studied in this review, considering various risk factors and non-coding RNAs, and holds promise for earlier and more accurate diagnosis, offering improved prognostic utility to medical teams and patients.
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
(2023)
Article
Respiratory System
Mohammad Talaei, Pauline M. Emmett, Raquel Granell, Hossein Tabatabaeian, Kate Northstone, Anna Bergstrom, Seif O. Shaheen
Summary: A study found that different dietary patterns in childhood are associated with lung function and incident asthma in adolescence. A 'health-conscious' diet was positively associated with lung function, while a diet high in processed food was negatively associated with lung function. However, there was no significant association between a 'traditional' diet and lung function or incident asthma.
RESPIRATORY RESEARCH
(2023)
Article
Cell & Tissue Engineering
Masoud Vazirzadeh, Negar Azarpira, Parsa Davoodi, Massoud Vosough, Kamran Ghaedi
Summary: Chronic liver diseases cause two million deaths annually worldwide. Liver transplantation is hindered by limited donor livers and lifelong side effects, leading researchers to explore tissue engineering as a promising alternative therapy for liver repair and regeneration. Biological scaffolds play a crucial role in tissue engineering by mimicking extracellular matrices and promoting biodegradability and biocompatibility.
STEM CELL REVIEWS AND REPORTS
(2022)