Dexmedetomidine Attenuates Cellular Injury and Apoptosis in H9c2 Cardiomyocytes by Regulating p-38MAPK and Endoplasmic Reticulum Stress

Mesenchymal stem cell-derived exosomes protect beta cells against hypoxia-induced apoptosis via miR-21 by alleviating ER stress and inhibiting p38 MAPK phosphorylation

(2020) Jin Chen et al.   Stem Cell Research & Therapy

Dexmedetomidine Alleviated Endoplasmic Reticulum Stress via Inducing ER-phagy in the Spinal Cord of Neuropathic Pain Model

(2020) Yongda Liu et al.   Frontiers in Neuroscience

Dexmedetomidine protects H9C2 against hypoxia/reoxygenation injury through miR-208b-3p/Med13/Wnt signaling pathway axis

(2020) Zhuoran Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Dexmedetomidine attenuates endoplasmic reticulum stress-induced apoptosis and improves neuronal function after traumatic brain injury in mice

(2020) Dongdong Sun et al.   BRAIN RESEARCH

The p38 Pathway: From Biology to Cancer Therapy

(2020) Adrián Martínez-Limón et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dexmedetomidine protects intestinal ischemia-reperfusion injury via inhibiting p38 MAPK cascades

(2020) Xiao-Ming Liu et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Multitarget Strategies to Reduce Myocardial Ischemia/Reperfusion Injury

(2019) Sean M. Davidson et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

High Glucose Suppresses Keratinocyte Migration Through the Inhibition of p38 MAPK/Autophagy Pathway

(2019) Lingfei Li et al.   Frontiers in Physiology

The brain protective effect of dexmedetomidine during surgery for paediatric patients with congenital heart disease

(2019) Jin Gong et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Oleate inhibits hepatic autophagy through p38 mitogen-activated protein kinase (MAPK)

(2019) Jie Ning et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ablation of Toll-like receptor 9 attenuates myocardial ischemia/reperfusion injury in mice

(2019) Rika Kitazume-Taneike et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dexmedetomidine preconditioning attenuates ischemia/reperfusion injury in isolated rat hearts with endothelial dysfunction

(2019) Liang He et al.   BIOMEDICINE & PHARMACOTHERAPY

Dexmedetomidine-induced cardioprotection is mediated by inhibition of high mobility group box-1 and the cholinergic anti-inflammatory pathway in myocardial ischemia-reperfusion injury

(2019) Juan Zhang et al.   PLoS One

Dexmedetomidine protects H9c2 cardiomyocytes against oxygen-glucose deprivation/reoxygenation-induced intracellular calcium overload and apoptosis through regulating FKBP12.6/RyR2 signaling

(2019) Mei Yuan et al.   Drug Design Development and Therapy

Dexmedetomidine attenuates neuronal injury after spinal cord ischaemia‐reperfusion injury by targeting the CNPY2‐endoplasmic reticulum stress signalling

(2019) Lina Zhao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Dexmedetomidine exerts a protective effect on ischemia-reperfusion injury after hepatectomy: A prospective, randomized, controlled study

(2019) Yu Zhang et al.   JOURNAL OF CLINICAL ANESTHESIA

Characteristics of Dexmedetomidine Postconditioning in the Field of Myocardial Ischemia–Reperfusion Injury

(2019) Sebastian Bunte et al.   ANESTHESIA AND ANALGESIA

Dehydroepiandrosterone resisted E. Coli O157:H7-induced inflammation via blocking the activation of p38 MAPK and NF-κB pathways in mice

(2019) Jinlong Zhao et al.   CYTOKINE

Dexmedetomidine Exerts Brain-Protective Effects Under Cardiopulmonary Bypass Through Inhibiting the Janus Kinase 2/Signal Transducers and Activators of Transcription 3 Pathway

(2019) Jijun Xiong et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Dexmedetomidine Inhibits Neuroinflammation by Altering Microglial M1/M2 Polarization Through MAPK/ERK Pathway

(2019) Zhengguo Qiu et al.   NEUROCHEMICAL RESEARCH

Endoplasmic Reticulum Chaperone GRP78 Protects Heart From Ischemia/Reperfusion Injury Through Akt ActivationNovelty and Significance

(2018) Xukun Bi et al.   CIRCULATION RESEARCH

Cardioprotection research must leave its comfort zone

(2018) Gerd Heusch   EUROPEAN HEART JOURNAL

Dexmedetomidine restores autophagy and cardiac dysfunction in rats with streptozotocin-induced diabetes mellitus

(2018) Ju Eun Oh et al.   ACTA DIABETOLOGICA

Dexmedetomidine alleviates cerebral ischemia-reperfusion injury by inhibiting endoplasmic reticulum stress dependent apoptosis through the PERK-CHOP-Caspase-11 pathway

(2018) Chong Liu et al.   BRAIN RESEARCH

Renoprotective effects of dexmedetomidine against ischemia-reperfusion injury in streptozotocin-induced diabetic rats

(2018) Seung Hyun Kim et al.   PLoS One

Dexmedetomidine protects against oxygen-glucose deprivation/reoxygenation injury-induced apoptosis via the p38 MAPK/ERK signalling pathway

(2017) Ke Wang et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Dexmedetomidine protects the heart against ischemia-reperfusion injury by an endothelial eNOS/NO dependent mechanism

(2016) Jaime A. Riquelme et al.   PHARMACOLOGICAL RESEARCH

Hepatitis B Virus Middle Protein Enhances IL-6 Production via p38 MAPK/NF-κB Pathways in an ER Stress-Dependent Manner

(2016) Yang-Xia Li et al.   PLoS One

Inhibition of p38 MAPK activation protects cardiac mitochondria from ischemia/reperfusion injury

(2015) Sarawut Kumphune et al.   PHARMACEUTICAL BIOLOGY

Endoplasmic reticulum stress induces the expression of COX-2 through activation of eIF2α, p38-MAPK and NF-κB in advanced glycation end products stimulated human chondrocytes

(2012) Zafar Rasheed et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mammalian MAPK Signal Transduction Pathways Activated by Stress and Inflammation: A 10-Year Update

(2012) John M. Kyriakis et al.   PHYSIOLOGICAL REVIEWS

Hypoxia protects articular chondrocytes from thapsigargin-induced apoptosis

(2009) Atul A. Chaudhari et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

ER stress is involved in B cell antigen receptor ligation-induced apoptosis

(2007) Bin-Cheng Yan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS