Copper-Catalyzed Borylative Difunctionalization of π-Systems

Organoboronates represent a cornerstone functional group in modern synthesis owing to their unique reactivity and divergent synthetic capability. Copper catalysis has become one of the most powerful methods to stereoselectively install boron across diverse pi-systems. Additionally, this method affords tremendous versatility enabled by difunctionalization of the pi-system by the addition of an electrophile. This review covers known electrophiles to intercept catalytic intermediates in borylative difunctionalization strategies that have been reported up to the end of May 2020.