Article
Chemistry, Multidisciplinary
Su-Bin Lee, Seung-Min Paek, Jae-Min Oh
Summary: The research proposed a method to immobilize AgNP on metal oxide for enhanced SERS activity. Characterization and SERS tests showed that the sample prepared at 600 degrees C exhibited the best performance.
Article
Nanoscience & Nanotechnology
Rishabh Rastogi, Hamed Arianfard, David Moss, Saulius Juodkazis, Pierre-Michel Adam, Sivashankar Krishnamoorthy
Summary: This study demonstrates the crucial impact of EM hot-spots on molecular detection sensitivity in plasmonic nanopillar arrays. Results show that the analyte dimensions have a significant influence on the sensitivity of hot-spots, and that fluorescence detection has advantages over Raman detection when facing spatial limitations.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Yanzhao Pang, Mingliang Jin
Summary: A highly aligned AgNW array film was prepared using a self-assembly method, which showed excellent signal reproducibility and detection ability at low concentrations. The uniform distribution of hot spots inside the AgNW substrate amplified the SERS signal.
Article
Chemistry, Multidisciplinary
Andreas Tsiamis, Francisco Diaz Sanchez, Niklas Hartikainen, Michael Chung, Srinjoy Mitra, Ying Chin Lim, Huey Ling Tan, Norbert Radacsi
Summary: This study presents a scalable method for developing ultrasensitive electrochemical biosensors by maximizing sensor conductivity through graphene wrapping of carbonized electrospun nanofibers. The effectiveness of the graphene wrap was determined visually and chemically, with the graphene-wrapped carbonized nanofiber electrode showing significantly improved performance. Despite inhibitive effects from the carbon glue used, the graphene-wrapped carbonized nanofibers exhibited potential for a highly conductive and inert sensing platform.
Article
Chemistry, Multidisciplinary
Dao Thi Nguyet Nga, Quan Doan Mai, Ha Anh Nguyen, Nguyen Le Nhat Trang, Pham Minh Khanh, Nguyen Quang Hoa, Vu Dinh Lam, Van-Tuan Hoang, Anh-Tuan Le
Summary: A functional ternary substrate consisting of MnO2 nanosheets, graphene oxide (GO) nanosheets, and plasmonic Ag nanoparticles (e-AgNPs) was developed for surface-enhanced Raman scattering (SERS) sensing systems. The substrate showed enhanced SERS sensing signal for organic chemicals without the need for chemical bonds, and improved sensing performance compared to individual components.
Article
Chemistry, Physical
Mingming Chen, Bowen Du, Qian Wang, Jiaxin Zhang, Xiajun Zhu, Zhengyu Lin, Yongqiang Dong, FengFu Fu, Ting Yu
Summary: Single-layer carbon dots are used as capping agents in the synthesis of silver nanoparticles, leading to the formation of nanohybrids that can self-assemble into different nanostructures. The aggregation of AgNPs/CDs is controlled by the key role of CDs, affecting surface plasmon absorption and SERS activity. Various dimensions of aggregated AgNPs/CDs serve as effective SERS substrates with strong localized surface plasmon resonance.
Article
Multidisciplinary Sciences
C. Awada, C. Dab, M. G. Grimaldi, A. Alshoaibi, F. Ruffino
Summary: This study highlights the high optical enhancement observed in Ag/Au alloys and porous gold nanostructures using SERS. The formation of Ag/Au alloy particles and subsequent dealloying process leading to the formation of Au nanoporous particles were observed. The highly enhancement factor in porous gold nanostructures is attributed to the presence of dense strong hot spots and large specific area, showing promising potential for SERS applications.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Eric Boateng Osei, Liliia Paniushkina, Konrad Wilhelm, Juergen Popp, Irina Nazarenko, Christoph Krafft
Summary: Extracellular vesicles (EVs) ranging in size from 60 to 800 nm were isolated from plasma of control and prostate cancer patients using differential centrifugation and ultrafiltration techniques. Spontaneous Raman and surface-enhanced Raman spectroscopy (SERS) were employed to identify fractions that best discriminate between control and cancer patients, with results showing that EV12 and EV120 fractions provide the most effective separation.
Article
Engineering, Environmental
Qing Yang, Shaoying Zhang, Jie Su, Shu Li, Xiaochen Lv, Jing Chen, Yongchao Lai, Jinhua Zhan
Summary: This study proposes a method that combines membrane filtration and surface-enhanced Raman spectroscopy to analyze trace nanoplastics in water. The method achieves high sensitivity detection of low-concentration nanoplastics by using a bifunctional Ag nanowire membrane to enrich and enhance their Raman spectra in situ.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Antonio Sasso, Angela Capaccio, Giulia Rusciano
Summary: This review focuses on the recent studies conducted by our group in the past decade, where novel nanofabrication techniques were successfully applied to SERS and TERS experiments for studying bio-systems and molecular species of environmental interest.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Analytical
Monica Ricci, Beatrice Fortuni, Raffaele Vitale, Qiang Zhang, Yasuhiko Fujita, Shuichi Toyouchi, Gang Lu, Susana Rocha, Tomoko Inose, Hiroshi Uji-I
Summary: The study introduced the use of silver nanowires as endoscopic probes for detecting intracellular Raman signals and proposed an advanced strategy to significantly enhance their performance. By uniformly forming gold structures on the smooth AgNW surface, high surface-enhanced Raman scattering efficiency was achieved, demonstrating applicability for molecular sensing in cells.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Shu Hu, Jingyu Wang, Yue-Jiao Zhang, Bao-Ying Wen, Si-Si Wu, Petar M. Radjenovic, Zhilin Yang, Bin Ren, Jian-Feng Li
Summary: In this study, the shell and structural effect of shell-isolated nanoparticle-enhanced Raman spectroscopy (SHINERS) were investigated. It was found that the field enhancement loss due to the shell could be overcome by optimizing the coupling geometry of the shell-isolated nanoparticles (SHINs), and signal enhancement could be further optimized by altering the aggregation geometries of the nanoparticles.
Article
Chemistry, Physical
Giuliana Faggio, Rossella Grillo, Nicola Lisi, Francesco Buonocore, Rosa Chierchia, Min Jung Kim, Gwan-Hyoung Lee, Andrea Capasso, Giacomo Messina
Summary: In this study, ultrasensitive graphene substrates were developed using ethanol Chemical Vapor Deposition (CVD), capable of detecting trace amounts of molecules down to extremely low concentrations. This exceptional result is attributed to two main features: more efficient charge transfer and a large number of grain boundaries that act as trapping sites for the molecules.
APPLIED SURFACE SCIENCE
(2022)
Article
Biochemical Research Methods
Lamyaa M. Almehmadi, Vibhav A. Valsangkar, Ken Halvorsen, Qiang Zhang, Jia Sheng, Igor K. Lednev
Summary: The growing demand for new drugs has led to the development of new techniques for drug discovery. SERS, a label-free technique, has been used to detect molecular interactions, and a SERS platform has been developed for the detection of protein-RNA binding. The results showed that only one peptide was able to bind to the RNA.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Optics
Lu Zhang, Chao Meng, Hao Yang, Wending Zhang
Summary: In this study, an azimuthal vector beam was used to illuminate the plasmonic tips circular cluster (PTCC) array, enhancing the electric near-field intensity and improving the sensitivity of surface-enhanced Raman spectroscopy (SERS). Experimental results showed that the azimuthal vector beam excitation achieved stronger electric near-field enhancement compared to linearly polarized beam and radial vector beam excitations. This research has important implications for sensing technologies, particularly trace amount detection.
CHINESE OPTICS LETTERS
(2023)
Article
Biochemical Research Methods
Yuqi Zhou, Masako Nishikawa, Hiroshi Kanno, Ruoxi Yang, Yuma Ibayashi, Ting-Hui Xiao, Walker Peterson, Maik Herbig, Nao Nitta, Shigeki Miyata, Yogendra Kanthi, Gustavo K. Rohde, Kyoji Moriya, Yutaka Yatomi, Keisuke Goda
Summary: This study used image-based single-cell profiling and temporal monitoring to investigate the long-term effects of Pfizer-BioNTech COVID-19 vaccines on platelet function. The results showed that there were no significant or persisting platelet aggregation trends following the vaccine doses.
Article
Chemistry, Analytical
Yasutaka Kitahama, Pablo Martinez Pancorbo, Hiroki Segawa, Machiko Marumi, Ting-Hui Xiao, Kotaro Hiramatsu, William Yang, Keisuke Goda
Summary: We propose a new measurement scheme based on Place & Play SERS, which utilizes an ultrathin, flexible, stretchable, adhesive, biointegratable gold-deposited PVA nanomesh substrate. This method allows for SERS measurement of an object by placing the substrate on top without touching, destroying, or sampling it. Experimental results validate this new measurement scheme and demonstrate its practical applications in fields such as food safety testing and forensic analysis.
ANALYTICAL METHODS
(2023)
Article
Physics, Applied
Jianhai He, Mohamed M. Abdel-Galeil, Mana Nemoto, Naoki Kishimoto, Shin-ichi Morita
Summary: Research on live cells using a Raman microscope (bio-Raman research) is versatile but complex. Non-negative matrix factorization (NMF) is an effective method to analyze bio-Raman data, but it lacks uniqueness in decomposition. This can cause cross-talks among factorized signals, disrupting quantitative analysis. To address this, a practical methodology of bio-Raman NMF is described.
APPLIED PHYSICS EXPRESS
(2023)
Article
Biochemical Research Methods
Yunjie Deng, Hui Min Tay, Yuqi Zhou, Xueer Fei, Xuke Tang, Masako Nishikawa, Yutaka Yatomi, Han Wei Hou, Ting-Hui Xiao, Keisuke Goda
Summary: Vascular stenosis caused by atherosclerosis leads to platelet activation and aggregation, resulting in thrombus formation. Antiplatelet drugs are commonly used but may not prevent recurrent thrombotic events due to limited understanding of their efficacy in the complex hemodynamic environment. We propose and demonstrate a method involving a 3D stenosis microfluidic chip and optical time-stretch quantitative phase imaging system for studying the efficacy of antiplatelet drugs under stenosis. Our method simulates the flow environment of vascular stenosis and enables high-resolution and statistical analysis of platelet aggregates. This method can assist in developing optimal pharmacologic strategies for patients with atherosclerosis.
Review
Chemistry, Multidisciplinary
Tamitake Itoh, Marek Prochazka, Zhen-Chao Dong, Wei Ji, Yuko S. Yamamoto, Yao Zhang, Yukihiro Ozaki
Summary: Surface-enhanced Raman scattering (SERS) and tip-enhanced Raman scattering (TERS) have opened up exciting research fields, but their practical applications are still limited. This review aims to update the recent fundamental and application studies of SERS and TERS and explore new directions and perspectives by combining their mechanisms and applications. It discusses topics such as plasmonic hotspots for SERS, angstrom-resolved TERS, chemical mechanisms, and bridging the gap between mechanism studies and applications.
Article
Biochemical Research Methods
Chenqi Zhang, Maik Herbig, Yuqi Zhou, Masako Nishikawa, Mohammad Shifat-E-Rabbi, Hiroshi Kanno, Ruoxi Yang, Yuma Ibayashi, Ting-Hui Xiao, Gustavo K. Rohde, Masataka Sato, Satoshi Kodera, Masao Daimon, Yutaka Yatomi, Keisuke Goda
Summary: Using a microfluidic imaging flow cytometer, the researchers measured the blood of 181 COVID-19 samples and 101 non-COVID-19 thrombosis samples. They trained a convolutional neural network to distinguish different blood cell types and performed image analysis for each subpopulation. Based on the obtained features, machine learning models were trained to classify COVID-19 and non-COVID-19 thrombosis, achieving a patient testing accuracy of 75%. The analysis was optimized for efficiency and implemented in an easy-to-use plugin, allowing real-time diagnosis on mid-range computers.
Article
Chemistry, Physical
Tamitake Itoh, Yuko S. Yamamoto
Summary: We investigated the origin of the identical polarization angle dependence between surface-enhanced resonant Raman scattering (SERRS) and plasmon resonance elastic scattering (PRES) for two types of single silver nanoparticle aggregates. The first type (Type I), in which the SERRS spectral envelopes are similar to the PRES spectra, shows the identical polarization dependence between the SERRS and PRES. The second type (Type II), in which the SERRS envelopes largely deviate from the PRES spectra, also exhibits identical polarization dependence.
JOURNAL OF PHYSICAL CHEMISTRY B
(2023)
Article
Chemistry, Physical
Tamitake Itoh, Yuko S. Yamamoto
Summary: In this study, we investigate the spectral relationships between electromagnetic enhancement, surface-enhanced resonant Raman scattering (SERRS), and surface-enhanced fluorescence (SEF) by using single silver nanoparticle dimers as a model system. We focus on the lowest-energy plasmon in far-field scattering and classify the spectral relationships into two types. Based on our analysis, we find that dipole-dipole and dipole-quadrupole-coupled plasmon resonance are responsible for the electromagnetic enhancement.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Optics
Weicheng Chen, Dian Wan, Qi He, Jiaqi Wang, Haofeng Hu, Tiegen Liu, Hon Ki Tsang, Zhenzhou Cheng
Summary: Short-wavelength mid-infrared (MIR) silicon photonics has various applications in optical communications, chemical analysis, and environmental monitoring. In this study, a relaxed-tolerance subwavelength grating (SWG) coupler design with dual-hole structures was demonstrated to overcome fabrication variations and improve reproducibility. The relaxed-tolerance SWG coupler achieved a peak coupling efficiency of -6.2 dB at a wavelength of 2.038 μm with a 1-dB bandwidth of about 30 nm.
OPTICS AND LASER TECHNOLOGY
(2023)
Article
Optics
Qi He, Senmiao Han, Weicheng Chen, Haofeng Hu, Tiegen Liu, Zhenzhou Cheng
Summary: Mid-infrared (Mid-IR) silicon photonics has gained significant attention in the development of chip-integrated molecular sensors. Microring resonators (MRRs) with high-quality factors, reproducibility in fabrication, and compact footprints are useful for sensing purposes. However, the limited availability and high cost of mid-IR equipment, such as tunable lasers or spectrometers, hinder the applications of MRR-based sensors. In this study, we propose a theoretical approach to overcome this limitation by using an MRR-based nitrogen dioxide gas sensor that utilizes a monochromatic mid-IR laser. Additionally, graphene is employed as a sensitizing medium to modify the phase of the propagating light in the silicon waveguide after gas molecule adsorption. The proposed sensor achieves a theoretical sensitivity of 1.259 x 10-5 RIU/ppm, a limit of detection of 5.1 ppm, and a detection range of 5135 ppm. This research is expected to pave the way for the development of chip-integrated, low-cost, and highly sensitive optical gas sensors.
OPTICS COMMUNICATIONS
(2023)
Article
Physics, Multidisciplinary
Weicheng Chen, Qi He, Rongxiang Guo, Dian Wan, Qun Han, Haofeng Hu, Jiaqi Wang, Yi Zou, Ting-Hui Xiao, Tiegen Liu, Zhenzhou Cheng
Summary: Mid-infrared (Mid-IR) Kerr frequency combs have great potential in sensing and spectroscopy. We theoretically study a technique for generating a mid-IR Kerr frequency comb using a monochromatic mid-IR laser and a graphene-on-silicon micro-resonator. The approach utilizes an electric-field-assisted resonance scanning technique and graphene-enhanced silicon Kerr nonlinearity. Our results show the generation of a soliton Kerr frequency comb with a wide spectral range, bandwidth, and frequency spacing. This study paves the way for the development of cost-effective and fast-tuning mid-IR Kerr frequency combs.
Article
Chemistry, Analytical
Haowei Duan, Yizhou Wang, Shi-Yang Tang, Ting-Hui Xiao, Keisuke Goda, Ming Li
Summary: This study presents a carbon-based E-CRISPR modified with gold nanoparticles and MXene Ti3C2 for stable and sensitive detection of nucleic acids. The developed sensor shows excellent analytical performance and long-term shelf life.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Physical
Tamitake Itoh, Yuko S. Yamamoto
Summary: The relationship between the enhancement of optical responses of molecules and plasmon resonance has been investigated using different techniques. Quantum optics predicts that this enhancement is directly related to optical absorption and indirectly related to Rayleigh scattering and extinction. A micro-spectroscopic method is developed to obtain various optical properties and electromagnetic (EM) enhancement in plasmonic systems. The results show that absorption reproduces the EM enhancement better than Rayleigh scattering or extinction, emphasizing the importance of absorption spectroscopy in evaluating EM enhancement in coupled plasmonic systems.
JOURNAL OF CHEMICAL PHYSICS
(2023)
Editorial Material
Optics
Ting-Hui Xiao, Yuqi Zhou, Keisuke Goda
Summary: In-silico clearing is a breakthrough method that corrects image blur caused by scattering and aberration, enabling deep optical imaging of biological samples. This technique provides researchers with unprecedented insights into three-dimensional biological systems, offering enormous potential for advancing biology and medicine to better understand living organisms and human health.
LIGHT-SCIENCE & APPLICATIONS
(2023)
Article
Engineering, Electrical & Electronic
Hedong Liu, Xiaobo Li, Zhenzhou Cheng, Tiegen Liu, Jingsheng Zhai, Haofeng Hu
Summary: Color polarimetric imaging provides multidimensional information for object properties and has various applications. However, polarimetric images have lower SNR and are more sensitive to noise than conventional color images, leading to noisy images and degraded polarization analysis. In this article, a 3-D CNN is proposed to denoise color polarimetric images by utilizing the coherence among space, color, and polarization. Experiments show that this method effectively removes noise and restores polarization information, suggesting potential applications in multidimensional imaging tasks.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2023)
