Enhancing intracellular accumulation and target engagement of PROTACs with reversible covalent chemistry
出版年份 2020 全文链接
标题
Enhancing intracellular accumulation and target engagement of PROTACs with reversible covalent chemistry
作者
关键词
-
出版物
Nature Communications
Volume 11, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2020-08-26
DOI
10.1038/s41467-020-17997-6
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Proteolysis-Targeting Chimeras as Therapeutics and Tools for Biological Discovery
- (2020) George M. Burslem et al. CELL
- Harnessing the Power of Proteolysis for Targeted Protein Inactivation
- (2020) Rati Verma et al. MOLECULAR CELL
- Unifying principles of bifunctional, proximity-inducing small molecules
- (2020) Christopher J. Gerry et al. Nature Chemical Biology
- Targeted Degradation of Oncogenic KRASG12C by VHL-Recruiting PROTACs
- (2020) Michael J. Bond et al. ACS Central Science
- Development of Dual and Selective Degraders of Cyclin-Dependent Kinases 4 and 6
- (2019) Baishan Jiang et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- PROTAC-Mediated Degradation of Bruton’s Tyrosine Kinase Is Inhibited by Covalent Binding
- (2019) Christopher P. Tinworth et al. ACS Chemical Biology
- A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo
- (2019) Longchuan Bai et al. CANCER CELL
- Targeting the C481S Ibrutinib-Resistance Mutation in Bruton’s Tyrosine Kinase Using PROTAC-Mediated Degradation
- (2018) Alexandru D. Buhimschi et al. BIOCHEMISTRY
- PROTAC-induced BTK degradation as a novel therapy for mutated BTK C481S induced ibrutinib-resistant B-cell malignancies
- (2018) Yonghui Sun et al. CELL RESEARCH
- Bruton’s Tyrosine Kinase Is Not Essential for B Cell Survival beyond Early Developmental Stages
- (2018) Lindsay E. Nyhoff et al. JOURNAL OF IMMUNOLOGY
- Delineating the role of cooperativity in the design of potent PROTACs for BTK
- (2018) Adelajda Zorba et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Quantitative Live-Cell Kinetic Degradation and Mechanistic Profiling of PROTAC Mode of Action
- (2018) Kristin M. Riching et al. ACS Chemical Biology
- CrbnI391Vis sufficient to conferin vivosensitivity to thalidomide and its derivatives in mice
- (2018) Emma C. Fink et al. BLOOD
- Dynamic Imaging of Small Molecule Induced Protein–Protein Interactions in Living Cells with a Fluorophore Phase Transition Based Approach
- (2018) Chan-I Chung et al. ANALYTICAL CHEMISTRY
- Quantitative Real-Time Imaging of Glutathione with Subcellular Resolution
- (2018) Xiqian Jiang et al. ANTIOXIDANTS & REDOX SIGNALING
- Bruton's Tyrosine Kinase degradation as a therapeutic strategy for cancer
- (2018) Dennis Dobrovolsky et al. BLOOD
- Humanized cereblon mice revealed two distinct therapeutic pathways of immunomodulatory drugs
- (2018) Yohannes Gemechu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Identification and Characterization of Von Hippel-Lindau-Recruiting Proteolysis Targeting Chimeras (PROTACs) of TANK-Binding Kinase 1
- (2017) Andrew P. Crew et al. JOURNAL OF MEDICINAL CHEMISTRY
- Structural basis of PROTAC cooperative recognition for selective protein degradation
- (2017) Morgan S Gadd et al. Nature Chemical Biology
- Reversible Reaction-Based Fluorescent Probe for Real-Time Imaging of Glutathione Dynamics in Mitochondria
- (2017) Jianwei Chen et al. ACS Sensors
- Intracellular drug bioavailability: a new predictor of system dependent drug disposition
- (2017) André Mateus et al. Scientific Reports
- Battling Btk Mutants With Noncovalent Inhibitors That Overcome Cys481 and Thr474 Mutations
- (2016) Adam R. Johnson et al. ACS Chemical Biology
- Strained Cyclic Disulfides Enable Cellular Uptake by Reacting with the Transferrin Receptor
- (2016) Daniel Abegg et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins
- (2015) Dennis L. Buckley et al. ACS Chemical Biology
- Quantitative Imaging of Glutathione in Live Cells Using a Reversible Reaction-Based Ratiometric Fluorescent Probe
- (2015) Xiqian Jiang et al. ACS Chemical Biology
- Ring Tension Applied to Thiol-Mediated Cellular Uptake
- (2015) Giulio Gasparini et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Prolonged and tunable residence time using reversible covalent kinase inhibitors
- (2015) J Michael Bradshaw et al. Nature Chemical Biology
- Catalytic in vivo protein knockdown by small-molecule PROTACs
- (2015) Daniel P Bondeson et al. Nature Chemical Biology
- Theoretical and Experimental Investigation of Thermodynamics and Kinetics of Thiol-Michael Addition Reactions: A Case Study of Reversible Fluorescent Probes for Glutathione Imaging in Single Cells
- (2015) Jianwei Chen et al. ORGANIC LETTERS
- Target engagement and drug residence time can be observed in living cells with BRET
- (2015) Matthew B. Robers et al. Nature Communications
- ZDOCK server: interactive docking prediction of protein-protein complexes and symmetric multimers
- (2014) B. G. Pierce et al. BIOINFORMATICS
- Targeting of the MET receptor tyrosine kinase by small molecule inhibitors leads to MET accumulation by impairing the receptor downregulation
- (2014) Dominic Leiser et al. FEBS LETTERS
- Design of Reversible, Cysteine-Targeted Michael Acceptors Guided by Kinetic and Computational Analysis
- (2014) Shyam Krishnan et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Resistance Mechanisms for the Bruton's Tyrosine Kinase Inhibitor Ibrutinib
- (2014) Jennifer A. Woyach et al. NEW ENGLAND JOURNAL OF MEDICINE
- CHARMM36 all-atom additive protein force field: Validation based on comparison to NMR data
- (2013) Jing Huang et al. JOURNAL OF COMPUTATIONAL CHEMISTRY
- A Comprehensive Mathematical Model for Three-Body Binding Equilibria
- (2013) Eugene F. Douglass et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Targeting BTK with Ibrutinib in Relapsed or Refractory Mantle-Cell Lymphoma
- (2013) Michael L. Wang et al. NEW ENGLAND JOURNAL OF MEDICINE
- PKSolver: An add-in program for pharmacokinetic and pharmacodynamic data analysis in Microsoft Excel
- (2010) Yong Zhang et al. COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
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