Review
Medicine, General & Internal
Xinzhe Feng, Junjie Qiao, Weidong Xu
Summary: Ankylosing spondylitis (AS) is a rheumatic bone and joint disease characterized by inflammation, erosion, and pathological bone formation. Mesenchymal stem cells (MSCs) play a crucial role in immune regulation and bone formation. However, factors like genetic background, internal environment, infection, and mechanical forces can alter the immune regulation and osteogenic capacity of MSCs in AS. This review analyzes the effects of these factors on MSCs and discusses the potential of MSCs in treating AS, providing insights for further research on inflammation and ectopic ossification.
POSTGRADUATE MEDICAL JOURNAL
(2023)
Article
Medicine, Research & Experimental
Hyun Jik Lee, Chang Woo Chae, Ho Jae Han
Summary: Mesenchymal stem cell (MSC) transplantation has potential for treating diabetes mellitus (DM) and its complications. However, hyperglycemia can cause senescence and dysfunction in transplanted and resident MSCs due to mitochondrial dysfunction. Improving mitochondrial function could enhance the therapeutic efficacy of MSC transplantation in DM.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Ting Huang, Tianyuan Zhang, Xinchi Jiang, Ai Li, Yuanqin Su, Qiong Bian, Honghui Wu, Ruyi Lin, Ni Li, Hongcui Cao, Daishun Ling, Jinqiang Wang, Yasuhiko Tabata, Zhen Gu, Jianqing Gao
Summary: Iron oxide nanoparticles (IONPs) can enhance the selective transfer of mitochondria from human mesenchymal stem cells (hMSCs) to diseased cells, promoting intercellular mitochondrial transfer and significantly mitigating fibrotic progression. The method shows potential for restoring mitochondrial bioenergetics in diseased cells.
Article
Biochemistry & Molecular Biology
Wenjun Lv, Xiufen Peng, Yun Tu, Yisong Shi, Guanbin Song, Qing Luo
Summary: Weightlessness in space leads to detrimental effects on astronauts, including bone loss, muscle atrophy, and impaired immune defense. The study investigates the effects of simulated microgravity on mesenchymal stem cells (MSCs) and the potential therapeutic target for weightlessness-related cell senescence and aging. The results suggest that mitochondrial dysfunction mediates MSC senescence induced by simulated microgravity and inhibition of Yes-associated protein (YAP) alleviates MSC senescence through targeting mitochondrial dysfunction.
Article
Biochemistry & Molecular Biology
Mengyu Li, Yejia Yu, Ke Xue, Jiayi Li, Geehun Son, Jiajia Wang, Wentao Qian, Shaoyi Wang, Jiawei Zheng, Chi Yang, Jing Ge
Summary: Through network pharmacology and molecular docking, estrogen-related receptor alpha (ERRα) was identified as the potential target of genistein. Knockdown of ERRα greatly weakened the anti-senescence effect of genistein on OVX-BMMSCs. Furthermore, ERRα knockdown inhibited the mitochondrial biogenesis and mitophagy induced by genistein in OVX-BMMSCs. In vivo, genistein inhibited trabecular bone loss and upregulated SIRT3 and PGC1α expression in the trabecular bone area of OVX rats. This study revealed the molecular mechanism by which genistein ameliorates senescence of OVX-BMMSCs through ERRα-mediated mitochondrial biogenesis and mitophagy, providing a basis for the development of therapeutic strategies against PMOP.
Review
Biochemistry & Molecular Biology
Javier Donate-Correa, Beatriz Martin-Carro, Jorge B. Cannata-Andia, Carmen Mora-Fernandez, Juan F. Navarro-Gonzalez
Summary: Reducing oxidative stress is crucial in preventing cellular senescence and aging. In kidney disease, targeting oxidative stress, mitochondrial dysfunction, and cellular senescence in kidney cells could be significant for controlling disease progression. This review focuses on the mechanisms linking oxidative stress damage and mitochondrial dysfunction in kidney disease, with a special emphasis on the role of the anti-aging Klotho protein and its modulation of signaling pathways involving known antioxidant systems and mitochondrial function regulators. Klotho is proposed as a promising therapeutic target in combating oxidative stress, mitochondria abnormalities, and cellular senescence in kidney disease patients.
Article
Chemistry, Multidisciplinary
Qiming Zhai, Xin Chen, Dongdong Fei, Xiaoyan Guo, Xiaoning He, Wanmin Zhao, Songtao Shi, John Justin Gooding, Fang Jin, Yan Jin, Bei Li
Summary: Chronic inflammation leads to mitochondrial dysfunction in tissue-specific mesenchymal stem cells (MSCs), but nanotechnology can be utilized to restore their function, providing an effective treatment for periodontitis and osteoarthritis.
Article
Genetics & Heredity
Shuizhong Cen, Mingxi Cai, Yihan Wang, Xiuyi Lu, Zhipeng Chen, Haobo Chen, Yingdong Fang, Changping Wu, Sujun Qiu, Zhenhua Liu
Summary: In this study, the expression profiles of differentially expressed (DE) long noncoding RNAs (lncRNAs) and mRNAs during adipogenesis in mesenchymal stem cells from patients with ankylosing spondylitis (ASMSCs) and healthy donors (HDMSCs) were analyzed. Several specific lncRNAs and mRNAs, as well as DE lncRNA-DE mRNA pairs related to the PPAR signaling pathway, were identified to potentially contribute to the enhanced adipogenic differentiation in ASMSCs.
FRONTIERS IN GENETICS
(2022)
Review
Cell Biology
Min Yin, Yan Zhang, Haibo Yu, Xia Li
Summary: The regenerative and immunomodulatory properties of mesenchymal stem cells (MSCs) have paved the way for their clinical application in various diseases, but the efficiency of MSC treatments can be affected by factors like cell aging or senescence. Understanding the relationship between senescence and hyperglycemia can lead to strategies to suppress MSC senescence in a hyperglycemic environment for better therapeutic outcomes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Andromachi Pouikli, Monika Maleszewska, Swati Parekh, Ming Yang, Chrysa Nikopoulou, Juan Jose Bonfiglio, Constantine Mylonas, Tonantzi Sandoval, Anna-Lena Schumacher, Yvonne Hinze, Ivan Matic, Christian Frezza, Peter Tessarz
Summary: This study reveals the impact of normal oxygen levels on the differentiation of bone-derived mesenchymal stem cells. High oxygen concentration promotes chromatin compaction and histone hypo-acetylation, resulting in osteogenic defects. Additionally, decreased activity of citrate carrier leads to the accumulation of acetyl-CoA inside mitochondria. Restoring cytosolic acetyl-CoA levels rescues the osteogenic defects.
Article
Chemistry, Multidisciplinary
Shikun Wang, Zhixiao Yao, Xinyu Zhang, Juehong Li, Chen Huang, Yuanming Ouyang, Yun Qian, Cunyi Fan
Summary: Tendon injury is a prevalent and challenging motor system disease. This study focuses on the insufficient regenerative capability and dysregulation of immune microenvironment as the main causes of functional loss. By designing a smart scaffold, the study successfully repairs the oxidative stress and mitochondrial impairment, remodels the microenvironment, and promotes tendon regeneration.
Article
Biochemistry & Molecular Biology
Clara Lefranc, Malou Friederich-Persson, Fabienne Foufelle, Aurelie Nguyen Dinh Cat, Frederic Jaisser
Summary: The study demonstrates that overexpression of MR in adipocytes can lead to mitochondrial dysfunction and cellular senescence, triggered by increased mitochondrial oxidative stress. This imbalance in mitochondrial dynamics and regeneration in the visceral adipose tissue results in aging and dysfunction, revealing new insights into the role of MR in adipose tissue dysfunction in obesity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Senrui Liu, Shengwen Cheng, Bowen Chen, Pengcheng Xiao, Jingdi Zhan, Jiacheng Liu, Zhuolin Chen, Junyan Liu, Tao Zhang, Yiting Lei, Wei Huang
Summary: This study addresses the issues of immune rejection and ethical concerns in stem cell therapy by constructing a ROS-responsive hydrogel loaded with pre-stimulant microvesicles (MVs). The results demonstrate that this method effectively mitigates cell senescence, improves mitochondrial function, and enhances cellular antioxidant capacity.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Ting Huang, Ruyi Lin, Yuanqin Su, Hao Sun, Xixi Zheng, Jinsong Zhang, Xiaoyan Lu, Baiqin Zhao, Xinchi Jiang, Lingling Huang, Ni Li, Jing Shi, Xiaohui Fan, Donghang Xu, Tianyuan Zhang, Jianqing Gao
Summary: The use of high-powered mesenchymal stem cells for efficient mitochondrial delivery can restore impaired mitochondrial homeostasis, recover cellular functions, and successfully mitigate the progression of pulmonary fibrosis.
NATURE COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Sudha Sharma, Papori Sharma, Tara Bailey, Susmita Bhattarai, Utsab Subedi, Chloe Miller, Hosne Ara, Srivatsan Kidambi, Hong Sun, Manikandan Panchatcharam, Sumitra Miriyala
Summary: Reactive oxygen species (ROS) are highly reactive molecules generated as a by-product of aerobic life, which can lead to oxidative stress and the formation of bioactive compounds like 4-hydroxynonenal (4-HNE). 4-HNE forms covalent adducts with proteins, nucleic acids, and lipids, affecting mitochondrial functions and promoting apoptosis.