Article
Multidisciplinary Sciences
Hidetaka Matsumoto, Junki Hoshino, Ryo Mukai, Kosuke Nakamura, Hideo Akiyama
Summary: Loading phase treatment with intravitreal brolucizumab may improve visual acuity and reduce exudative changes in eyes with nAMD associated with type 1 CNV, but careful monitoring for brolucizumab-related intraocular inflammation is necessary.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
Yinchen Shen, Hanying Wang, Xiaoyin Xu, Chong Chen, Shaopin Zhu, Lu Cheng, Junwei Fang, Kun Liu, Xun Xu
Summary: This study investigated the relationship between serum metabolome and treatment response to anti-VEGF therapy in nAMD and PCV patients. The study found that metabolites such as LPC and diacylglycerophosphocholine impact the response to conbercept treatment, with LPC 18:0 identified as a potential biomarker to discriminate responders from non-responders. The findings suggest that metabolites may be useful for guiding treatment options in nAMD and PCV.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Tingting Sun, Qingquan Wei, Peng Gao, Yongjie Zhang, Qing Peng
Summary: The study investigated cytokine and chemokines profiling in the aqueous humor of nAMD patients, finding lower levels of basic fibroblast growth factor and RANTES, and higher levels of VEGF-A compared to the control group. After IVR treatment, levels of Eotaxin increased while VEGF-A decreased in nAMD patients.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Ophthalmology
Huiying Zhou, Xinyu Zhao, Youxin Chen
Summary: The study found significant differences in plasma concentrations of multiple cytokines between nAMD and PCV patients and controls, suggesting potential involvement in the pathogenesis of the diseases. The measurement of leukemia inhibitory factor in plasma may serve as a differentiating factor between nAMD and PCV.
ASIA-PACIFIC JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Endocrinology & Metabolism
Xinyuan Zhang, Bingjie Qiu, Zhizhong Gong, Xiaosi Chen, Yanhong Wang, Yao Nie
Summary: This study investigates the differential regulation of lipid metabolism mediated by apolipoproteins in polypoidal choroidal vasculopathy (PCV) and neovascular age-related macular degeneration (nAMD). The results suggest that lipid profiles and apolipoproteins are differentially regulated in PCV, nAMD, and their subtypes, indicating different pathogenicity contributes to the different phenotypes of PCV and nAMD.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Ophthalmology
Assaf Hilely, Adrian Au, K. Bailey Freund, Anat Loewenstein, Eric H. Souied, Dinah Zur, Riccardo Sacconi, Enrico Borrelli, Enrico Peiretti, Claudio Iovino, Yoshimi Sugiura, Abdallah A. Ellabban, Jordi Mones, Nadia K. Waheed, Sengul Ozdek, Duygu Yalinbas, Sarah Thiele, Luisa Salles de Moura Mendonca, Mee Yon Lee, Won Ki Lee, Pierre Turcotte, Vittorio Capuano, Meryem Filali Ansary, Usha Chakravarthy, Albrecht Lommatzsch, Frederic Gunnemann, Daniel Pauleikhoff, Michael S. Ip, Giuseppe Querques, Frank G. Holz, Richard F. Spaide, SriniVas Sadda, David Sarraf
Summary: This study evaluated the patterns of subretinal fluid in eyes with non-neovascular AMD and found that SRF may be a result of RPE decompensation and RPE pump failure.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Medicine, General & Internal
Jae-Hui Kim, Jong-Woo Kim, Chul-Gu Kim
Summary: This study revealed a trend in the selection of ranibizumab and aflibercept for initial treatment of neovascular AMD and PCV, with ranibizumab preferred in older patients and those with type 3 MNV, and aflibercept highly preferred in patients with PCV. The variance in patient characteristics and efficacy of the two agents may have influenced this trend.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Caijiao Yi, Jian Liu, Wen Deng, Chang Luo, Jinyan Qi, Mei Chen, Heping Xu
Summary: This study investigated the effect of ageing on subretinal fibrosis secondary to choroidal neovascularization and the mechanism of action. The results showed that ageing increased the number of circulating fibrocytes and the profibrotic potential of BM-derived macrophages. Additionally, aged mice had significantly more severe subretinal fibrosis compared to young mice. The transplantation of BM from aged mice significantly increased subretinal fibrosis in young mice.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Ophthalmology
Faruque D. Ghanchi, Corinne Fulcher, Zeid Madanat, Faris Mdanat
Summary: The study demonstrated that OCT-A has high sensitivity and specificity for detecting CNV in treatment-naive nAMD patients, and suggested the potential use of SHRM and DLS as additional biomarkers for diagnosis.
Article
Ophthalmology
Marco Pellegrini, Federico Bernabei, Andrea Mercanti, Stefano Sebastiani, Enrico Peiretti, Claudio Iovino, Giamberto Casini, Pasquale Loiudice, Vincenzo Scorcia, Giuseppe Giannaccare
Summary: This study evaluated choroidal vascular changes in nAMD patients treated with aflibercept injections, showing significant decreases in choroidal thickness and vascularity after treatment, which were significantly correlated with baseline choroidal vascularity index.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Review
Pharmacology & Pharmacy
Pengxiang Zhou, Siqian Zheng, Ente Wang, Peng Men, Suodi Zhai
Summary: Conbercept is well-tolerated and effective in improving vision and fundus condition in patients with neovascular age-related macular degeneration and diabetic macular edema compared with laser photocoagulation, intravitreal triamcinolone acetonide, and placebo. Further large-sample and long-term studies are needed.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Ophthalmology
Jae Hui Kim, Jong Woo Kim, Chul Gu Kim
Summary: This study investigated the incidence, risk factors, and impact on visual outcomes of SRH in patients with nAMD and PCV who discontinued treatment. SRH development led to poor visual prognosis in those who stopped treatment, and type 3 MNV had a relatively high risk of SRH occurrence.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Review
Cell Biology
Hanna Helotera, Kai Kaarniranta
Summary: Age-related macular degeneration (AMD) is the leading cause of visual impairment in the aging population. It is classified into dry and neovascular forms, with neovascular AMD being associated with angiogenesis and inflammatory regulators.
Article
Ophthalmology
Clement K. Chan, Wesley T. Beaulieu, Brandon J. Lujan, Maziar Lalezary, Daniella Lent-Schochet, Therlinder Lo, Glenn Yiu
Summary: The purpose of this study was to investigate the impact of prophylactic ranibizumab injections on drusen volume, macular thinning, and GA progression in eyes with intermediate AMD. The results showed that prophylactic ranibizumab did not appear to affect these parameters. Additionally, there was no difference in the conversion rate to neovascular AMD between the PR and sham injection groups.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2023)
Article
Ophthalmology
Soo Chang Cho, JoonHee Cho, Kyu Hyung Park, Se Joon Woo
Summary: The study found that the incidence rate of massive submacular haemorrhage was significantly higher in patients with polypoidal choroidal vasculopathy compared to those with typical neovascular age-related macular degeneration. The number of photodynamic therapies, cluster type of polypoidal lesion, and number of anti-VEGF injections were significantly associated with the risk of massive submacular haemorrhage.
ACTA OPHTHALMOLOGICA
(2021)