Article
Orthopedics
Z. Shao, B. Wang, Y. Shi, C. Xie, C. Huang, B. Chen, H. Zhang, G. Zeng, H. Liang, Y. Wu, Y. Zhou, N. Tian, A. Wu, W. Gao, X. Wang, X. Zhang
Summary: In vitro, QUE inhibits SASP factors expression and senescence phenotype in IL-10-treated NPCs. QUE suppresses IL-1 beta induced activation of the NF-kappa B pathway cascades. In vivo, QUE ameliorates the IDD process in the puncture-induced rat model.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Review
Chemistry, Medicinal
Farhad Eisvand, Amir Tajbakhsh, Veronique Seidel, Mohammad Reza Zirak, Jamshid Tabeshpour, Abolfazl Shakeri
Summary: Endoplasmic reticulum (ER) stress is implicated in many diseases, making modulation of ER stress pathways an attractive therapeutic target. Quercetin, a plant-derived flavonoid, has various beneficial effects and can be utilized with nanotechnology to enhance its activity in combating ER stress-related diseases.
PHYTOTHERAPY RESEARCH
(2022)
Article
Environmental Sciences
Jicang Wang, Lulu Ding, Ke Wang, Ruxue Huang, Wenjing Yu, Bingzhao Yan, Hongwei Wang, Cai Zhang, Zijun Yang, Zongping Liu
Summary: This study aimed to determine the protective effect of quercetin (Que) on cadmium (Cd)-induced hepatotoxicity. Through in vivo and in vitro experiments using rat models, the researchers found that Cd caused liver injury and cell apoptosis, and activated endoplasmic reticulum stress (ERS) signaling pathways. However, Que was able to improve hepatocyte vitality, reduce liver damage and oxidative stress caused by Cd.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Biochemistry & Molecular Biology
Chen-Yu Zhang, Wen-Jing Zhong, Yu-Biao Liu, Jia-Xi Duan, Nan Jiang, Hui-Hui Yang, Sheng-Chao Ma, Ling Jin, Jie-Ru Hong, Yong Zhou, Cha-Xiang Guan
Summary: The study identified the critical role of epoxyeicosatrienoic acids (EETs) in alleviating alveolar epithelial cell (AEC) senescence. By promoting the expression of antioxidants, EETs can inhibit endoplasmic reticulum stress and alleviate AEC senescence. Inhibiting the degradation of EETs can also delay age-related pulmonary fibrosis and provide new targets for the treatment of chronic lung diseases.
Article
Environmental Sciences
Jian Lu, Cheng Zhang, Weiguo Wang, Wenping Xu, Weidong Chen, Liming Tao, Zhong Li, Yang Zhang, Jiagao Cheng
Summary: Glyphosate (GLY), a widely used herbicide, poses chronic exposure and health risks to the environment and population. This study demonstrates that GLY induces senescence in cardiomyocytes through ROS-mediated DNA damage, and causes cardiotoxicity in zebrafish associated with DNA and mitochondrial damage. It also reveals the activation of ER stress pathway as a mechanism for GLY-induced cardiotoxicity. These findings highlight the importance of examining the potential cardiotoxic effects of GLY.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Review
Oncology
Jiahua Liu, Runzi Zheng, Yanghuan Zhang, Shuting Jia, Yonghan He, Jing Liu
Summary: This review provides an overview of the molecular mechanisms, microenvironmental factors, and therapeutic strategies of skin aging and melanoma, and discusses potential common targets between melanoma and cell senescence.
Article
Biochemistry & Molecular Biology
Kazuya Kusama, Naoya Yamauchi, Kanoko Yoshida, Mana Azumi, Mikihiro Yoshie, Kazuhiro Tamura
Summary: Decidualization, a crucial step for embryo implantation and placentation, can be enhanced by senolytic agents such as Quercetin and Dasatinib. Treatment with a combination of these agents synergistically increases the expression of decidualization markers and senescence markers in decidualizing ESCs, offering a potential therapeutic strategy for infertility related to endometrial receptivity and embryo implantation dysfunctions.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Pharmacology & Pharmacy
Kimia Keylani, Fariba Arbab Mojeni, Amirmohammad Khalaji, Asma Rasouli, Dlnya Aminzade, Mohammad Amin Karimi, Pantea Majma Sanaye, Nazanin Khajevand, Nasrin Nemayandeh, Mohadeseh Poudineh, Mehdi Azizabadi Farahani, Mohammad Ali Esfandiari, Sepehr Haghshoar, Ali Kheirandish, Erfan Amouei, Amir Abdi, Arash Azizinezhad, Afshin Khani, Niloofar Deravi
Summary: Flavonoids, a group of compounds found in natural health products and plant-based foods, have different subclasses with specific structures. Scientific data has shown that regular consumption of dietary flavonoids can reduce chronic inflammation and oxidative stress, thereby potentially preventing cardiovascular diseases. Endoplasmic reticulum stress is closely related to the development of cardiovascular diseases, and treating this stress could be a crucial point in managing these diseases. This review discusses the effects of flavonoids on the endoplasmic reticulum and their role in the prevention and treatment of cardiovascular diseases.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mitzi M. Gonzales, Valentina R. Garbarino, Tiffany F. Kautz, Juan Pablo Palavicini, Marisa Lopez-Cruzan, Shiva Kazempour Dehkordi, Julia J. Mathews, Habil Zare, Peng Xu, Bin Zhang, Crystal Franklin, Mohamad Habes, Suzanne Craft, Ronald C. Petersen, Tamara Tchkonia, James L. Kirkland, Arash Salardini, Sudha Seshadri, Nicolas Musi, Miranda E. Orr
Summary: This study examined the feasibility of orally delivered senolytic therapy for Alzheimer's disease. The results showed that the treatment had a positive impact on the safety, tolerability, and feasibility of patients, and the drugs were able to penetrate the central nervous system. Biomarker data provided insights into the senolytic effects, but further research with larger sample sizes and placebo-controlled studies is needed for confirmation.
Article
Behavioral Sciences
Chenkang Wang, Yu Kang, Panwen Liu, Weiwei Liu, Wenhui Chen, Toshihiko Hayashi, Kazunori Mizuno, Shunji Hattori, Hitomi Fujisaki, Takashi Ikejima
Summary: Excessive physical exercise can result in damage to vital tissues, including the hippocampus, which is important for learning and memory. A combination of dasatinib and quercetin, known as senolytic drugs, selectively kill senescent cells. In this study, rats subjected to excessive swimming training were treated with dasatinib and quercetin, which improved exercise performance and prevented deficits in learning and memory. The drugs reduced senescent cells and apoptosis in the hippocampus, ultimately alleviating the negative effects of overtraining.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Hao Ding, Menghui Jiang, Daochuan Li, Yanjie Zhao, Dianke Yu, Rong Zhang, Wen Chen, Jingbo Pi, Rui Chen, Lianhua Cui, Yuxin Zheng, Jinmei Piao
Summary: Previous studies have shown that long-term exposure to fine particulate matter (PM2.5) increases the morbidity and mortality of pulmonary diseases. Nrf2 plays a pivotal role in protecting against oxidative stress induced by PM2.5.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Cell Biology
Dilara Demirci, Bengisu Dayanc, Fatma Aybuke Mazi, Serif Senturk
Summary: Cellular senescence is a state of stable cell cycle arrest triggered by various insults, with potential adverse implications such as inflammation, cancer stemness, senescence reversal, therapy resistance, and disease recurrence, which can be mitigated by eliminating senescent cells or inhibiting their SASP production to enhance cancer therapy efficacy.
Review
Biochemistry & Molecular Biology
Andrea Deledda, Emanuele Giordano, Fernanda Velluzzi, Giovanna Flore, Sara Franceschelli, Lorenza Speranza, Patrizio Ripari
Summary: Living organisms need to consume energy for survival. Cellular energy exchanges produce waste products that can contribute to cellular aging and damage if not properly disposed of. Many genes are associated with aging, with some promoting it and others blocking it. Calorie restriction has been found to promote longevity pathways, and research is exploring CR-mimetic substances that can have the same effect. Certain phytonutrients and minerals have been found to promote a longer and healthier life.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agriculture, Dairy & Animal Science
Weihan Yang, Runfeng Liu, Qinqiang Sun, Xingchen Huang, Junjun Zhang, Liangfeng Huang, Pengfei Zhang, Ming Zhang, Qiang Fu
Summary: This study found that quercetin could attenuate the effects of endoplasmic reticulum stress on granulosa cells by the PERK/CHOP signaling pathway, providing a novel strategy for inhibiting the apoptosis of granulosa cells.
Article
Biochemistry & Molecular Biology
Reziyamu Wufuer, Zhuo Fan, Jianxin Yuan, Ze Zheng, Shaofan Hu, Guiyin Sun, Yiguo Zhang
Summary: Nrf1 and Nrf2 play different roles in response to oxidative or reductive stresses. Nrf1 enhances cell defense against reductive stress, while Nrf2 is more involved in the defense against oxidative stress. Both Nrf1 and Nrf2 regulate the expression of critical genes to protect against redox stress and endoplasmic reticulum stress. Redox-sensing sites within Nrf1 are important for its protein stability and transcriptional activity.
Article
Geriatrics & Gerontology
Robertina Giacconi, Patrizia D'Aquila, Marco Malavolta, Francesco Piacenza, Alexander Burkle, Maria Moreno Villanueva, Martijn E. T. Dolle, Eugene Jansen, Tilman Grune, Efstathios S. Gonos, Claudio Franceschi, Miriam Capri, Daniela Gradinaru, Beatrix Grubeck-Loebenstein, Ewa Sikora, Wolfgang Stuetz, Daniela Weber, Olivier Toussaint, Florence Debacq-Chainiaux, Antti Hervonen, Mikko Hurme, P. Eline Slagboom, Christiane Schon, Jurgen Bernhardt, Nicolle Breusing, Talbot Duncan, Giuseppe Passarino, Dina Bellizzi, Mauro Provinciali
Summary: This study found that the concentration of blood bacterial DNA (BB-DNA) was higher in the general population compared to individuals from long-living families and their spouses. BB-DNA was found to be associated with smoking, Charlson Comorbidity Index (CCI), leukocyte subsets, and some oxidative stress markers in the general population.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Geriatrics & Gerontology
Laura Kananen, Mikko Hurme, Alexander Buerkle, Maria Moreno-Villanueva, Jurgen Bernhardt, Florence Debacq-Chainiaux, Beatrix Grubeck-Loebenstein, Marco Malavolta, Andrea Basso, Francesco Piacenza, Sebastiano Collino, Efstathios S. Gonos, Ewa Sikora, Daniela Gradinaru, Eugene H. J. M. Jansen, Martijn E. T. Dolle, Michel Salmon, Wolfgang Stuetz, Daniela Weber, Tilman Grune, Nicolle Breusing, Andreas Simm, Miriam Capri, Claudio Franceschi, Eline Slagboom, Duncan Talbot, Claude Libert, Jani Raitanen, Seppo Koskinen, Tommi Harkanen, Sari Stenholm, Mika Ala-Korpela, Terho Lehtimaki, Olli T. Raitakari, Olavi Ukkola, Mika Kahonen, Marja Jylha, Juulia Jylhava
Summary: Circulating cell-free DNA (cf-DNA) levels are associated with age, sex, smoking, physical activity, vegetable consumption, ageing phenotypes, and various biomarkers. Higher cf-DNA levels were found in men, especially middle-aged men and women who smoke, and older frail individuals. Inflammatory markers, metabolites, and antioxidant levels were correlated with cf-DNA levels. These findings have implications for future studies on the epidemiology and biological mechanisms of cf-DNA and its potential as a clinical marker.
Article
Biochemistry & Molecular Biology
Robertina Giacconi, Patrizia D'Aquila, Marta Balietti, Cinzia Giuli, Marco Malavolta, Francesco Piacenza, Laura Costarelli, Demetrio Postacchini, Giuseppe Passarino, Dina Bellizzi, Mauro Provinciali
Summary: Microbial dysbiosis leads to alterations in gut barrier and bacterial translocation, resulting in increased blood bacterial DNA that promotes peripheral and neuro inflammation and contributes to cognitive impairment. It also affects the production of brain-derived neurotrophic factor, which plays a role in the etiopathogenesis of Alzheimer's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Robertina Giacconi, Maurizio Cardelli, Francesco Piacenza, Elisa Pierpaoli, Elisabetta Farnocchia, MirKo Di Rosa, Anna Rita Bonfigli, Tiziana Casoli, Francesca Marchegiani, Fiorella Marcheselli, Rina Recchioni, Pierpaolo Stripoli, Roberta Galeazzi, Antonio Cherubini, Massimiliano Fedecostante, Riccardo Sarzani, Chiara Di Pentima, Piero Giordano, Roberto Antonicelli, Mauro Provinciali, Fabrizia Lattanzio
Summary: This study aimed to investigate the association between cytomegalovirus (CMV) reactivation and inflammation as well as in-hospital mortality in older patients with severe COVID-19. Among 156 geriatric COVID-19 patients, 12.2% showed CMV reactivation. CMV reactivation was found to be an independent risk factor for in-hospital mortality in COVID-19 patients younger than 87 years old.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Maria Elisa Giuliani, Veronica Barbi, Giorgia Bigossi, Serena Marcozzi, Robertina Giacconi, Maurizio Cardelli, Francesco Piacenza, Fiorenza Orlando, Elena Ciaglia, Monica Cattaneo, Alessia Mongelli, Carlo Gaetano, Mauro Provinciali, Annibale Alessandro Puca, Marco Malavolta
Summary: This study found that the homozygous genotype of the Longevity-Associated Variant (LAV) in BPIFB4 is enriched in long-living individuals and gene transfer of LAV-BPIFB4 in aged mice showed improvements in aging biomarkers and health. These findings support the use of LAV-BPIFB4 gene therapy to induce beneficial effects on epigenetic mechanisms associated with aging and frailty in humans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Robertina Giacconi, Francesco Piacenza, Valentina Aversano, Michele Zampieri, Alexander Buerkle, Maria Moreno Villanueva, Martijn E. T. Dolle, Eugene Jansen, Tilman Grune, Efstathios S. Gonos, Claudio Franceschi, Miriam Capri, Birgit Weinberger, Ewa Sikora, Olivier Toussaint, Florence Debacq-Chainiaux, Wolfgang Stuetz, Pieternella Eline Slagboom, Juergen Bernhardt, Maria Luisa Fernandez-Sanchez, Mauro Provinciali, Marco Malavolta
Summary: Plasma selenium levels are influenced by age, sex, nutrition, and inflammation. Inadequate selenium intake can accelerate aging and increase the risk of age-related diseases.
Article
Nutrition & Dietetics
Francesco Piacenza, Robertina Giacconi, Laura Costarelli, Marco Malavolta
Summary: This preliminary study investigated the fractional Zn absorption (FZA) after the supplementation of three different Zn complexes on eight healthy volunteers. The results showed that the FZA of Zn-Aspartate was significantly higher than other forms of Zn, and the FZA of Zn-Gluconate was significantly higher than ZnSO4. These results suggest that using Zn-Aspartate in individuals at risk of Zn deficiency could improve the Zn absorption rate.
Article
Cell Biology
Serena Marcozzi, Maria Elisa Giuliani, Giovanni Lai, Robertina Giacconi, Francesco Piacenza, Giorgia Bigossi, Marco Malavolta
Summary: This perspective review explores the mechanisms and implications of senescent cell spreading on frailty, as well as its therapeutic development. The focus is on emerging age-related biological factors, such as microbiome and virome alterations, and their significant contribution to the accumulation rate of senescent cells. These factors particularly affect the musculoskeletal system and cerebral functions, two key domains of frailty. Understanding these mechanisms can lead to the development of tailored interventions for diverse patients.
Article
Microbiology
Robertina Giacconi, Rossella Donghia, Graziana Arborea, Maria Teresa Savino, Mauro Provinciali, Fabrizia Lattanzio, Giusy Rita Caponio, Sergio Coletta, Antonia Bianco, Maria Notarnicola, Caterina Bonfiglio, Giuseppe Passarino, Patrizia DAquila, Dina Bellizzi, Pasqua Letizia Pesole
Summary: This study found that patients with colorectal cancer have higher levels of bacterial DNA in their plasma compared to healthy individuals, and this is associated with the size of the tumor mass.
Review
Geriatrics & Gerontology
Serena Marcozzi, Giorgia Bigossi, Maria Elisa Giuliani, Robertina Giacconi, Francesco Piacenza, Maurizio Cardelli, Dario Brunetti, Agnese Segala, Alessandra Valerio, Enzo Nisoli, Fabrizia Lattanzio, Mauro Provinciali, Marco Malavolta
Summary: This study provides a comprehensive evaluation of the role of senescent cells in driving inflammation and frailty. The results indicate that the burden of senescent cells related to musculoskeletal and cerebral health has the strongest causal link to frailty. These findings are important for understanding the role of cellular senescence in frailty and developing personalized therapies.
Article
Biochemistry & Molecular Biology
Raffaella Lazzarini, Maria Fiorella Tartaglione, Veronica Ciarapica, Francesco Piva, Matteo Giulietti, Gianluca Fulgenzi, Margherita Martelli, Caterina Ledda, Ermanno Vitale, Marco Malavolta, Lory Santarelli, Massimo Bracci
Summary: This study found that high-irradiance blue or red light exposure reduces the viability of keratinocytes and induces cell death and cell cycle arrest. It also affects mitochondrial density and morphology. Proteomic analysis identified the key roles of TXNRD1 and AKR1C3 in the cellular response to high-irradiance blue or red light exposure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)