期刊
JACC-CARDIOVASCULAR IMAGING
卷 14, 期 6, 页码 1249-1264出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jcmg.2020.06.038
关键词
inflammation; macrophage; ultrasmall superparamagnetic particles of iron oxide; cardiac magnetic resonance
资金
- MRC [MC_PC_12040, G0701127] Funding Source: UKRI
Cardiac magnetic resonance (CMR) plays a crucial role in evaluating myocardial anatomy, function, and tissue characteristics, especially as inflammation is increasingly recognized as a key factor in various myocardial diseases. The use of ultrasmall superparamagnetic particles of iron oxide (USPIO) in CMR enhances imaging of myocardial and vascular inflammation, offering valuable information on the cellular inflammatory component.
Cardiac magnetic resonance (CMR) is at the forefront of noninvasive methods for the assessment of myocardial anatomy, function, and most importantly tissue characterization. The role of CMR is becoming even more significant with an increasing recognition that inflammation plays a major role for various myocardial diseases such as myocardial infarction, myocarditis, and takotsubo cardiomyopathy. Ultrasmall superparamagnetic particles of iron oxide (USPIO) are nanoparticles that are taken up by monocytes and macrophages accumulating at sites of inflammation. In this context, USPIO-enhanced CMR can provide valuable additional information regarding the cellular inflammatory component of myocardial and vascular diseases. Here, we will review the recent diagnostic applications of USPIO in terms of imaging myocardial and vascular inflammation, and highlight some of their future potential.
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