期刊
CURRENT CANCER DRUG TARGETS
卷 16, 期 6, 页码 480-488出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1568009616666160328113006
关键词
Cisplatin; combination delivery; drug delivery; drug resistance; prodrug; tumor therapy
类别
资金
- National Science Foundation [DMR-1410853]
- Wayne State University, Chemical Engineering and Materials Science
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [1410853] Funding Source: National Science Foundation
Cisplatin is one of the leading chemotherapy drugs currently used in clinical settings. However, its serious side effects and its resistance developed by tumor cells hinder its usage. To decrease its side effects and maintain anti-cancer efficiency, various cisplatin based formulations were developed. In this minireview, we summarized the recent progress of cisplatin delivery strategies, including direct delivery, prodrug delivery and combination delivery. Key challenges preventing the development of improved drug formulations were identified, and effective approaches to address these issues were discussed in the context of these recent works.
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