Review
Pharmacology & Pharmacy
Rui Alvites, Mariana Branquinho, Ana C. Sousa, Bruna Lopes, Patricia Sousa, Ana Colette Mauricio
Summary: Mesenchymal Stem/Stromal Cells (MSCs) have high clinical value and have been extensively studied. Their immunomodulatory influence occurs through both direct and paracrine routes, but the mechanisms are not fully understood. This review summarizes the immunoregulatory capacity of MSCs and their secretion products, with a focus on migration, homing, direct cell action, and paracrine activity, and explores related techniques.
Review
Biochemistry & Molecular Biology
Yutong Huang, Qiang Wu, Paul Kwong Hang Tam
Summary: Mesenchymal stem cells (MSCs) have multiple properties, including self-renewal, immunomodulation, and regenerative medicine, making them a potential therapeutic strategy for immune disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell & Tissue Engineering
Li Zhou, Huimin Zhu, Xue Bai, Jiagui Huang, Yue Chen, Jun Wen, Xuemei Li, Bowen Wu, Yongjun Tan, Mingfen Tian, Jiangxia Ren, Mengxia Li, Qin Yang
Summary: Ischemic stroke is a major cause of death and disability. Stem cell transplantation has emerged as a potential treatment that offers hope for ischemic stroke patients.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Cell & Tissue Engineering
Guoqiang Yang, Xuehui Fan, Yingchun Liu, Pingping Jie, Maryam Mazhar, Yong Liu, Nathupakorn Dechsupa, Li Wang
Summary: Mesenchymal stem cells (MSCs) are considered highly promising for allogeneic cell therapy due to their multipotent nature and ability to display potent and varied functions in different diseases. MSCs can improve immune-modulatory functions in diseases through their native immunomodulation, high self-renewal characteristic, and secretory and trophic properties. Previous studies have shown that the immunomodulatory role of MSCs relies on their secretion ability. This review discusses the immunomodulatory capabilities of MSCs and promising strategies to enhance their potential utilization in clinical research.
STEM CELL REVIEWS AND REPORTS
(2023)
Review
Cell & Tissue Engineering
Batol Abbasi, Karim Shamsasenjan, Majid Ahmadi, Seyedeh Ameneh Beheshti, Mahshid Saleh
Summary: This article discusses the interaction and signaling pathway between NK cells and MSCs, as well as their importance in clinical applications.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cell Biology
Chunxue Zhang, Liqiang Zhou, Zhen Wang, Wenxia Gao, Wei Chen, Huina Zhang, Bo Jing, Xu Zhu, Lei Chen, Changhong Zheng, Kaiyan Shi, Li Wu, Liming Cheng, Kunshan Zhang, Yi Eve Sun
Summary: This study revealed variations in cell proliferation and immune modulatory functions of MSCs from different donors, with IFN-gamma and NF-kappa B signaling being positively associated with immune modulatory function. Activation of these pathways could eradicate donor-dependent variations, but overall transcriptomic differences between donor-derived MSCs still exist.
CELL DEATH & DISEASE
(2021)
Review
Allergy
Ming Wang, Ning Zhao, Chengshuo Wang, Zi-Bing Jin, Luo Zhang
Summary: Allergic rhinitis is a common chronic inflammatory disorder that significantly impacts patients' health and quality of life. Current treatments for allergic rhinitis are limited in their ability to restore immune balance and target specific allergens. Mesenchymal stem cells (MSCs) offer a potential therapeutic strategy for allergic rhinitis due to their immune privilege and strong immunomodulatory effects. Recent studies have investigated the use of MSCs in animal models of allergic rhinitis and have shown promising results. This review discusses the immunomodulatory effects of MSCs on allergic airway inflammation, highlights recent research on the role of MSCs in modulating immune cells, and explores the clinical potential of MSC-based therapy for allergic rhinitis.
Review
Cell & Tissue Engineering
Thomas Kirwin, Ana Gomes, Ravi Amin, Annam Sufi, Sahil Goswami, Brian Wang
Summary: This review discusses the role of stem cells in atherosclerosis, focusing on mesenchymal stem cells and their modulatory effects on vascular physiology and disease. It also covers their origin, identification markers, differentiation potential, and proposes novel solutions to overcome limitations in MSC therapy.
REGENERATIVE MEDICINE
(2021)
Review
Microbiology
Carl Randall Harrell, Biljana Popovska Jovicic, Valentin Djonov, Vladislav Volarevic
Summary: Mesenchymal stem cells play a crucial role in combating viral infections by modulating the activity of immune cells, producing cytokines, and promoting tissue repair. Their therapeutic potential in treating viral diseases is significant.
Article
Biochemistry & Molecular Biology
Alasdair G. Kay, Kane Treadwell, Paul Roach, Rebecca Morgan, Rhys Lodge, Mairead Hyland, Anna M. Piccinini, Nicholas R. Forsyth, Oksana Kehoe
Summary: This study evaluated the therapeutic potential of extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) in an antigen-induced model of arthritis. The results showed that these EVs reduced knee-joint swelling, improved histopathological outcomes, and regulated T cell polarization. Among the different conditions tested, EVs cultured under normoxic conditions demonstrated the optimal therapeutic effect.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biotechnology & Applied Microbiology
Jiaxuan Zou, Weinan Yang, Wushi Cui, Congsun Li, Chiyuan Ma, Xiaoxiao Ji, Jianqiao Hong, Zihao Qu, Jing Chen, An Liu, Haobo Wu
Summary: Tendon-bone insertion (TBI) injuries, such as anterior cruciate ligament injury and rotator cuff injury, often require surgical treatment. Mesenchymal stem cells (MSCs) have shown therapeutic potential in promoting tissue repair and regeneration. MSCs exert their effects through the release of extracellular vesicles called exosomes, which transfer bioactive molecules to recipient cells, influencing their physiological and pathological processes. In this article, the prospective applications of MSC-derived exosomes in TBI injuries are discussed, along with the roles and underlying mechanisms of MSC-extracellular vesicles in promoting tendon-bone healing. The current challenges and future research directions are also explored.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Review
Biology
Gi Beom Kim, Oog-Jin Shon, Min-Soo Seo, Young Choi, Wook Tae Park, Gun Woo Lee
Summary: Although conventional MSC-based therapies have limitations, MSC-derived exosomes offer advantages such as small dimensions, low immunogenicity, and potent therapeutic effects for osteoarthritis treatment. Exosomes are nano-sized vesicles containing nucleic acids, functional proteins, and bioactive lipids, secreted by various cell types. They play a role in tissue repair, immune regulation, and inflammation reduction, demonstrating potential for a new therapeutic approach in osteoarthritis. Further research is needed to confirm their clinical effectiveness and feasibility.
Review
Gastroenterology & Hepatology
Carl Randall Harrell, Dragica Pavlovic, Valentin Djonov, Vladislav Volarevic
Summary: Mesenchymal stem cells (MSCs) have shown potential in attenuating detrimental immune response and acute inflammation in acute liver failure (ALF). MSCs and MSC-derived exosomes (MSC-Exos) can modulate immune cells in the liver and deliver immunoregulatory factors to injured hepatocytes and immune cells. This review emphasizes the molecular and cellular mechanisms behind the therapeutic potential of MSCs in liver regeneration.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Cell Biology
Li-Chi Chen, Hsin-Wen Wang, Chieh-Cheng Huang
Summary: The study enhanced the therapeutic potential of 3D MSC spheroids by optimizing cultivation conditions, leading to increased expression of multiple pro-regenerative paracrine signaling molecules and immunomodulatory factors by MSCs, potentially associated with the hypoxic niche in the spheroid core and metabolic reconfiguration of MSCs.
Review
Immunology
Sylwia Dabrowska, Anna Andrzejewska, Miroslaw Janowski, Barbara Lukomska
Summary: Mesenchymal stem cells (MSCs) possess supportive, differentiating, and immunoregulatory functions, while the extracellular vesicles (EVs) they produce can serve as a potential cellular therapy tool.
FRONTIERS IN IMMUNOLOGY
(2021)