期刊
TRENDS IN PARASITOLOGY
卷 37, 期 1, 页码 35-47出版社
CELL PRESS
DOI: 10.1016/j.pt.2020.09.007
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资金
- 'Juan de la Cierva-Incorporacion' program of the Ministerio de Ciencia, Innovacion y Universidades (MCIU) [IJC2018-036660-I]
- JIN project 'ULYSSES' - MCIU [RTI2018-093463-J-100]
- Agencia Estatal de Investigacion (AEI)
- Fondo Europeo de Desarrollo Regional (FEDER, UE)
- Junta de Castilla y Leon
- European Social Fund
- MCIU [AGL2015-67023-C2-2-R, PID2019-108782RB-C22]
Understanding the molecular interactions between parasites and host tissues is crucial for developing effective parasite control strategies. Research on the early events of fasciolosis caused by Fasciola hepatica is limited, with most studies focusing on adult worms.
Unraveling the molecular interactions governing the first contact between parasite and host tissues is of paramount importance to the development of effective control strategies against parasites. In fasciolosis, a foodborne trematodiasis caused mainly by Fasciola hepatica, these early interactions occur between the juvenile worm and the host intestinal wall a few hours after ingestion of metacercariae, the infectious stage of the parasite. However, research on these early events is still scarce and the majority of studies have focused on the adult worm. Here, we review current knowledge on the biology and biochemistry of F. hepatica juveniles and their molecular relationships with the host tissues and identify the research needs and gaps to be covered in the future.
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