Article
Microbiology
Ali Mazloum, Antoinette Van Schalkwyk, Roman Chernyshev, Andrey Shotin, Fedor I. Korennoy, Alexey Igolkin, Alexander Sprygin
Summary: This study investigates the molecular epidemiology and evolution of African swine fever virus (ASFV) using sequences from the central variable region (CVR) located within the B602L gene. The sequences were compared to previously published data and clustered into six distinct groups. These findings suggest that CVR sequences can be used as informative markers to study the epidemiology and spread of ASFV in different regions.
Article
Infectious Diseases
Katherukamem Rajukumar, Dhanapal Senthilkumar, Govindarajulu Venkatesh, Fateh Singh, Vishnu P. Patil, Subbiah Kombiah, Chakradhar Tosh, Chandan K. Dubey, Arnab Sen, Nagendra N. Barman, Amitav Chakravarty, Biswajit Dutta, Seema R. Pegu, Arpita Bharali, Vijendra P. Singh
Summary: African swine fever (ASF) has caused high mortality outbreaks in pigs in the states of Arunachal Pradesh and Assam in India, with the first confirmed cases of ASF in domestic pigs in the country. Genetic analyses show that the Indian ASF viruses are similar to post-2007-p72-genotype II viruses reported from Asia and Europe, indicating the transboundary expansion of ASF outbreaks in the region.
TRANSBOUNDARY AND EMERGING DISEASES
(2021)
Article
Infectious Diseases
Hu Suk Lee, Krishna K. Thakur, Vuong Nghia Bui, Thanh Long Pham, Anh Ngoc Bui, Tung Duy Dao, Vu Thi Thanh, Barbara Wieland
Summary: The study modeled various scenarios of ASF virus transmission in Vietnam and evaluated control strategies using NAADSM. Indirect contact played an important role in transmitting the ASF virus, and movement restrictions were found to be effective in minimizing transmission between farms. High biosecurity standards were also shown to contribute to reducing disease spread.
TRANSBOUNDARY AND EMERGING DISEASES
(2021)
Article
Infectious Diseases
Ha Thi Thanh Tran, Anh Duc Truong, Anh Kieu Dang, Duc Viet Ly, Chinh Thi Nguyen, Nhu Thi Chu, Tuan Van Hoang, Huyen Thi Nguyen, Hoang Vu Dang
Summary: Most ASFV strains detected in Vietnam since 2019 belong to the p72 genotype II and intergenic region II variant. Further investigation in the Capital Hanoi region revealed the co-circulation of two different variants, IGR I and IGR II, in the domestic pig population.
TRANSBOUNDARY AND EMERGING DISEASES
(2021)
Article
Immunology
Maksym Bezymennyi, Oleksandr Tarasov, Ganna V. Kyivska, Nataliia A. Mezhenska, Svitlana Mandyhra, Ganna Kovalenko, Mykola Sushko, Nataliia Hudz, Serhii V. Skorokhod, Roman Datsenko, Larysa Muzykina, Elaina Milton, Maryna A. Sapachova, Serhii Nychyk, Ihor Halka, Maciej Frant, Falk Huettmann, Devin M. Drown, Anton Gerilovych, Andrii A. Mezhenskyi, Eric Bortz, Christian E. Lange
Summary: African swine fever (ASF) is a viral disease that originated in Africa and has spread to Europe and Asia, causing high mortality in domestic pig populations. In Ukraine, ASF outbreaks have been reported since 2012, with the highest numbers in 2017 and 2018. The spread of ASF in Ukraine shows a directional pattern from the eastern and northern borders towards the western and southern regions, and wild boars may have played a role in the early spread. However, human activity is now the main driver of spread, and effective mitigation strategies have led to a decline in outbreaks since 2019.
Article
Veterinary Sciences
Nguyen Tuan Anh Mai, Thi Bich Ngoc Trinh, Van Tam Nguyen, Thi Ngoc Ha Lai, Nam Phuong Le, Thi Thu Huyen Nguyen, Thi Lan Nguyen, Aruna Ambagala, Duc Luc Do, Van Phan Le
Summary: African swine fever (ASF) is a devastating disease affecting the global swine industry, with control relying on biosecurity, rapid detection, and elimination. Research suggests that the spot removal approach could successfully control ASF outbreaks in commercial sow barns in Vietnam, but not in fattening pens.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Veterinary Sciences
Dimitrije Glisic, Vesna Milicevic, Dejan Krnjaic, Ivan Toplak, Radisa Prodanovic, Carmina Gallardo, Sonja Radojicic
Summary: This study provides a comprehensive report on the molecular characteristics of African swine fever virus variants in Serbia between 2019 and 2022. Multiple ASFV strains belonging to genotype II are circulating in Serbia, as evidenced by the genetic analysis of four genomic regions. These findings contribute to the knowledge of circulating strains of ASFV in Europe.
VETERINARY RESEARCH COMMUNICATIONS
(2023)
Article
Microbiology
Minh Nam Nguyen, Tram T. N. Ngo, Duyen M. T. Nguyen, Danh Cong Lai, Hai N. Nguyen, Trang T. P. Nguyen, Joo Young Lee, Toan T. Nguyen, Duy T. Do
Summary: This study identified high similarity and lack of genetic diversity among African swine fever virus strains circulating in central and southern Vietnam, which were found to be identical to previously identified strains in Vietnam and China.
CURRENT MICROBIOLOGY
(2022)
Article
Microbiology
Xun Wang, Xiaoying Wang, Xiaoxiao Zhang, Sheng He, Yaosheng Chen, Xiaohong Liu, Chunhe Guo
Summary: African swine fever (ASF) has been spreading in China since its introduction in 2018. In this study, we analyzed the whole genome of an ASF outbreak strain from Guangdong province, China. The results revealed that the China/GD/2019 strain is a new variant with specific deletions and mutations. This research provides insights into the genomic diversity and genetic variation of ASFV.
Article
Veterinary Sciences
Thinh Nguyen-Thi, Linh Pham-Thi-Ngoc, Que Nguyen-Ngoc, Sinh Dang-Xuan, Hu Suk Lee, Hung Nguyen-Viet, Pawin Padungtod, Thuy Nguyen-Thu, Thuy Nguyen-Thi, Thang Tran-Cong, Karl M. Rich
Summary: The 2019 African swine fever outbreaks in Vietnam had severe impacts on the pig sector, resulting in significant economic losses for farmers, particularly medium- and large-farmers. The outbreak also halved the volume of pigs traded and posed adverse effects on the domestic supply and demand for pork.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Veterinary Sciences
Moctar Sidi, Habibata Lamouni Zerbo, Bruno Lalidia Ouoba, Tirumala Bharani K. Settypalli, Gregorie Bazimo, Hamidou Sandaogo Ouandaogo, Boubacar N'paton Sie, Ilboudo Sidwatta Guy, Drabo Dji-tombo Adama, Joseph Savadogo, Anne Kabore-Ouedraogo, Marietou Guitti Kindo, Jenna E. Achenbach, Giovanni Cattoli, Charles E. Lamien
Summary: The outbreak of African swine fever (ASF) in central Burkina Faso was caused by African swine fever virus (ASFV) isolates belonging to genotype I and serogroup 4. The study also revealed the existence of multiple variants, emphasizing the importance of molecular characterization in understanding the evolution of ASFV isolates and the link between epidemics.
BMC VETERINARY RESEARCH
(2022)
Article
Veterinary Sciences
Nguyen Tuan Anh Mai, Van Phai Dam, Ki-Hyun Cho, Van Tam Nguyen, Nguyen Van Tuyen, Thi Lan Nguyen, Aruna Ambagala, Jee-Yong Park, Van Phan Le
Summary: African swine fever virus (ASFV) causes the deadly disease African swine fever (ASF) in both domestic pigs and wild boars. ASF has become endemic in Vietnam since its first appearance in early 2019. Previous research identified specific genetic characteristics of ASFV strains circulating in Vietnam, and this study reports the discovery of a new genetic variant in the intergenic region IV of ASFV in the Vietnamese pig population.
VETERINARY RESEARCH COMMUNICATIONS
(2023)
Article
Infectious Diseases
Germaine L. Minoungou, Mariame Diop, Marthin Dakouo, Abdoul Karim Ouattara, Tirumala Bharani K. Settypalli, Modou M. Lo, Satigui Sidibe, Estelle Kanyala, Yaya Sidi Kone, Moctar Sidi Diallo, Anne Ouedraogo, Kadiatou Coulibaly, Victorine Ouedraogo, Ibrahim Sow, Mamadou Niang, Jenna Elizabeth Achenbach, Abel Wade, Hermann Unger, Adama Diallo, Giovanni Cattoli, Charles Euloge Lamien, Jacques Simpore
Summary: The study revealed genetic diversity of ASFV in Burkina Faso, Mali, and Senegal, with all viruses belonging to genotype I. Different TRS variants were found in the three countries, indicating the need for continuous monitoring of ASFV isolates. Urgent establishment of a regional plan for the control and eradication of ASF in West Africa is emphasized to prevent further spread of the virus.
TRANSBOUNDARY AND EMERGING DISEASES
(2021)
Article
Virology
Ki-Hyun Cho, Da-Young Kim, Min-Kyung Jang, Seong-Keun Hong, Ji-Hyoung Ryu, Hae-Eun Kang, Jee-Yong Park
Summary: A study in South Korea found genetic variations among African swine fever virus strains, with one strain being different from the others. This is important for understanding the spread and control of the virus.
Article
Microbiology
Xianghan Duan, Yuan Wen, Panxue Wu, Jiangling Peng, Yanlong Zhou, Guoqiang Zhu, Dan Li, Yi Ru, Wenping Yang, Haixue Zheng
Summary: African swine fever (ASF) is a severe and highly contagious disease caused by the ASF virus (ASFV) in pigs and wild boars. Understanding the function of ASFV genes is important for developing effective vaccines. The study identified a conserved gene (I329L) and created a recombinant virus with the gene deletion to investigate its function. Transcriptome sequencing was performed and differentially expressed genes were analyzed, providing new insights for ASFV research.
VETERINARY MICROBIOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Thi Hao Vu, Yeojin Hong, Anh Duc Truong, Jiae Lee, Sooyeon Lee, Ki-Duk Song, Jihye Cha, Hoang Vu Dang, Ha Thi Thanh Tran, Hyun S. Lillehoj, Yeong Ho Hong
Summary: In this study, the gene expression related to cytokine-cytokine receptor interactions in resistant and susceptible chickens infected with avian influenza virus was investigated. The results showed that resistant chickens exhibited stronger immune responses and antiviral activity than susceptible chickens against HPAIV infection.
Article
Veterinary Sciences
Ha Thi Thanh Tran, Anh Duc Truong, Anh Kieu Dang, Duc Viet Ly, Nhu Thi Chu, Tuan Van Hoang, Huyen Thi Nguyen, Christopher L. Netherton, Hoang Vu Dang
Summary: The study identified two principal variants of African swine fever virus in Vietnam and developed a sub-grouping method, which may provide insights into the evolution of the virus and the relationship between geographically separated outbreaks.
VETERINARY MEDICINE AND SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Thi Hao Vu, Yeojin Hong, Anh Duc Truong, Sooyeon Lee, Jubi Heo, Hyun S. Lillehoj, Yeong Ho Hong
Summary: Resistant Ri chickens show higher antiviral activity compared to susceptible Ri chickens, and H5N1-infected resistant Ri chickens exhibit immune responses and antiviral activity through the MAPK signaling pathway.
Article
Agriculture, Dairy & Animal Science
Anh Duc Truong, Suyeon Kang, Hoang Vu Dang, Yeojin Hong, Thi Hao Vu, Jubi Heo, Nhu Thi Chu, Huyen Thi Nguyen, Ha Thi Thanh Tran, Yeong Ho Hong
Summary: In this study, 27 differentially expressed miRNAs were identified in the serum of African swine fever virus (ASFV)-infected pigs. These miRNAs were found to be associated with immune response, virus-host interactions, and several viral genes. This study provides important insights into the pathogenesis of ASFV and the host's immune response during an acute infection.
JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Veterinary Sciences
Thi Hao Vu, Jubi Heo, Yeojin Hong, Suyeon Kang, Ha Thi Thanh Tran, Hoang Vu Dang, Anh Duc Truong, Yeong Ho Hong
Summary: Highly pathogenic avian influenza viruses (HPAIVs) have high infectivity and mortality rates in chickens, causing significant economic impact on the poultry sector. This study aimed to elucidate the pathogenic mechanism of HPAIV through gene set enrichment analysis (GSEA) comparing resistant and susceptible chicken lines. The results showed that resistant chickens exhibited stronger antiviral responses to HPAIV infection. This study provides insights into the immune responses of genetically disparate chickens against HPAIV.
JOURNAL OF VETERINARY SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
Anh Duc Truong, Ha Thi Thanh Tran, Huyen Thi Nguyen, Yeong Ho Hong, Hyun S. Lillehoj, Hoang Vu Dang, Ki-Duk Song, Nhu Thi Chu
Summary: This study identified and characterized the chicken interleukin-1 receptor type 2 (chIL-1R2) in chicken immunity. The chIL-1R2 protein can specifically bind to chicken IL-1f3. The expression of chIL-1R2 can be induced by viral infection and regulated through NF-kB/JNK/MEK-mediated signaling pathways.
Article
Agriculture, Dairy & Animal Science
Anh Duc Truong, Ha Thi Thanh Tran, Nhu Thi Chu, Huyen Thi Nguyen, Thi Hao Vu, Yeojin Hong, Ki-Duk Song, Hoang Vu Dang, Yeong Ho Hong
Summary: In this study, 20 FGF genes were identified in chickens and their roles in embryo development and immune responses were investigated. The study revealed interactions between FGF genes and MAPK genes, and their involvement in stimulating signaling pathways and regulating immune responses. The findings provide valuable insights into the functions of FGFs in chickens.
Article
Veterinary Sciences
Anh Tuan Tran, Anh Duc Truong, Dung Thi Kim Nguyen, Hung Tuan Nguyen, Thanh Thuy Nguyen, Ha Thi Thanh Tran, Hoang Vu Dang
Summary: Preliminary information about the LSD virus isolated from the first outbreaks in Vietnam has been reported. The LSDV strain from Vietnam was further analyzed to better understand this viral pathogen. The study found that the LSDV strain caused typical signs of LSD and showed different cytokine profiles in in vitro and in vivo studies, providing important insights into the cellular immune mechanisms against LSDV infection.
VETERINARY RESEARCH COMMUNICATIONS
(2023)
Article
Agriculture, Dairy & Animal Science
Jeong-Woong Park, Marc Ndimukaga, Jaerung So, Sujung Kim, Anh Duc Truong, Ha Thi Thanh Tran, Hoang Vu Dang, Ki-Duk Song
Summary: In this study, the chicken IFI6 gene (chIFI6) was identified and its transcriptional regulation in HPAIV-infected chickens was studied. It was found that the expression of chIFI6 was significantly increased in the lungs, spleens, and tracheas of HPAIV-infected chickens compared to the control group. TLR3 signals were found to regulate the transcription of chIFI6 in chicken cells.
JOURNAL OF ANIMAL SCIENCE AND TECHNOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Sooyeon Lee, Suyeon Kang, Jubi Heo, Yeojin Hong, Thi Hao Vu, Anh Duc Truong, Hyun S. Lillehoj, Yeong Ho Hong
Summary: This study analyzed the miRNA expression profiles in resistant and susceptible lines of Ri chickens infected with HPAI H5N1 virus. The results revealed the potential regulatory roles of miRNAs in the immune response of these chicken lines against HPAI H5N1 virus infection in the lungs.
JOURNAL OF ANIMAL SCIENCE AND TECHNOLOGY
(2023)
Article
Veterinary Sciences
Ha Thi Thanh Tran, Anh Duc Truong, Nhu Thi Chu, Hoai Nam Vu, Huyen Thi Nguyen, Tinh Nguyen, Fatimah Siti, Hans Lee, Alexander De Leon, Andrew G. Yersin, Hoang Vu Dang
Summary: This study investigated the protective role of beta-glucan against African swine fever virus (ASFV) infection in a porcine alveolar macrophage (PAM) model. The results demonstrated that beta-glucan showed immune stimulation against ASFV and protected PAMs against ASFV infection in vitro. Beta-glucan pre-treatment also increased the expression levels of IFN alpha and IL-6, indicating its potential in enhancing host immune responses against ASFV.
OPEN VETERINARY JOURNAL
(2022)
