Article
Oncology
Zhengcheng Liu, Louqian Zhang, Weifeng Tang, Rusong Yang
Summary: Patients undergoing non-intubated uniportal subxiphoid thoracoscopic extended thymectomy had successful outcomes without the need for intubation or thoracotomy. The procedure had short operative time, chest tube duration, and hospital stay. Histologic examination showed early-stage thymomas and there were rare side effects.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Review
Oncology
Mingbo Tang, Yifeng Shao, Junxue Dong, Xinliang Gao, Shixiong Wei, Jianzun Ma, Yang Hong, Zhiqin Li, Taiyu Bi, Yipeng Yin, Wenyu Zhang, Wei Liu
Summary: This study used a meta-analysis to examine the incidence of postoperative myasthenia gravis (PMG) and risk factors in patients with non-MG thymoma. The results showed that the incidence of PMG in preoperative patients with non-MG thymoma was 8%. Preoperative seropositive acetylcholine receptor antibody, open thymectomy, non-R0 resection, WHO type B, and postoperative inflammation were identified as risk factors for PMG.
FRONTIERS IN ONCOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Yuanyuan Liu, Jinghao Zhang, Wenbin Wu, Hui Zhang, Chen Zhao, Miao Zhang
Summary: This study investigated the efficacy of subxiphoid thoracoscopic thymectomy in patients with myasthenia gravis. The results showed that the surgery is technically feasible, but more high-quality evidence is needed to support its use.
INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Jia-Hao Jiang, Jian Gao, Yi Zhang, Hao Wang, Li-Jie Tan, Jian-Yong Ding
Summary: The study explored the feasibility and safety of modified subxiphoid thoracoscopic thymectomy for patients with locally invasive thymomas. The use of an auxiliary sternal retractor during the procedure resulted in good recovery postoperatively without serious complications.
ANNALS OF THORACIC SURGERY
(2021)
Article
Medicine, Research & Experimental
Zhu Haoshuai, Zou Jianyong, Yang Lei, Zeng Bo, Jiefei Xiao, Xin Zhang, Zhenguang Chen, Su Chunhua
Summary: In patients with thymomatous MG undergoing thymectomy, it takes on average 6 months to achieve a 3 point reduction in QMGS and 30 months for another 3 point reduction. Older age (>=42 years) and higher Masaoka-Koga stage (>I) are associated with a lower probability of achieving a reduction in QMGS.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Surgery
Ahmed AL-Bulushi, Issa Al Salmi, Fatma Al Rahbi, AbdulAziz Al Farsi, Suad Hannawi
Summary: This study investigated the epidemiology of patients with myasthenia gravis who underwent thymectomy at the Royal Hospital in Muscat, Oman over the past three decades. The results showed that post-thymectomy, most patients experienced significant clinical improvement, with a small percentage achieving complete clinical remission.
ASIAN JOURNAL OF SURGERY
(2021)
Article
Clinical Neurology
Jinwei Zhang, Peng Zhang, Hui Zhang, Yuantao Cui, Yuan Chen, Peng Lv, Xin Li
Summary: This study retrospectively analyzed the postthymectomy outcomes and factors affecting the prognosis of thymomatous generalized myasthenia gravis (TGMG) in 86 patients. The results showed that male sex and disease duration < 11.5 weeks were independent predictors of complete stable remission (CSR) in TGMG postthymectomy. Patients with onset age < 52.8 years and symptoms of ocular and limb muscle weakness had a higher probability of achieving CSR compared to those with onset age > 52.8 years and symptoms of bulbar muscle weakness. Female sex was an independent predictor of MG symptom exacerbation in TGMG postthymectomy.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Hye Yoon Chung, Ha Young Shin, Young-Chul Choi, Hyung Jun Park, Jin Gu Lee, Chang Young Lee, Byung Jo Park, Gi Jeong Kim, Seung Woo Kim
Summary: This study found that the presence of germinal centers in thymic tissues could be a significant risk factor for the development of myasthenia gravis (MG) after thymoma resection. Even in patients without clinical symptoms of MG, postthymectomy MG should be considered, especially if thymic germinal centers are observed.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Deepak Menon, Hans Katzberg, Carolina Barnett, Prodipto Pal, Andrea Bezjak, Shaf Keshavjee, Vera Bril
Summary: The World Health Organization pathological subtype of thymoma did not correlate with Myasthenia Gravis outcomes. However, positive acetylcholine antibody serology, presence of TFH, and non-recurrence of thymoma predict a favorable outcome.
Editorial Material
Clinical Neurology
Steven Karceski
Summary: The study examines the impact of different surgical approaches on thymectomy in Myasthenia Gravis patients, aiming to determine the most effective method with the lowest risk and highest benefit. Modern surgical techniques, including minimally invasive approaches with robotic assistance, have revolutionized treatment options and outcomes for MG patients. The question of which surgical approach is best for MG may seem simple but entails complex considerations and evaluations.
Article
Genetics & Heredity
Jinwei Zhang, Zeyang Zhang, Hui Zhang, Yuantao Cui, Yuan Chen, Peng Lv, Peng Zhang
Summary: This study aimed to explore the clinical predictors of post-thymectomy OMG prognosis. The study found that RNS-positivity and histotype B2/B3 thymoma were independent predictors of conversion to GMG in OMG patients after thymectomy, while thymic hyperplasia and stage I thymoma predicted CSR.
ORPHANET JOURNAL OF RARE DISEASES
(2022)
Article
Multidisciplinary Sciences
Hiroaki Yoshikawa, Yumi Adachi, Yosikazu Nakamura, Nagato Kuriyama, Hiroyuki Murai, Yoshiko Nomura, Yasunari Sakai, Kazuo Iwasa, Yutaka Furukawa, Satoshi Kuwabara, Makoto Matsui
Summary: This study examined the prevalence and clinical features of myasthenia gravis (MG) in Japan in 2017. The results showed that the prevalence of MG had doubled compared to a previous study in 2006. The onset age of MG shifted towards the elderly, and the male-female ratio became almost equal. The study also categorized patients into four groups and found differences in clinical features and treatment approaches among them.
Article
Cardiac & Cardiovascular Systems
Debora Brascia, Marco Lucchi, Vittorio Aprile, Melania Guida, Roberta Ricciardi, Federico Rea, Giovanni Maria Comacchio, Marco Schiavon, Maria Carlotta Marino, Stefano Margaritora, Elisa Meacci, Gregorio Spagni, Amelia Evoli, Giulia Lorenzoni, Giulia De Iaco, Angela De Palma, Giuseppe Marulli
Summary: This study retrospectively investigated the neurological and surgical outcomes in patients with severe myasthenia gravis (MG) who underwent thymectomy. It was found that thymectomy resulted in good perioperative outcomes and satisfactory long-term neurological improvement, especially in patients younger than 50 years, with MGFA class V and anti-AChR+ MG.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Francesco Guerrera, Pierre Emmanuel Falcoz, Bernhard Moser, Dirk van Raemdonck, Andrea Bille', Alper Toker, Lorenzo Spaggiari, Luca Ampollini, Claudia Filippini, Pascal Alexandre Thomas, Bram Verdonck, Paolo Mendogni, Clemens Aigner, Luca Voltolini, Nuria Novoa, Miriam Patella, Sara Mantovani, Ivan Gomes Bravio, Charalambos Zisis, Angela Guirao, Francesco Londero, Miguel Congregado, Gaetano Rocco, Bert Du Pont, Nicola Martucci, Matthias Esch, Alessandro Brunelli, Frank C. Detterbeck, Federico Venuta, Walter Weder, Enrico Ruffini, Walter Klepetko, Anne Olland, Daisuke Nonaka, Berker Ozkan, Giorgio Lo Iacono, Cesare Braggio, Pier Luigi Filosso, Geoffrey Brioude, Paul van Schil, Mario Nosotti, Daniel Valdivia, Stefano Bongiolatti, Ilhan Inci, Rontogianni Dimitra, David Sanchez, William Grossi, Sergio Moreno-Merino, Martin Teschner
Summary: The study compared the short- and long-term outcomes of simple thymomectomy (ST) versus thymothymectomy (TT) in non-myasthenia gravis (MG) early-stage thymomas. The TT group had significantly better 5-year freedom from recurrence and 5-year overall survival rate compared to the ST group, without an increase in postoperative morbidity rate.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Article
Clinical Neurology
Ahwon Kim, Seok-Jin Choi, Chang Hyun Kang, Seonkyung Lee, Hyoshin Son, Jin-Ah Kim, Je-Young Shin, Sung-Min Kim, Yoon-Ho Hong, Jung-Joon Sung
Summary: This study found that pre- and postoperative levels of anti-acetylcholine receptor antibody (AChR-Ab) are associated with post-thymectomy MG. Additionally, patients who undergo extended thymectomy have a lower risk of post-thymectomy MG, while those with larger thymomas and histological types A or AB according to WHO classification have a higher risk of developing post-thymectomy MG.