Review
Food Science & Technology
Seyed Zachariah Moradi, Faramarz Jalili, Negin Farhadian, Tanuj Joshi, Mingfu Wang, Liang Zou, Hui Cao, Mohammad Hosein Farzaei, Jianbo Xiao
Summary: Neurodegenerative diseases remain a challenge for modern therapeutics, with organ transplantation, stem cell therapy, and other regenerative approaches offering limited solutions. While significant advancements have been made in medical science, the field of neuronal regeneration faces obstacles in fully addressing damaged tissues and neurodegenerative diseases.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Biochemistry & Molecular Biology
Yao Tian, Yuanliangzi Tian, Zhixiao Yuan, Yutian Zeng, Shuai Wang, Xiaolan Fan, Deying Yang, Mingyao Yang
Summary: This review discusses the role of iron metabolism in aging and age-related neurodegenerative diseases, as well as recent developments in using iron chelators as treatment strategies. Understanding iron metabolism is crucial for filling the knowledge gap in this field.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Yelizhati Ruzha, Junjun Ni, Zhenzhen Quan, Hui Li, Hong Qing
Summary: VTN is a multifunctional glycoprotein that plays various physiological roles and is involved in cell attachment, migration, neural differentiation, neurogenesis, and also has neuroprotective effects on the brain. It is associated with the blood-brain barrier and neurodegenerative diseases, although its exact function in these contexts is not fully understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Yi-Hsuan Wu, Hsi-Lung Hsieh
Summary: The heme oxygenase system, particularly HO-1 and HO-2, plays an important role in the nervous system. Dysregulation of HO-1 is associated with neurodegenerative diseases.
Review
Biotechnology & Applied Microbiology
Akram Bardestani, Shiva Ebrahimpour, Ali Esmaeili, Abolghasem Esmaeili
Summary: Iron oxide nanoparticles (IONPs) have been proposed as targeted carriers to deliver therapeutic molecules in the central nervous system (CNS), but they may damage neural tissue. Quercetin (QC) has neuroprotective effects, but poor solubility and low bioavailability have led to the development of QC-involved nanoparticles. Combining quercetin with superparamagnetic iron oxide nanoparticles (QCSPIONs) can improve cognitive dysfunction and promote neurogenesis without toxicity by inhibiting protein aggregation and acting against iron overload.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Sandra Barreiro, Barbara Silva, Solida Long, Madalena Pinto, Fernando Remiao, Emilia Sousa, Renata Silva
Summary: This study suggests that fiscalins have neuroprotective effects against neurodegenerative diseases and potential as new drugs for treatment and prevention.
Review
Biochemistry & Molecular Biology
Rong Liu, Jiahua Yang, Yinghui Li, Junxia Xie, Jun Wang
Summary: This review summarizes the protective and toxic effects of HO-1, its potential mechanism, and its role in neurodegenerative diseases and related drug research.
JOURNAL OF NEUROCHEMISTRY
(2023)
Review
Neurosciences
Taryn E. Murray, Christy M. Richards, Victoria N. Robert-Gostlin, Anna K. Bernath, Ivan A. Lindhout, Andis Klegeris
Summary: Astrocytes, as support cells of the central nervous system, can release diverse molecules that are potentially neurotoxic. Some of these molecules are known to cause damage to surrounding cells and tissues, while further studies are required to confirm the direct neurotoxic effects of others.
BRAIN RESEARCH BULLETIN
(2022)
Review
Medical Laboratory Technology
Jiayin Gao, Qionglin Zhou, Di Wu, Linxi Chen
Summary: Iron is crucial for life, but excess can be toxic. Mitochondria play a central role in iron utilization, and disruption in iron homeostasis can lead to disease development. Understanding iron metabolism is important in addressing various pathologic states.
CLINICA CHIMICA ACTA
(2021)
Review
Cell Biology
Irene Chaves-Coira, Nuria Garcia-Magro, Jonathan Zegarra-Valdivia, Ignacio Torres-Aleman, Angel Nunez
Summary: Aging is a physiological process accompanied by a decline in cognitive performance. The cholinergic neurons of the basal forebrain play a crucial role in cognitive processes and sleep/wakefulness cycle. Investigating the changes in basal forebrain activity during healthy aging is important as it can provide insights into neurodegenerative diseases such as Alzheimer's disease.
Review
Neurosciences
Yingying Ji, Kai Zheng, Shiming Li, Caili Ren, Ying Shen, Lin Tian, Haohao Zhu, Zhenhe Zhou, Ying Jiang
Summary: Ferroptosis, as a newly discovered form of cell death, plays a key role in the occurrence and development of neurodegenerative diseases. However, the underlying mechanism of ferroptosis in these diseases remains unclear, and further research is needed to explore its therapeutic potential.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Plant Sciences
Jie Zheng, Shanshan Hu, Jinxin Wang, Xulan Zhang, Ding Yuan, Changcheng Zhang, Chaoqi Liu, Ting Wang, Zhiyong Zhou
Summary: Icariin improves neuronal degeneration associated with aging and increases the staining of Nissl bodies by upregulating autophagy-related proteins and p-AMPK, and downregulating p-MTOR in aging rats.
PHARMACEUTICAL BIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lucia Bossoni, Ingrid Hegeman-Kleinn, Sjoerd G. van Duinen, Marjolein Bulk, Lena H. P. Vroegindeweij, Janneke G. Langendonk, Lydiane Hirschler, Andrew Webb, Louise Van der Weerd
Summary: The off-resonance saturation method was effective in detecting iron in gray matter structures in postmortem brain tissue, with iron concentrations obtained via this method shown to be in agreement with existing literature. This method can be used to study diseases characterized by brain iron accumulation and complement other iron-sensitive parametric methods.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Review
Cell Biology
Jiancheng Yang, Qinghua Tang, Yuhong Zeng
Summary: Iron overload is a common problem in chronic and common diseases, and melatonin has been found to have iron chelating and antioxidant properties, making it a potential therapy for iron overload-related disorders.
AGEING RESEARCH REVIEWS
(2022)
Review
Biochemistry & Molecular Biology
Anna Cozzi, Paolo Santambrogio, Maddalena Ripamonti, Ermanna Rovida, Sonia Levi
Summary: Neuroferritinopathy is a rare genetic movement disorder characterized by the production of ferritin that cannot properly manage iron, leading to harmful consequences for cells. It shares features with Neurodegeneration with Brain Iron Accumulation and also demonstrates signs of accelerated aging, making it a potentially valuable model for studying aging processes.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Paolo Arosio, Fernando Carmona, Raffaella Gozzelino, Federica Maccarinelli, Maura Poli
BIOCHEMICAL JOURNAL
(2015)
Editorial Material
Pharmacology & Pharmacy
Jaime Kapitulnik
FRONTIERS IN PHARMACOLOGY
(2015)
Review
Biochemistry & Molecular Biology
Raffaella Gozzelino, Paolo Arosio
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2016)
Article
Biochemistry & Molecular Biology
Ana C. Martins, Joana I. Almeida, Illyane S. Lima, Antonino S. Kapitao, Raffaella Gozzelino
Article
Immunology
Rafiou Agoro, Sulayman Benmerzoug, Stephanie Rose, Melanie Bouyer, Raffaella Gozzelino, Irene Garcia, Bernhard Ryffel, Valerie F. J. Quesniaux, Catherine Mura
JOURNAL OF INFECTIOUS DISEASES
(2017)
Review
Biochemistry & Molecular Biology
Raffaella Gozzelino, Miguel P. Soares
ANTIOXIDANTS & REDOX SIGNALING
(2014)
Article
Biochemistry & Molecular Biology
Bahtiyar Yilmaz, Silvia Portugal, Tuan M. Tran, Raffaella Gozzelino, Susana Ramos, Joana Gomes, Ana Regalado, Peter J. Cowan, Anthony J. F. d'Apice, Anita S. Chong, Ogobara K. Doumbo, Boubacar Traore, Peter D. Crompton, Henrique Silveira, Miguel P. Soares
Review
Immunology
Miguel P. Soares, Raffaella Gozzelino, Sebastian Weis
TRENDS IN IMMUNOLOGY
(2014)
Article
Pharmacology & Pharmacy
Carlos Penha-Goncalves, Raffaella Gozzelino, Luciana V. de Moraes
FRONTIERS IN PHARMACOLOGY
(2014)
Article
Multidisciplinary Sciences
Susana Ramos, Ana Rita Carlos, Balamurugan Sundaram, Viktoria Jeney, Ana Ribeiro, Raffaella Gozzelino, Claudia Bank, Erida Gjini, Faouzi Braza, Rui Martins, Temitope Wilson Ademolue, Birte Blankenhaus, Zelia Gouveia, Pedro Faisca, Damian Trujillo, Silvia Cardoso, Sofia Rebelo, Laura del Barrio, Abolfazl Zarjou, Subhashini Bolisetty, Anupam Agarwal, Miguel P. Soares
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Biochemistry & Molecular Biology
Illyane Sofia Lima, Ana Catarina Pego, Joao Tomas Barros, Ana Rita Prada, Raffaella Gozzelino
Summary: There is currently no cure for neurodegenerative diseases like Parkinson's disease. The progression of PD is significantly contributed by apoptosis, necroptosis, and ferroptosis, which may correlate to different disease stages and symptom severities. The efficacy of therapeutic approaches against neuronal death in PD might depend on the death program they target and its relevance to a specific phase of the disease.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Biology
Angelo Ferreira Chora, Dora Pedroso, Eleni Kyriakou, Nadja Pejanovic, Henrique Colaco, Raffaella Gozzelino, Andre Barros, Katharina Willmann, Tiago Velho, Catarina F. Moita, Isa Santos, Pedro Pereira, Silvia Carvalho, Filipa Batalha Martins, Joao A. Ferreira, Sergio Fernandes de Almeida, Vladimir Benes, Josef Anrather, Sebastian Weis, Miguel P. Soares, Arie Geerlof, Jacques Neefjes, Michael Sattler, Ana C. Messias, Ana Neves-Costa, Luis Ferreira Moita, Yousef Abu-Amer
Summary: Anthracyclines, a class of commonly used and effective anticancer drugs, were found to decrease the transcription of NF-kappa B-dependent gene targets and disturb the complexes formed between NF-kappa B subunit RelA and its DNA-binding sites. The anthracycline variants without inducing DNA damage also suppressed inflammation, which has implications for cancer therapy and the development of anti-inflammatory drugs with limited side effects.
Article
Microbiology
Illyane S. Lima, Ana C. Pego, Ana C. Martins, Ana R. Prada, Joao Tomas Barros, Gracelino Martins, Raffaella Gozzelino
Summary: Age-related dysbiosis can lead to sub-chronic inflammation, which primes the brain for neuroinflammation and neurodegenerative diseases. This study confirmed that the effects induced by age-related dysbiosis, rather than aging itself, increase the risk of Parkinson's disease (PD) onset. Germ-free (GF) mice were resistant to PD, but this resistance was reversed when they were colonized with stool from conventional old animals. Changes in gut microbiota composition can be targeted preventively by iron chelators to protect against neuroinflammation and the development of severe PD.
Review
Chemistry, Medicinal
Ana Ferreira, Pedro Neves, Raffaella Gozzelino