Article
Biotechnology & Applied Microbiology
Zhongli Lei, Jie Zhou, Miao Liang, Yan Xiao, Zhihong Liu
Summary: In this study, glutathione stabilized alloy Au/Ag NCs were synthesized for the fluorescence detection of PPi and PPase based on a Zn2+-regulated AIE strategy. This method offers a simple procedure, high sensitivity and stability, and low toxicity. Additionally, the AIE behaviors of the Au/Ag NCs were studied, providing fundamental understanding of the AIE properties of water-soluble alloy NCs and potential for further applications.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Chemistry, Analytical
Xin Zheng, Qiumeng Chen, Zhixiao Zhang, Zhaoli Wang, Zhengjun Gong
Summary: Researchers have designed a fluorescence-enhanced copper nanocluster based on tannic acid templating, which can be used as a new fluorescent probe for tetracycline detection. The modified probe showed good linearity and low detection limit, and demonstrated promising application prospects in actual water samples.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Physical
Ji Zheng, Jia-Nan Wang, Ting Wang, Kun Wu, Rong-Jia Wei, Weigang Lu, Dan Li
Summary: A series of Ag/Au clusters with high-energy phosphorescence have been synthesized, showing tunable luminescence color through the modulation of substituents. These heterometallic clusters exhibit over 23-fold boost in phosphorescence quantum yield compared to their homometallic Ag(I) analogues.
JOURNAL OF PHYSICAL CHEMISTRY C
(2021)
Article
Chemistry, Analytical
Guowen Li, Xiufang Huang, Chifang Peng, Fengxia Sun
Summary: Through optimizing the synthesis of silver nanoclusters (Ag NCs) using DNA templates, it was found that the fluorescence intensity of T base-extended DNA-templated Ag NCs was more than three times higher than C-riched DNA-templated Ag NCs. A turn-off fluorescence sensor based on the brightest DNA-Ag NCs was constructed for the sensitive detection of dimethoate, ethion, and phorate in lake water samples.
Article
Chemistry, Multidisciplinary
Jing Fu, Yujin Miao, Di Zhang, Yongjie Zhang, Luyao Meng, Xinrui Ni, Jinglin Shen, Wei Qi
Summary: Through supramolecular self-assembly strategies, the luminescence intensity of gold nanoclusters stabilized by D-/L-penicillamine (D-/L-AuNCs) was enhanced by poly(allylamine hydrochloride) (PAH), forming macroscopic wheat-shaped superstructures. This study has important theoretical and practical implications for understanding the self-assembly mechanism of nanoclusters and constructing chiroptical materials.
Article
Biophysics
Yi Pan, Xinlin Wei, Xiaodong Guo, Hui Wang, Haiyun Song, Canping Pan, Naifeng Xu
Summary: A dual-model colorimetric/fluorescent immune probe based on Au-Ag NCs and PEI-Au NPs was successfully constructed for rapid and ultrasensitive detection of DICO, with improved sensitivity in ic-ELISA method and a quantitative LOD in LFIA method. The fluorescence signal significantly enhanced the detection sensitivity in ic-ELISA method with a LOD of 0.62 ng/mL, while the fluorescence model detection in LFIA method achieved a quantitative LOD at the level of 1.59 ng/mL.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Analytical
Yafang Sun, Ziping Zhou, Peiwen Peng, Tong Shu, Lei Su, Xueji Zhang
Summary: Gold nanoclusters with versatile optical properties and low cytotoxicity are widely used in biomedical sensing and imaging. Previous studies have focused on acquiring the brightest species of gold nanoclusters, neglecting other types. In this study, a series of gold nanoclusters rich in surface Au(0) were successfully prepared using aged bovine serum albumin (BSA) and pH control during synthesis. It was found that slightly increasing the alkalinity during synthesis generated the darkest gold nanoclusters with strong absorption. The addition of Au3+ quenched the emission of the brightest gold nanoclusters but increased that of the darkest ones. Utilizing this effect, a ratiometric sensor for toxic Au3+ was constructed.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Shuo Liu, Peng Zhang, Yuming Miao, Chenmin Li, Yu-e Shi, Jinhua Liu, Yun-kai Lv, Zhenguang Wang
Summary: A detection platform was developed for the selective and sensitive identification of paraoxon residue in agricultural products. The platform enables quantitative detection with low detection limit and strong tolerance to interference species. These findings not only provide new insights for the functionalization of metal nanoclusters, but also offer an inspiring strategy for analytic techniques in nanomedicine and environmental science.
Article
Chemistry, Physical
Dipankar Bain, Aarti Devi, Sikta Rashi, Sikta Chakraborty, Sarita Kolay, Amitava Patra
Summary: Aggregation-induced emission (AIE) of D-penicillamine-capped Au-14 nanoclusters (NCs) was explored with the introduction of zinc ions. The interaction between the carboxylate groups of penicillamine ligands and zinc ions formed large cross-linked aggregates, leading to significant photoluminescence enhancement. The pH conditions were found to control the photophysical properties of these aggregates. The zinc-induced Au-14 NCs exhibited a 50-fold increase in photoluminescence and were used as a probe for detecting zinc ions.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Review
Chemistry, Multidisciplinary
Tingting Li, Haifeng Zhu, Zhennan Wu
Summary: Aggregation-induced emission (AIE)-type metal nanoclusters (NCs) are a novel type of luminescent metal NCs whose aggregates have shown superior performance compared to individual NCs, and have gained significant attention over the past decade. This article provides a concise overview of the progress made in this field, covering design strategies and applications. The design strategies discussed include solvent-induction, cation-induction, crystallization-induction, pH-induction, ligand inheritance, surface constraint, and minerals- and MOF-confinement. The article also highlights the practical applications of AIE-type metal NCs in areas such as bioimaging, biological diagnosis and therapy, LEDs, detection assays, and circularly polarized luminescence (CPL). The article concludes with viewpoints on the promises and challenges of AIE-type metal NCs and their potential to stimulate new vitality in the field of metal NCs in the future.
Article
Chemistry, Multidisciplinary
Pei Zhou, Nirmal Goswami, Tiankai Chen, Xiaoman Liu, Xin Huang
Summary: The research discusses the relay luminescence enhancement of luminescent Au nanoclusters (Au NCs) through aggregation-induced emission (AIE), as well as the emergence of reduced aggregation-caused luminescence by adjusting the temperature of the Au NC solution. By attaching a thermosensitive polymer on the surface of Au NCs, the optical properties can be manipulated for practical applications.
Article
Chemistry, Analytical
Wang Chen, Xingping Zhang, Qian Zhang, Guohao Zhang, Shixiang Wu, Hualin Yang, Yu Zhou
Summary: A dual-readout immunoassay based on Ce4+ oxidizing TMB and Ce3+ inducing AIE of AuNCs was developed for the detection of OTA in corn samples. The LODs were as low as 0.62 ng/mL for fluorescent assay and 0.81 ng/mL for colorimetric assay, with the recoveries of OTA ranging from 94.4% to 107.7% in the fluorescent mode and 93.7% to 106.9% in the colorimetric mode.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Multidisciplinary
Jin-jin Tian, Dian-dian Deng, Long Wang, Zhao Chen, Shouzhi Pu
Summary: A tetraphenylethene-modified rhodanine derivative was designed and synthesized, exhibiting excellent fluorescence properties and multiple applications such as aggregation-induced emission enhancement, solvatochromic fluorescence effect, reversible mechanochromic fluorescence behavior, and sensitive detection of Hg2+.
FRONTIERS IN CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Yi Zhang, Zhangdi Lu, Anrui Feng, Jacky W. Y. Lam, Zhenguang Wang, Yu-e Shi, Ben Zhong Tang
Summary: Selective fluorescence assay for Al3+ based on green-emissive Cu nanoclusters (Cu NCs) was proposed. Al3+ induces the aggregation of Cu NCs, enhancing the photoluminescence intensity. These results provide new insights for the fluorescence mechanisms and offer a functional luminescent material for various applications.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Analytical
Tingting Pan, Ting Zhou, Yifeng Tu, Jilin Yan
Summary: A fluorescence method for measuring acid phosphatase (ACP) activity was developed in this study. It was found that in a weakly acidic environment, the generation of ascorbic acid enhanced gold nanocluster fluorescence through the reduction of Ce4+ to Ce3+, allowing for linear measurement of ACP activity. The whole analysis process was completed in 1.5 hours with results in good agreement with a reference method, demonstrating the effectiveness of the method.
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)