Article
Clinical Neurology
Karmele Olaciregui Dague, Juri-Alexander Witt, Randi von Wrede, Christoph Helmstaedter, Rainer Surges
Summary: This study retrospectively analyzed the data of 13 patients and found that Deep brain stimulation (DBS) is effective in treating epilepsy, with 54.5% of patients achieving a significant reduction in seizure frequency. However, there were issues with off-target electrode implantation and psychiatric side effects.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Linda J. Dalic, Aaron E. L. Warren, Kristian J. Bulluss, Wesley Thevathasan, Annie Roten, Leonid Churilov, John S. Archer
Summary: In this study, deep brain stimulation to the centromedian thalamic nucleus (CM-DBS) was found to reduce electrographic seizures in patients with Lennox-Gastaut syndrome (LGS), with 50% of participants experiencing a >= 50% reduction in diary-recorded seizures after 3 months of stimulation.
ANNALS OF NEUROLOGY
(2022)
Review
Neurosciences
Ana Carolina P. Campos, Rosana L. Pagano, Nir Lipsman, Clement Hamani
Summary: Treatment-resistant depression (TRD) affects millions of individuals worldwide and deep brain stimulation (DBS) has been proposed as an adjuvant therapy for TRD. The antidepressant efficacy of DBS is still controversial, and its mechanisms of action remain poorly understood. Astrocytes, which play a major role in brain homeostasis, neuroinflammation, and neuroplasticity, may be pivotal in understanding the effects of DBS on TRD.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Neurosciences
Marco Prenassi, Linda Borellini, Tommaso Bocci, Elisa Scola, Sergio Barbieri, Alberto Priori, Roberta Ferrucci, Filippo Cogiamanian, Marco Locatelli, Paolo Rampini, Maurizio Vergari, Stefano Pastore, Bianca Datola, Sara Marceglia
Summary: The presence of post-surgery edema after deep brain stimulation implantation in Parkinson's disease patients is correlated with the quality of local field potential recordings, particularly with the localization of the edema.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Chemistry, Analytical
Elodie Murias Lopes, Ricardo Rego, Manuel Rito, Clara Chamadoira, Duarte Dias, Joao Paulo Silva Cunha
Summary: Deep brain stimulation of the Anterior Nucleus of the Thalamus (ANT-DBS) is an effective therapy in epilepsy, and identifying the DBS-target is crucial for successful outcomes. This study used ANT-LFPs recorded with the Percept (TM) PC neurostimulator to develop machine learning-based methodologies for target identification, achieving promising accuracy rates. Contact 3 on the left hemisphere and contacts 2 and 3 on the right hemisphere showed higher signatures of the ANT-target, providing potential for improved guidance in DBS target identification.
Article
Clinical Neurology
Jan Roediger, Till A. Dembek, Gregor Wenzel, Konstantin Butenko, Andrea A. Kuehn, Andreas Horn
Summary: A data-driven model was developed to suggest optimal stimulation parameters for Parkinson's disease patients undergoing deep brain stimulation treatment, improving motor outcomes while minimizing the risk of side effects caused by stimulation. This approach may provide guidance for future DBS programming.
MOVEMENT DISORDERS
(2022)
Review
Medicine, Research & Experimental
Oskar Puk, Magdalena Jablonska, Pawel Sokal
Summary: This systematic review consolidates findings on the immunological and endocrine effects of Deep Brain Stimulation (DBS) and Spinal Cord Stimulation (SCS), revealing that both these neurostimulation techniques have anti-inflammatory effects by modulating local immune responses. These findings provide a foundation for future research in this field.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Engineering, Biomedical
Wenhao Wu, Jun Zhou, Panling Huang, Chunyang Pan, Zhixiang Huang, Changfeng Xu
Summary: This paper investigates the influence of longitudinal vibration on friction force during needle insertion, and experiments show that vibration can change friction force by affecting the equivalent friction coefficient and the positive pressure of tissue against the needle.
ANNALS OF BIOMEDICAL ENGINEERING
(2021)
Review
Geriatrics & Gerontology
Markey C. Olson, Holly Shill, Francisco Ponce, Sana Aslam
Summary: This systematic review aims to investigate the complications and risk of hospitalization following deep brain stimulation (DBS) surgery, and it is found that when candidates are carefully screened, DBS is a relatively low-risk procedure, but the hospitalization rate is somewhat increased for DBS patients. Further research is needed to determine the relative influence of more advanced disease vs. DBS itself in the increased rate of hospitalization.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Neurosciences
Roxanne Lofredi, Cem-Georg Auernig, Siobhan Ewert, Friederike Irmen, Leon A. Steiner, Ute Scheller, Bernadette C. M. van Wijk, Simon Oxenford, Andrea A. Kuhn, Andreas Horn
Summary: Lead-DBS is a reliable and easy-to-use software tool for precise localization of deep brain stimulation electrodes. This study investigates the differences introduced by different raters and imaging types in the manual refinement process of electrode localization using Lead-DBS. The results show similar outcomes for all users, with an increase in variability when using postoperative MRI and standard space normalization. These findings contribute to the understanding of Lead-DBS and its potential use in formal training and imaging research in the field of deep brain stimulation.
Article
Neurosciences
Joshua K. K. Wong, Helen S. S. Mayberg, Doris D. D. Wang, R. Mark Richardson, Casey H. H. Halpern, Lothar Krinke, Mattia Arlotti, Lorenzo Rossi, Alberto Priori, Sara Marceglia, Ro'ee Gilron, James F. F. Cavanagh, Jack W. W. Judy, Svjetlana Miocinovic, Annaelle D. D. Devergnas, Roy V. V. Sillitoe, Stephanie Cernera, Carina R. R. Oehrn, Aysegul Gunduz, Wayne K. K. Goodman, Erika A. A. Petersen, Helen Bronte-Stewart, Robert S. S. Raike, Mahsa Malekmohammadi, David Greene, Petra Heiden, Huiling Tan, Jens Volkmann, Valerie Voon, Luming Li, Pankaj Sah, Terry Coyne, Peter A. A. Silburn, Cynthia S. S. Kubu, Anna Wexler, Jennifer Chandler, Nicole R. R. Provenza, Sarah R. R. Heilbronner, Marta San Luciano, Christopher J. J. Rozell, Michael D. D. Fox, Coralie de Hemptinne, Jaimie M. M. Henderson, Sameer A. A. Sheth, Michael S. S. Okun
Summary: The Deep Brain Stimulation (DBS) Think Tank X was held in Orlando FL on August 17-19, 2022, with the theme of women in neuromodulation. Dr. Helen Mayberg, the keynote speaker, discussed the development of DBS for depression. The consensus among the speakers was that DBS has expanded in scope but certain indications have faced challenges.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Clinical Neurology
Jimmy C. Yang, Katie L. Bullinger, Faical Isbaine, Abdulrahman Alwaki, Enrico Opri, Jon T. Willie, Robert E. Gross
Summary: CM deep brain stimulation (DBS) shows promise in treating drug-resistant generalized epilepsy and bifrontal epilepsy, with a significant reduction in seizure frequency observed in patients. Further studies are needed to explore the optimal use of CM DBS in different types of epilepsy and its impact on treatment outcomes.
JOURNAL OF NEUROSURGERY
(2022)
Article
Neurosciences
Ro'ee Gilron, Simon Little, Robert Wilt, Randy Perrone, Juan Anso, Philip A. Starr
Summary: Adaptive deep brain stimulation is a promising new technology for treating various diseases, with successful algorithms needing to consider the influence of sleep.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Till A. Dembek, Alexandra Hellerbach, Hannah Jergas, Markus Eichner, Jochen Wirths, Haidar Salimi Dafsari, Michael T. Barbe, Stefan Hunsche, Veerle Visser-Vandewalle, Harald Treuer
Summary: Directional deep brain stimulation (DBS) leads are widely used, but determining their orientation accurately from postoperative CT scans is crucial. An enhanced algorithm based on center of mass shifts of directional markers compared to their expected geometric center was found to be the most reliable method for resolving orientation ambiguity in DBS leads. This DiODe v2 algorithm offers an automated solution for determining the orientation of directional DBS leads.
Review
Neurosciences
Faisal Alosaimi, Jackson Tyler Boonstra, Sonny Tan, Yasin Temel, Ali Jahanshahi
Summary: DBS is a successful paradigm for treating movement disorders, but its specific mechanisms and effects on neurotransmitter dynamics are still not fully understood. This review discusses the role of neurotransmitter dynamics in mediating DBS effects in Parkinson's disease.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Maarten Haemels, Donatienne Van Weehaeghe, Evy Cleeren, Patrick Dupont, Johan van Loon, Tom Theys, Koen Van Laere, Wim Van Paesschen, Karolien Goffin
Summary: The study discovered that increased relative ictal perfusion in the contralateral central region significantly predicted good postoperative outcomes in patients with refractory focal epilepsy.
ACTA NEUROLOGICA BELGICA
(2022)
Review
Clinical Neurology
Birgit Coucke, Lura Van Gerven, Steven De Vleeschouwer, Frank Van Calenbergh, Johannes van Loon, Tom Theys
Summary: Cerebrospinal fluid (CSF) leakage is a major complication after elective neurosurgical procedures, with skull base surgery having the highest rate. Standardized procedures are needed to reduce the incidence of postoperative CSF leakage and its associated healthcare costs.
NEUROSURGICAL REVIEW
(2022)
Article
Clinical Neurology
Levente Hadady, Peter Klivenyi, Daniel Fabo, Sandor Beniczky
Summary: This study evaluated the direct user experience with wearable seizure detection devices in the home environment. The results showed that users were overall satisfied with the device, found it easy to use, and believed that it improved their quality of life. In the home environment, most users experienced seizure detection sensitivity similar to previous validation studies, with a relatively low false alarm rate. The use of the device resulted in a decrease in seizure-related injuries for some patients and improved the accuracy of seizure diaries for the majority. Nonvalidated devices had lower retention rate, satisfaction, sensitivity, and improvement in quality of life compared to validated devices.
Review
Clinical Neurology
Christophe Oosterbos, Thomas Decramer, Sofie Rummens, Frank Weyns, Annie Dubuisson, Jeroen Ceuppens, Sophie Schuind, Justus Groen, Johannes van Loon, Lukas Rasulic, Robin Lemmens, Tom Theys
Summary: The daily management of patients with foot drop due to peroneal nerve entrapment varies between conservative treatment and early surgery, with no high-quality evidence to guide current practice. Ultrasound and MRI have good accuracy in diagnosis, while further research is needed to focus on the role of EDX in prognostication of this condition. No definitive recommendation on the optimal treatment strategy can be made, warranting future randomized controlled trials.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Levente Hadady, Peter Klivenyi, Emilio Perucca, Stefan Rampp, Daniel Fabo, Csaba Bereczki, Guido Rubboli, Ali A. Asadi-Pooya, Michael R. Sperling, Sandor Beniczky
Summary: The study validated that the use of the algorithm recommending ASMs based on individual characteristics is associated with better outcomes compared to using less desirable ASMs, including higher retention rates, higher seizure freedom rates, and fewer discontinuations due to adverse effects. The freely available decision support system proved to be beneficial for healthcare professionals in prescribing medication for individuals with epilepsy.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Editorial Material
Anesthesiology
Steven Smeijers, Kuan Hua Kho, Jan De Vlieger, Anais Van Hoylandt, Bart Nuttin, Tom Theys
Article
Clinical Neurology
Steven Smeijers, Johannes van Loon, Evy Cleeren, Katrien Jansen, Wim van Paesschen, Tom Theys
Summary: This study reviews two rare subtypes of frontal lobe epilepsy, orbitofrontal epilepsy and frontomesial cingulate epilepsy. The authors discuss the anatomical and functional characteristics, as well as the connectivity and electroclinical characterization of these subtypes. Noninvasive and invasive localization concepts, surgical considerations, and outcomes are also discussed. The study emphasizes the importance of early referral to specialized epilepsy surgery centers.
ZEITSCHRIFT FUR EPILEPTOLOGIE
(2022)
Article
Medicine, Research & Experimental
Lisa Goudman, Philippe Rigoard, Maxime Billot, Ann De Smedt, Manuel Roulaud, Maarten Moens
Summary: This study found that it is not possible to distinguish between SCS-naive patients and patients with previous SCS experience based on routine clinical parameters, which has significant implications for research and clinical settings.
Article
Clinical Neurology
Jukka Peltola, Albert A. Colon, Jose Pimentel, Volker Coenen, Antonio Gil-Nagel, Antonio Goncalves Ferreira, Kai S. Lehtimaki, Philippe Ryvlin, Rod Taylor, Linda Ackermans, Jacqueline Ardesch, Carla G. Bentes, Magdalena Bosak, Jorge E. Burneo, Clara Chamadoira, Christian Elger, Lorand Eross, Daniel Fabo, Howard Faulkner, Jacek Gawlowicz, Alireza Gharabaghi, Maurizio Iacoangeli, Jozsef Janszky, Soila H. Jarvenpaa, Elisabeth Kaufmann, Kuan H. Kho, Eva Kumlien, Helmut Laufs, Christian Lettieri, Paulo Linhares, Soheyl Noachtar, Andrew K. Parrent, Ekaterina Pataraia, Nikunj K. Patel, Ana Rita Peralta, Attila Racz, Alexandre Rainha A. Campos, Ricardo Rego, Riccardo Ricciuti, Sabine Rona, Rob P. W. Rouhl, Andreas Schulze-Bonhage, Rick Schuurman, Mathieu Sprengers, Albert Sufianov, Yasin Temel, Tom Theys, Wim Van Paesschen, Dirk Van Roost, Rui Vaz, Kristl Vonck, Louis Wagner, Jack C. Zwemmer, Abdallah Abouihia, Thomas Brionne, Frans Gielen, Paul A. J. M. Boon
Summary: The MORE registry provides real-world evidence that deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) is effective and safe in reducing seizure frequency in patients with drug-resistant epilepsy. The study also suggests that the volume of surgeries performed at the center may affect treatment outcomes.
Article
Clinical Neurology
Vasiliki Bougou, Michael Vanhoyland, Thomas Decramer, Anais Van Hoylandt, Steven Smeijers, Bart Nuttin, Philippe De Vloo, Wim Vandenberghe, Alice Nieuwboer, Peter Janssen, Tom Theys
Summary: This study investigated the neural activity changes during cycling in patients with Parkinson's disease. The results showed that both active and passive cycling caused suppression of beta activity, while active cycling also led to stronger high gamma band activity. Furthermore, patients with freezing of gait exhibited stronger beta suppression during passive cycling.
MOVEMENT DISORDERS
(2023)
Article
Medicine, Research & Experimental
Birgit Coucke, Anais Van Hoylandt, Mark Jorissen, Jeroen Meulemans, Thomas Decramer, Johannes van Loon, Vincent Vander Poorten, Tom Theys, Laura Van Gerven
Summary: This study aims to investigate the use of autologous leukocyte- and platelet-rich fibrin (L-PRF) membranes as an alternative to commercially available fibrin sealants in endoscopic endonasal transsphenoidal approaches (EETA) for skull base reconstruction. The trial will be conducted in three different centers in Belgium, with patients randomized into L-PRF group and commercially available fibrin sealants group. The primary endpoint is postoperative cerebrospinal fluid leakage, and secondary endpoints include identification of risk factors for reconstruction failure, assessment of rhinological symptoms, and interference with postoperative imaging.
Article
Clinical Neurology
Christophe Oosterbos, Lukas Rasulic, Sofie Rummens, Carlotte Kiekens, Johannes van Loon, Robin Lemmens, Tom Theys
Summary: There are significant variations in the treatment strategies for foot drop caused by peroneal nerve entrapment, with decisions primarily based on individual beliefs and experiences of physicians. Non-invasive treatment and neurolysis are commonly used, but the duration of treatment varies greatly. This survey highlights the need for future controlled studies.
Meeting Abstract
Clinical Neurology
A. Billet, A. Boogers, W. Vandenberghe, B. Nuttin, T. Theys, M. Mc Laughlin, P. De Vloo
MOVEMENT DISORDERS
(2022)
Article
Medical Laboratory Technology
Laura Van Hese, Steven De Vleeschouwer, Tom Theys, Emma Lariviere, Lien Solie, Raf Sciot, Tiffany Porta Siegel, Steffen Rex, Ron M. A. Heeren, Eva Cuypers
Summary: This study developed and validated a mass spectrometry-based technique for molecular characterization of high- and low-grade glioma tissue during surgery. The rapid evaporative ionization mass spectrometry (REIMS) technique could differentiate between different glioma subtypes with high accuracy, providing real-time information for intra-operative decision-making.
JOURNAL OF MASS SPECTROMETRY AND ADVANCES IN THE CLINICAL LAB
(2022)
Correction
Clinical Neurology
Birgit Coucke, Laura Van Gerven, Steven De Vleeschouwer, Frank Van Calenbergh, Johannes van Loon, Tom Theys
NEUROSURGICAL REVIEW
(2022)