Article
Chemistry, Multidisciplinary
Fei Peng, Yuqiang Xiang, Hui Wang, Yanjie Hu, Rui Zhou, Yonggang Hu
Summary: Vaccines, especially subunit vaccines, are crucial for defending against infectious diseases. The Bacillus amyloliquefaciens spore@zeolitic imidazolate framework-8 (ZIF-8) vaccine platform, with ovalbumin (OVA) encapsulated in the ZIF-8 shells, shows several advantages and enhances immunization efficacy.
Article
Biotechnology & Applied Microbiology
Feng Guo, Zhonghao Xu, Wendong Zhang, Tongxin Wang, Xiaoxuan Di, Qian Zhang, Zihan Zhu
Summary: Enzymes immobilized in metal-organic frameworks have shown promise as hybrid materials, with the CAT@ZIF-8 composite designed for high enzyme loading, stability, and reusability. The composite exhibited improved enzyme activity and stability compared to free CAT, and displayed excellent reusability for treating wastewater from food processing. The developed CAT@MOF shows potential for efficiently removing H2O2 under harsh conditions.
BIOPROCESS AND BIOSYSTEMS ENGINEERING
(2021)
Article
Biotechnology & Applied Microbiology
Qing Li, Ruixia Feng, Zhaohui Chang, Xiaojun Liu, Hao Tang, Qian Bai
Summary: In this study, superoxide dismutase (SOD) was successfully immobilized in zeolite imidazolate framework-8 (ZIF-8) and formed SOD@ZIF-8. It was found that SOD@ZIF-8 had the ability to eliminate reactive oxygen species (ROS) and protect cells from damage.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Chemistry, Medicinal
Michal G. Nowak, Andrzej S. Skwarecki, Maria J. Milewska
Summary: The structures of many antibacterial, antifungal, or antiprotozoal agents are based on amino acid scaffolds. The amino acid skeleton is crucial for their antimicrobial activity, particularly in the case of aminophosphonate or aminoboronate analogs. The synthesis of amino acid antimicrobials presents a specific challenge, especially in terms of enantioselective methods.
Article
Biotechnology & Applied Microbiology
Siqi Bao, Shuanghui Sun, Lin Li, Lei Xu
Summary: In this study, Ag-TiO2/ZIF-8 material with good environmental friendliness and biological antibacterial activity was prepared by solvothermal method. The structure and morphology of the synthesized material were characterized, and it was found that 20 wt.% Ag-TiO2/ZIF-8 had the best bacteriostatic effect on Escherichia coli and Bacillus subtilis under dark and UV conditions. The excellent antibacterial activity of Ag-TiO2/ZIF-8 is attributed to the synergistic effect of Ag-TiO2 and ZIF-8 under UV light.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Physical
Shixuan Sun, Yong Xiang, Hualong Xu, Meiwen Cao, Daoyong Yu
Summary: ZIF-8 nanozymes were successfully synthesized using non-ionic surfactant Triton X-100, which showed enhanced catalytic activity at high temperature and activity dependence on crystal size.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Chemistry, Medicinal
Eleni Sflakidou, Panayiotis Dalezis, Dimitrios T. Trafalis, Vasiliki Sarli
Summary: Novel steroidal alkylating agents with POPAM-OH demonstrated significant anticancer efficacy and reduced toxicity in vitro and in vivo, making them promising candidates for cancer therapy.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Physical
Eunbi Kim, Ahmad Umar, Sadia Ameen, Rajesh Kumar, Ahmed A. Ibrahim, Mohsen A. M. Alhamami, M. S. Akhtar, Sotirios Baskoutas
Summary: In this study, ZIF-8/GO and ZIF-8/rGO composites were synthesized and characterized for electrochemical sensing of Cu2+ ions. The composites were prepared by dispersing GO or rGO in a solution of Zn(NO3)2·6H2O and 2-methylimidazole in anhydrous methanol. Various techniques were used to investigate the structural, morphological, and chemical properties of the materials. The ZIF-8/GO composite-based Cu2+ ion sensor exhibited superior sensitivity and LOD compared to ZIF-8/rGO and ZIF-8 alone, demonstrating its potential in electrochemical sensing applications.
SURFACES AND INTERFACES
(2023)
Article
Chemistry, Applied
Marta Perez-Miana, Javier U. Resendiz-Ordonez, Joaquin Coronas
Summary: By optimizing parameters and utilizing a hydraulic press at high pressure, ZIFs can be synthesized with high reaction yield. This green, fast and versatile method may provide a possible pathway for future synthesis of other MOFs.
MICROPOROUS AND MESOPOROUS MATERIALS
(2021)
Article
Chemistry, Organic
Gangarajulu Kesavulu, Biguvu Balachandra, Kavirayani R. Prasad
Summary: The use of lithio tris(methylthio)methane as an anion equivalent enables the synthesis of α-amino acids. Reactions with nonracemic sulfinimines yield α-sulfinamido trithioformates with excellent diastereoselectivity. Conversion of trithioformates to diverse functionalities such as α-amino acid thioesters, esters, anilides, amides, and di/tripeptides is achieved without epimerization of chiral centers.
Article
Chemistry, Multidisciplinary
Yufei Wang, Mengke Wang, Xiaoxue Wang, Wenyan Ma, Junxue Liu, Jiyang Li
Summary: Novel and highly efficient peroxidase mimics CDs@Cu-ZIF-8 were designed and prepared by introducing copper ions into non-active ZIF-8 nanocrystals. The synergy of CDs and the Cu-ZIF-8 matrix enhances host-guest electron transfer and accelerates catalytic electron transfer process. CD@Cu-ZIF-8 displays superior peroxidase-like activity and glutathione detection, with a limit of detection of 0.15 μM.
MATERIALS CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Multidisciplinary
Mostafa Roudgar-Amoli, Amin Alizadeh, Ebrahim Abedini, Zahra Shariatinia
Summary: To achieve high-performance DSSCs, new and effective photoelectrode materials, namely CuCoO2 and ZnO, were successfully synthesized through a hydrothermal process and heat treatment of ZIF-8, respectively. The composite heterostructures of CuCoO2/ZnO demonstrated improved photovoltaic properties, making them promising photoanodes for DSSCs. The physicochemical characteristics and photovoltaic performance of the fabricated materials were thoroughly studied and discussed. CuCoO2/ZnO (0.1 : 1) showed the best performance among all cells, with a PCE of 6.27% and enhanced Voc, Jsc, FF, and IPCE.
Article
Environmental Sciences
Xu Song, Jingqian Mo, Yuting Fang, Shumin Luo, Jingjing Xu, Xu Wang
Summary: We prepared a double-layer magnetic nanocomposite Fe3O4@ZIF-8@ZIF-67 by layer-by-layer self-assembly, and used it for the removal of tetracycline from water. The Fe3O4@ZIF-8@ZIF-67 demonstrated a high adsorption capacity and removal efficiency for tetracycline due to its outstanding porous structure. Advanced characterization techniques confirmed the adsorption and oxidation mechanisms involved.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemical Research Methods
Weiwei Liu, Farouk Semcheddine, Hui Jiang, Xuemei Wang
Summary: In this study, a multifunctional nanocomposite was successfully synthesized, which could efficiently load an anticancer drug and had excellent cell imaging and photothermal functions. After modification with folic acid, the composite material could target tumor cells and showed a highly effective inhibitory effect against various tumor cells through a chemo-photothermal synergistic effect.
BIOCONJUGATE CHEMISTRY
(2022)
Article
Engineering, Chemical
Mahmood Zarak, Saleem Atif, Xiaoting Meng, Miao Tian
Summary: This study demonstrates an interfacial design strategy to disperse TiO2@ZIF-8 composites into a thin-film composite (TFC) membrane, improving the polymer-filler compatibility and mass transfer coefficient, and enhancing the mechanical stability and mass transfer efficiency of the membrane.
CHEMICAL ENGINEERING RESEARCH & DESIGN
(2022)
Article
Chemistry, Physical
Jianping Liang, Jie Zeng, Xiaojuan Huang, Tengteng Zhu, Yonglong Gong, Chen Dong, Xiangrong Wang, Lingzhi Zhao, Lei Xie, Kang Liang, Qiongxiang Tan, Yali Cui, Biao Kong, Wenli Hui
Summary: With the increasing global threat of diseases and infections, the development of a fast, low-cost, and easy-to-use point-of-care testing system is essential. This study proposes a rapid visual detection method that integrates loop-mediated isothermal amplification and lateral flow assay for various analytes. The method does not require DNA extraction and prevents false positive results. The whole detection process can be completed within 25 minutes, and the accuracy is measured using the polymorphisms of methylenetetrahydrofolate reductase.
Review
Chemistry, Multidisciplinary
Joel Yong, Albert S. S. Mellick, John Whitelock, Joseph Wang, Kang Liang
Summary: The application of nanomotors for cancer diagnosis and therapy combined with precision nanomedicine offers a promising solution to the issues encountered in passive nanoparticle development. This article aims to provide nanomotor and nanomedicine researchers with a comprehensive understanding of cancer cell biology, biochemistry, cell membrane compositions, and extracellular surfaces. The review includes an overview of the state-of-the-art nanomotors for cancer therapy and diagnosis, recommendations for future research directions, and a biomolecular targeting toolbox for selecting targeting molecules and cell surface targets. It is hoped that this review will inspire and guide future nanomotor and nanomedicine research.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Qianyi Zhang, Jieying Liang, Andre Bongers, Joseph J. Richardson, Kang Liang, Zi Gu
Summary: The researchers propose a facile and generalizable film-coating method using zeolitic imidazole framework-8 (ZIF-8) to immobilize antibodies on various nanoparticles for enhanced cell targeting. This method allows efficient assembly of different model and therapeutic antibodies on nanoparticles via biomineralized film-coating, resulting in high antibody loading and targeting efficiencies. The antibodies selectively bind to ZIF-8 via their Fc regions, exposing the functional Fab regions to the biological target and improving the cell targeting ability of antibody-coated nanoparticles.
Article
Nanoscience & Nanotechnology
Napatsakorn Kamkrua, Thitaphat Ngernsutivorakul, Saksorn Limwichean, Pitak Eiamchai, Chanonthorn Chananonnawathorn, Viyapol Pattanasetthakul, Raffaele Ricco, Kiattawee Choowongkomon, Mati Horprathum, Noppadon Nuntawong, Tanujjal Bora, Raju Botta
Summary: In this study, a SERS-based aptasensor platform was developed for the sensitive and selective detection of the herbicide paraquat (PQ) by modifying gold (Au) nanoparticle SERS substrates with a thiol-containing aptamer. The aptamer-modified SERS substrates showed improved sensitivity and selective detection of PQ, with a limit of detection estimated to be 0.10 ± 0.03 μM. The developed aptasensor platform demonstrated good stability and selectivity against interferences from other similar herbicides and insecticides in natural water samples.
ACS APPLIED NANO MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Jie Zhang, Zhishang Li, Qi Zhang, Lin Zhang, Tongtong Ma, Xinyue Ma, Kang Liang, Yibin Ying, Yingchun Fu
Summary: In this study, a unique nanolaminate film consisting of MXene nanosheets intercalated with MOF nanoparticles was developed. The intercalation of MOFs created nanochannels between MXene nanosheets, promoting fast water permeance. The film integrated size exclusion and selective adsorption mechanisms, enabling a rapid and selective liquid phase separation paradigm that performs simultaneous multiple chemicals and nanoparticles sieving.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Jieying Liang, Juanfang Ruan, Bosiljka Njegic, Aditya Rawal, Jason Scott, Jiangtao Xu, Cyrille Boyer, Kang Liang
Summary: Selecting an appropriate support material for enzyme immobilization is crucial in the development of functional biosystems. Covalent-organic frameworks (COFs) with metal-free and highly stable properties are found to be ideal supports. COF-LZU1, among three COFs developed in this study, is found to retain the highest activity when horseradish peroxidase (HRP) is incorporated. The structural analysis reveals that COF-LZU1 has the weakest interaction with the hydrated enzyme, easiest accessibility to the substrate, and optimal conformation of enzyme, which promote the bioactivity of HRP-COF-LZU1. COF-LZU1 also serves as a versatile nanoplatform for encapsulating multiple enzymes, providing superior protection under harsh conditions and during recycling. The understanding of interfacial interactions, substrate diffusion, and enzyme conformation alteration within COF matrices opens up possibilities for designing ideal biocatalysts and broad applications of these nanosystems.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Multidisciplinary Sciences
Ruoxin Wang, Jianhao Qian, Xiaofang Chen, Ze-Xian Low, Yu Chen, Hongyu Ma, Heng-An Wu, Cara M. Doherty, Durga Acharya, Zongli Xie, Matthew R. Hill, Wei Shen, Fengchao Wang, Huanting Wang
Summary: Engineering heterostructured membranes using different two-dimensional materials is an effective way to design membranes for selective gas molecule transport. In this study, a simple and versatile pyro-layering approach was developed to fabricate heterostructured membranes using boron nitride nanosheets as the scaffold and graphene nanosheets derived from a chitosan precursor as the filler. The rearrangement of graphene nanosheets during the pyro-layering treatment formed precise nanochannels and spacing, enabling selective hydrogen transport.
NATURE COMMUNICATIONS
(2023)
Article
Nanoscience & Nanotechnology
Peiji Deng, Yixian Liu, Yunliang Liu, Yaxi Li, Ruqiang Wu, Lijun Meng, Kang Liang, Yixiang Gan, Fen Qiao, Naiyun Liu, Zhenhui Kang, Haitao Li
Summary: In this study, a leaf-like MOF-derived Ni/Zn bimetallic co-doped nitrogen-coordinated porous carbon (Ni/Zn-NPC) was developed as an efficient electrocatalyst for NH3 synthesis. The resulting electrocatalyst achieved a high ammonia production rate under mild reaction conditions and exhibited excellent stability after microwave treatment.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Xin Zhang, Shan Zhou, Lei Xie, Hui Zeng, Tianyi Liu, Yanan Huang, Miao Yan, Qirui Liang, Kang Liang, Lei Jiang, Biao Kong
Summary: Light-controlled nanochannels composed of 4-aminothiophenol and gold nanoparticles-modified mesoporous titania nanopillar arrays and alumina oxide (4-ATP-Au-MTI/AAO) are fabricated by the interfacial super-assembly strategy. Under illumination, the wettability of the nanochannel changes, resulting in a significant improvement of the photoresponsive current. This work opens a new route for the fabrication of high-performance light-controlled nanochannels by coupling light-responsive materials and light-responsive molecules.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biochemical Research Methods
Joel Yong, Karen Hakobyan, Jiangtao Xu, Albert S. S. Mellick, John Whitelock, Kang Liang
Summary: The use of metal-organic frameworks (MOFs) as delivery systems for biologically functional macromolecules has been widely explored. Optimizing encapsulation efficiency is important for different biological applications. In this study, protein quantitation methods were compared to assess the encapsulation efficiency of ZIF-8 MOFs for bovine serum albumin (BSA) and catalase (CAT). Variances were observed among the methods, with fluorometric quantitation providing the most consistent results. BCA and Bradford assays were sensitive to background interference from the MOF linker 2-methylimidazole.
BIOTECHNOLOGY JOURNAL
(2023)
Article
Environmental Sciences
Jieying Liang, Kang Liang
Summary: Micropollutant contamination and global warming are urgent environmental issues. Traditional technologies face challenges in efficiency and selectivity. Nanobiohybrids, combining nanomaterials and biosystems, have emerged as eco-friendly technologies. They show excellent performance in micropollutant removal, carbon dioxide conversion, and sensing of toxic ions and organic micropollutants.
ENVIRONMENTAL RESEARCH
(2023)
Article
Chemistry, Physical
Azra Sourjah, Colin S. M. Kang, Cara M. Doherty, Durga Acharya, Luke A. O'Dell, Jennifer M. Pringle
Summary: This study reports on a new type of organic ionic plastic crystal (OIPC) based on morpholinium, and investigates the effects of cation and anion choice on the electrolyte properties. The results show significant differences in phase transition temperature, conductivity, and vacancy volume for different morpholinium-based OIPCs. These insights are important for developing new electrolytes with optimized thermal and transport properties for clean energy applications.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Chemistry, Multidisciplinary
Jueyi Xue, Mengnan Zhang, Joel Yong, Qianfan Chen, Joseph Wang, Jiangtao Xu, Kang Liang
Summary: This study reports a biocatalytic nanomotor based on a covalent-organic framework (COF) that exhibits intelligent and switchable motion triggered by a blue-to-red light switch. The nanomotor enhances contaminant removal in aqueous solutions when exposed to blue light, but deactivates its motion and contaminant removal under red light. The study explores the assembly strategy of the COF-based nanomotor and its light-controlled propulsion performance, providing insights for the design and practical applications of nanomotors.
Article
Engineering, Chemical
Muhammad Yazid Bin Zulkifli, Ruiqi Chen, Rijia Lin, Yuqi Yao, Milton Chai, Dominique Appadoo, Wupeng Wang, Zhonghua Zhu, Kang Liang, Vicki Chen, Jingwei Hou
Summary: This research explores the impact of silver ions on the properties of ZIF-62 glass, revealing their influence on phase conversion and gas separation selectivity. The findings provide valuable insights for composite integration and highlight the potential of AgZIF-62 glass in gas separation applications.
Article
Chemistry, Physical
Matthew E. Potter, Alice E. Oakley, Joshua J. M. Le Brocq, Lauren N. Riley, Marina Carravetta, Stephen M. King, Cara M. Doherty, Bart D. Vandegehuchte, Robert Raja
Summary: In this study, hierarchical solid-acid zeotypes were synthesized by modifying traditional synthetic procedures and adding a hydrocarbon surfactant. Small angle neutron scattering, positron annihilation lifetime spectroscopy, and porosimetry were used to qualitatively describe the porosity and investigate the connectivity of micropores and mesopores in the hierarchical materials. By varying the quantity of the mesoporogen, the size and nature of the mesopores could be finely tuned. Catalytic studies revealed distinct acid sites in the micropores and weaker silanol groups lining the mesopores, influencing the catalytic performance in n-butane isomerization and ethanol dehydration reactions.
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
Article
Chemistry, Multidisciplinary
Abu Talha Aqueel Ahmed, Sankar Sekar, Shubhangi S. Khadtare, Nurul Taufiqu Rochman, Bathula Chinna, Abu Saad Ansari
Summary: In this study, MnCo2S4 nanosheet catalyst was successfully synthesized and found to exhibit superior performance in hydrogen evolution. Compared to MnCo2S4, MnCo2S4 showed low overpotentials, moderate Tafel slope, and excellent sustainability. The outstanding performance can be attributed to the increased number of electrochemically active sites and enhanced electronic conductivity on the catalyst surface.
Article
Chemistry, Multidisciplinary
Victor V. Maltsev, Elena A. Volkova, Elizaveta V. Koporulina, Diana D. Mitina, Vladimir L. Kosorukov, Anna I. Jiliaeva, Daniil A. Naprasnikov, Konstantin N. Gorbachenya, Viktor E. Kisel
Summary: The phase relationships, crystal properties and luminescence kinetics of two complex systems were studied, including unit cell parameters, segregation coefficients of impurities, and lifetimes of energy levels.
Article
Chemistry, Multidisciplinary
Xiaoman Zhang, Wangwang Xu, W. J. Meng, Andrew C. Meng
Summary: This study successfully grew high-quality single crystal AlScN nanowires through ultra-high vacuum reactive sputtering technique and characterized their structure and properties. The nanowires exhibit significantly reduced mosaic spread and predominantly single ferroelectric domains, as well as a high piezoelectric constant.
Article
Chemistry, Multidisciplinary
Tom E. de Vries, Elias Vlieg, Rene de Gelder
Summary: Networks are important for describing relationships between people, roads between cities, reactions between chemicals, and other interactions. Bipartiteness, dividing the network into two groups, can facilitate the study of the network's structure. We have developed an algorithm that can find a near-optimal bipartisation within a reasonable time frame and used it to uncover the hidden structure of the CSD cocrystal network.
Article
Chemistry, Multidisciplinary
Chuchu Han, Jing Yang, Xin Zhang, Aisen Li, Jiang Peng
Summary: An elastic crystal based on a photo-reactive acylhydrazone derivative is reported, which exhibits reversible bending behavior under UV irradiation and heating. The crystal undergoes reversible E<->Z isomerization under light and heating conditions. The crystal demonstrates excellent elastic properties and the bending can be controlled to control the output direction of red light.
Article
Chemistry, Multidisciplinary
Lingfeng Zhang, Yu Wang, Yefeng Wang, Shuai Liu, Na Zhang, Mingmin Yang, Haixia Ma, Zhaoqi Guo
Summary: This study designs and synthesizes a series of high-energy salts compounds without heavy metal ions and azide groups. The molecular structures and stability of the compounds are confirmed through single-crystal X-ray diffraction and intermolecular interaction analysis. Furthermore, the thermal stability, energetic properties, and electrical initiation properties of the compounds are investigated, suggesting their potential as primary explosives.
