期刊
SCIENCE OF THE TOTAL ENVIRONMENT
卷 762, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.scitotenv.2020.143106
关键词
In vitro fertilization and embryo transfer; Rare earth elements; Lanthanum; Spontaneous abortion; Reproductive toxicity
资金
- National Natural Science Foundation of China [42077390, 82071715, 41771527, 81673177]
- Capital Clinical Medical Application and Development Funds from Beijing Municipal Science and Technology Commission, China [Z181100001718132]
This study investigated the association between light rare earth elements exposure and in vitro fertilization-embryo transfer outcomes, finding that higher serum lanthanum concentration was linked to increased risks of clinical pregnancy failure and preclinical spontaneous abortion. The study suggests that a high serum lanthanum concentration may negatively impact IVF-ET outcomes.
The adverse health effects of rare earth elements (REEs) on reproductive health remain a subject of debate, and few clinical observations are available. This study investigated the association between light REEs (LREEs) exposure and the outcome of in vitro fertilization-embryo transfer (IVF-ET). We recruited a total of 305 women undergoing IVF-ET in Beijing City and Shandong Province of northern China. Their demographic information and lifestyle characteristics were collected using questionnaires at enrollment. Fasting blood samples were collected on the day before the IVF-ET treatment cycle began. Serum concentrations of the LREEs of concernwere analyzed using inductively coupled plasma-mass spectrometry, and four LREEs were measured with a high detection rate, including lanthanum (La), cerium (Ce), praseodymium (Pr), and neodymium (Nd). We found that a higher serum La concentration was associated with a 30% increased likelihood of clinical pregnancy failure [relative risk (RR)= 1.30, 95% confidence interval (CI): 1.00-1.67] and a 230% increased likelihood of preclinical spontaneous abortion (RR = 3.30, 95% CI: 1.57-6.94). Therewas a negative correlation between serum La concentration and the number of good-quality oocytes. For the other LREEs, no statistically significant associations were observed. We concluded that a high serum La concentration may have an adverse effect on IVF-ET outcomes. (C) 2020 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据